6-K

FORM 6-K

U.S. SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

Report of Foreign Private Issuer

Pursuant to Rule 13a-16 or 15d-16 of

the Securities Exchange Act of 1934

Commission File Number: 001-38757

For the month of February 2023

TAKEDA PHARMACEUTICAL COMPANY LIMITED

(Translation of registrant’s name into English)

1-1, Nihonbashi-Honcho 2-Chome

Chuo-ku, Tokyo 103-8668

Japan

(Address of principal executive offices)

Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form 40-F.

Form 20-F  ☒            Form 40-F  ☐

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1):  ☐

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7):  ☐

Information furnished on this form:

EXHIBIT

Exhibit<br>Number
1.	(English Translation) Summary of Financial Statements for theNine-month Period EndedDecember31, 2022
99.1	Financial Appendix

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

	TAKEDA PHARMACEUTICAL COMPANY LIMITED
Date: February 2, 2023	By:	/s/ Norimasa Takeda
		Norimasa Takeda<br><br>Chief Accounting Officer and Corporate Controller

Summary of Financial Statements for the Nine-month Period Ended December 31, 2022 (IFRS, Consolidated)

February 2, 2023

Takeda Pharmaceutical Company Limited		Stock exchange listings:	Tokyo, Nagoya, Fukuoka, Sapporo
TSE Code:	4502	URL: https://www.takeda.com
Representative:	Christophe Weber, President & CEO
Contact:	Christopher O'Reilly	Telephone: +81-3-3278-2306	Email: takeda.ir.contact@takeda.com
	Global Head of IR, Global Finance

Scheduled date of securities report submission: February 7, 2023

Scheduled date of dividend payment commencement: -

Supplementary materials for the financial statements: Yes

Presentation to explain the financial statements: Yes

(Million JPY, rounded to the nearest million)

1.	Consolidated Financial Results for the Nine-month Period Ended December 31, 2022 (April 1 to December 31, 2022)

(1)Consolidated Operating Results (year to date)

	(Percentage figures represent changes over the same period of the previous year)
	Revenue		Operating profit	Profit before tax	Net profitfor the period
	(Million JPY)	(%)	(Million )	(Million )	(Million )
Nine-month Period Ended December 31, 2022	3,071,322	13.9	401,943	327,175	285,903
Nine-month Period Ended December 31, 2021	2,695,717	11.0	462,463	356,618	241,541
	Net profit attributable to<br>owners of the Company		Total comprehensiveincome for the period	Basic earningsper share	Diluted earningsper share
	(Million JPY)	(%)	(Million )	()	()
Nine-month Period Ended December 31, 2022	285,883	18.4	750,209	184.32	182.65
Nine-month Period Ended December 31, 2021	241,417	34.9	459,044	154.09	153.03
	Core Operating Profit		Core EPS
	(Billion JPY)	(%)	()
Nine-month Period Ended December 31, 2022	954.7	26.0	456
Nine-month Period Ended December 31, 2021	757.9	(2.9)	333

All values are in Japanese Yen.

(2)Consolidated Financial Position

	Total assets<br>(Million JPY)	Total equity<br>(Million JPY)	Equity attributable<br>to owners of the<br>Company<br>(Million JPY)	Ratio of equity<br>attributable to<br>owners of the<br>Company to total<br>assets (%)	Equity attributable<br>to owners of the<br>Company per<br>share (JPY)
As of December 31, 2022	13,504,705	6,176,498	6,175,978	45.7	3,972.91
As of March 31, 2022	13,178,018	5,683,523	5,683,019	43.1	3,665.61
2. Dividends
---
	Annual dividends per share ()
---	---	---	---	---
	1st quarter end	3rd quarter end	Year-end	Total
For the Fiscal Year Ended March 31, 2022	—	—	90.00	180.00
For the Fiscal Year Ending March 31, 2023	—	—
For the Fiscal Year Ending March 31, 2023 (Projection)			90.00	180.00

All values are in Japanese Yen.

(Note) Modifications in the dividend projection from the latest announcement: None

3.	Forecasts for Consolidated Operating Results (Actual Exchange Rate basis) for the Fiscal Year Ending March 31, 2023 (April 1, 2022 to March 31, 2023)
	(Percentage figures represent changes from previous fiscal year)
---	---	---	---	---	---	---	---	---
	Revenue		Operating profit		Profit beforeincome taxes	Net profit attributable to owners of the Company		Basic earnings<br>per share
	(Million JPY)	(%)	(Million JPY)	(%)	(Million )	(Million JPY)	(%)	(JPY)
For the Fiscal Year Ending March 31, 2023	3,930,000	10.1	530,000	15.0	426,000	307,000	33.4	197.83
(Note) Modifications in forecasts of consolidated operating results from the latest announcement: None
Forecasts for Core financial measures are shown below.
	(Percentage figures represent changes from previous fiscal year)
	Core Revenue		Core Operating Profit		Core EPS
	(Million JPY)	(%)	(Million JPY)	(%)	()
For the Fiscal Year Ending March 31, 2023	3,930,000	14.9	1,180,000	23.5	525

All values are in Japanese Yen.

(Note) Modifications in forecasts of consolidated operating results from the latest announcement: None

The definition of Core financial measures is stated in the Attachment.

4.	Management Guidance (Constant Exchange Rate basis) for the Fiscal Year Ending March 31, 2023 (April 1, 2022 to March 31, 2023)

Takeda uses growth in its Core financial measures on a Constant Exchange Rate basis (“Core Growth at CER”) to provide its Management Guidance. The full year management guidance for the fiscal year ending March 31, 2023 (FY2022) has not been changed from the management guidance announced at the FY2021 financial results announcement on May 11, 2022.

	Core Revenue Growth	Core Operating Profit Growth	Core EPS Growth
	(%)	(%)	(%)
For the Fiscal Year Ending March 31, 2023	Low-single-digit growth	High-single-digit growth	High-single-digit growth

The definition of Constant Exchange Rate change is stated in the Attachment.

▪Additional Information

(1) Changes in significant subsidiaries during the period	: No
(changes in specified subsidiaries resulting in the change in consolidation scope)
(2) Changes in accounting policies and changes in accounting estimates
1) Changes in accounting policies required by IFRS	: No
2) Changes in accounting policies other than 1)	: No
3) Changes in accounting estimates	: No
(3) Number of shares outstanding (common stock)
1) Number of shares outstanding (including treasury stock) at period end:
December 31, 2022	1,582,290,825 shares
March 31, 2022	1,582,252,525 shares
2) Number of shares of treasury stock at period end:
December 31, 2022	27,766,370 shares
March 31, 2022	31,891,746 shares
3) Average number of outstanding shares (for the nine-month period ended December 31):
December 31, 2022	1,550,992,486 shares
December 31, 2021	1,566,730,171 shares

▪This summary of quarterly financial statements is not subject to quarterly review by the external auditor

▪Note to ensure appropriate use of forecasts and guidance, and other noteworthy items

| • | Takeda applies International Financial Reporting Standards (IFRS), and the disclosure information in this document is based on IFRS. | | --- | --- || • | All forecasts and management guidance in this document are based on information currently available to management, and do not represent a promise or guarantee to achieve these forecasts. Various uncertain factors could cause actual results to differ, such as changes in the business environment and fluctuations in foreign exchange rates. Should any significant event occur which requires the forecasts or guidance to be revised, Takeda will disclose it in a timely manner. | | --- | --- || • | For details of the forecasts for consolidated operating results and the management guidance, please refer to "1. Financial Highlights for the Nine-month Period Ended December 31, 2022 (3) Outlook for the Fiscal Year Ending March 31, 2023" on page 9. | | --- | --- || • | Supplementary materials for the financial statements including the Quarterly Financial Report and Earnings Presentation of the conference call on February 2, 2023, and its audio will be promptly posted on Takeda’s website. | | --- | --- |

(Takeda Website):

https://www.takeda.com/investors/financial-results/

Takeda Pharmaceutical Company Limited (4502)

Summary of Financial Statements for the Nine-month

Period Ended December 31, 2022 (Consolidated)

Attachment Index

1. Financial Highlights for theNine-month Period EndedDecember 31, 2022	2
(1) Business Performance	2
(2) Consolidated Financial Position	7
(3) Outlook for the Fiscal Year Ending March 31, 2023	9
(4) Other	11
2. Condensed Interim Consolidated Financial Statements [IFRS] and Major Notes	12
(1) Condensed Interim Consolidated Statements of Profit or Loss	12
(2) Condensed Interim Consolidated Statements of Comprehensive Income	13
(3) Condensed Interim Consolidated Statements of Financial Position	14
(4) Condensed Interim Consolidated Statements of Changes in Equity	16
(5) Condensed Interim Consolidated Statement of Cash Flows	18
(6) Notes to Condensed Interim Consolidated Financial Statements	20
[Financial Appendix]

Takeda Pharmaceutical Company Limited (4502)

Summary of Financial Statements for the Nine-month

Period Ended December 31, 2022 (Consolidated)

1. Financial Highlights for the Nine-month Period Ended December 31, 2022

(1) Business Performance

(i) Consolidated Financial Results (April 1 to December 31, 2022)

		Billion or percentage
	FY2021 Q3YTD				Change versus the same period of the previous fiscal year
			Actual % Change			CER % Change*1
Revenue		2,695.7		3,071.3		375.6	13.9	%	(0.7)	%
Cost of sales		(798.5)		(934.3)		(135.8)	17.0	%	3.4	%
Selling, general and administrative expenses		(662.9)		(742.5)		(79.6)	12.0	%	(2.2)	%
Research and development expenses		(382.5)		(472.4)		(89.9)	23.5	%	4.9	%
Amortization and impairment losses on intangible assets associated with products		(323.6)		(409.2)		(85.6)	26.4	%	5.4	%
Other operating income		34.3		16.7		(17.6)	(51.3)	%	(54.4)	%
Other operating expenses		(100.0)		(127.6)		(27.6)	27.6	%	8.6	%
Operating profit		462.5		401.9		(60.5)	(13.1)	%	(20.3)	%
Finance income and (expenses), net		(100.6)		(71.6)		29.0	(28.8)	%	(31.6)	%
Share of loss of investments accounted for using the equity method		(5.3)		(3.1)		2.1	(40.4)	%	(58.1)	%
Profit before tax		356.6		327.2		(29.4)	(8.3)	%	(16.5)	%
Income tax expenses		(115.1)		(41.3)		73.8	(64.1)	%	(61.3)	%
Net profit for the period		241.5		285.9		44.4	18.4	%	4.8	%

All values are in Japanese Yen.

*1 Please refer to (ii) Core Results (April 1 to December 31, 2022), Definition of Core financial measures and Constant Exchange Rate change, for the definition.

Revenue. Revenue for the nine-month period ended December 31, 2022 was 3,071.3 billion JPY, an increase of 375.6 billion JPY, or 13.9% (CER % change: -0.7%), compared to the same period of the previous fiscal year. The increase is primarily attributable to growth from business momentum and favorable foreign exchange rates, offsetting the decrease of revenue in the current period due to the sale of a portfolio of diabetes products in Japan to Teijin Pharma Limited for 133.0 billion JPY, which was recorded as revenue in the same period of the previous fiscal year.

Revenue of our core therapeutic areas (i.e. Gastroenterology (“GI”), Rare Diseases, Plasma-Derived Therapies (“PDT”) Immunology, Oncology, and Neuroscience) increased by 522.1 billion JPY, or 23.6%, compared to the same period of the previous fiscal year, to 2,735.6 billion JPY. Each of our core therapeutic areas, except Oncology, contributed to positive revenue growth due to growth from business momentum and favorable foreign exchange rates. Generic erosion and intensified competition impacted certain Oncology products in the current period.

Revenue outside of our core therapeutic areas significantly decreased by 146.5 billion JPY, or 30.4%, compared to the same period of the previous fiscal year to 335.7 billion JPY, largely due to the aforementioned non-recurring 133.0 billion JPY selling price of the diabetes portfolio in Japan, which was recorded as revenue in the same period of the previous fiscal year.

Takeda Pharmaceutical Company Limited (4502)

Summary of Financial Statements for the Nine-month

Period Ended December 31, 2022 (Consolidated)

Revenue by Geographic Region

The following shows revenue by geographic region:

	Billion or percentage
	FY2021 Q3YTD	Change versus the same period of the previous fiscal year
Revenue:			Actual % change		CER % change*1
Japan*2	530.2	(140.4)		(26.5)	%	(26.8)	%
United States	1,297.0	324.8		25.0	%	2.6	%
Europe and Canada	541.0	91.4		16.9	%	7.9	%
Asia (excluding Japan)	139.8	29.3		20.9	%	6.5	%
Latin America	93.5	27.9		29.8	%	10.3	%
Russia/CIS	43.6	23.1		53.0	%	15.6	%
Other*3	50.6	19.6		38.7	%	43.4	%
Total	2,695.7	375.6		13.9	%	(0.7)	%

All values are in Japanese Yen.

