8-K

ALEXANDRIA REAL ESTATE EQUITIES, INC. (ARE)

8-K 2021-10-25 For: 2021-10-25
View Original
Added on April 01, 2026

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): October 25, 2021

ALEXANDRIA REAL ESTATE EQUITIES, INC.

(Exact name of registrant as specified in its charter)

Maryland 1-12993 95-4502084
(State or other jurisdiction of<br>incorporation) (Commission File Number) (I.R.S. Employer Identification No.)

26 North Euclid Avenue, Pasadena, California 91101

(Address of principal executive offices) (Zip code)

Registrant’s telephone number, including area code: (626) 578-0777

N/A

(Former name or former address, if changed since last report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐            Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐            Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐           Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐            Pre-commencement communications pursuant to Rule 13e-4 (c) under the Exchange Act (17 CFR 240.13e-4 (c))

Securities registered pursuant to Section 12(b) of the Exchange Act:

Title of each class Trading Symbol(s) Name of each exchange on which registered
Common Stock, $.01 par value per share ARE New York Stock Exchange

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Item 2.02.  Results of Operations and Financial Condition.

On October 25, 2021, Alexandria Real Estate Equities, Inc. (the “Company”) issued a press release entitled “Alexandria Real Estate Equities, Inc. Reports Third Quarter Ended September 30, 2021 Financial and Operating Results.”  The press release referred to certain supplemental information that is available on the Company’s website at www.are.com.  A copy of the press release and supplemental information are attached hereto as Exhibit 99.1.

The information contained in this Item 2.02, including the exhibit referenced herein, is being furnished and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section.  Such information shall not be incorporated by reference into any filing under the Securities Act of 1933, as amended (the “Securities Act”), or the Exchange Act, whether made before or after the date hereof, regardless of any general incorporation language in such filing.

Item 9.01.  Financial Statements and Exhibits.

(d)  Exhibits.

99.1     Alexandria Real Estate Equities, Inc.’s Earnings Press Release and Supplemental Information for the Third Quarter Ended September 30, 2021

104 Cover Page Interactive Data File (embedded within the Inline XBRL document)

Forward-Looking Statements

This current report on Form 8-K contains forward-looking statements within the meaning of Section 27A of the Securities Act, and Section 21E of the Exchange Act.  These statements include words such as “forecast,” “guidance,” “projects,” “estimates,” “anticipates,” “goals,” “believes,” “expects,” “intends,” “may,” “plans,” “seeks,” “should,” or “will,” or the negative of these words or similar words.  Forward-looking statements involve certain risks and uncertainties, and actual results may differ materially from those discussed in each such statement.  A number of important factors could cause actual results to differ materially from those included within or contemplated by the forward-looking statements, including, but not limited to, the factors described in the Company’s filings with the Securities and Exchange Commission, including the Company’s most recent annual report on Form 10-K and any subsequent quarterly reports on Form 10-Q.  The Company does not undertake any responsibility to update any of these factors or to announce publicly any revisions to any of the forward-looking statements contained in this or any other document, whether as a result of new information, future events, or otherwise.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

ALEXANDRIA REAL ESTATE EQUITIES, INC.
October 25, 2021 By: /s/ Joel S. Marcus
Joel S. Marcus
Executive Chairman
By: /s/ Stephen A. Richardson
Stephen A. Richardson
Co-Chief Executive Officer
By: /s/ Peter M. Moglia
Peter M. Moglia
Co-Chief Executive Officer and <br>Co-Chief Investment Officer
By: /s/ Dean A. Shigenaga
Dean A. Shigenaga
President and Chief Financial Officer

Document

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(1)Source: Centers for Disease Control and Prevention/National Center for Health Statistics, “Provisional Drug Overdose Death Counts: Dashboard,” accessed October 14, 2021. The latest reported provisional data for drug overdose deaths may not be complete. The predicted provisional count, which accounts for incomplete reporting, exceeds 99,000 overdose deaths.

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(1)Liquidity as of September 30, 2021. Refer to “Key credit metrics” of our Supplemental Information for additional details.

(2)As of September 30, 2021.

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(1)Represents credit rating levels from Moody’s Investors Service and S&P Global Ratings for publicly traded U.S. REITs, from Bloomberg Professional Services as of September 30, 2021.

(2)As of the date of this report.

(3)As of September 30, 2021. Refer to “Annual rental revenue” and “Investment-grade or publicly traded large cap tenants” in the “Definitions and reconciliations” of our Supplemental Information for additional details.

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(1)Represents credit rating levels from Moody’s Investors Service and S&P Global Ratings for publicly traded U.S. REITs, from Bloomberg Professional Services as of September 30, 2021.

(2)As of the date of this report. A credit rating is not a recommendation to buy, sell, or hold securities and may be subject to revision or withdrawal at any time.

