SUSQUEHANNA INTERNATIONAL GROUP, LLP
Position in SPRO — Spero Therapeutics, Inc.
CIK 1446194
BALA CYNWYD, PA
Position in SPRO
as of Jun 30, 2026
· filed Aug 14, 2026
Position Value
$1,678,030
+$898,542 QoQ
Shares Held
759,290
+127.9% QoQ
Ownership
1.30%
of shares outstanding
% of Portfolio
0.00%
of 13F equity value
Holder Rank
#6
of 59 holders
Holding Since
Jun 2020
24 quarters on record
Voting authority
Sole 100%
Shared 0%
None 0%
Common Shares in SPRO Over Time
Shares Held
Position Value (USD)
Derivatives in SPRO
reported options exposure · as of Jun 30, 2026CallValue
$30,277
CallShares
13,700
PutValue
$76,466
PutShares
34,600
Notional value of option positions as reported on Form 13F. Calls and puts are disclosed separately and do not net against the common-share stake above.
Position in Biotechnology
Healthcare · as of Jun 30, 2026SUSQUEHANNA INTERNATIONAL GROUP, LLP holds $1,653,301,875 across 349 Biotechnology names. SPRO ranks #91 (0.1% of the industry book) .
| # | Ticker | Company | Shares | Value (USD) | Open |
|---|---|---|---|---|---|
| 1 | ABVX |
Abivax S.A.
|
1,053,896 | $140,442,180 | |
| 2 | CYTK |
Cytokinetics Inc
|
1,549,458 | $131,998,327 | |
| 3 | REGN |
Regeneron Pharmaceuticals, Inc.
|
180,219 | $112,373,755 | |
| 4 | ALNY |
Alnylam Pharmaceuticals, Inc.
|
294,460 | $88,641,293 | |
| 5 | MDGL |
Madrigal Pharmaceuticals, Inc.
|
148,610 | $79,796,139 | |
| 6 | INSM |
INSMED Inc
|
729,354 | $77,763,723 | |
| 7 | VRTX |
Vertex Pharmaceuticals Inc / Ma
|
144,174 | $71,615,550 | |
| 8 | AGIO |
Agios Pharmaceuticals, Inc.
|
1,375,558 | $51,046,957 |
All Filings in SPRO
Export CSV
43 filing rows on record
| Report Date | Value (USD) | Shares | Type | Discretion | Filed | |
|---|---|---|---|---|---|---|
| 2026-06-30 | $30,277 | 13,700 | Call | Other | 2026-08-14 | |
| 2026-06-30 | $1,678,030 | 759,290 | Shares | Other | 2026-08-14 | |
| 2026-06-30 | $76,466 | 34,600 | Put | Other | 2026-08-14 | |
| 2026-03-31 | $113,490 | 48,500 | Put | Other | 2026-05-15 | |
| 2026-03-31 | $779,488 | 333,115 | Shares | Other | 2026-05-15 | |
| 2025-12-31 | $684,321 | 293,700 | Shares | Other | 2026-02-17 | |
| 2025-09-30 | $20,492 | 10,900 | Put | Other | 2025-11-14 | |
| 2025-06-30 | $141,230 | 48,700 | Put | Other | 2025-08-14 | |
| 2025-06-30 | $202,460 | 69,814 | Shares | Other | 2025-08-14 | |
| 2024-12-31 | $30,647 | 29,755 | Shares | Other | 2025-02-14 | |
| 2024-09-30 | $59,253 | 44,219 | Shares | Defined | 2024-11-14 | |
| 2024-06-30 | $29,994 | 23,073 | Shares | Defined | 2024-08-15 | |
| 2024-03-31 | $33,712 | 19,600 | Call | Defined | 2024-05-07 | |
| 2023-12-31 | $26,586 | 18,086 | Shares | Defined | 2024-02-14 | |
| 2023-09-30 | $24,421 | 20,183 | Shares | Defined | 2023-11-14 | |
| 2023-06-30 | $64,320 | 44,359 | Shares | Defined | 2023-08-11 | |
| 2023-03-31 | $38,488 | 26,544 | Shares | Defined | 2023-05-16 | |
| 2022-12-31 | $39,271 | 22,700 | Put | Defined | 2023-02-14 | |
| 2022-12-31 | $112,623 | 65,100 | Call | Defined | 2023-02-14 | |
| 2022-12-31 | $87,622 | 50,649 | Shares | Defined | 2023-02-14 | |
| 2022-09-30 | $138,572 | 69,286 | Shares | Defined | 2022-11-14 | |
| 2022-09-30 | $55,600 | 27,800 | Call | Defined | 2022-11-14 | |
| 2022-09-30 | $247,800 | 123,900 | Put | Defined | 2022-11-14 | |
| 2022-06-30 | $40,121 | 54,145 | Shares | Defined | 2022-08-15 | |
| 2022-03-31 | $583,630 | 67,084 | Shares | Defined | 2022-05-16 | |
| 2021-12-31 | $240,150 | 15,000 | Put | Defined | 2022-04-05 | |
| 2021-12-31 | $1,203,679 | 75,183 | Shares | Defined | 2022-04-05 | |
| 2021-12-31 | $376,235 | 23,500 | Call | Defined | 2022-04-05 | |
| 2021-09-30 | $745,605 | 40,500 | Call | Defined | 2021-11-15 | |
| 2021-09-30 | $731,760 | 39,748 | Shares | Defined | 2021-11-15 | |
| 2021-09-30 | $616,735 | 33,500 | Put | Defined | 2021-11-15 | |
| 2021-06-30 | $339,228 | 24,300 | Put | Defined | 2021-08-11 | |
| 2021-06-30 | $410,424 | 29,400 | Call | Defined | 2021-08-11 | |
| 2021-06-30 | $578,753 | 41,458 | Shares | Defined | 2021-08-11 | |
| 2021-03-31 | $241,408 | 16,400 | Call | Defined | 2021-05-17 | |
| 2021-03-31 | $775,744 | 52,700 | Put | Defined | 2021-05-17 | |
| 2021-03-31 | $1,018,373 | 69,183 | Shares | Defined | 2021-05-17 | |
| 2020-12-31 | $519,652 | 26,800 | Call | Defined | 2021-02-16 | |
| 2020-12-31 | $1,436,372 | 74,078 | Shares | Defined | 2021-02-16 | |
| 2020-12-31 | $763,966 | 39,400 | Put | Defined | 2021-02-16 | |
| 2020-09-30 | $302,436 | 27,100 | Put | Defined | 2020-11-16 | |
| 2020-09-30 | $640,673 | 57,408 | Shares | Defined | 2020-11-16 | |
| 2020-06-30 | $544,582 | 40,250 | Shares | Defined | 2020-08-14 | |
| No filing history on record for this holder in this stock. | ||||||