*1 Please refer to (ii) Core Results (April 1 to December 31, 2022), Definition of Core financial measures and Constant Exchange Rate change, for the definition.

*2 The 133.0 billion JPY selling price of the sale of diabetes portfolio in Japan is included in the nine-month period ended December 31, 2021.

*3 Other includes the Middle East, Oceania and Africa.

Revenue by Therapeutic Area

The following shows revenue by therapeutic area:

	Billion or percentage
	FY2021 Q3YTD	Change versus the same period of the previous fiscal year
Revenue:			Actual % change		CER % change*1
GI	665.7	191.8		28.8	%	11.1	%
Rare Diseases	462.9	90.7		19.6	%	5.0	%
Rare Hematology	211.6	21.1		10.0	%	(3.4)	%
Rare Genetics and Other	251.3	69.6		27.7	%	12.2	%
PDT Immunology	363.2	139.2		38.3	%	17.6	%
Oncology	359.1	(14.1)		(3.9)	%	(12.6)	%
Neuroscience	362.6	114.5		31.6	%	10.2	%
Other*2	482.2	(146.5)		(30.4)	%	(35.4)	%
Total	2,695.7	375.6		13.9	%	(0.7)	%

All values are in Japanese Yen.

*1 Please refer to (ii) Core Results (April 1 to December 31, 2022), Definition of Core financial measures and Constant Exchange Rate change, for the definition.

*2 The 133.0 billion JPY selling price of the sale of diabetes portfolio in Japan is included in the nine-month period ended December 31, 2021.

Year-on-year change in revenue for this nine-month period in each of our main therapeutic areas was primarily attributable to the following products:

•GI. In Gastroenterology, revenue was 857.5 billion JPY, a year-on-year increase of 191.8 billion JPY, or 28.8% (CER % change: 11.1%). Growth was driven by Takeda’s top-selling product ENTYVIO (for ulcerative colitis (“UC”) and Crohn’s disease (“CD”)), with sales of 547.9 billion JPY and a year-on-year increase of 152.5 billion JPY, or 38.6%. Sales of ENTYVIO in the U.S. increased by 122.4 billion JPY, or 46.0%, to 388.3 billion JPY, driven by a continued increase in the first line biologic inflammatory bowel disease (“IBD”) population both in UC and CD and favorable foreign exchange rates. Sales of ENTYVIO in Europe and Canada increased by 20.2 billion JPY, or 19.7%, to 122.4 billion JPY, supported by continued launches of the subcutaneous formulation and favorable foreign exchange rates. In the Growth and Emerging Markets, the increase in sales of ENTYVIO was led by growth in Brazil. Sales of GATTEX/REVESTIVE (for short bowel syndrome) were 78.2 billion JPY, an increase of 21.6 billion JPY, or 38.1%, primarily due to increased market penetration and new country launches, including Japan in August 2021, and favorable foreign exchange rates. Sales of DEXILANT (for acid reflux disease) were 55.1 billion JPY, an increase of 15.0 billion JPY, or 37.3% versus the same period of the previous fiscal year, due to the increased sales of authorized generics in the U.S. and favorable foreign exchange rates. Sales of TAKECAB/VOCINTI (for acid-related diseases) were 84.5 billion JPY, an increase of 6.2 billion JPY, or 7.9%, versus the same period of the previous fiscal year, primarily due to increased sales in China, partially offset by the decrease of sales in Japan, due to a negative impact associated with the market expansion re-pricing applied in April 2022, despite

Takeda Pharmaceutical Company Limited (4502)

Summary of Financial Statements for the Nine-month

Period Ended December 31, 2022 (Consolidated)

an increase in volume. Sales of PENTASA (for UC) were 7.3 billion JPY, a decrease of 8.5 billion JPY, or 53.7%, versus the same period of the previous fiscal year due to generic erosion in the U.S. from May 2022.

•Rare Diseases. In Rare Diseases, revenue was 553.6 billion JPY, a year-on-year increase of 90.7 billion JPY, or 19.6% (CER % change: 5.0%).

Revenue in Rare Hematology increased by 21.1 billion JPY, or 10.0% (CER % change: -3.4%), to 232.6 billion JPY. Sales of ADVATE (for hemophilia A), ADYNOVATE/ADYNOVI (for hemophilia A) and FEIBA (for hemophilia A and B) increased by 2.8 billion JPY or 3.1% to 92.1 billion JPY, 4.0 billion JPY or 8.7% to 49.9 billion JPY, and 3.6 billion JPY or 12.5% to 32.6 billion JPY, respectively, primarily due to favorable foreign exchange rates partially offset by negative impacts from competition in the U.S. Other Rare Hematology products in aggregate increased year-on-year, primarily due to additional indications, newly consolidated products, and favorable foreign exchange rates.

Revenue in Rare Genetics and Other was 321.0 billion JPY, a year-on-year increase of 69.6 billion JPY, or 27.7% (CER % change: 12.2%). Sales of TAKHZYRO (for hereditary angioedema) were 116.9 billion JPY, an increase of 38.5 billion JPY, or 49.0%, versus the same period of the previous fiscal year primarily due to expansion of the prophylactic market, continued geographic expansion and strong patient uptake as well as favorable foreign exchange rates. Sales of REPLAGAL (for Fabry disease) increased by 11.0 billion JPY, or 27.8%, to 50.6 billion JPY, primarily due to the succession to manufacturing and marketing rights in Japan by Takeda upon expiration of the relevant license agreement in February 2022. Sales of other enzyme replacement therapies ELAPRASE (for Hunter syndrome) and VPRIV (for Gaucher disease) increased by 7.3 billion JPY and 4.2 billion JPY, respectively, primarily due to favorable foreign exchange rates. Sales of LIVTENCITY (for post-transplant cytomegalovirus (“CMV”) infection/disease), which was first launched in the U.S. in December 2021, followed by several other countries, were 7.3 billion JPY in the current period.

•PDT Immunology. In Plasma-Derived Therapies (“PDT”) Immunology, revenue increased by 139.2 billion JPY, or 38.3% (CER % change: 17.6%) compared to the same period of the previous fiscal year, to 502.4 billion JPY. Aggregate sales of immunoglobulin products were 390.5 billion JPY, an increase of 112.2 billion JPY, or 40.3%, compared to the same period of the previous fiscal year. Sales of each of our three global immunoglobulin brands marked double digit percentage of revenue growth, due to continued strong demand globally and growing supply, especially in the U.S., where the pandemic pressure is now easing, as well as favorable foreign exchange rates. Those include GAMMAGARD LIQUID/KIOVIG (for the treatment of primary immunodeficiency (“PID”) and multifocal motor neuropathy (“MMN”)), and subcutaneous immunoglobulin therapies (CUVITRU and HYQVIA) which are growing due to their benefit to patients and convenience in administration compared to intravenous therapies. Aggregate sales of albumin products including HUMAN ALBUMIN and FLEXBUMIN (primarily used for hypovolemia and hypoalbuminemia) were 85.5 billion JPY, an increase of 24.0 billion JPY, or 39.1%, versus the same period of the previous fiscal year driven by strong albumin demand in the U.S. and in China and favorable exchange rates.

•Oncology. In Oncology, revenue was 345.0 billion JPY, a year-on-year decrease of 14.1 billion JPY, or 3.9% (CER % change: -12.6%), impacted by the rapid generic erosion of VELCADE (for multiple myeloma) sales in the U.S. Sales of VELCADE decreased by 59.7 billion JPY, or 70.7%, versus the same period of the previous fiscal year to 24.7 billion JPY predominantly due to multiple generic entrants in the U.S. starting in May 2022. Sales of NINLARO (for multiple myeloma) were 75.9 billion JPY, an increase of 5.2 billion JPY, or 7.3%, versus the same period of the previous fiscal year, aided by favorable foreign exchange rates, which were offset partially by intensified competition and decreased demand mainly in the U.S. Sales of ADCETRIS (for malignant lymphomas) were 65.8 billion JPY, an increase of 14.0 billion JPY, or 27.0%, versus the same period of the previous fiscal year, led by strong growth in countries such as Argentina, Italy and Japan. Sales of ICLUSIG (for leukemia) were 35.5 billion JPY, an increase of 8.8 billion JPY, or 33.1%, versus the same period of the previous fiscal year, due to steady growth in the U.S. and also aided by favorable foreign exchange rates. Sales of ALUNBRIG (for non-small cell lung cancer) were 15.8 billion JPY, an increase of 5.6 billion JPY, or 55.7%, benefiting from strong demand in European countries and the Growth and Emerging Markets such as China. Sales of ZEJULA (for ovarian cancer) were 9.8 billion JPY, an increase of 4.1 billion JPY, or 70.9%, primarily led by Japan where it was helped by a newly launched tablet formulation in June 2022, in addition to a capsule formulation. Sales of LEUPLIN/ENANTONE (for endometriosis, uterine fibroids, premenopausal breast cancer, prostatic cancer, etc.), an off-patent product, increased by 3.0 billion JPY, or 3.6%, versus the same period of the previous fiscal year to 85.2 billion JPY mainly due to favorable foreign exchange rates. Sales of EXKIVITY (for non-small cell lung cancer), which was first launched in the U.S. in September 2021, followed by several other countries, were 2.2 billion JPY in the current period.

•Neuroscience. In Neuroscience, revenue was 477.1 billion JPY, a year-on-year increase of 114.5 billion JPY, or 31.6% (CER % change: 10.2%). Sales of VYVANSE/ELVANSE (for attention deficit hyperactivity disorder (“ADHD”)) were 335.4 billion JPY, an increase of 90.5 billion JPY, or 36.9%, versus the same period of the previous fiscal year mainly driven by the growth of the adult market in the U.S., Europe and Canada and favorable foreign exchange rates. Sales of TRINTELLIX (for major depressive disorder (“MDD”)) were 79.7 billion JPY, an increase of 16.7 billion JPY, or 26.4%, versus the same period of the previous fiscal year, due to increasing prescriptions in the U.S. and Japan and favorable

Takeda Pharmaceutical Company Limited (4502)

Summary of Financial Statements for the Nine-month

Period Ended December 31, 2022 (Consolidated)

foreign exchange rates. Sales of INTUNIV (for ADHD) increased by 4.1 billion JPY, or 32.8%, versus the same period of the previous fiscal year, to 16.6 billion JPY driven by an increase of sales in Japan. Sales of ADDERALL XR (for ADHD) also increased, by 3.1 billion JPY or 19.6% versus the same period of the previous fiscal year, to 19.1 billion JPY mainly due to a shortage of generic versions of the instant release formulation marketed by competitors and favorable foreign exchange rates.

Cost of Sales. Cost of Sales increased by 135.8 billion JPY, or 17.0% (CER % change: 3.4%), to 934.3 billion JPY. The increase was primarily due to the depreciation of the yen and a sales increase in our core therapeutic areas as compared to the same period of the previous fiscal year. The Cost of Sales Ratio increased by 0.8 pp compared to the same period of the previous fiscal year to 30.4%. The main reason for the increase in the Cost of Sales Ratio was the effect of the sale of a portfolio of diabetes products in Japan with the selling price of 133.0 billion JPY being recorded in revenue in the same period of the previous fiscal year.

Selling, General and Administrative (SG&A) expenses. SG&A expenses increased by 79.6 billion JPY, or 12.0% (CER % change: -2.2%) compared to the same period of the previous fiscal year, to 742.5 billion JPY, mainly due to the impact from the depreciation of the yen in the current period.

Research and Development (R&D) expenses. R&D expenses increased by 89.9 billion JPY, or 23.5% (CER % change: 4.9%) compared to the same period of the previous fiscal year, to 472.4 billion JPY, mainly due to the impact from the depreciation of the yen in the current period.

Amortization and Impairment Losses on Intangible Assets Associated with Products. Amortization and Impairment Losses on Intangible Assets Associated with Products increased by 85.6 billion JPY, or 26.4% (CER % change: 5.4%) compared to the same period of the previous fiscal year, to 409.2 billion JPY, mainly due to the impact from the depreciation of the yen in the current period and an increase in impairment charges for certain assets related to in-process R&D and marketed products.

Other Operating Income. Other Operating Income was 16.7 billion JPY, a decrease of 17.6 billion JPY, or 51.3% (CER % change: -54.4%), compared to the same period of the previous fiscal year primarily due to a change in fair value of financial assets and liabilities associated with contingent consideration arrangements recognized and certain settlement proceeds recorded in the same period of the previous fiscal year.

Other Operating Expenses. Other Operating Expenses were 127.6 billion JPY, an increase of 27.6 billion JPY, or 27.6% (CER % change: 8.6%), compared to the same period of the previous fiscal year, primarily due to increases in reserves and provisions mainly for certain assets and pre-launch inventory during the current period, partially offset by a decrease in restructuring expenses attributable to the decrease in Shire integration costs.

