Stocks
SPRO Spero Therapeutics, Inc.

SPRO

Spero Therapeutics, Inc.

Company with tickers: SPRO

CIK

1701108

CUSIP

84833T103

Shares Outstanding

57,901,493

Price History Institutional Holders Short Volume Short Interest Fails to Deliver SEC Filings Earnings Calls Insider Trades Congressional Trades

Date	Insider	Role	Type	Shares	Price	Value	After
2026-05-04	Rajavelu Esther	See Remarks	Sell	25,240	$2.51	$63,352	986,851
2026-02-06	Rajavelu Esther	See Remarks	Sell	37,101	$2.36	$87,558	1,062,907
2026-02-06	Rajavelu Esther	See Remarks	Sell	50,816	$2.36	$119,926	1,012,091
2026-02-06	Keutzer Timothy	Chief Operating Officer	Sell	18,652	$2.36	$44,019	742,506
2026-02-04	Keutzer Timothy	Chief Operating Officer	Sell	3,471	$2.24	$7,775	761,158
2026-02-03	Keutzer Timothy	Chief Operating Officer	Sell	24,224	$2.14	$51,839	764,629
2026-02-02	Keutzer Timothy	Chief Operating Officer	Award	68,000	—	—	807,744
2026-02-02	Keutzer Timothy	Chief Operating Officer	Sell	18,891	$2.20	$41,560	788,853
2026-02-02	Keutzer Timothy	Chief Operating Officer	Award	137,000	—	—	137,000
2026-02-02	Rajavelu Esther	See Remarks	Award	498,000	—	—	498,000
2026-02-02	Rajavelu Esther	See Remarks	Sell	18,442	$2.20	$40,572	1,100,008
2026-02-02	Rajavelu Esther	See Remarks	Award	249,000	—	—	1,118,450
2025-11-07	Rajavelu Esther	See Remarks	Sell	40,270	$2.37	$95,440	869,450
2025-08-28	Keutzer Timothy	Chief Operating Officer	Sell	1,695	$1.97	$3,339	739,744
2025-08-28	Mahadevia Ankit	Director	Sell	6,572	$1.97	$12,947	703,294
2025-06-12	Mahadevia Ankit	Director	Award	20,000	—	—	709,866
2025-06-12	Jackson Scott Thomas	Director	Award	20,000	—	—	75,000
2025-06-12	Tregoning Kathleen	Director	Award	20,000	—	—	75,000
2025-06-12	Deshpande Milind	Director	Award	20,000	—	—	91,454
2025-06-12	VINK PATRICK V.J.J.	Director	Award	20,000	—	—	75,000
2025-06-12	Smith Cynthia	Director	Award	20,000	—	—	75,000
2025-06-12	Pottage John C Jr	Director	Award	20,000	—	—	75,000
2025-06-12	THOMAS FRANK E	Director	Award	20,000	—	—	75,000
2025-05-02	Rajavelu Esther	See Remarks	Award	185,000	—	—	909,720
2025-02-05	Keutzer Timothy	Chief Operating Officer	Sell	27,643	$0.78	$21,562	766,359
2025-02-05	Keutzer Timothy	Chief Operating Officer	Sell	24,920	$0.78	$19,438	741,439
2025-02-05	Keutzer Timothy	Chief Operating Officer	Sell	3,974	$0.78	$3,100	794,002
2025-02-05	Shukla Sath	EVP, Chief Financial Officer	Sell	6,139	$0.78	$4,788	1,886,077
2025-02-05	Shukla Sath	EVP, Chief Financial Officer	Sell	106,408	$0.78	$82,998	1,736,883
2025-02-05	Shukla Sath	EVP, Chief Financial Officer	Sell	42,786	$0.78	$33,373	1,843,291
2025-02-05	Mahadevia Ankit	Director	Sell	13,959	$0.78	$10,888	745,126
2025-02-05	Mahadevia Ankit	Director	Sell	55,260	$0.78	$43,103	689,866
2025-02-05	Rajavelu Esther	See Remarks	Sell	20,689	$0.78	$16,137	724,720
2025-02-03	Keutzer Timothy	Chief Operating Officer	Award	266,139	—	—	797,976
2025-02-03	Shukla Sath	EVP, Chief Financial Officer	Award	751,407	—	—	1,892,216
2025-02-03	Rajavelu Esther	See Remarks	Award	266,139	—	—	645,409
2025-02-03	Rajavelu Esther	See Remarks	Award	100,000	—	—	745,409
2024-11-08	Rajavelu Esther	See Remarks	Sell	17,245	$1.30	$22,419	379,270
2024-11-07	Rajavelu Esther	See Remarks	Sell	23,351	$1.31	$30,590	396,515
2024-08-27	Keutzer Timothy	Chief Operating Officer	Sell	2,213	$1.35	$2,988	531,837
2024-08-27	Mahadevia Ankit	Director	Sell	5,912	$1.35	$7,981	759,085
2024-08-27	Shukla Sath	EVP, Chief Financial Officer	Sell	2,757	$1.35	$3,722	1,140,809
2024-08-05	Shukla Sath	EVP, Chief Financial Officer	Sell	17,641	$1.31	$23,110	1,143,566
2024-08-02	Shukla Sath	EVP, Chief Financial Officer	Sell	14,800	$1.32	$19,536	1,161,207
2024-05-29	Tregoning Kathleen	Director	Award	20,000	—	—	55,000
2024-05-29	THOMAS FRANK E	Director	Award	20,000	—	—	55,000
2024-05-29	Jackson Scott Thomas	Director	Award	20,000	—	—	55,000
