STATE OF WISCONSIN INVESTMENT BOARD

Position in SYRE — Spyre Therapeutics, Inc.

CIK 854157 MADISON, WI

Position in SYRE

as of Mar 31, 2026 · filed May 15, 2026 Compact

Position Value

$1,337,820

+$445,045 QoQ

Shares Held

26,523

-2.7% QoQ

Ownership

0.031%

of shares outstanding

% of Portfolio

0.00%

of 13F equity value

Holder Rank

—

not a current holder

Holding Since

Mar 2024

9 quarters on record

Voting authority Sole 100% Shared 0% None 0%

Healthcare · as of Mar 31, 2026

STATE OF WISCONSIN INVESTMENT BOARD holds $473,893,216 across 164 Biotechnology names. SYRE ranks #77 (0.3% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	VRTX	Vertex Pharmaceuticals Inc / Ma	136,548	$60,974,143
2	REGN	Regeneron Pharmaceuticals, Inc.	55,274	$42,706,903
3	ALNY	Alnylam Pharmaceuticals, Inc.	68,883	$22,791,318
4	INSM	INSMED Inc	114,346	$18,697,857
5	XENE	Xenon Pharmaceuticals Inc.	254,483	$14,798,186
6	MRNA	Moderna, Inc.	227,162	$11,539,829
7	INCY	Incyte Corp	116,878	$11,000,557
8	TECH	BIO-TECHNE Corp	208,871	$10,915,598

9 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-03-31	$1,337,820	26,523	-2.7%	Shares	Sole	2026-05-15
2025-12-31	$892,775	27,252	-18.8%	Shares	Sole	2026-02-17
2025-09-30	$562,230	33,546	-4.3%	Shares	Sole	2025-11-14
2025-06-30	$524,638	35,046	+0.4%	Shares	Sole	2025-08-14
2025-03-31	$563,127	34,901	+10.9%	Shares	Sole	2025-05-15
2024-12-31	$732,947	31,484	+71.9%	Shares	Sole	2025-02-14
2024-09-30	$538,644	18,315	+31.5%	Shares	Sole	2024-11-14
2024-06-30	$327,541	13,932	-4.8%	Shares	Sole	2024-08-14
2024-03-31	$554,991	14,632	—	Shares	Sole	2024-05-14
No filing history on record for this holder in this stock.