Operating Profit. As a result of the above factors, Operating Profit decreased by 60.5 billion JPY, or 13.1% (CER % change: -20.3%) compared to the same period of the previous fiscal year to 401.9 billion JPY.

Net Finance Expenses. Net Finance Expenses were 71.6 billion JPY in the current period, a decrease of 29.0 billion JPY, or 28.8% (CER % change: 31.6%) compared to Net Finance Expenses of 100.6 billion JPY for the same period of the previous fiscal year. This decrease was mainly driven by a positive impact from the remeasurement of warrants to purchase stocks of companies held by Takeda as well as a gain on prior equity method investments related to the acquisitions of GammaDelta Therapeutics and Adaptate Biotherapeutics in April 2022.

Share of Loss of Investments Accounted for Using the Equity Method. Share of Loss of Investments Accounted for Using the Equity Method was 3.1 billion JPY, a decrease of 2.1 billion JPY, or 40.4% (CER % change: -58.1%), compared to the same period of the previous fiscal year.

Income Tax Expenses. Income Tax Expenses were 41.3 billion JPY, a decrease of 73.8 billion JPY, or 64.1% (CER % change; -61.3%), compared to the same period of the previous year. This decrease was primarily due to a tax charge of 64.6 billion JPY for tax and interest, net of 0.5 billion JPY of associated tax benefit, arising from tax assessment involving Irish taxation of the break fee Shire received from AbbVie in connection with the terminated offer to acquire Shire made by AbbVie in 2014 in the same period of the previous year as well as decreased tax charges for US international tax provisions and tax benefits from recognition of deferred tax assets in the current period. These decreases were partially offset by the tax benefits from internal entity restructuring transactions in the same period of the previous year.

Takeda Pharmaceutical Company Limited (4502)

Summary of Financial Statements for the Nine-month

Period Ended December 31, 2022 (Consolidated)

Net Profit for the Period. Net Profit for the Period decreased by 44.4 billion JPY, or 18.4% (CER % change: 4.8%), compared to the same period of the previous fiscal year to 285.9 billion JPY.

(ii) Core Results (April 1 to December 31, 2022)

Definition of Core financial measures and Constant Exchange Rate change

Core Revenue represents revenue adjusted to exclude significant items unrelated to Takeda's core operations.

Core Operating Profit represents net profit adjusted to exclude income tax expenses, the share of profit or loss of investments accounted for using the equity method, finance expenses and income, other operating expenses and income, amortization and impairment losses on acquired intangible assets and other items unrelated to Takeda’s core operations, such as non-recurring items, purchase accounting effects and transaction related costs.

Core EPS represents net profit adjusted to exclude the impact of items excluded in the calculation of Core Operating Profit, and other non-operating items (e.g. amongst other items, fair value adjustments and the imputed financial charge related to contingent consideration) that are unusual, non-recurring in nature or unrelated to Takeda’s ongoing operations and the tax effect of each of the adjustments, divided by the average outstanding shares (excluding treasury shares) of the reporting periods presented.

CER (Constant Exchange Rate) change eliminates the effect of foreign exchange rates from year-over-year comparisons by translating Reported or Core results for the current period using corresponding exchange rates in the same period of the previous fiscal year.

Results of Core Operations

	Billion or percentage
	FY2021 Q3YTD	Change versus the same period of the previous fiscal year
			Actual % change		CER % change
Core Revenue	2,562.7	508.6		19.8	%	4.5	%
Core Operating Profit	757.9	196.7		26.0	%	9.7	%
Core EPS (yen)	333	123		37.0	%	17.1	%

All values are in Japanese Yen.

Core Revenue for the nine-month period ended December 31, 2022 was 3,071.3 billion JPY, an increase of 508.6 billion JPY, or 19.8% (CER % change: 4.5%), compared to the same period of the previous fiscal year. Core revenue for the nine-month period ended December 31, 2021, was 2,562.7 billion JPY, which excluded the non-recurring 133.0 billion JPY selling price of the diabetes portfolio in Japan. There were no significant items unrelated to Takeda's core operations excluded from revenue in the current period, resulting in Core revenue for the current period being the same as Reported revenue at 3,071.3 billion JPY. Business momentum was led by Takeda’s Growth and Launch Products* which totaled 1,199.6 billion JPY, a year-on-year increase of 350.7 billion JPY, or 41.3% (CER % change: 20.4%).

*    Takeda’s Growth and Launch Products

GI: ENTYVIO, ALOFISEL

Rare Diseases: TAKHZYRO, LIVTENCITY

PDT Immunology: Immunoglobulin products including GAMMAGARD LIQUID/KIOVIG, HYQVIA, and CUVITRU,

Albumin products including HUMAN ALBUMIN and FLEXBUMIN

Oncology: ALUNBRIG, EXKIVITY

Other: SPIKEVAX Intramuscular Injection, NUVAXOVID Intramuscular Injection

Core Operating Profit for the current period was 954.7 billion JPY, an increase of 196.7 billion JPY or 26.0% (CER % change: 9.7%) compared to the same period of the previous fiscal year driven by revenue growth in our core therapeutic areas and the depreciation of the yen in the current period.

Core EPS for the current period was 456 yen, an increase of 123 yen, or 37.0% (CER % change: 17.1%), compared to the same period of the previous fiscal year.

Takeda Pharmaceutical Company Limited (4502)

Summary of Financial Statements for the Nine-month

Period Ended December 31, 2022 (Consolidated)

(2) Consolidated Financial Position

Assets. Total Assets as of December 31, 2022 were 13,504.7 billion JPY, reflecting an increase of 326.7 billion JPY compared to the previous fiscal year-end. Goodwill and Property, Plant and Equipment increased by 283.2 billion JPY and 73.6 billion JPY respectively mainly due to the effect of foreign currency translation. In addition, Inventories increased by 74.1 billion JPY. These increases were partially offset by a decrease in Cash and Cash Equivalents of 164.6 billion JPY.

Liabilities. Total Liabilities as of December 31, 2022 were 7,328.2 billion JPY, reflecting a decrease of 166.3 billion JPY compared to the previous fiscal year-end. Trade and Other Payables and Deferred Tax Liabilities decreased by 135.2 billion JPY and 62.8 billion JPY, respectively. In addition, Bonds and Loans decreased by 58.5 billion JPY to 4,286.9 billion JPY* primarily due to the redemption of bonds partially offset by an increase due to the effect of foreign currency translation. These decreases were partially offset by an increase in Other Liabilities of 54.5 billion JPY.

* The carrying amount of Bonds was 3,565.0 billion JPY and Loans was 721.9 billion JPY as of December 31, 2022. Breakdown of Bonds and Loans carrying amount is as follows.

Bonds:

Name of Bond<br> (Face Value if Denominated in<br> Foreign Currency)	Issuance	Maturity	Carrying Amount<br>(Billion JPY)
Unsecured US dollar denominated senior notes (1,301 million USD)	June 2015	June 2025 ~<br>June 2045	172.3
Unsecured US dollar denominated senior notes (4,000 million USD)	September 2016	September 2023 ~<br>September 2026	508.2
Unsecured Euro denominated senior notes (3,000 million EUR)	November 2018	November 2026 ~<br>November 2030	419.7
Unsecured US dollar denominated senior notes (2,250 million USD)	November 2018	November 2023 ~<br>November 2028	295.5
Hybrid bonds (subordinated bonds)	June 2019	June 2079	498.7
Unsecured US dollar denominated senior notes (7,000 million USD)	July 2020	March 2030 ~<br>July 2060	918.1
Unsecured Euro denominated senior notes (3,600 million EUR)	July 2020	July 2027 ~ <br>July 2040	503.1
Unsecured JPY denominated senior bonds	October 2021	October 2031	249.4
Total			3,565.0

Loans:

Name of Loan<br> (Face Value if Denominated in<br> Foreign Currency)	Execution	Maturity	Carrying Amount<br>(Billion JPY)
Syndicated loans	April 2016	April 2023 ~ <br>April 2026	200.0
Syndicated loans	April 2017	April 2027	113.5
Syndicated loans<br>(1,500 million USD)	April 2017	April 2027	197.8
Bilateral loans	March 2016 ~ <br>April 2017	March 2023 ~ <br>March 2026	210.0
Other			0.6
Total			721.9

Takeda Pharmaceutical Company Limited (4502)

Summary of Financial Statements for the Nine-month

Period Ended December 31, 2022 (Consolidated)

On April 23, 2022, Takeda redeemed 219 million USD of unsecured U.S. dollar-denominated senior notes issued in June 2015 in advance of their original maturity date of June 23, 2022. Following this, on October 27, 2022, Takeda redeemed 1,000 million USD of unsecured U.S. dollar-denominated senior notes issued in November 2018 in advance of their original maturity date of November 26, 2023. Furthermore, on November 21, 2022, Takeda redeemed 750 million EUR of unsecured floating rate senior notes issued in November 2018 on their maturity date.

Equity. Total Equity as of December 31, 2022 was 6,176.5 billion JPY, an increase of 493.0 billion JPY compared to the previous fiscal year-end. This was primarily resulted from an increase of 446.0 billion JPY in Other Components of Equity mainly due to fluctuation in currency translation adjustments reflecting the depreciation of yen and an increase in Retained Earnings of 28.0 billion JPY. The increase in Retained Earnings was primarily attributable to Net Profit for the Period largely offset by the dividends payments of 278.3 billion JPY.

Consolidated Cash Flows

	Billion
	FY2021 Q3YTD
Net cash from (used in) operating activities	747.5
Net cash from (used in) investing activities	(172.5)
Net cash from (used in) financing activities	(826.5)
Net increase (decrease) in cash and cash equivalents	(251.4)
Cash and cash equivalents at the beginning of the year	966.2
Effects of exchange rate changes on cash and cash equivalents	9.5
Cash and cash equivalents at the end of the period	724.3

All values are in Japanese Yen.

Net cash from operating activities was 683.5 billion JPY for the current period compared to 747.5 billion JPY for the same period of the previous year. The decrease of 64.1 billion JPY was primarily driven by unfavorable impacts from changes in trade and other payables as well as trade and other receivables compared to the same period of the previous year. These were partially offset by a favorable impact from changes in provisions and higher net profit for the period adjusted for non-cash items and other adjustments reflecting sales increases in core therapeutic areas and favorable foreign exchange rates, while there was the decrease of cash from the sale of Japan diabetes portfolio in the same period of prior fiscal year.

Net cash used in investing activities was 168.6 billion JPY for the current period compared to 172.5 billion JPY for the same period of the previous year. This decrease of 3.9 billion JPY was mainly due to a decrease of 49.7 billion JPY in acquisition of business (net of cash and cash equivalents acquired), partially offset by an increase of 38.2 billion JPY in acquisition of intangible assets.

Net cash used in financing activities was 702.5 billion JPY for the current period compared to 826.5 billion JPY for the same period of the previous year. The decrease of 123.9 billion JPY was mainly due to a decrease in repayments of bonds and long-term loans, net of proceeds from issuance of bonds upon refinancing, of 104.1 billion JPY. In addition, there was a decrease in purchase of treasury shares of 25.6 billion JPY resulting from the higher share buybacks conducted in the same period of the previous year compared to the current period.

Takeda Pharmaceutical Company Limited (4502)

Summary of Financial Statements for the Nine-month

Period Ended December 31, 2022 (Consolidated)

(3) Outlook for the Fiscal Year Ending March 31, 2023

Based on Takeda's financial results through the nine-month period ended December 31, 2022, and taking into account the anticipated financial outlook for the remaining three-month period of the fiscal year ending March 31, 2023 (FY2022), the full year consolidated reported forecast for FY2022 has not been revised from the latest forecast announced on October 27, 2022.

Full Year Reported Forecast for the Fiscal Year Ending March 31, 2023 (FY2022)

			Billion or percentage
	FY2021<br>Actual Results	FY2022<br>Latest Forecast<br>(October 27, 2022)	vs. FY2021 Actual Results
Revenue	3,569.0	3,930.0	361.0	%
Operating profit	460.8	530.0	69.2	%
Profit before tax	302.6	426.0	123.4	%
Net profit for the year<br><br>(attributable to owners of the Company)	230.1	307.0	76.9	%
EPS (JPY)	147.14	197.83	50.69	%
Core Revenue	3,420.5	3,930.0	509.5	%
Core Operating Profit	955.2	1,180.0	224.8	%
Core EPS (JPY)	425	525	100	%

All values are in Japanese Yen.