2024-05-29	VINK PATRICK V.J.J.	Director	Award	20,000	—	—	55,000
2024-05-29	Deshpande Milind	Director	Award	20,000	—	—	71,454
2024-05-29	Mahadevia Ankit	Director	Award	20,000	—	—	764,997
2024-05-29	Smith Cynthia	Director	Award	20,000	—	—	55,000
2024-05-29	Pottage John C Jr	Director	Award	20,000	—	—	55,000
2024-02-05	Shukla Sath	EVP, Chief Financial Officer	Sell	45,093	$1.45	$65,385	1,176,007
2024-02-02	HAMED KAMAL	Chief Medical Officer	Sell	28,075	$1.37	$38,463	788,117
2024-02-02	Keutzer Timothy	Chief Operating Officer	Sell	30,971	$1.36	$42,121	534,050
2024-02-02	JOSEPH TAMARA L	Chief Legal Officer	Sell	30,906	$1.37	$42,341	531,615
2024-02-02	Shukla Sath	EVP, Chief Financial Officer	Sell	30,901	$1.37	$42,334	1,221,100
2024-02-02	Mahadevia Ankit	Director	Sell	63,795	$1.37	$87,399	744,997
2024-02-01	HAMED KAMAL	Chief Medical Officer	Award	239,731	—	—	816,192
2024-02-01	Keutzer Timothy	Chief Operating Officer	Award	239,731	—	—	565,021
2024-02-01	JOSEPH TAMARA L	Chief Legal Officer	Award	239,731	—	—	562,521
2024-02-01	Shukla Sath	EVP, Chief Financial Officer	Award	679,501	—	—	1,252,001
2024-02-01	Rajavelu Esther	See Remarks	Award	119,866	—	—	419,866
2024-01-02	Tregoning Kathleen	Director	Award	35,604	$1.12	$39,876	35,604
2023-11-13	Rajavelu Esther	See Remarks	Award	300,000	—	—	300,000
2023-11-06	Rajavelu Esther	See Remarks	Other	0	—	—	0
2023-10-05	THOMAS FRANK E	Director	Award	20,000	—	—	35,000
2023-10-05	Tregoning Kathleen	Director	Award	20,000	—	—	35,000
2023-10-05	Deshpande Milind	Director	Award	20,000	—	—	51,454
2023-10-05	VINK PATRICK V.J.J.	Director	Award	20,000	—	—	35,000
2023-10-05	Smith Cynthia	Director	Award	20,000	—	—	35,000
2023-10-05	Jackson Scott Thomas	Director	Award	20,000	—	—	35,000
2023-10-05	Pottage John C Jr	Director	Award	20,000	—	—	35,000
2023-10-05	Mahadevia Ankit	Director	Award	20,000	—	—	808,792
2023-09-13	HAMED KAMAL	Chief Medical Officer	Sell	39,496	$1.27	$50,160	576,461
2023-08-29	Shukla Sath	EVP, Chief Financial Officer	Sell	4,163	$1.30	$5,412	572,500
2023-08-28	JOSEPH TAMARA L	Chief Legal Officer	Sell	1,854	$1.26	$2,336	322,790
2023-08-28	Keutzer Timothy	Chief Operating Officer	Sell	1,854	$1.26	$2,336	325,290
2023-08-28	Mahadevia Ankit	Director	Sell	9,040	$1.26	$11,390	788,792
2023-08-28	Shukla Sath	EVP, Chief Financial Officer	Sell	1,854	$1.26	$2,336	576,663
2023-08-01	Shukla Sath	EVP, Chief Financial Officer	Award	266,000	—	—	578,517
2023-07-15	DiPalma Stephen J.	See Remarks	Other	0	—	—	0
2023-06-12	HAMED KAMAL	Chief Medical Officer	Award	140,000	—	—	615,957
2023-02-03	Mahadevia Ankit	Director	Sell	12,286	$1.81	$22,238	797,832
2023-02-02	Keutzer Timothy	Chief Operating Officer	Sell	3,394	$1.86	$6,313	327,144
2023-02-02	JOSEPH TAMARA L	Chief Legal Officer	Sell	3,394	$1.86	$6,313	324,644
2023-02-02	Shukla Sath	EVP, Chief Financial Officer	Sell	9,504	$1.83	$17,372	312,517
2023-02-01	HAMED KAMAL	Chief Medical Officer	Award	265,957	—	—	475,957
2023-02-01	Keutzer Timothy	Chief Operating Officer	Award	265,957	—	—	330,538
2023-02-01	JOSEPH TAMARA L	Chief Legal Officer	Award	265,957	—	—	328,038
2023-02-01	Shukla Sath	EVP, Chief Financial Officer	Award	265,957	—	—	322,021
2023-02-01	Mahadevia Ankit	Director	Award	531,914	—	—	810,118
2023-01-03	Tregoning Kathleen	Director	Award	30,943	$1.29	$39,916	30,943
2023-01-03	VINK PATRICK V.J.J.	Director	Award	15,471	$1.29	$19,958	15,471
2022-11-07	GLAXOSMITHKLINE PLC	10% Owner	Other	9,190,606	—	—	9,190,606
2022-09-22	Aquilo Capital Management, LLC	10% Owner	Sell	1,335,512	$2.25	$3,005,303	3,985,719
2022-09-22	Aquilo Capital Management, LLC	10% Owner	Sell	566,284	$2.25	$1,274,309	3,419,435
2022-09-15	Pottage John C Jr	Director	Award	15,000	—	—	15,000
2022-09-15	Jackson Scott Thomas	Director	Award	15,000	—	—	15,000
2022-09-15	Deshpande Milind	Director	Award	15,000	—	—	31,454