Sio Capital Management, LLC

CIK

1482416

Location

NEW YORK, NY

Portfolio Value

Micro $0

Diversification

Diversified

Filing Date

Global Rank

#2,191 / 8,586 ▲ 109

Top Industry

Biotechnology 45.4%

3Y Alpha vs SPY

-1.3%

Period ended 3 months ago

Filed May 14, 2026 · 33d

25 quarters · since Mar 2020

Clone Performance

Jun 2023–Jun 2026 · vs SPY

Hypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.

Cloned portfolio

+72.5%

SPY

+78.1%

Annualised alpha

-1.3%

Max drawdown

−37.3%

Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.

Portfolio Concentration

72 positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025

Top Position

7.1%

−0.1 pts

Top 5

26.7%

−6.7 pts

Top 10

45.2%

−6.6 pts

HHI

302

Diversified−69

Portfolio Trend

25 quarters · across all stocks

Sector Breakdown

As of Mar 31, 2026

Sector	% Portfolio	Value	Positions
Healthcare	92.5%	$643,534,248	70
Industrials	7.1%	$49,281,682	1
Unclassified	0.4%	$3,060,613	1

Last Quarter's Activity

Export CSV

Mar 31, 2026 vs Dec 31, 2025

Added To

Positions the filer increased

24 positions

Ticker	Company	Δ Shares	Shares	Value
AVR	Anteris Technologies Global Corp.	+3,508,324	5,382,965	$29,875,455
WAY	Waystar Holding Corp.	+1,028,511	1,642,236	$39,594,309
VIR	Vir Biotechnology, Inc.	+1,020,277	1,498,620	$13,427,635
AQST	Aquestive Therapeutics, Inc.	+929,792	1,922,887	$7,979,981
PMVP	PMV Pharmaceuticals, Inc.	+440,032	3,076,580	$3,814,959
MMS	Maximus, Inc.	+268,521	768,825	$49,281,682
TARA	Protara Therapeutics, Inc.	+254,445	1,969,839	$10,262,861
RAPP	Rapport Therapeutics, Inc.	+181,544	366,809	$11,477,453
ICLR	Icon PLC	+179,156	306,358	$33,901,576
ANIP	Ani Pharmaceuticals Inc	+178,271	265,543	$20,420,256
IBIO	iBio, Inc.	+164,268	904,268	$1,718,109
HAE	Haemonetics Corp	+128,041	220,672	$12,437,073
CRNX	Crinetics Pharmaceuticals, Inc.	+125,046	249,887	$9,075,895
LIVN	LivaNova PLC	+99,233	421,615	$26,797,849
ABVX	Abivax S.A.	+92,676	135,800	$15,121,330
COR	Cencora, Inc.	+84,994	100,894	$31,694,841
TYRA	Tyra Biosciences, Inc.	+79,437	605,439	$23,188,313
EWTX	Edgewise Therapeutics, Inc.	+31,505	268,986	$8,473,059
CCRN	Cross Country Healthcare Inc	+29,572	1,098,393	$10,324,894
ORKA	Oruka Therapeutics, Inc.	+14,370	132,496	$6,498,928
TFX	Teleflex Inc	+7,924	94,800	$11,339,028
IRON	Disc Medicine, Inc.	+7,617	65,203	$4,169,079
GPCR	Structure Therapeutics Inc.	+7,593	209,093	$10,078,282
DRUG	Bright Minds Biosciences Inc.	+4,200	86,083	$6,281,476
No positions match the current search.