Major assumptions used in preparing the FY2022 Reported Forecast

		Billion JPY or percentage
	FY2021<br>Actual Results	FY2022<br>Latest Forecast<br>(October 27, 2022)
FX rates	1 USD = 112 JPY<br>1 Euro = 131 JPY <br>1 RUB = 1.5 JPY <br>1 BRL = 20.9 JPY <br>1 CNY = 17.4 JPY	1 USD = 132 JPY<br>1 Euro = 138 JPY<br>1 RUB = 2.1 JPY<br>1 BRL = 26.4 JPY<br>1 CNY = 19.8 JPY
R&D expenses	(526.1)	(620.0)
Amortization of intangible assets associated with products	(418.8)	(480.0)
Of which Shire acquisition related	(339.7)	(390.0)
Impairment of intangible assets associated with products	(54.1)	(50.0)
Other operating income	43.1	13.0
Other operating expenses	(159.1)	(100.0)
Japan diabetes portfolio divestiture gain	131.4	—
Other Core Operating Profit adjustments	(36.9)	(33.0)
Of which Shire acquisition related to unwind of inventories step-up	(31.9)	(25.0)
Finance income and (expenses), net	(142.9)	(105.0)
Free cash flow	943.7	650.0 - 750.0
Capital expenditures (cash flow base)	(186.0)	(260.0 - 310.0)
Depreciation and amortization (excluding intangible assets associated with products)	(161.0)	(160.0)
Cash tax rate on adjusted EBITDA (excluding divestitures)	~12%	Mid-teen %

Takeda Pharmaceutical Company Limited (4502)

Summary of Financial Statements for the Nine-month

Period Ended December 31, 2022 (Consolidated)

Management Guidance

Beginning from FY2022, Takeda uses growth in its Core financial measures on a Constant Exchange Rate basis (“Core Growth at CER”) to provide its Management Guidance. The full year management guidance for the fiscal year ending March 31, 2023 (FY2022) has not been changed from the management guidance announced at the FY2021 financial results announcement on May 11, 2022.

	FY2022 Management Guidance<br>Core Growth at CER (%)*
Core Revenue Growth	Low-single-digit growth
Core Operating Profit Growth	High-single-digit growth
Core EPS Growth	High-single-digit growth

* Please refer to 1. Financial Highlights for the Nine-month Period Ended December 31, 2022, (1) Business Performance, (ii) Core Results (April 1 to December 31, 2022), Definition of Core financial measures and Constant Exchange Rate change, for the definition.

Other assumptions used in preparing the FY2022 Reported Forecast and the Management Guidance

•Based on currently available information, Takeda expects that its financial results for FY2022 will not be materially affected by COVID-19 or the crisis in Ukraine and Russia and, accordingly, Takeda's FY2022 reported forecast and the management guidance reflect this expectation.

•The FY2022 reported forecast and the management guidance include approximately 50.0 billion JPY revenue contribution from COVID-19 vaccines.

•Free cash flow and capital expenditures assumptions do not include the impact of acquisitions that have been announced but not completed yet, including the upfront cash payment for the acquisition of NDI-034858 from Nimbus Therapeutics, LLC, for 4 billion USD, as the exact timing of cash payment is dependent upon deal close.

Forward looking statements

All forecasts in this document are based on information currently available to management, and do not represent a promise or guarantee to achieve these forecasts. Various uncertain factors could cause actual results to differ, such as changes in the business environment and fluctuations in foreign exchange rates. Should any significant event occur which requires the forecast to be revised, the Company will disclose it in a timely manner.

Takeda Pharmaceutical Company Limited (4502)

Summary of Financial Statements for the Nine-month

Period Ended December 31, 2022 (Consolidated)

(4) Other

Takeda's Initiatives to Mitigate the Impact of COVID-19

Takeda's response to COVID-19 continues to focus on protecting the health and safety of our employees, our ability to ensure our medicines are available to patients who rely on them and playing our part to reduce transmission and support the communities where our employees live and work. While vaccines are becoming more broadly available, we continue to strictly adhere to local public health guidance across our geographies in addition to the internal protocols we have put in place, and monitor any potential impacts of the effects and evolution of COVID-19, including new variants, on our business activities.

Takeda is manufacturing NUVAXOVID Intramuscular Injection, a novel recombinant protein-based COVID-19 vaccine which was licensed, with manufacturing technologies transferred, from Novavax, at its Hikari facility and has been distributing it in Japan since May 2022. Also, Takeda will continue to provide distribution support in bringing an mRNA COVID-19 vaccine, SPIKEVAX Intramuscular Injection, to Japan through its partnership with Moderna.

Takeda’s Operations in Ukraine and Russia

Our commitment to patients, regardless of where they live, and to our people is unwavering and is even more important in times of crisis. Takeda is making every effort to protect our colleagues in Ukraine and to continue to supply patients in Ukraine and in the region with much needed treatments.

Takeda discontinued activities in Russia that are not essential to maintaining the supply of medicines to patients and providing ongoing support to our employees. This includes suspending all new investments, suspending advertising and promotion, not initiating new clinical trials and stopping enrollment of new patients in ongoing clinical trials. Our focus only on essential activities is consistent with our values and ethical responsibility to our patients in Ukraine, Russia and the region who depend on our treatments. This commitment notwithstanding, we are adhering to all international sanctions imposed on Russia.

We will be increasing our humanitarian relief efforts, including monetary and medicine donations to benefit people affected by the conflict in Ukraine, and we will continue to assess new ways to provide support as we look to meet the needs of patients across the region.

In the nine-month period ended December 31, 2022, revenue attributable to Russia/CIS represented 2.2% of Takeda’s total consolidated revenue of 3,071.3 billion, as indicated in the Revenue by Region in 1. Financial Highlights for the Nine-month Period Ended December 31, 2022, (1) Business Performance, (i) Consolidated Financial Results (April 1 to December 31, 2022). There was no material financial impact on Takeda’s financial results for the current period resulting from the crisis in these countries. However, depending on the future status of the crisis, our results of operations and financial conditions could be adversely affected.

Takeda Pharmaceutical Company Limited (4502)

Summary of Financial Statements for the Nine-month

Period Ended December 31, 2022 (Consolidated)

2. Condensed Interim Consolidated Financial Statements [IFRS] and Major Notes

(1) Condensed Interim Consolidated Statements of Profit or Loss

Revenue
Cost of sales
Selling, general and administrative expenses
Research and development expenses
Amortization and impairment losses on intangible assets associated with products
Other operating income
Other operating expenses
Operating profit
Finance income
Finance expenses
Share of loss of investments accounted for using the equity method
Profit before tax
Income tax expenses
Net profit for the period
Attributable to:
Owners of the Company
Non-controlling interests
Net profit for the period
Earnings per share ()
Basic earnings per share
Diluted earnings per share

All values are in Japanese Yen.

Takeda Pharmaceutical Company Limited (4502)

Summary of Financial Statements for the Nine-month

Period Ended December 31, 2022 (Consolidated)

(2) Condensed Interim Consolidated Statements of Comprehensive Income

	(millions)
	Nine-month Period Ended December 31,
	2021
Net profit for the period	241,541
Other comprehensive income (loss)
Items that will not be reclassified to profit or loss:
Changes in fair value of financial assets measured at fair value through other comprehensive income	(5,951)
Remeasurement of defined benefit pension plans	(2,912)
	(8,862)
Items that may be reclassified subsequently to profit or loss:
Exchange differences on translation of foreign operations	206,582
Cash flow hedges	13,958
Hedging cost	5,969
Share of other comprehensive loss of investments accounted for using the equity method	(145)
	226,365
Other comprehensive income for the period, net of tax	217,503
Total comprehensive income for the period	459,044
Attributable to:
Owners of the Company	458,887
Non-controlling interests	157
Total comprehensive income for the period	459,044

All values are in Japanese Yen.

Takeda Pharmaceutical Company Limited (4502)

Summary of Financial Statements for the Nine-month

Period Ended December 31, 2022 (Consolidated)

(3) Condensed Interim Consolidated Statements of Financial Position

	(millions)
	As of March 31, 2022
ASSETS
Non-current assets:
Property, plant and equipment	1,582,800
Goodwill	4,407,749
Intangible assets	3,818,544
Investments accounted for using the equity method	96,579
Other financial assets	233,554
Other non-current assets	82,611
Deferred tax assets	362,539
Total non-current assets	10,584,376
Current assets:
Inventories	853,167
Trade and other receivables	696,644
Other financial assets	25,305
Income taxes receivable	27,733
Other current assets	141,099
Cash and cash equivalents	849,695
Assets held for sale	—
Total current assets	2,593,642
Total assets	13,178,018
LIABILITIES AND EQUITY
LIABILITIES
Non-current liabilities:
Bonds and loans	4,141,418
Other financial liabilities	468,943
Net defined benefit liabilities	145,847
Income taxes payable	21,634
Provisions	52,199
Other non-current liabilities	67,214
Deferred tax liabilities	451,511
Total non-current liabilities	5,348,764
Current liabilities:
Bonds and loans	203,993
Trade and other payables	516,297
Other financial liabilities	196,071
Income taxes payable	200,918
Provisions	443,502
Other current liabilities	584,949
Liabilities held for sale	—
Total current liabilities	2,145,730
Total liabilities	7,494,495

All values are in Japanese Yen.

Takeda Pharmaceutical Company Limited (4502)

Summary of Financial Statements for the Nine-month

Period Ended December 31, 2022 (Consolidated)

	(millions)
	As of March 31, 2022
EQUITY
Share capital	1,676,263
Share premium	1,708,873
Treasury shares	(116,007)
Retained earnings	1,479,716
Other components of equity	934,173
Equity attributable to owners of the company	5,683,019
Non-controlling interests	504
Total equity	5,683,523
Total liabilities and equity	13,178,018

All values are in Japanese Yen.

Takeda Pharmaceutical Company Limited (4502)

Summary of Financial Statements for the Nine-month

Period Ended December 31, 2022 (Consolidated)

(4) Condensed Interim Consolidated Statements of Changes in Equity

Nine-month period ended December 31, 2021 (From April 1 to December 31, 2021)

	(millions)
	Equity attributable to owners of the company
	Sharecapital	Share<br>premium		Treasury<br>shares	Retained<br>earnings	Other components of equity
			Changes in fair value of financial assets measured at fair value through other comprehensive income
As of April 1, 2021	1,668,145	1,688,424		(59,552)	1,509,906	400,798	41,983
Net profit for the period					241,417
Other comprehensive income (loss)						206,337	(5,883)
Comprehensive income (loss) for the period	—	—		—	241,417	206,337	(5,883)
Transactions with owners:
Issuance of new shares	8,118	14,036
Acquisition of treasury shares				(54,451)
Disposal of treasury shares		(0)		1
Dividends					(284,246)
Changes in ownership					(2,143)
Transfers from other components of equity					1,992		(4,904)
Share-based compensation		32,057
Exercise of share-based awards		(36,955)		22,989
Total transactions with owners	8,118	9,138		(31,461)	(284,397)	—	(4,904)
As of December 31, 2021	1,676,263	1,697,562		(91,013)	1,466,926	607,135	31,196

All values are in Japanese Yen.

	Equity attributable to owners of the company
	Other components of equity
	Cash flow<br>hedges	Hedging<br>cost	Remeasurements of defined benefit pension plans	Total <br>other components of equity	Total <br>equity attributable to owners of the Company	Non-<br>controlling<br>interests	Total<br>equity
As of April 1, 2021	(68,075)	(8,592)	—	366,114	5,173,037	4,140	5,177,177
Net profit for the period				—	241,417	124	241,541
Other comprehensive income (loss)	13,958	5,969	(2,912)	217,470	217,470	33	217,503
Comprehensive income (loss) for the period	13,958	5,969	(2,912)	217,470	458,887	157	459,044
Transactions with owners:
Issuance of new shares				—	22,154		22,154
Acquisition of treasury shares				—	(54,451)		(54,451)
Disposal of treasury shares				—	1		1
Dividends				—	(284,246)		(284,246)
Changes in ownership				—	(2,143)	(3,804)	(5,948)
Transfers from other components of equity			2,912	(1,992)	—		—
Share-based compensation				—	32,057		32,057
Exercise of share-based awards				—	(13,966)		(13,966)
Total transactions with owners	—	—	2,912	(1,992)	(300,594)	(3,804)	(304,399)
As of December 31, 2021	(54,116)	(2,623)	—	581,592	5,331,330	493	5,331,822

Takeda Pharmaceutical Company Limited (4502)

Summary of Financial Statements for the Nine-month

Period Ended December 31, 2022 (Consolidated)

Nine-month period ended December 31, 2022 (From April 1 to December 31, 2022)

		(millions)
	Equity attributable to owners of the company
	Share<br>capital		Share<br>premium		Treasury<br>shares		Retained<br>earnings		Other components of equity
						Changes in fair value of financial assets measured at fair value through other comprehensive income
As of April 1, 2022		1,676,263		1,708,873		(116,007)		1,479,716		984,141	22,068
Effect of hyperinflation								(1,960)		4,121
Restated opening balance		1,676,263		1,708,873		(116,007)		1,477,756		988,263	22,068
Net profit for the period								285,883
Other comprehensive income (loss)										480,326	698
Comprehensive income (loss) for the period		—		—		—		285,883		480,326	698
Transactions with owners:
Issuance of new shares		71		71
Acquisition of treasury shares				(5)		(27,056)
Disposal of treasury shares				0		1
Dividends								(278,321)
Transfers from other components of equity								22,402			(9,424)
Share-based compensation				45,823
Exercise of share-based awards				(42,727)		42,749
Total transactions with owners		71		3,162		15,693		(255,919)		—	(9,424)
As of December 31, 2022		1,676,334		1,712,036		(100,314)		1,507,720		1,468,588	13,341

All values are in Japanese Yen.

