TWO SIGMA SECURITIES, LLC
Broker-DealerPosition in SYRE — Spyre Therapeutics, Inc.
CIK 1450144
NEW YORK, NY
Position in SYRE
as of Mar 31, 2026
· filed May 15, 2026
Position Value
$345,564
New position
Shares Held
6,851
first reported quarter
Ownership
0.008%
of shares outstanding
% of Portfolio
0.06%
of 13F equity value
Holder Rank
—
not a current holder
Holding Since
Mar 2026
1 quarter on record
Voting authority
Sole 100.ToString("F0")%
Shared 0.ToString("F0")%
None 0.ToString("F0")%
Position in Biotechnology
Healthcare · as of Mar 31, 2026TWO SIGMA SECURITIES, LLC holds $12,820,189 across 97 Biotechnology names. SYRE ranks #8 (2.7% of the industry book) .
| # | Ticker | Company | Shares | Value (USD) | Open |
|---|---|---|---|---|---|
| 1 | BMRN |
Biomarin Pharmaceutical Inc
|
22,096 | $1,248,203 | |
| 2 | INCY |
Incyte Corp
|
11,772 | $1,107,980 | |
| 3 | APLS |
Apellis Pharmaceuticals, Inc.
|
23,779 | $956,629 | |
| 4 | REGN |
Regeneron Pharmaceuticals, Inc.
|
1,135 | $876,946 | |
| 5 | TERN |
Terns Pharmaceuticals, Inc.
|
11,908 | $627,789 | |
| 6 | PSTV |
Plus Therapeutics, Inc.
|
142,812 | $580,530 | |
| 7 | ABVX |
Abivax S.A.
|
3,936 | $438,273 | |
| 8 | SYRE |
Spyre Therapeutics, Inc.
This page
|
6,851 | $345,564 |
All Filings in SYRE
Export CSV
1 filing row on record
| Report Date | Value (USD) | Shares | Type | Discretion | Filed | |
|---|---|---|---|---|---|---|
| 2026-03-31 | $345,564 | 6,851 | Shares | Sole | 2026-05-15 | |
| No filing history on record for this holder in this stock. | ||||||