(3)As of September 30, 2021. Refer to “Key credit metrics” of our Supplemental Information for additional details.

(4)Quarter annualized.

(5)As of September 30, 2021.

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(1)Source: Barron’s, “The 10 Most Sustainable REITs, According to Calvert,” February 19, 2021.

(2)Relative to a 2015 baseline for buildings in operation that Alexandria directly manages.

(3)For buildings in operation that Alexandria indirectly and directly manages.

(4)Reflects sum of annual like-for-like progress from 2015 to 2020.

(5)Reflects progress for all buildings in operation in 2020 that Alexandria indirectly and directly manages.

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Table of Contents
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September 30, 2021 EARNINGS PRESS RELEASE Page Page
--- --- --- ---
Third Quarter Ended September 30, 2021, Financial and Operating Results 1 Earnings Call Information and About the Company 7
Acquisitions 4 Consolidated Statements of Operations 8
Dispositions and Sales of Partial Interest 5 Consolidated Balance Sheets 9
Guidance 6 Funds From Operations and Funds From Operations per Share 10
SUPPLEMENTAL INFORMATION Page Page
Company Profile 13 External Growth / Investments in Real Estate
Investor Information 14 Investments in Real Estate 32
Financial and Asset Base Highlights 15 New Class A Development and Redevelopment Properties:
High-Quality, Diverse, and Innovative Tenants 17 Recent Deliveries 34
Class A Properties in AAA Locations 18 Current Projects 36
Occupancy 19 Summary of Pipeline 40
Internal Growth Construction Spending 43
Key Operating Metrics 20 Joint Venture Financial Information 44
Same Property Performance 21 Balance Sheet Management
Leasing Activity 22 Investments 46
Contractual Lease Expirations 23 Key Credit Metrics 47
Top 20 Tenants 24 Summary of Debt 48
Summary of Properties and Occupancy 25 Definitions and Reconciliations
Property Listing 26 Definitions and Reconciliations 51

This document includes “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Please refer to page 7 of this Earnings Press Release and our Supplemental Information for further information.

This document is not an offer to sell or a solicitation to buy securities of Alexandria Real Estate Equities, Inc. Any offers to sell or solicitations to buy our securities shall be made only by means of a prospectus approved for that purpose. Unless otherwise indicated, the “Company,” “Alexandria,” “ARE,” “we,” “us,” and “our” refer to Alexandria Real Estate Equities, Inc. and our consolidated subsidiaries.

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Alexandria Real Estate Equities, Inc., at the Vanguard of the Life Science Industry,

Providing High-Quality Office/Laboratory Space to Meet Historic-High Demand, Reports:

3Q21 and YTD 3Q21 Net Income per Share – Diluted of $0.67 and $3.38, respectively;

3Q21 and YTD 3Q21 FFO per Share – Diluted, As Adjusted, of $1.95 and $5.80, respectively

PASADENA, Calif. – October 25, 2021 – Alexandria Real Estate Equities, Inc. (NYSE:ARE) announced financial and operating results for the third quarter ended September 30, 2021.

Key highlights YTD
Operating results 3Q20 3Q21 3Q20
Total revenues:
In millions 547.8 $ 545.0 $ 1,537.2 $ 1,421.9
Growth % (1) 8.1 % (1)
Net income attributable to Alexandria’s common stockholders – diluted
In millions 101.3 $ 79.3 $ 490.6 $ 324.2
Per share 0.67 $ 0.63 $ 3.38 $ 2.61
Funds from operations attributable to Alexandria’s common stockholders – diluted, as adjusted
In millions 296.0 $ 230.7 $ 841.3 $ 677.1
Per share 1.95 $ 1.83 $ 5.80 $ 5.46
(1)3Q20 includes a termination fee of 89.5 million. Growth for 3Q21 and YTD 3Q21 was 20.2% and 15.4%, respectively, excluding this termination fee.

All values are in US Dollars.

Strategic relationship with Moderna, Inc. leads to new HQ and R&D facility at 325 Binney Street, representing largest life science lease executed in Company history

In September 2021, we signed a 15-year full-building lease with Moderna, Inc. to develop, construct, and operate its new headquarters and core R&D facility at 325 Binney Street, a leading-edge 462,100 RSF property designed to be the most sustainable laboratory building in Cambridge, representing the largest life science lease in Company history.

Historic-high year-to-date leasing volume and continued strong rental rate growth

•During YTD 3Q21, historic demand for our high-quality office/laboratory space translated into 5.4 million RSF of leasing activity in only nine months, representing the highest leasing activity in Company history, surpassing our record annual leasing of 5.1 million RSF in 2019.