	Equity attributable to owners of the company
	Other components of equity
	Cash flow<br>hedges	Hedging<br>cost	Remeasurements of defined benefit pension plans	Total <br>other components of equity	Total <br>equity attributable to owners of the Company	Non-<br>controlling<br>interests	Total<br>equity
As of April 1, 2022	(65,901)	(6,135)	—	934,173	5,683,019	504	5,683,523
Effect of hyperinflation				4,121	2,161		2,161
Restated opening balance	(65,901)	(6,135)	—	938,294	5,685,180	504	5,685,684
Net profit for the period				—	285,883	19	285,903
Other comprehensive income (loss)	(17,584)	(12,107)	12,977	464,310	464,310	(4)	464,306
Comprehensive income (loss) for the period	(17,584)	(12,107)	12,977	464,310	750,193	16	750,209
Transactions with owners:
Issuance of new shares				—	142		142
Acquisition of treasury shares				—	(27,062)		(27,062)
Disposal of treasury shares				—	1		1
Dividends				—	(278,321)		(278,321)
Transfers from other components of equity			(12,977)	(22,402)	—		—
Share-based compensation				—	45,823		45,823
Exercise of share-based awards				—	22		22
Total transactions with owners	—	—	(12,977)	(22,402)	(259,395)	—	(259,395)
As of December 31, 2022	(83,486)	(18,242)	—	1,380,202	6,175,978	520	6,176,498

Takeda Pharmaceutical Company Limited (4502)

Summary of Financial Statements for the Nine-month

Period Ended December 31, 2022 (Consolidated)

(5) Condensed Interim Consolidated Statements of Cash Flows

	(millions)
	Nine-month Period Ended December 31,
	2021
Cash flows from operating activities:
Net profit for the period	241,541
Depreciation and amortization	430,877
Impairment losses	14,666
Equity-settled share-based compensation	32,057
Loss (gain) on sales and disposal of property, plant and equipment	258
Gain on divestment of business and subsidiaries	(1,095)
Change in fair value of financial assets and liabilities associated with contingent consideration arrangements, net	(9,683)
Finance (income) and expenses, net	100,589
Share of loss of investments accounted for using the equity method	5,255
Income tax expenses	115,077
Changes in assets and liabilities:
Decrease in trade and other receivables	82,243
Increase in inventories	(39,268)
Decrease in trade and other payables	(1,797)
Increase (decrease) in provisions	(70,098)
Decrease in other financial liabilities	(51,158)
Other, net	(858)
Cash generated from operations	848,607
Income taxes paid	(107,224)
Tax refunds and interest on tax refunds received	6,138
Net cash from operating activities	747,521
Cash flows from investing activities:
Interest received	2,468
Dividends received	2,598
Acquisition of property, plant and equipment	(87,673)
Proceeds from sales of property, plant and equipment	412
Acquisition of intangible assets	(46,541)
Acquisition of investments	(7,600)
Proceeds from sales and redemption of investments	16,065
Acquisition of businesses, net of cash and cash equivalents acquired	(49,672)
Proceeds from sales of business, net of cash and cash equivalents divested	2,138
Other, net	(4,683)
Net cash used in investing activities	(172,487)

All values are in Japanese Yen.

Takeda Pharmaceutical Company Limited (4502)

Summary of Financial Statements for the Nine-month

Period Ended December 31, 2022 (Consolidated)

	(millions)
	Nine-month Period Ended December 31,
	2021
Cash flows from financing activities:
Net decrease in short-term loans and commercial papers	(2)
Proceeds from issuance of bonds and long-term loans	249,334
Repayments of bonds and long-term loans	(635,047)
Acquisition of treasury shares	(52,538)
Interest paid	(84,917)
Dividends paid	(273,024)
Repayments of lease liabilities	(29,904)
Other, net	(366)
Net cash used in financing activities	(826,465)
Net decrease in cash and cash equivalents	(251,430)
Cash and cash equivalents at the beginning of the year	966,222
Effects of exchange rate changes on cash and cash equivalents	9,549
Cash and cash equivalents at the end of the period	724,341

All values are in Japanese Yen.

Takeda Pharmaceutical Company Limited (4502)

Summary of Financial Statements for the Nine-month

Period Ended December 31, 2022 (Consolidated)

(6) Notes to Condensed Interim Consolidated Financial Statements

(Significant Uncertainty Regarding Going Concern Assumption)

Not applicable.

(Significant Accounting Policies)

Significant accounting policies adopted for the condensed interim consolidated financial statements are the same as those adopted for the consolidated financial statements of the fiscal year ended March 31, 2022.

Takeda calculated income tax expenses for the nine-month period ended December 31, 2022, based on the estimated average annual effective tax rate.

(Significant Changes in Equity Attributable to Owners of the Company)

Not applicable.

(Significant Subsequent Events)

Not applicable.

20

Document

Exhibit 99.1

FINANCIAL APPENDIX
Definition of Non-IFRS Measures
---	---	---
	Definition of Core Financial Measures, Constant Exchange Rate change, and Free Cash Flow	A-1
	Definition of EBITDA/Adjusted EBITDA and Net Debt	A-2
Reconciliations and Other Financial Information
	FY2022 Q3 YTD Reported Results with Actual and CER % Change	A-3
	FY2022 Q3 (Oct-Dec) Reported Results with Actual and CER % Change	A-4
	FY2022 Q3 YTD Core Results with Actual and CER % Change	A-5
	FY2022 Q3 (Oct-Dec) Core Results with Actual and CER % Change	A-6
	FY2022 Q3 YTD Reconciliation from Reported to Core	A-7
	FY2022 Q3 (Oct-Dec) Reconciliation from Reported to Core	A-8
	FY2021 Q3 YTD Reconciliation from Reported to Core	A-9
	FY2021 Q3 (Oct-Dec) Reconciliation from Reported to Core	A-10
	Free Cash Flow	A-11
	FY2022 Q3 YTD Net Debt to Adjusted EBITDA	A-12
	FY2021 Net Debt to Adjusted EBITDA	A-13
	FY2022 Q3 YTD and FY2021 Q3 YTD Net Profit to Adjusted EBITDA Bridge	A-14
	FY2022 Q3 YTD Net Profit to Adjusted EBITDA LTM Bridge	A-15
	FY2022 Full Year FX Rates Assumptions and Currency Sensitivity	A-16
	CAPEX, depreciation and amortization and impairment losses	A-17
	FY2022 Full Year Detailed Forecast	A-18
	FY2022 Full Year Core Operating Profit Adjustment Items & Cash Flow Forecast	A-19
	FY2022 Full Year Reconciliation from Reported Operating Profit to Core Operating Profit Forecast	A-20
Important Notice
	Important Notice	A-21

Definition of Core Financial Measures, Constant Exchange Rate change, and Free Cash Flow

Core Revenue represents revenue adjusted to exclude significant items unrelated to Takeda’s core operations.

Core Operating Profit represents net profit adjusted to exclude income tax expenses, the share of profit or loss of investments accounted for using the equity method, finance expenses and income, other operating expenses and income, amortization and impairment losses on acquired intangible assets and other items unrelated to Takeda’s core operations, such as non-recurring items, purchase accounting effects and transaction related costs.

Core EPS represents net profit adjusted to exclude the impact of items excluded in the calculation of Core Operating Profit, and other non-operating items (e.g. amongst other items, fair value adjustments and the imputed financial charge related to contingent consideration) that are unusual, non-recurring in nature or unrelated to Takeda’s ongoing operations and the tax effect of each of the adjustments, divided by the average outstanding shares (excluding treasury shares) of the reporting periods presented.

CER (Constant Exchange Rate) change eliminates the effect of foreign exchange rates from year-over-year comparisons by translating Reported or Core results for the current period using corresponding exchange rates in the same period of the previous fiscal year.

We present Free Cash Flow because we believe that this measure is useful to investors as similar measures of liquidity are frequently used by securities analysts, investors and other interested parties in the evaluation of companies in our industry. Free Cash Flow is also used by our management to evaluate our liquidity and our cash flows, particularly as they relate to our ability to meet our liquidity requirements and to support our capital allocation policies. We also believe that Free Cash Flow is helpful to investors in understanding how our strategic divestitures of non-core businesses and of portions of our investment portfolio contribute to the cash flows and liquidity available to us.

We define Free Cash Flow as cash flows from operating activities, subtracting acquisition of property, plant and equipment (“PP&E”), intangible assets and investments as well as removing any other cash that is not available to Takeda’s immediate or general business use, and adding proceeds from sales of PP&E, as well as from sales of investments and businesses, net of cash and cash equivalents divested.

The usefulness of Free Cash Flow to investors has significant limitations including, but not limited to, (i) it may not be comparable to similarly titled measures used by other companies, including those in our industry, (ii) it does not reflect the effect of our current and future contractual and other commitments requiring the use or allocation of capital and (iii) the addition of proceeds from sales and redemption of investments and the proceeds from sales of business, net of cash and cash equivalents divested do not reflect cash received from our core ongoing operations. Free Cash Flow should not be considered in isolation and is not, and should not be viewed as, a substitute for cash flows from operating activities or any other measure of liquidity presented in accordance with IFRS. The most directly comparable measure under IFRS for Free Cash Flow is net cash from operating activities.

A-1

Definition of EBITDA/Adjusted EBITDA and Net Debt

We present EBITDA and Adjusted EBITDA because we believe that these measures are useful to investors as they are frequently used by securities analysts, investors and other interested parties in the evaluation of companies in our industry. We further believe that Adjusted EBITDA is helpful to investors in identifying trends in its business that could otherwise be obscured by certain items unrelated to ongoing operations because they are highly variable, difficult to predict, may substantially impact our results of operations and may limit the ability to evaluate our performance from one period to another on a consistent basis.

EBITDA and Adjusted EBITDA should not be considered in isolation or construed as alternatives to operating income, net profit for the year or any other measure of performance presented in accordance with IFRS. These non-IFRS measures may not be comparable to similarly-titled measures presented by other companies.

The usefulness of EBITDA and Adjusted EBITDA to investors has limitations including, but not limited to, (i) they may not be comparable to similarly titled measures used by other companies, including those in our industry, (ii) they exclude financial information and events, such as the effects of an acquisition or amortization of intangible assets, that some may consider important in evaluating our performance, value or prospects for the future, (iii) they exclude items or types of items that may continue to occur from period to period in the future and (iv) they may not exclude all items which investors may consider to be unrelated to our long-term operations. These non-IFRS measures are not, and should not be viewed as, substitutes for IFRS reported net income (loss). We encourage investors to review our historical financial statements in their entirety and caution investors to IFRS measures as the primary means of evaluating our performance, value and prospects for the future, and EBITDA and Adjusted EBITDA as supplemental measures.

We define EBITDA as consolidated net profit before income tax expenses, depreciation and amortization and net interest expense. We define Adjusted EBITDA as EBITDA further adjusted to exclude impairment losses, other operating expenses and income (excluding depreciation and amortization), finance expenses and income (excluding net interest expense), our share of loss from investments accounted for under the equity method and other items that management believes are unrelated to our core operations such as purchase accounting effects and transaction related costs.

The most closely comparable measure presented in accordance with IFRS is net profit for the year. Please refer to Net Profit to Adjusted EBITDA Bridge for a reconciliation to the respective most closely comparable measures presented in accordance with IFRS.

We present Net Debt because we believe that it is useful to investors in that our management uses it to monitor and evaluate our indebtedness, net of cash and cash equivalents, and, in conjunction with Adjusted EBITDA, to monitor our leverage. We also believe that similar measures of indebtedness are frequently used by securities analysts, investors and other interested parties in the evaluation of companies in our industry.

