Stocks
SYRE Spyre Therapeutics, Inc.

SYRE

Spyre Therapeutics, Inc.

Company with tickers: SYRE

CIK

1636282

CUSIP

00773J202

Shares Outstanding

86,259,358

Price Holdings Short Volume Short Interest Fails to Deliver SEC Filings Earnings Calls Insider Trading Congress Trades

Date	Insider	Role	Type	Shares	Price	Value	After
2026-04-01	Turtle Cameron	Director	Sell	12,344	$49.20	$607,325	630,196
2026-04-01	Sloan Sheldon	Chief Medical Officer	Convert	7,958	$21.66	$172,370	7,958
2026-04-01	Sloan Sheldon	Chief Medical Officer	Sell	7,958	$50.00	$397,900	0
2026-04-01	Sloan Sheldon	Chief Medical Officer	Convert	7,958	—	—	87,542
2026-04-01	Burrows Scott L	Chief Financial Officer	Sell	6,200	$49.21	$305,102	99,294
2026-04-01	Burrows Scott L	Chief Financial Officer	Convert	7,500	$14.50	$108,750	105,494
2026-04-01	Burrows Scott L	Chief Financial Officer	Convert	7,500	—	—	394,857
2026-03-03	Burrows Scott L	Chief Financial Officer	Convert	2,500	$14.50	$36,250	100,494
2026-03-03	Burrows Scott L	Chief Financial Officer	Sell	2,300	$40.56	$93,288	98,194
2026-03-03	Burrows Scott L	Chief Financial Officer	Convert	2,500	—	—	402,357
2026-03-02	Turtle Cameron	Director	Sell	5,900	$41.73	$246,207	651,640
2026-02-02	Turtle Cameron	Director	Sell	957	$31.82	$30,452	671,583
2026-01-21	HENDERSON MICHAEL THOMAS	Chief Business Officer	Other	63,227	—	—	168,606
2026-01-09	Burrows Scott L	Chief Financial Officer	Award	140,000	—	—	140,000
2026-01-09	Turtle Cameron	Director	Award	528,000	—	—	528,000
2026-01-09	Sloan Sheldon	Chief Medical Officer	Award	140,000	—	—	140,000
2026-01-09	King-Jones Heidy	See Remarks	Award	140,000	—	—	140,000
2026-01-02	Turtle Cameron	Director	Sell	12,709	$30.47	$387,243	674,198
2025-12-01	Turtle Cameron	Director	Sell	10,995	$28.73	$315,886	690,912
2025-11-03	Turtle Cameron	Director	Sell	28,155	$23.13	$651,225	718,752
2025-09-02	Burrows Scott L	Chief Financial Officer	Sell	18,428	$16.26	$299,639	97,994
2025-05-29	Fairmount Funds Management LLC	Director	Award	25,000	—	—	25,000
2025-05-29	Stelzer Laurie	Director	Award	25,000	—	—	25,000
2025-05-29	Milligan Sandra	Interim CEO & President	Award	25,000	—	—	25,000
2025-05-29	McKenna Mark C.	Director	Award	25,000	—	—	25,000
2025-05-29	HENDERSON MICHAEL THOMAS	Chief Business Officer	Award	25,000	—	—	25,000
2025-05-29	Albers Jeffrey W.	Director	Award	25,000	—	—	25,000
2025-01-15	Burrows Scott L	Chief Financial Officer	Award	95,500	—	—	95,500
2025-01-15	Sloan Sheldon	Chief Medical Officer	Award	95,500	—	—	95,500
2025-01-15	Turtle Cameron	Director	Award	370,000	—	—	370,000
2025-01-15	King-Jones Heidy	See Remarks	Award	95,500	—	—	95,500
2025-01-10	HENDERSON MICHAEL THOMAS	Chief Business Officer	Other	105,379	—	—	105,379
2024-11-06	Albers Jeffrey W.	Director	Sell	6,700	$36.76	$246,313	27,360
2024-10-25	Albers Jeffrey W.	Director	Sell	300	$36.43	$10,929	34,060
2024-10-01	Sloan Sheldon	Chief Medical Officer	Award	400,000	—	—	400,000
2024-10-01	Sloan Sheldon	Chief Medical Officer	Other	0	—	—	0
2024-09-03	Burrows Scott L	Chief Financial Officer	Sell	18,531	$28.17	$522,074	116,422
2024-05-14	Fairmount Funds Management LLC	Director	Award	11,323	—	—	11,323
2024-05-14	Milligan Sandra	Interim CEO & President	Award	21,980	—	—	21,980
2024-05-14	Albers Jeffrey W.	Director	Award	11,323	—	—	11,323
2024-05-14	Stelzer Laurie	Director	Award	11,323	—	—	11,323
2024-05-14	HENDERSON MICHAEL THOMAS	Chief Business Officer	Award	11,323	—	—	11,323
2024-05-14	Milligan Sandra	Interim CEO & President	Other	0	—	—	0
2024-04-25	Fairmount Funds Management LLC	Director	Convert	3,639,680	—	—	4,018,101
2024-04-25	Fairmount Funds Management LLC	Director	Other	406,038	—	—	406,038
2024-04-25	Fairmount Funds Management LLC	Director	Convert	90,992	—	—	346,045