•Continued strong leasing activity and rental rate growth during 3Q21 and YTD 3Q21 over expiring rates on renewed and re-leased space:

3Q21 YTD 3Q21
Total leasing activity – RSF 1,810,630 5,422,127
Leasing of development and redevelopment space – RSF 1,005,890 (1) 2,071,750
Lease renewals and re-leasing of space:
RSF (included in total leasing activity above) 671,775 2,666,313
Rental rate increases 35.3% 39.4%
Rental rate increases (cash basis) 19.3% 22.3%
(1)Represents the second highest leasing quarter of development and redevelopment square footage in Company history.

Continued strong net operating income and internal growth

•Net operating income (cash basis) of $1.3 billion for 3Q21 annualized, up $234.3 million, or 21.2%, compared to 3Q20 annualized, excluding the effect of income recognized during 3Q20 aggregating $86.2 million, which comprised a termination fee of $89.5 million and related expenses of $3.3 million.

•95% of our leases contain contractual annual rent escalations approximating 3%.

•Same property net operating income growth:

•3.0% and 7.1% (cash basis) for 3Q21 over 3Q20.

•4.1% and 7.3% (cash basis) for YTD 3Q21 over YTD 3Q20.

A REIT industry-leading high-quality tenant roster with high-quality revenues and cash flows, strong margins, and operational excellence

Percentage of annual rental revenue in effect from investment-grade or publicly traded large cap tenants 53 %
Occupancy of operating properties in North America 94.4 %
Occupancy of operating properties in North America (excluding vacancy at recently acquired properties) 98.5 % (1)
Operating margin 70 %
Adjusted EBITDA margin 68 %
Weighted-average remaining lease term:
All tenants 7.4 years
Top 20 tenants 10.6 years

(1)Excludes 1.6 million RSF, or 4.1%, of vacancy at recently acquired properties, representing lease-up opportunities that are expected to provide incremental annual rental revenues in excess of $59 million upon full lease-up. Excluding acquired vacancies, occupancy was 98.5% as of September 30, 2021, up 80 bps from 97.7% as of December 31, 2020. Refer to “Occupancy” in our Supplemental Information.

Credit rating outlook improvement

In October 2021, S&P Global Ratings upgraded our corporate issuer credit rating outlook to BBB+/Positive from BBB+/Stable as a result of our consistently strong operating performance and long-term positive fundamentals.

Strong and flexible balance sheet with significant liquidity

•Investment-grade credit ratings ranked in the top 10% among all publicly traded U.S. REITs as of September 30, 2021.

•Net debt and preferred stock to Adjusted EBITDA of 5.8x and fixed-charge coverage ratio of 5.1x for 3Q21 annualized.

•Net debt to gross assets of 28% as of September 30, 2021.

•$4.0 billion of liquidity as of September 30, 2021.

| Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 | 1 | | --- | --- || Third Quarter Ended September 30, 2021, Financial and Operating Results (continued) | | --- | | September 30, 2021 |

Continued dividend strategy to share growth in cash flows with stockholders

Common stock dividend declared for 3Q21 of $1.12 per common share, aggregating $4.42 per common share for the twelve months ended September 30, 2021, up 24 cents, or 6%, over the twelve months ended September 30, 2020. Our FFO payout ratio of 58% for the three months ended September 30, 2021, allows us to continue to share growth in cash flows from operating activities with our stockholders while also retaining a significant portion for reinvestment.

Sustained strength in tenant collections

•Tenant collections remain consistently high, with 99.6% of October 2021 billings collected as of the date of this release.

•As of September 30, 2021, our tenant receivables balance of $7.7 million continues to be near historical lows.

Key items included in operating results

Key items included in net income attributable to Alexandria’s common stockholders:
YTD
3Q21 3Q20 3Q21 3Q20 3Q21 3Q20 3Q21 3Q20
(In millions, except per share amounts) Amount Per Share – Diluted Amount Per Share – Diluted
Unrealized (losses) gains on non-real estate investments $ (14.4) $ (14.0) $ (0.10) $ (0.11) $ 183.3 $ 140.5 $ 1.26 $ 1.13
Significant realized gains on non-real estate investments 52.4 (1) 0.35 110.1 0.76
(Loss) gain on sales of real estate (0.4) 1.6 0.01 2.3 1.6 0.02 0.01
Impairment of real estate (42.6) (1) (7.7) (0.28) (0.06) (52.7) (30.5) (0.37) (0.24)
Impairment of non-real estate investments (24.5) (0.20)
Loss on early extinguishment of debt (52.8) (0.42) (67.3) (52.8) (0.46) (0.42)
Termination fee(1) 86.2 0.69 86.2 0.69
Acceleration of stock compensation expense due to executive officer resignation (4.5) (0.04) (4.5) (0.04)
Total $ (5.0) $ 8.8 $ (0.03) $ 0.07 $ 175.7 $ 116.0 $ 1.21 $ 0.93
(1)Refer to “Funds from operations and funds from operations per share” of this Earnings Press Release for additional details.