We define Net Debt first by calculating the sum of the current and non-current portions of bonds and loans as shown on our consolidated statement of financial position, which is then adjusted to reflect (i) the use of prior 12-month average exchange rates for non-JPY debt outstanding at the beginning of the period and the use of relevant spot rates for new non-JPY debt incurred and existing non-JPY debt redeemed during the reporting period, which reflects the methodology our management uses to monitor our leverage, and (ii) a 50% equity credit applied to our aggregate principal amount of 500.0 billion hybrid (subordinated) bonds issued in June 2019 by S&P Global Rating Japan in recognition of the equity-like features of those bonds pursuant to such agency’s ratings methodology. From this figure, we deduct cash and cash equivalents, excluding cash that is temporarily held by Takeda on behalf of third parties related to vaccine operations and the trade receivables sales program, to calculate Net Debt.

The usefulness of Net Debt to investors has significant limitations including, but not limited to, (i) it may not be comparable to similarly titled measures used by other companies, including those in our industry, (ii) it does not reflect the amounts of interest payments to be paid on our indebtedness, (iii) it does not reflect any restrictions on our ability to prepay or redeem any of our indebtedness, (iv) it does not reflect any fees, costs or other expenses that we may incur in converting cash equivalents to cash, in converting cash from one currency into another or in moving cash within our consolidated group, (v) it applies to gross debt an adjustment for average foreign exchange rates which, although consistent with our financing agreements, does not reflect the actual rates at which we would be able to convert one currency into another and (vi) it reflects an equity credit due to the fact that the amounts of our subordinated bonds, although we believe it to be reasonable, do not affect the status of those instruments as indebtedness. Net Debt should not be considered in isolation and are not, and should not be viewed as, a substitute for bonds and loans or any other measure of indebtedness presented in accordance with IFRS.

The most directly comparable measures under IFRS for Net Debt is bonds and loans. Please refer to Net Debt to Adjusted EBITDA for a reconciliation to this measure.

A-2

FY2022 Q3 YTD Reported Results with Actual and CER % Change
(Billion JPY)	FY2021<br><br>Q3 YTD		FY2022<br><br>Q3 YTD		vs. PY
---	---	---	---	---	---	---	---
		ACTUAL % CHANGE			CER % CHANGE*1
Revenue	2,695.7		3,071.3		375.6	13.9%	(0.7)%
Cost of sales	(798.5)		(934.3)		(135.8)	(17.0)%	(3.4)%
Gross profit	1,897.3		2,137.0		239.8	12.6%	(2.4)%
Margin	70.4	%	69.6	%		(0.8) pp	(1.2) pp
SG&A expenses	(662.9)		(742.5)		(79.6)	(12.0)%	2.2%
R&D expenses	(382.5)		(472.4)		(89.9)	(23.5)%	(4.9)%
Amortization of intangible assets associated with products	(309.1)		(370.6)		(61.5)	(19.9)%	(0.4)%
Impairment losses on intangible assets associated with products	(14.6)		(38.6)		(24.0)	(165.0)%	(112.2)%
Other operating income	34.3		16.7		(17.6)	(51.3)%	(54.4)%
Other operating expenses	(100.0)		(127.6)		(27.6)	(27.6)%	(8.6)%
Operating profit	462.5		401.9		(60.5)	(13.1)%	(20.3)%
Margin	17.2	%	13.1	%		(4.1) pp	(3.4) pp
Finance income	42.9		55.1		12.2	28.4%	17.6%
Finance expenses	(143.5)		(126.8)		16.8	11.7%	16.9%
Share of profit (loss) of investments accounted for using the equity method	(5.3)		(3.1)		2.1	40.4%	58.1%
Profit before tax	356.6		327.2		(29.4)	(8.3)%	(16.5)%
Income tax expenses	(115.1)		(41.3)		73.8	64.1%	61.3%
Net profit for the period	241.5		285.9		44.4	18.4%	4.8%
Non-controlling interests	(0.1)		(0.0)		0.1	84.4%	87.8%
Net profit attributable to owners of the Company	241.4		285.9		44.5	18.4%	4.9%
Basic EPS (yen)	154.09		184.32		30.23	19.6%	5.9%
*1 Please refer to A-1 Definition of Core Financial Measures, Constant Exchange Rate change, and Free Cash Flow, for the definition.
Note: % change versus prior year is presented as positive when favorable to profits, and negative when unfavorable to profits.

A-3

FY2022 Q3 (Oct-Dec) Reported Results with Actual and CER % Change
(Billion JPY)	FY2021 Q3<br><br>(Oct-Dec)		FY2022 Q3<br><br>(Oct-Dec)		vs. PY
---	---	---	---	---	---	---	---
		ACTUAL % CHANGE			CER % CHANGE*1
Revenue	901.3		1,096.6		195.3	21.7%	2.6%
Cost of sales	(281.4)		(336.0)		(54.6)	(19.4)%	(2.3)%
Gross profit	619.9		760.6		140.7	22.7%	2.7%
Margin	68.8	%	69.4	%		0.6 pp	0.1 pp
SG&A expenses	(231.1)		(262.3)		(31.2)	(13.5)%	3.8%
R&D expenses	(128.4)		(174.6)		(46.3)	(36.0)%	(11.9)%
Amortization of intangible assets associated with products	(105.0)		(129.8)		(24.8)	(23.6)%	0.9%
Impairment losses on intangible assets associated with products	(13.1)		(5.8)		7.3	55.8%	65.1%
Other operating income	14.7		3.2		(11.5)	(78.3)%	(77.7)%
Other operating expenses	(40.6)		(44.3)		(3.7)	(9.1)%	11.2%
Operating profit	116.5		147.0		30.5	26.2%	10.8%
Margin	12.9	%	13.4	%		0.5 pp	1.0 pp
Finance income	4.1		41.7		37.5	905.5%	918.1%
Finance expenses	(46.7)		(79.7)		(33.0)	(70.7)%	(57.1)%
Share of profit (loss) of investments accounted for using the equity method	(1.7)		(1.8)		(0.0)	(2.1)%	20.3%
Profit before tax	72.2		107.2		35.0	48.4%	33.6%
Income tax expenses	(14.4)		12.0		26.4	―	―
Net profit for the period	57.8		119.1		61.3	106.1%	87.1%
Non-controlling interests	(0.1)		(0.0)		0.0	56.3%	65.2%
Net profit attributable to owners of the Company	57.8		119.1		61.4	106.2%	87.2%
Basic EPS (yen)	36.91		76.63		39.72	107.6%	88.5%
*1 Please refer to A-1 Definition of Core Financial Measures, Constant Exchange Rate change, and Free Cash Flow, for the definition.
Note: % change versus prior year is presented as positive when favorable to profits, and negative when unfavorable to profits.

A-4

FY2022 Q3 YTD Core Results with Actual and CER % Change
(Billion JPY)	FY2021<br><br>Q3 YTD		FY2022<br><br>Q3 YTD		vs. PY
---	---	---	---	---	---	---	---
		ACTUAL % CHANGE			CER % CHANGE*1
Revenue	2,562.7		3,071.3		508.6	19.8%	4.5%
Cost of sales	(764.7)		(901.7)		(137.0)	(17.9)%	(4.2)%
Gross profit	1,798.0		2,169.6		371.7	20.7%	4.6%
Margin	70.2	%	70.6	%		0.5 pp	0.1 pp
SG&A expenses	(659.1)		(742.9)		(83.8)	(12.7)%	1.6%
R&D expenses	(380.9)		(472.1)		(91.2)	(23.9)%	(5.3)%
Operating profit	757.9		954.7		196.7	26.0%	9.7%
Margin	29.6	%	31.1	%		1.5 pp	1.5 pp
Finance income	25.2		9.2		(16.0)	(63.7)%	(69.4)%
Finance expenses	(114.2)		(114.2)		0.0	0.0%	4.9%
Share of profit (loss) of investments accounted for using the equity method	3.8		2.5		(1.3)	(34.2)%	(29.6)%
Profit before tax	672.7		852.1		179.4	26.7%	9.0%
Income tax expenses	(151.1)		(144.9)		6.2	4.1%	15.1%
Net profit for the period	521.6		707.2		185.6	35.6%	15.9%
Non-controlling interests	(0.1)		(0.0)		0.1	84.4%	87.8%
Net profit attributable to owners of the Company	521.5		707.2		185.7	35.6%	15.9%
Basic EPS (yen)	333		456		123	37.0%	17.1%
*1 Please refer to A-1 Definition of Core Financial Measures, Constant Exchange Rate change, and Free Cash Flow, for the definition.
Note: % change versus prior year is presented as positive when favorable to profits, and negative when unfavorable to profits.

A-5

FY2022 Q3 (Oct-Dec) Core Results with Actual and CER % Change
(Billion JPY)	FY2021 Q3<br><br>(Oct-Dec)		FY2022 Q3<br><br>(Oct-Dec)		vs. PY
---	---	---	---	---	---	---	---
		ACTUAL % CHANGE			CER % CHANGE*1
Revenue	901.3		1,096.6		195.3	21.7%	2.6%
Cost of sales	(270.6)		(330.1)		(59.5)	(22.0)%	(4.7)%
Gross profit	630.7		766.4		135.7	21.5%	1.7%
Margin	70.0	%	69.9	%		(0.1) pp	(0.6) pp
SG&A expenses	(230.4)		(262.4)		(32.0)	(13.9)%	3.5%
R&D expenses	(128.1)		(174.6)		(46.5)	(36.3)%	(12.1)%
Operating profit	272.2		329.5		57.3	21.0%	1.1%
Margin	30.2	%	30.0	%		(0.2) pp	(0.4) pp
Finance income	1.6		39.5		37.9	2,333.4%	2,395.0%
Finance expenses	(32.2)		(76.2)		(44.0)	(136.8)%	(119.3)%
Share of profit (loss) of investments accounted for using the equity method	0.9		(0.2)		(1.1)	―	―
Profit before tax	242.6		292.5		50.0	20.6%	1.0%
Income tax expenses	(56.9)		(32.0)		24.9	43.7%	56.7%
Net profit for the period	185.6		260.5		74.9	40.3%	18.7%
Non-controlling interests	(0.1)		(0.0)		0.0	56.3%	65.2%
Net profit attributable to owners of the Company	185.6		260.5		74.9	40.4%	18.7%
Basic EPS (yen)	119		168		49	41.3%	19.5%
*1 Please refer to A-1 Definition of Core Financial Measures, Constant Exchange Rate change, and Free Cash Flow, for the definition.
Note: % change versus prior year is presented as positive when favorable to profits, and negative when unfavorable to profits.

A-6

FY2022 Q3 YTD Reconciliation from Reported to Core
(Billion )	REPORTED		REPORTED TO CORE ADJUSTMENTS						CORE
---	---	---	---	---	---	---	---	---	---
		Impairment of<br>intangible<br>assets		Other<br>operating income/<br>expenses		Others
Revenue	3,071.3								3,071.3
Cost of sales	(934.3)							32.6	(901.7)
Gross profit	2,137.0							32.6	2,169.6
SG&A expenses	(742.5)							(0.4)	(742.9)
R&D expenses	(472.4)							0.3	(472.1)
Amortization of intangible assets associated with products	(370.6)		370.6						—
Impairment losses on intangible assets associated with products	(38.6)				38.6				—
Other operating income	16.7						(16.7)		—
Other operating expenses	(127.6)						127.6		—
Operating profit	401.9		370.6		38.6		111.0	32.5	954.7
Margin	13.1	%							31.1%
Finance income and (expenses), net	(71.6)							(33.4)	(105.0)
Share of profit (loss) of investments accounted for using the equity method	(3.1)							5.6	2.5
Profit before tax	327.2		370.6		38.6		111.0	4.8	852.1
Tax expenses	(41.3)		(79.4)		(8.2)		(24.1)	8.0	(144.9)
Non-controlling interests	(0.0)								(0.0)
Net profit attributable to owners of the Company	285.9		291.2		30.4		86.9	12.8	707.2
EPS (yen)	184								456
Number of shares (millions)	1,551								1,551

All values are in Japanese Yen.

A-7

FY2022 Q3 (Oct-Dec) Reconciliation from Reported to Core
(Billion )	REPORTED		REPORTED TO CORE ADJUSTMENTS						CORE
---	---	---	---	---	---	---	---	---	---
		Impairment of<br>intangible<br>assets		Other<br>operating income/<br>expenses		Others
Revenue	1,096.6								1,096.6
Cost of sales	(336.0)							5.9	(330.1)
Gross profit	760.6							5.9	766.4
SG&A expenses	(262.3)							(0.1)	(262.4)
R&D expenses	(174.6)							0.1	(174.6)
Amortization of intangible assets associated with products	(129.8)		129.8						—
Impairment losses on intangible assets associated with products	(5.8)				5.8				—
Other operating income	3.2						(3.2)		—
Other operating expenses	(44.3)						44.3		—
Operating profit	147.0		129.8		5.8		41.1	5.8	329.5
Margin	13.4	%							30.0%
Finance income and (expenses), net	(38.1)							1.3	(36.8)
Share of profit (loss) of investments accounted for using the equity method	(1.8)							1.6	(0.2)
Profit before tax	107.2		129.8		5.8		41.1	8.7	292.5
Tax expenses	12.0		(27.9)		(1.2)		(11.0)	(4.0)	(32.0)
Non-controlling interests	(0.0)								(0.0)
Net profit attributable to owners of the Company	119.1		101.9		4.6		30.1	4.7	260.5
EPS (yen)	77								168
Number of shares (millions)	1,555								1,555

All values are in Japanese Yen.