2024-02-15	Turtle Cameron	Director	Award	400	$9.82	$3,928	746,907
2024-02-01	McKenna Mark C.	Director	Award	40,000	—	—	40,000
2024-02-01	Turtle Cameron	Director	Award	277,750	—	—	277,750
2024-02-01	Burrows Scott L	Chief Financial Officer	Award	70,000	—	—	70,000
2024-02-01	King-Jones Heidy	See Remarks	Award	63,000	—	—	63,000
2024-02-01	McKenna Mark C.	Director	Other	0	—	—	0
2023-12-29	Fairmount Funds Management LLC	Director	Other	3,435,480	—	—	0
2023-12-29	Fairmount Funds Management LLC	Director	Other	437,037	—	—	437,037
2023-12-29	Fairmount Funds Management LLC	Director	Other	16,667	—	—	16,667
2023-12-22	Burrows Scott L	Chief Financial Officer	Award	134,953	—	—	134,953
2023-12-07	Fairmount Funds Management LLC	Director	Award	16,667	$600.00	$10,000,200	16,667
2023-11-24	Fairmount Funds Management LLC	Director	Other	85,887	—	—	0
2023-11-24	Fairmount Funds Management LLC	Director	Other	3,435,480	—	—	3,435,480
2023-11-24	Turtle Cameron	Director	Other	723,440	—	—	746,507
2023-11-24	Turtle Cameron	Director	Other	18,086	—	—	0
2023-11-22	Albers Jeffrey W.	Director	Award	50,000	—	—	50,000
2023-11-22	Stelzer Laurie	Director	Award	50,000	—	—	50,000
2023-11-22	Turtle Cameron	Director	Award	374,000	—	—	374,000
2023-11-22	Albers Jeffrey W.	Director	Other	0	—	—	0
2023-11-22	Stelzer Laurie	Director	Other	0	—	—	0
2023-09-01	Burrows Scott L	Chief Financial Officer	Award	10,121,441	—	—	10,121,441
2023-09-01	King-Jones Heidy	See Remarks	Other	0	—	—	0
2023-09-01	King-Jones Heidy	See Remarks	Award	13,495,255	—	—	13,495,255
2023-09-01	Burrows Scott L	Chief Financial Officer	Other	0	—	—	0
2023-06-22	Magovcevic-Liebisch Ivana	Director	Award	1,950,000	—	—	1,950,000
2023-06-22	Smith Hunter C	Chief Financial Officer	Award	1,950,000	—	—	1,950,000
2023-06-22	Alspaugh Jonathan	President and CFO	Award	19,787,969	—	—	19,787,969
2023-06-22	Lawton Alison Frances	Director	Award	1,950,000	—	—	1,950,000
2023-06-22	Turtle Cameron	Director	Other	0	—	—	0
2023-06-22	Turtle Cameron	Director	Other	0	—	—	0
2023-06-22	Turtle Cameron	Director	Other	576,699	—	—	576,699
2023-06-22	HENDERSON MICHAEL THOMAS	Chief Business Officer	Other	0	—	—	0
2023-06-22	Cox Russell J.	Director	Award	1,950,000	—	—	1,950,000
2023-06-22	Fairmount Funds Management LLC	Director	Other	0	—	—	0
2023-06-22	Fairmount Funds Management LLC	Director	Other	0	—	—	0
2023-06-22	Fairmount Funds Management LLC	Director	Other	276,082	—	—	276,082
2023-02-23	Neuman Linda L	Chief Medical Officer	Award	550,000	—	—	550,000
2023-02-23	Kastenmayer James Paul	General Counsel	Award	500,000	—	—	500,000
2023-02-23	Hanley Jr. Michael Conick	Chief Business Officer	Award	500,000	—	—	500,000
2023-02-23	Alspaugh Jonathan	President and CFO	Award	640,000	—	—	640,000
2022-11-29	Goldberg Jeff Marc	Director, President and CEO	Other	0	—	—	0
2022-11-29	Goldberg Jeff Marc	Director, President and CEO	Award	1,884,838	—	—	1,884,838
2022-11-14	Neuman Linda L	Chief Medical Officer	Award	25,000	—	—	25,000
2022-11-14	Neuman Linda L	Chief Medical Officer	Other	4,000	—	—	4,000
2022-11-14	Neuman Linda L	Chief Medical Officer	Other	0	—	—	0
2022-08-25	Souza Marcio	Chief Operating Officer	Buy	90,000	$0.56	$50,472	90,000
2022-08-23	Kastenmayer James Paul	General Counsel	Award	130,000	—	—	130,000
2022-08-23	Alspaugh Jonathan	President and CFO	Award	130,000	—	—	130,000
2022-08-23	Kastenmayer James Paul	General Counsel	Other	0	—	—	0
2022-08-23	Kastenmayer James Paul	General Counsel	Other	4,000	—	—	4,000
2022-08-23	Sloan Leslie	Chief Operating Officer	Award	130,000	—	—	130,000
2022-08-23	Hanley Jr. Michael Conick	Chief Business Officer	Award	130,000	—	—	130,000
2022-06-08	Hanley Jr. Michael Conick	Chief Business Officer	Buy	28,200	$0.71	$20,022	36,200
2022-06-07	Shanafelt Armen	Director	Award	43,000	—	—	43,000