Alexandria at the vanguard of innovation for over 750 tenants, with a focus to accommodate current tenant needs plus a path for their future growth

During 3Q21, we completed acquisitions in our key life science cluster submarkets aggregating 5.6 million SF, comprising 4.9 million RSF of value-creation opportunities and 0.7 million RSF of operating space, for an aggregate purchase price of $989.7 million.

Robust leasing activity of development and redevelopment projects

Historically high demand for our value-creation development and redevelopment projects of high-quality office/laboratory space, as well as continued operational excellence at our world-class, sophisticated laboratory facilities, and strong execution by our team, has translated into record leases executed in the nine months ended September 30, 2021, aggregating 2.1 million RSF, related to our development and redevelopment projects.

Value-creation development and redevelopment projects expected to generate significant growth in rental revenues and cash flows

Our highly leased value-creation pipeline of current and near-term projects that are under construction or will commence in the next six quarters is expected to generate significant incremental revenues, as follows:

Under Construction Key Projects Expected to Commence<br><br>Construction in the Next Six Quarters(1) Incremental Projected<br>Annual Rental Revenues
4.3 Million RSF 3.4 Million RSF > $615 Million
37 Properties + 20 Properties =
79% Leased/Negotiating 80% Leased/Negotiating
(1)We expect to commence construction of other projects in 2022.

•Approximately 93% of leased/negotiating activity related to the 7.7 million RSF of projects under construction or expected to commence construction in the next six quarters, is from existing relationships.

•In October 2021, our Alexandria Center® for Life Science – Fenway campus received entitlement rights to develop 450,000 SF of office/laboratory space.

Delivery of fully leased value-creation projects

•During 3Q21, we placed into service development and redevelopment projects aggregating 238,163 RSF that are 100% leased across four submarkets.

•Commencement of three value-creation projects aggregating 1.1 million RSF during 3Q21, including a 462,100 RSF development project at 325 Binney Street in our Cambridge submarket and a 229,000 RSF development project at 751 Gateway Boulevard in our South San Francisco submarket, which are 100% leased and 100% negotiating, respectively.

•Annual net operating income (cash basis) is expected to increase by $45 million upon the burn-off of initial free rent from recently delivered projects.

Key strategic transactions that generated capital for investment into our highly leased value-creation pipeline and acquisitions with development and redevelopment opportunities

•During 3Q21, we completed dispositions of and sales of partial interests in real estate assets aggregating $339.4 million in our key life science cluster submarkets.

•In October 2021, we completed the recapitalization of two consolidated real estate joint ventures in our Mission Bay submarket:

409 and 499 Illinois Street 1500 Owens Street
(Dollars in thousands) Alexandria JV Partner Alexandria JV Partner
Previous ownership 60 40 % 50.1 % 49.9 %
Recapitalization in October 2021 25 75 % 25 % 75 %
Sale of ownership interest 35 25.1 %
Sales price (our share) 274,681
Capitalization rate 5.0%
Capitalization rate (cash) 4.2%

All values are in US Dollars.

We retained control over these joint ventures and continue to consolidate them in our financial statements. Refer to “Dispositions and sales of partial interest” of this Earnings Press Release for additional details on these transactions.

| Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 | 2 | | --- | --- || Third Quarter Ended September 30, 2021, Financial and Operating Results (continued) | | --- | | September 30, 2021 |

Balance sheet management

Key metrics as of September 30, 2021

•$38.6 billion of total market capitalization.

•$29.3 billion of total equity capitalization.

•No debt maturities prior to 2024.

•11.9 years weighted-average remaining term of debt as of September 30, 2021.

•Investment-grade credit ratings ranked in the top 10% among all publicly traded U.S. REITs as of September 30, 2021.

3Q21 Goal
Quarter Trailing 4Q21
Annualized 12 Months Annualized
Net debt and preferred stock to Adjusted EBITDA 5.8x 6.2x Less than or equal to 5.2x
Fixed-charge coverage ratio 5.1x 4.8x Greater than or equal to 5.0x Value-creation pipeline of new Class A development and redevelopment projects as a percentage of gross assets 3Q21
--- ---
Under construction projects 7%
Pre-leased/negotiating near-term projects and key pending acquisition 2%
Income-producing/potential cash flows/covered land play(1) 5%
Land 2%

(1)Includes projects that have existing buildings that are generating or can generate operating cash flows. Also includes development rights associated with existing operating campuses.

Key capital events

•During 3Q21, we issued 2.5 million shares under our ATM program at a price of $200.73 per share (before underwriting discounts) and received net proceeds of $492.3 million. As of 3Q21, we have no amounts remaining under our ATM program. We expect to establish a new ATM program during 4Q21.