A-8

FY2021 Q3 YTD Reconciliation from Reported to Core
(Billion )	REPORTED		REPORTED TO CORE ADJUSTMENTS												CORE
---	---	---	---	---	---	---	---	---	---	---	---	---	---	---	---
		Impairment of<br>intangible<br>assets		Other<br>operating income/<br>expenses		Sale of Japan diabetes portfolio		Irish<br><br>Tax<br><br>Assessment<br><br>*1		TEVA JV related accounting adjustments		Others
Revenue	2,695.7								(133.0)						2,562.7
Cost of sales	(798.5)								0.6					33.1	(764.7)
Gross profit	1,897.3								(132.4)					33.1	1,798.0
SG&A expenses	(662.9)								1.0					2.8	(659.1)
R&D expenses	(382.5)													1.6	(380.9)
Amortization of intangible assets associated with products	(309.1)		309.1												—
Impairment losses on intangible assets associated with products	(14.6)				14.6										—
Other operating income	34.3						(33.2)						(1.1)		—
Other operating expenses	(100.0)						100.0								—
Operating profit	462.5		309.1		14.6		66.9		(131.4)				(1.1)	37.5	757.9
Margin	17.2	%													29.6%
Finance income and (expenses), net	(100.6)													11.6	(89.0)
Share of profit (loss) of investments accounted for using the equity method	(5.3)												6.6	2.4	3.8
Profit before tax	356.6		309.1		14.6		66.9		(131.4)				5.5	51.5	672.7
Tax expenses	(115.1)		(68.9)		(3.6)		(17.5)		40.2		64.6		(1.7)	(49.1)	(151.1)
Non-controlling interests	(0.1)														(0.1)
Net profit attributable to owners of the Company	241.4		240.2		10.9		49.4		(91.2)		64.6		3.8	2.3	521.5
EPS (yen)	154														333
Number of shares (millions)	1,567														1,567

All values are in Japanese Yen.

*1 Tax charges of 64.6 billion JPY arising from the tax assessment involving Irish taxation of the break fee Shire received from AbbVie in connection with the terminated offer to acquire Shire made by AbbVie in 2014, net of 0.5 billion JPY of associated tax benefit.

A-9

FY2021 Q3 (Oct-Dec) Reconciliation from Reported to Core
(Billion )	REPORTED		REPORTED TO CORE ADJUSTMENTS											CORE
---	---	---	---	---	---	---	---	---	---	---	---	---	---	---
		Impairment of<br>intangible<br>assets		Other<br>operating income/<br>expenses		Sale of Japan diabetes portfolio		Irish<br><br>Tax<br><br>Assessment<br><br>*1	TEVA JV related accounting adjustments		Others
Revenue	901.3													901.3
Cost of sales	(281.4)												10.8	(270.6)
Gross profit	619.9												10.8	630.7
SG&A expenses	(231.1)												0.7	(230.4)
R&D expenses	(128.4)												0.3	(128.1)
Amortization of intangible assets associated with products	(105.0)		105.0											—
Impairment losses on intangible assets associated with products	(13.1)				13.1									—
Other operating income	14.7						(14.4)					(1.1)	0.7	—
Other operating expenses	(40.6)						40.6							—
Operating profit	116.5		105.0		13.1		26.2					(1.1)	12.5	272.2
Margin	12.9	%												30.2%
Finance income and (expenses), net	(42.6)												12.0	(30.6)
Share of profit (loss) of investments accounted for using the equity method	(1.7)											6.6	(4.0)	0.9
Profit before tax	72.2		105.0		13.1		26.2					5.5	20.5	242.6
Tax expenses	(14.4)		(23.4)		(3.1)		(6.0)			0.9		(1.7)	(9.2)	(56.9)
Non-controlling interests	(0.1)													(0.1)
Net profit attributable to owners of the Company	57.8		81.6		10.0		20.2			0.9		3.8	11.3	185.6
EPS (yen)	37													119
Number of shares (millions)	1,565													1,565

All values are in Japanese Yen.

*1 Interest on tax charges arising from the tax assessment involving Irish taxation of the break fee Shire received from AbbVie in connection with the terminated offer to acquire Shire made by AbbVie in 2014.

A-10

Free Cash Flow
(Billion JPY)	FY2021<br>Q3 YTD	FY2022<br>Q3 YTD	Change versus the previous year
---	---	---	---	---
Net profit	241.5	285.9	44.4	18.4%
Depreciation, amortization and impairment loss	445.5	545.0	99.4
Decrease (increase) in trade working capital	41.2	(172.4)	(213.5)
Income taxes paid	(107.2)	(173.4)	(66.1)
Tax refunds and interest on tax refunds received	6.1	8.3	2.2
Other	120.3	190.0	69.7
Net cash from operating activities	747.5	683.5	(64.1)	(8.6)%
Adjustment for cash temporarily held by Takeda on behalf of third parties*1	47.0	76.2	29.2
Acquisition of PP&E	(87.7)	(104.9)	(17.2)
Proceeds from sales of PP&E	0.4	0.1	(0.3)
Acquisition of intangible assets	(46.5)	(84.7)	(38.2)
Acquisition of investments	(7.6)	(5.4)	2.2
Proceeds from sales and redemption of investments	16.1	20.6	4.5
Proceeds from sales of business, net of cash and cash equivalents divested	2.1	—	(2.1)
Free Cash Flow	671.3	585.2	(86.1)	(12.8)%
*1 Adjustment refers to changes in cash balance that is temporarily held by Takeda on behalf of third parties related to vaccine operations and the trade receivables sales program.

A-11

FY2022 Q3 YTD Net Debt to Adjusted EBITDA
NET DEBT/ADJUSTED EBITDA RATIO		NET INCREASE (DECREASE) IN CASH
---	---	---	---	---	---	---	---
(Billion )		(Billion JPY)	FY2021<br>Q3 YTD	FY2022<br>Q3 YTD	Change versus the previous year
Cash and cash equivalents*1		Net cash from operating activities	747.5	683.5	(64.1)	(8.6)	%
Book value debt on consolidated statements of financial position		Acquisition of PP&E	(87.7)	(104.9)
Hybrid bond 50% equity credit		Proceeds from sales of PP&E	0.4	0.1
FX adjustment*2		Acquisition of intangible assets	(46.5)	(84.7)
Gross debt*3		Acquisition of investments	(7.6)	(5.4)
Net cash (debt)		Proceeds from sales and redemption of investments	16.1	20.6
		Acquisition of business, net of cash and cash equivalents acquired	(49.7)	—
Net debt/Adjusted EBITDA ratio	x	Proceeds from sales of business, net of cash and cash equivalents divested	2.1	—
		Net decrease in short-term loans and commercial papers	(0.0)	—
Adjusted EBITDA (LTM)*4		Repayment of long-term loans	(414.1)	(0.1)
		Proceeds from issuance of bonds	249.3	—
		Repayment of bonds	(220.9)	(281.5)
		Purchase of treasury shares	(52.5)	(26.9)
		Interest paid	(84.9)	(86.6)
		Dividends paid	(273.0)	(269.0)
		Others	(29.9)	(32.7)
		Net increase (decrease) in cash	(251.4)	(187.7)	63.7	(25.3)	%
*1 Includes short-term investments which mature or become due within one year from the reporting date and excludes cash temporarily held by Takeda on behalf of third parties related to vaccine operations and the trade receivables sales program.
*2 FX adjustment refers to change from month-end rate to average rate used for non- debt calculation outstanding at the beginning of the period to match with adjusted EBITDA (which is calculated based on average rates). New non- debt incurred and existing non- debt redeemed during the reporting period are translated to at relevant spot rates as of the relevant date.
*3 Bonds and loans of current and non-current liabilities. 250Bn yen reduction in debt due to 500Bn yen hybrid bond issuance in June 2019, given that the hybrid bond qualifies for 50% equity credit for leverage purposes. Includes non-cash adjustments related to debt amortization and FX impact.
*4 LTM represents Last Twelve Months (January 2022 - December 2022). Calculated by subtracting FY2021 Q3 YTD from FY2021 Full Year and adding FY2022 Q3 YTD.

All values are in Japanese Yen.

A-12

FY2021 Net Debt to Adjusted EBITDA
NET DEBT/ADJUSTED EBITDA RATIO		NET INCREASE (DECREASE) IN CASH
---	---	---	---	---	---	---	---
(Billion )		(Billion JPY)	FY2020	FY2021	vs. PY
Cash and cash equivalents*1		Net cash from operating activities	1,010.9	1,123.1	112.2	11.1	%
Book value debt on consolidated statements of financial position		Acquisition of PP&E	(111.2)	(123.3)
Hybrid bond 50% equity credit		Proceeds from sales of PP&E	46.5	1.8
FX adjustment*2		Acquisition of intangible assets	(125.3)	(62.8)
Gross debt*3		Acquisition of investments	(12.6)	(8.3)
Net cash (debt)		Proceeds from sales and redemption of investments	74.6	16.9
		Acquisition of business, net of cash and cash equivalents acquired	—	(49.7)
Net debt/Adjusted EBITDA ratio	x	Proceeds from sales of business, net of cash and cash equivalents divested	530.4	28.2
		Net increase (decrease) in short-term loans and commercial papers	(149.0)	(0.0)
Adjusted EBITDA		Repayment of long-term loans	(792.5)	(414.1)
		Proceeds from issuance of bonds	1,179.5	249.3
		Repayment of bonds	(859.2)	(396.0)
		Purchase of treasury shares	(2.1)	(77.5)
		Interest paid	(107.3)	(108.2)
		Dividends paid	(283.4)	(283.7)
		Others	(83.1)	(41.1)
		Net increase (decrease) in cash	316.1	(145.3)	(461.4)	－
*1 Includes short-term investments which mature or become due within one year from the reporting date and excludes cash temporarily held by Takeda on behalf of third parties related to vaccine operations and the trade receivables sales program.
*2 FX adjustment refers to change from month-end rate to average rate used for non- debt calculation outstanding at the beginning of the period to match with adjusted EBITDA (which is calculated based on average rates). New non- debt incurred and existing non- debt redeemed during the reporting period are translated to at relevant spot rates as of the relevant date.
*3 Bonds and loans of current and non-current liabilities. 250Bn yen reduction in debt due to 500Bn yen hybrid bond issuance in June 2019, given that the hybrid bond qualifies for 50% equity credit for leverage purposes. Includes non-cash adjustments related to debt amortization and FX impact.

All values are in Japanese Yen.

A-13

FY2022 Q3 YTD and FY2021 Q3 YTD Net Profit to Adjusted EBITDA Bridge
(Billion JPY)	FY2021<br>Q3 YTD	FY2022<br>Q3 YTD	Change versus the previous year
---	---	---	---	---
Net profit	241.5	285.9	44.4	18.4%
Income tax expenses	115.1	41.3
Depreciation and amortization	430.9	503.0
Interest expense, net	86.7	86.0
EBITDA	874.2	916.2	42.0	4.8%
Impairment losses	14.7	42.0
Other operating expense (income), net, excluding depreciation and amortization and other miscellaneous expenses (non-cash item)	59.5	105.4
Finance expense (income), net, excluding interest income and expense, net	13.9	(14.4)
Share of loss on investments accounted for under the equity method	5.3	3.1
Other adjustments:	(46.6)	77.2
Non-core expense related to COVID-19	7.2	8.4
Sales of Japan diabetes portfolio and other non-core product divestitures	(131.4)	—
Impact on profit related to fair value step up of inventory in Shire acquisition	24.8	24.9
Other costs*1	52.9	43.9
Adjusted EBITDA	920.9	1,129.5	208.6	22.7%
*1 Includes adjustments for non-cash equity-based compensation expense and other one time non-cash expense.