Trimmed

Positions the filer reduced

16 positions

Ticker	Company	Δ Shares	Shares	Value
OGN	Organon & Co.	−2,555,857	865,908	$5,186,788
HYPR	Hyperfine, Inc.	−1,000,000	1,000,000	$1,080,000
SNY	Sanofi	−732,015	239,671	$11,547,348
NMTC	NEUROONE MEDICAL TECHNOLOGIES Corp	−643,426	496,614	$385,869
CNTX	Context Therapeutics Inc.	−423,714	917,922	$2,404,955
ZBH	Zimmer Biomet Holdings, Inc.	−323,029	62,613	$5,661,467
ELTX	Elicio Therapeutics, Inc.	−285,200	11,700	$125,073
CELC	Celcuity Inc.	−283,224	193,843	$22,125,240
PRQR	ProQR Therapeutics N.V.	−209,466	1,954,715	$3,166,638
OVID	Ovid Therapeutics Inc.	−175,114	1,252,381	$2,780,285
CNC	Centene Corp	−174,350	100,000	$3,274,000
DNTH	Dianthus Therapeutics, Inc. /DE/	−104,458	370,045	$31,054,176
BHVN	Biohaven Ltd.	−80,838	1,163,926	$9,846,813
BMRN	Biomarin Pharmaceutical Inc	−38,462	194,226	$10,971,826
SI	Shoulder Innovations, Inc.	−17,330	210,641	$3,060,613
ALGS	Aligos Therapeutics, Inc.	−8,700	327,237	$2,431,370
No positions match the current search.

New Positions

Positions the filer opened this quarter

21 positions

Ticker	Company	Shares	Value
CORT	Corcept Therapeutics Inc	674,759	$27,199,535
GSK	GSK plc	385,879	$21,296,662
ABT	Abbott Laboratories	186,574	$19,155,552
EMBC	Embecta Corp.	1,847,850	$16,334,994
SION	Sionna Therapeutics, Inc.	294,340	$11,800,090
MNPR	Monopar Therapeutics	173,506	$9,506,393
EYPT	EyePoint, Inc.	721,785	$9,303,808
CMPS	COMPASS Pathways plc	1,506,525	$8,331,083
OCUL	Ocular Therapeutix, Inc	968,597	$8,204,016
RLMD	Relmada Therapeutics, Inc.	965,000	$6,716,400
ZBIO	Zenas BioPharma, Inc.	331,730	$6,485,321
QDEL	QuidelOrtho Corp	359,011	$5,898,550
REPL	Replimune Group, Inc.	720,036	$5,508,275
OKUR	OnKure Therapeutics, Inc.	1,078,965	$4,466,915
IMNM	Immunome Inc.	165,110	$3,610,955
IART	Integra Lifesciences Holdings Corp	383,140	$3,609,178
ANTX	AN2 Therapeutics, Inc.	657,200	$2,247,624
SER	Serina Therapeutics, Inc.	1,000,000	$1,940,000
ERAS	Erasca, Inc.	5,000	$80,900
OSCR	Oscar Health, Inc.	3,000	$34,410
SLP	Simulations Plus, Inc.	200	$2,364
No positions match the current search.

Sold Out

Positions the filer fully exited

14 positions

Ticker	Company	Shares	Value
CI	Cigna Group	172,203	$47,395,431
RYTM	Rhythm Pharmaceuticals, Inc.	265,700	$28,440,528
KVUE	Kenvue Inc.	1,465,442	$25,278,874
XLO	Xilio Therapeutics, Inc.	2,134,537	$19,125,451
BTSG	BrightSpring Health Services, Inc.	308,010	$11,534,974
CRL	Charles River Laboratories International, Inc.	54,985	$10,968,407
MODD	Modular Medical, Inc.	785,824	$8,581,198
MCK	Mckesson Corp	6,400	$5,249,856
FULC	Fulcrum Therapeutics, Inc.	382,000	$4,320,420
ALKS	Alkermes plc.	95,353	$2,667,976
IDYA	IDEAYA Biosciences, Inc.	75,730	$2,617,986
OTLK	Outlook Therapeutics, Inc.	1,125,400	$1,778,132
AVTX	Avalo Therapeutics, Inc.	72,173	$1,310,661
NXTC	NextCure, Inc.	10,940	$155,238
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

0 positions · $0 total · Consumer Defensive only · as of Mar 31, 2026

All sectors Healthcare Industrials

No positions to show.