•As of September 30, 2021, we had outstanding forward equity sales agreements aggregating $771.9 million to sell 4.6 million shares of our common stock. We expect to settle these forward equity sales agreements in 4Q21.

Investments

•As of September 30, 2021, our investments aggregated $2.0 billion, including unrealized gains of $929.8 million.

•Investment income of $67.1 million for 3Q21 included $81.5 million in realized gains and $14.4 million in unrealized losses.

Industry and ESG leadership: catalyzing and leading the way for positive change to benefit human health and society

•In October 2021, our ESG commitment and leadership was recognized in the 2021 Global Real Estate Sustainability Benchmark (“GRESB”) Real Estate Assessment, including the following achievements: (i) Global Sector Leader and a 5 Star rating — GRESB’s highest rating — in the Diversified Listed sector for buildings in development, (ii) #2 ranking in the U.S. in the Science & Technology sector for buildings in operation, and (iii) fourth consecutive “A” disclosure score.

•In October 2021, Alexandria received an ESG Rating of A from MSCI as a result of our continued advancement of green building opportunities, recognition of talent management programs, and below-industry-average turnover rate, among other achievements. Our MSCI ESG Rating of A is currently ranked in the top 10% among all publicly traded U.S. equity REITs. An MSCI ESG Rating is designed to measure a company’s resilience to long-term industry-material ESG risks.

•In September 2021, Alexandria achieved the Fitwel Viral Response Certification With Distinction, the highest certification level within the Fitwel Viral Response module, for the second consecutive year. This evidence-based, third-party certification recognizes the Company's comprehensive and rigorous approach to protecting the health of its building occupants.

•In September 2021, the National September 11 Memorial & Museum honored Joel S. Marcus, our executive chairman and founder, for Distinction in Civic Engagement and Renewal, recognizing his meaningful contributions to and unwavering support of the 9/11 Memorial & Museum and its mission. As an active supporter of the Memorial & Museum since it opened in 2014, Mr. Marcus has served as a member of its board of trustees since his appointment in 2018 by former New York City Mayor Michael Bloomberg.

•In September 2021, OneFifteen, an innovative non-profit healthcare ecosystem dedicated to the full and sustained recovery of people living with addiction, received an honorable mention in Fast Company’s 2021 Innovation by Design Awards in the Impact category. Alexandria led the design and development of the pioneering OneFifteen campus in Dayton, Ohio, which houses a unique, evidence-based model encompassing a full continuum of care in one location, from intake, medication-assisted treatment, and residential living to family reunification, job training, and community transition.

•In July 2021, Alexandria Venture Investments, our strategic venture capital platform, was recognized by Silicon Valley Bank in its Healthcare Investments and Exits: Mid-Year 2021 Report as the most active biopharma corporate investor by new deal volume from 2020 to 1H21 for the fourth consecutive year and as the most active new Series A investor in biopharma from 2020 to 1H21. Alexandria’s venture activity provides us with, among other things, mission-critical data and knowledge on innovations and trends.

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Acquisitions
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September 30, 2021
(Dollars in thousands)
Property Submarket/Market Date of<br>Purchase Number of Properties Operating<br>Occupancy Square Footage Purchase Price
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Acquisitions With Development/Redevelopment Opportunities(1)
Future Development Active Development/Redevelopment Operating With Future Development/ Redevelopment Operating(2) Operating Total
Completed in 1H21 49 95% 4,507,706 980,934 1,571,982 2,238,467 80,032 8,631,231 $ 2,952,205
Completed in 3Q21:
Other Other/Greater Boston 8/24/21 4 45% 440,992 453,869 173,276 1,068,137 192,000
1122 El Camino Real South San Francisco/<br><br>San Francisco Bay Area 9/14/21 1 100% 700,000 223,232 700,000 105,250
Pacific Technology Park (50% interest in consolidated JV) Sorrento Mesa/San Diego 8/5/21 5 100% 228,871 315,481 544,352 85,750
Other Other/San Diego 7/21/21 9 77% 64,235 211,440 98,428 374,103 135,484
3029 East Cornwallis Road Research Triangle/Research Triangle 7/30/21 N/A 1,055,000 1,055,000 91,000
Other Various Various 8 95% 1,178,188 414,286 148,665 158,916 1,900,055 380,213
27 90% 3,438,415 453,869 1,251,105 (4) 562,574 (4) 158,916 (4) 5,641,647 989,697
Completed in October 2021:
Other 2 75% 185,228 185,228 203,800
Pending acquisition:
Charles Park Cambridge/<br><br>Greater Boston December 2021 2 N/A TBD(5) 400,000 400,000 815,000
Total 80 7,946,121 1,834,803 3,008,315 2,801,041 238,948 14,858,106 $ 4,960,702
2021 guidance range 4,460,000 – 5,460,000
2022 pending acquisition:
Mercer Mega Block Lake Union/Seattle 1Q22(6) N/A 800,000 800,000 $ 143,500

All values are in US Dollars.