A-14

FY2022 Q3 YTD Net Profit to Adjusted EBITDA LTM Bridge
(Billion JPY)	FY2021<br>Full Year<br>(Apr-Mar)	FY2021<br>Q3 YTD<br>(Apr - Dec)	FY2022<br>Q3 YTD<br>(Apr - Dec)	FY2022<br><br>Q3 YTD LTM*1<br><br>(Jan-Dec)
---	---	---	---	---
Net profit	230.2	241.5	285.9	274.5
Income tax expenses	72.4	115.1	41.3	(1.4)
Depreciation and amortization	583.2	430.9	503.0	655.3
Interest expense, net	117.8	86.7	86.0	117.2
EBITDA	1,003.6	874.2	916.2	1,045.6
Impairment losses	54.5	14.7	42.0	81.8
Other operating expense (income), net, excluding depreciation and amortization and other miscellaneous expenses (non-cash item)	106.3	59.5	105.4	152.1
Finance expense (income), net, excluding interest income and expense, net	25.1	13.9	(14.4)	(3.2)
Share of loss on investments accounted for under the equity method	15.4	5.3	3.1	13.2
Other adjustments:	(30.2)	(46.6)	77.2	93.6
Non-core expense related to COVID-19	10.4	7.2	8.4	11.6
Sale of Japan diabetes portfolio	(144.8)	(131.4)	—	(13.4)
Impact on profit related to fair value step up of inventory in Shire acquisition	31.9	24.8	24.9	32.0
Other costs*2	72.4	52.9	43.9	63.4
Adjusted EBITDA	1,174.5	920.9	1,129.5	1,383.2
EBITDA from divested products*3	(6.6)			(1.9)
Adjusted EBITDA (LTM)	1,168.0			1,381.2
*1 LTM represents Last Twelve Months (January 2022 - December 2022). Calculated by subtracting FY2021 Q3 YTD from FY2021 Full Year and adding FY2022 Q3 YTD.
*2 Includes adjustments for non-cash equity-based compensation expense and other one time non-cash expense.
*3 Represents adjustments for EBITDA from divested products which are removed as part of LTM Adjusted EBITDA.

A-15

FX Rates and FY2022 Currency Sensitivity
Average Exchange Rates vs.						Impact of depreciation of yen from October 2022 to March 2023 on FY2022 forecast (100 million )
---	---	---	---	---	---	---	---	---	---	---	---	---	---
	FY2021<br>Actual<br>(Apr-Dec)		FY2022<br>Actual<br>(Apr-Dec)	FY2022<br>Assumption<br>(Apr-Mar)			Revenue<br>(IFRS)		Operating<br>Profit<br>(IFRS)		Net Profit<br>(IFRS)		Core<br>Operating<br>Profit<br>(non-IFRS)
	111		136	132		1% depreciation	86.9		14.0		10.5		31.4
		66.1			10.7			23.9
	131		140	138		1% depreciation	22.0		(14.7)		(15.5)		(11.7)
		16.0			(10.6)			(8.5)
RUB	1.5		2.2	2.1		1% depreciation	2.9		1.6		1.6		1.8
CNY	17.2		19.8	19.8				5.1		5.1		5.1
BRL	20.7		26.5	26.4				2.4		2.4		2.5

All values are in Japanese Yen.

A-16

CAPEX, Depreciation and Amortization and Impairment Losses
(Billion )	FY2021<br>Q3 YTD	FY2022<br>Q3 YTD	vs. PY		FY2022 Latest<br>Forecast<br>(Oct 27, 2022)
---	---	---	---	---	---
Capital expenditures*1	134.2	189.6	55.4	41.3%	260.0 to 310.0
Tangible assets	87.7	104.9	17.2	19.6%
Intangible assets	46.5	84.7	38.2	82.0%
*1 Cash flow base
Depreciation and amortization	428.4	500.5	72.2	16.8%	640.0
Depreciation of tangible assets*2 (A)	99.6	110.8	11.2	11.3%
Amortization of intangible assets (B)	328.8	389.7	60.9	18.5%
Of which Amortization associated with products (C)	309.1	370.6	61.5	19.9%	480.0
Of which Amortization excluding intangible assets     associated with products (D)	19.7	19.1	(0.6)	(3.2)%
*2 Excluding depreciation from investment properties
Depreciation and amortization (excluding intangible assets associated with products) (A)+(D)	119.3	129.9	10.6	8.9%	160.0
Impairment losses	14.7	38.9	24.2	165.3%
Impairment losses associated with products	14.6	38.6	24.0	165.0%	50.0
Amortization and impairment losses on intangible assets associated with products	323.6	409.2	85.6	26.4%	530.0
*Capital expenditures in the latest forecast do not include the impact of acquisitions that have been announced but not completed yet, including the upfront cash payment for the acquisition of NDI-034858 from Nimbus Therapeutics, LLC, for 4 billion , as the exact timing of cash payment is dependent upon deal close.

All values are in US Dollars.

A-17

FY2022 Detailed Forecast
(BN JPY)	FY2021<br>Actual	FY2022<br>Latest<br>Forecast<br>(Oct 27, 2022)	FY2022<br>Latest<br>Forecast<br>% change vs. PY
---	---	---	---
Revenue	3,569.0	3,930.0	10.1%
R&D expenses	(526.1)	(620.0)	(17.9)%
Amortization of intangible assets associated with products	(418.8)	(480.0)	(14.6)%
Impairment losses on intangible assets associated with products	(54.1)	(50.0)	7.6%
Other operating income	43.1	13.0	(69.9)%
Other operating expenses	(159.1)	(100.0)	37.1%
Operating profit	460.8	530.0	15.0%
Finance income (expenses), net	(142.9)	(105.0)	26.5%
Profit before tax	302.6	426.0	40.8%
Net profit attributable to owners of the Company	230.1	307.0	33.4%
Basic EPS (yen)	147	198	34.4%
Core Revenue*1	3,420.5	3,930.0	14.9%
Core Operating Profit*1	955.2	1,180.0	23.5%
Core EPS (yen)	425	525	23.6%
USD/JPY (yen)	112	132	18.3%
EUR/JPY (yen)	131	138	5.9%

*1 Please refer to A-1 Definition of Core Financial Measures, Constant Exchange Rate change, and Free Cash Flow, for the definition and A-20 FY2022 Full Year Reconciliation from Reported Operating Profit to Core Operating Profit Forecast, for reconciliation.

A-18

FY2022 Core Operating Profit Adjustment Items & Cash Flow Forecast
CORE OPERATING PROFIT ADJUSTMENT ITEMS
---	---	---
(Billion JPY)	FY2022<br>Q3 YTD	FY2022<br>Latest<br>Forecast<br>(Oct 27, 2022)
Amortization of intangible assets associated with products	370.6	480.0
Of which Shire-acquisition related	300.9	390.0
Impairment losses on intangible assets associated with products	38.6	50.0
Other operating income	(16.7)	(13.0)
Other operating expenses	127.6	100.0
Other Core Operating Profit adjustments	32.5	33.0
Of which Shire-acquisition related to unwind of inventories step-up	24.9	25.0
Total core operating profit adjustments	552.7	650.0
CASH FLOW GUIDANCE
(Billion JPY)	FY2022<br>Q3 YTD	FY2022<br>Latest<br>Forecast<br>(Oct 27, 2022)
Free cash flow*1	585.2	650.0 to 750.0
CAPEX (cash flow base)*1	(189.6)	(260.0) to (310.0)
Depreciation and amortization (excluding intangible assets associated with products)	(129.9)	(160.0)
Cash tax rate on adjusted EBITDA (excluding divestitures)	N/A	mid-teen %

*1 Free cash flow and capital expenditures in the latest forecast do not include the impact of acquisitions that have been announced but not completed yet, including the upfront cash payment for the acquisition of NDI-034858 from Nimbus Therapeutics, LLC,

for 4 billion USD, as the exact timing of cash payment is dependent upon deal close.

A-19

FY2022 Reconciliation from Reported Operating Profit to Core Operating Profit Forecast
(Billion )	REPORTED		REPORTED TO CORE ADJUSTMENTS						CORE
---	---	---	---	---	---	---	---	---	---
		Impairment of<br>intangible<br>assets		Other<br>operating<br>income<br>(expenses)		Others
Revenue	3,930.0								3,930.0
Cost of sales								28.0
Gross Profit								28.0
SG&A and R&D expenses								5.0
Amortization of intangible assetsassociated with products	(480.0)		480.0						—
Impairment losses on intangible assets associated with products	(50.0)				50.0				—
Other operating income	13.0						(13.0)		—
Other operating expenses	(100.0)						100.0		—
Operating profit	530.0		480.0		50.0		87.0	33.0	1,180.0

All values are in Japanese Yen.

A-20

Important Notice

For the purposes of this notice, “report” means this document, any oral presentation, any question and answer session and any written or oral material discussed or distributed by Takeda Pharmaceutical Company Limited (“Takeda”) regarding this report. This report (including any oral briefing and any question-and-answer in connection with it) is not intended to, and does not constitute, represent or form part of any offer, invitation or solicitation of any offer to purchase, otherwise acquire, subscribe for, exchange, sell or otherwise dispose of, any securities or the solicitation of any vote or approval in any jurisdiction. No shares or other securities are being offered to the public by means of this report. No offering of securities shall be made in the United States except pursuant to registration under the U.S. Securities Act of 1933, as amended, or an exemption therefrom. This report is being given (together with any further information which may be provided to the recipient) on the condition that it is for use by the recipient for information purposes only (and not for the evaluation of any investment, acquisition, disposal or any other transaction). Any failure to comply with these restrictions may constitute a violation of applicable securities laws.

The companies in which Takeda directly and indirectly owns investments are separate entities. In this report, “Takeda” is sometimes used for convenience where references are made to Takeda and its subsidiaries in general. Likewise, the words “we”, “us” and “our” are also used to refer to subsidiaries in general or to those who work for them. These expressions are also used where no useful purpose is served by identifying the particular company or companies.

The product names appearing in this document are trademarks or registered trademarks owned by Takeda, or their respective owners.

Forward-Looking Statements

This report and any materials distributed in connection with this report may contain forward-looking statements, beliefs or opinions regarding Takeda’s future business, future position and results of operations, including estimates, forecasts, targets and plans for Takeda. Without limitation, forward-looking statements often include words such as “targets”, “plans”, “believes”, “hopes”, “continues”, “expects”, “aims”, “intends”, “ensures”, “will”, “may”, “should”, “would”, “could”, “anticipates”, “estimates”, “projects” or similar expressions or the negative thereof. These forward-looking statements are based on assumptions about many important factors, including the following, which could cause actual results to differ materially from those expressed or implied by the forward-looking statements: the economic circumstances surrounding Takeda’s global business, including general economic conditions in Japan and the United States; competitive pressures and developments; changes to applicable laws and regulations, including global health care reforms; challenges inherent in new product development, including uncertainty of clinical success and decisions of regulatory authorities and the timing thereof; uncertainty of commercial success for new and existing products; manufacturing difficulties or delays; fluctuations in interest and currency exchange rates; claims or concerns regarding the safety or efficacy of marketed products or product candidates; the impact of health crises, like the novel coronavirus pandemic, on Takeda and its customers and suppliers, including foreign governments in countries in which Takeda operates, or on other facets of its business; the timing and impact of post-merger integration efforts with acquired companies; the ability to divest assets that are not core to Takeda’s operations and the timing of any such divestment(s); the extent to which our internal energy conservation measures and future advancements in renewable energy or low carbon energy technology will enable us to reduce our greenhouse gas emissions; and other factors identified in Takeda’s most recent Annual Report on Form 20-F and Takeda’s other reports filed with the U.S. Securities and Exchange Commission, available on Takeda’s website at: https://www.takeda.com/investors/sec-filings/ or at www.sec.gov. Takeda does not undertake to update any of the forward-looking statements contained in this report or any other forward-looking statements it may make, except as required by law or stock exchange rule. Past performance is not an indicator of future results and the results or statements of Takeda in this report may not be indicative of, and are not an estimate, forecast, guarantee or projection of Takeda’s future results.

A-21

Financial Information and Certain Non-IFRS Financial Measures

Takeda’s financial statements are prepared in accordance with International Financial Reporting Standards (“IFRS”).

This report and materials distributed in connection with this report include certain financial measures not presented in accordance with IFRS, such as Core Revenue, Core Operating Profit, Core Net Profit, Core EPS, Constant Exchange Rate (“CER”) change, Net Debt, EBITDA, Adjusted EBITDA and Free Cash Flow. Takeda’s management evaluates results and makes operating and investment decisions using both IFRS and non-IFRS measures included in this presentation. These non-IFRS measures exclude certain income, cost and cash flow items which are included in, or are calculated differently from, the most closely comparable measures presented in accordance with IFRS. By including these non-IFRS measures, management intends to provide investors with additional information to further analyze Takeda’s performance and core results, including when controlling for the effect of fluctuations in exchange rates. Takeda’s non-IFRS measures are not prepared in accordance with IFRS and such non-IFRS measures should be considered a supplement to, and not a substitute for, measures prepared in accordance with IFRS (which we sometimes refer to as “reported” measures). Investors are encouraged to review the definitions and reconciliations of non-IFRS financial measures to their most directly comparable IFRS measures.

Medical information

This report contains information about products that may not be available in all countries, or may be available under different trademarks, for different indications, in different dosages, or in different strengths. Nothing contained herein should be considered a solicitation, promotion or advertisement for any prescription drugs including the ones under development.

A-22