(1)We expect to provide total estimated costs and related yields for development and redevelopment projects in the future, subsequent to the commencement of construction. Refer to “New Class A development and redevelopment properties: current projects” in our Supplemental Information for additional details on active development and redevelopment projects.

(2)Represents the operating component of our value-creation acquisitions that is not expected to undergo development or redevelopment.

(3)Represents total square footage upon completion of development or redevelopment of a new Class A property. Square footage presented includes RSF of buildings currently in operations with future development or redevelopment opportunities. We intend to demolish and develop or redevelop the existing properties upon expiration of the existing in-place leases. Refer to “Definitions and reconciliations” of this Supplemental Information for additional details on value-creation square feet currently included in rental properties.

(4)We expect the acquisitions completed during the three months ended September 30, 2021 to generate initial annual net operating income of $35.9 million. These acquisitions included 27 operating properties with a weighted-average acquisition date of July 26, 2021 (weighted by initial annual net operating income).

(5)We expect to pursue additional entitlement opportunities for future development of additional office/laboratory space.

(6)We continue to diligently work through various long-lead-time due diligence items. We are working toward completion of all due diligence items as soon as possible.

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Dispositions and Sales of Partial Interest
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September 30, 2021
(Dollars in thousands) Capitalization Rate<br>(Cash Basis) Sales Price per RSF Consideration in Excess of Book Value(2)
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Property Submarket/Market Date of Sale Interest Sold RSF Capitalization Rate Sales Price(1)
Completed YTD 3Q21:
213 East Grand Avenue South San Francisco/<br><br>San Francisco Bay Area 4/22/21 70 % 300,930 4.5 % 4.0 % $ 301,000 $ 1,429 $ 103,679
400 Dexter Avenue North Lake Union/Seattle 7/23/21 70 % 290,111 4.1 % 4.2 % 254,814 $ 1,255 $ 95,467
260 Townsend Street SoMa/San Francisco Bay Area 7/30/21 100 % 66,682 N/A N/A 49,000 (3) $ 735 (3)
220 and 240 2nd Avenue South SoDo/Seattle 7/29/21 100 % 80,160 N/A N/A 24,100 $ 301 $
Land Other/San Diego 3/12/21 100 % 185,000 N/A N/A 22,900 N/A (4)
9444 Waples Street Sorrento Mesa/San Diego 8/5/21 50 % 88,380 N/A N/A 11,469 $ 260 $
663,283
Completed in October 2021:
409 and 499 Illinois Street Mission Bay/San Francisco<br><br>Bay Area 10/5/21 35 % (5) 455,069 5.0 % 4.2 % 274,681 $ 1,366 $ 113,756
1500 Owens Street Mission Bay/San Francisco<br><br>Bay Area 10/5/21 25.1 % (5) 158,267
937,964
Pending dispositions or sales of partial interest:
(6) Greater Boston 4Q21 TBD 800,000 (7) TBD TBD
(6) San Francisco Bay Area 4Q21 TBD 400,000 (7) TBD TBD
(8) Various 4Q21 TBD 500,000 (7) TBD TBD
$ 2,637,964
2021 guidance range $ 1,670,000 $ 2,670,000

(1)For sales of partial interests, represents the contractual sales price for the percentage interest of the property sold by us.

(2)For each partial interest sale, we retained control over the newly formed real estate joint venture and therefore continued to consolidate this property. We accounted for the difference between the consideration received and the book value of the interest sold as an equity transaction, with no gain or loss recognized in earnings.

(3)The sales price includes the assumption by the buyer of a secured loan for $28.2 million. Upon completion of the sale, we recognized a loss on sale of real estate aggregating $435 thousand.

(4)During the three months ended March 31, 2021, we recognized $2.8 million of gains on sales of real estate related to the completion of two real estate dispositions.

(5)Refer to “Key strategic transactions that generated capital for investment into our highly leased value-creation pipeline and acquisitions with development and redevelopment opportunities” on page 2 of this Earnings Press Release for additional details.

(6)Transactions are currently under negotiation of purchase and sale agreements.

(7)Represents the approximate aggregate sales price for each transaction. A significant amount of the proceeds from pending dispositions were subject to completion of lease negotiations prior to advancing the disposition process.

(8)Represents two transactions in early negotiations with potential buyers.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 5
Guidance
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September 30, 2021
(Dollars in millions, except per share amounts)

The following updated guidance is based on our current view of existing market conditions and assumptions for the year ending December 31, 2021. There can be no assurance that actual amounts will not be materially higher or lower than these expectations. Also, refer to our discussion of “forward-looking statements” on page 7 of this Earnings Press Release for additional details.

2021 Guidance 2021 Guidance Midpoint
Summary of Key Changes in Guidance As of 10/25/21 As of 7/26/21 Summary of Key Changes in Sources and Uses of<br><br>Capital Guidance As of 10/25/21 As of 7/26/21
EPS, FFO per share, and FFO per share, as adjusted See updates below Real estate dispositions and partial interest sales $2,170 $1,920
Occupancy(1) 93.3% to 93.9% 94.3% to 94.9% Construction(2) $2,110 $1,910
Rental rate increases 33.0% to 36.0% 31.0% to 34.0%
Rental rate increases (cash basis) 19.0% to 22.0% 18.0% to 21.0%
Projected 2021 Earnings per Share and Funds From Operations per Share Attributable to Alexandria’s Common Stockholders – Diluted
--- --- ---
As of 10/25/21 As of 7/26/21
Earnings per share(3) 3.91 to 3.93 3.46 to 3.54
Depreciation and amortization of real estate assets
Gain on sales of real estate
Impairment of real estate – rental properties(4)
Allocation to unvested restricted stock awards
Funds from operations per share(5) 9.08 to 9.10 8.95 to 9.03
Unrealized gains on non-real estate investments
Significant realized gains on non-real estate investments(4)
Impairment of real estate(4)
Loss on early extinguishment of debt
Allocation to unvested restricted stock awards
Other
Funds from operations per share, as adjusted(5) 7.74 to 7.76 7.71 to 7.79
Midpoint 7.75 7.75

All values are in US Dollars.

Key Assumptions Low High
Occupancy percentage in North America as of December 31, 2021(1) 93.3% 93.9%
Lease renewals and re-leasing of space:
Rental rate increases 33.0% 36.0%
Rental rate increases (cash basis) 19.0% 22.0%
Same property performance:
Net operating income increase 2.0% 4.0%
Net operating income increase (cash basis) 4.7% 6.7%
Straight-line rent revenue $ 119 $ 129
General and administrative expenses $ 146 $ 151
Capitalization of interest $ 172 $ 182
Interest expense $ 128 $ 138
Key Credit Metrics 2021 Guidance
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Net debt and preferred stock to Adjusted EBITDA – 4Q21 annualized Less than or equal to 5.2x
Fixed-charge coverage ratio – 4Q21 annualized Greater than or equal to 5.0x Key Sources and Uses of Capital Range Midpoint Certain<br>Completed Items
--- --- --- --- --- --- --- --- --- ---
Sources of capital:
Net cash provided by operating activities after dividends $ 210 $ 250 $ 230
Incremental debt 1,415 575 995
2020 debt capital proceeds held in cash 150 250 200
Real estate dispositions and partial interest sales (refer to page 5) 1,670 2,670 2,170 $ 938
Common equity 2,975 3,975 3,475 $ 3,533 (6)
Total sources of capital $ 6,420 $ 7,720 $ 7,070
Uses of capital:
Construction (refer to page 43)(2) $ 1,960 $ 2,260 $ 2,110
Acquisitions (refer to page 4) 4,460 5,460 4,960 $ 4,146
Total uses of capital $ 6,420 $ 7,720 $ 7,070
Incremental debt (included above):
Issuance of unsecured senior notes payable $ 1,750 $ 1,750 $ 1,750 $ 1,750
Principal repayments of unsecured senior notes payable (650) (650) (650) $ (650)
Unsecured senior line of credit, commercial paper, and other 315 (525) (105)
Incremental debt $ 1,415 $ 575 $ 995

(1)Updated guidance for occupancy percentage in North America as of December 31, 2021, reflects vacancy at one recently acquired property that closed in 3Q21, and two pending acquisitions expected to close in 4Q21, representing lease-up opportunities that will contribute to growth in cash flows. One of the two pending acquisitions includes value-creation opportunities while the other pending acquisition is 50% under lease negotiation. Excluding vacancy at recently acquired properties, we expect occupancy for properties in North America as of December 31, 2021 to increase by approximately 100 bps compared to December 31, 2020. Refer to “Occupancy” of our Supplemental Information for additional details.

(2)Increase in construction guidance was primarily driven by recent pre-leasing/negotiating activity, which has provided additional visibility and accelerated our spending requirements on our active and near-term value-creation projects.

(3)Excludes unrealized gains or losses after September 30, 2021, that are required to be recognized in earnings and are excluded from funds from operations per share, as adjusted.

(4)Refer to “Funds from operations and funds from operations per share” of this Earnings Press Release for additional details.

(5)Refer to “Funds from operations and funds from operations, as adjusted, attributable to Alexandria’s common stockholders” in “Definitions and reconciliations” of our Supplemental Information for additional details.

(6)Refer to “Key capital events” on page 3 of this Earnings Press Release for additional details. During the nine months ended September 30, 2021, we issued 16.2 million shares of common stock and received net proceeds of $2.8 billion. We expect to issue 4.6 million shares in 4Q21 to settle our remaining outstanding forward equity sales agreements and receive net proceeds of approximately $771.9 million.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 6
Earnings Call Information and About the Company
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September 30, 2021

We will host a conference call on Tuesday, October 26, 2021, at 3:00 p.m. Eastern Time (“ET”)/noon Pacific Time (“PT”), which is open to the general public, to discuss our financial and operating results for the third quarter ended September 30, 2021. To participate in this conference call, dial (833) 366-1125 or (412) 902-6738 shortly before 3:00 p.m. ET/noon PT and ask the operator to join the call for Alexandria Real Estate Equities, Inc. The audio webcast can be accessed at www.are.com in the “For Investors” section. A replay of the call will be available for a limited time from 5:00 p.m. ET/2:00 p.m. PT on Tuesday, October 26, 2021. The replay number is (877) 344-7529 or (412) 317-0088, and the access code is 10159105.

Additionally, a copy of this Earnings Press Release and Supplemental Information for the third quarter ended September 30, 2021, is available in the “For Investors” section of our website at www.are.com or by following this link: http://www.are.com/fs/2021q3.pdf.

For any questions, please contact Joel S. Marcus, executive chairman and founder; Stephen A. Richardson, co-chief executive officer; Peter M. Moglia, co-chief executive officer and co-chief investment officer; Dean A. Shigenaga, president and chief financial officer; Paula Schwartz, managing director of Rx Communications Group, at (917) 322-2216; or Sara M. Kabakoff, vice president – communications, at (626) 578-0777.

About the Company

Alexandria Real Estate Equities, Inc. (NYSE:ARE), an S&P 500® urban office real estate investment trust (“REIT”), is the first, longest-tenured, and pioneering owner, operator, and developer uniquely focused on collaborative life science, agtech, and technology campuses in AAA innovation cluster locations, with a total market capitalization of $38.6 billion as of September 30, 2021, and an asset base in North America of 63.9 million square feet (“SF”). The asset base in North America includes 38.7 million RSF of operating properties and 4.3 million RSF of Class A properties undergoing construction, 8.9 million RSF of near-term and intermediate-term development and redevelopment projects, and 12.0 million SF of future development projects. Founded in 1994, Alexandria pioneered this niche and has since established a significant market presence in key locations, including Greater Boston, the San Francisco Bay Area, New York City, San Diego, Seattle, Maryland, and Research Triangle. Alexandria has a longstanding and proven track record of developing Class A properties clustered in urban life science, agtech, and technology campuses that provide our innovative tenants with highly dynamic and collaborative environments that enhance their ability to successfully recruit and retain world-class talent and inspire productivity, efficiency, creativity, and success. Alexandria also provides strategic capital to transformative life science, agtech, and technology companies through our venture capital platform. We believe our unique business model and diligent underwriting ensure a high-quality and diverse tenant base that results in higher occupancy levels, longer lease terms, higher rental income, higher returns, and greater long-term asset value. For additional information on Alexandria, please visit www.are.com.

***********

This document includes “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Such forward-looking statements include, without limitation, statements regarding our 2021 earnings per share attributable to Alexandria’s common stockholders – diluted, 2021 funds from operations per share attributable to Alexandria’s common stockholders – diluted, net operating income, and our projected sources and uses of capital. You can identify the forward-looking statements by their use of forward-looking words, such as “forecast,” “guidance,” “goals,” “projects,” “estimates,” “anticipates,” “believes,” “expects,” “intends,” “may,” “plans,” “seeks,” “should,” “targets,” or “will,” or the negative of those words or similar words. These forward-looking statements are based on our current expectations, beliefs, projections, future plans and strategies, anticipated events or trends, and similar expressions concerning matters that are not historical facts, as well as a number of assumptions concerning future events. There can be no assurance that actual results will not be materially higher or lower than these expectations. These statements are subject to risks, uncertainties, assumptions, and other important factors that could cause actual results to differ materially from the results discussed in the forward-looking statements. Factors that might cause such a difference include, without limitation, our failure to obtain capital (debt, construction financing, and/or equity) or refinance debt maturities, lower than expected yields, increased interest rates and operating costs, adverse economic or real estate developments in our markets (including the impact of the ongoing COVID-19 pandemic), our failure to successfully place into service and lease any properties undergoing development or redevelopment and our existing space held for future development or redevelopment (including new properties acquired for that purpose), our failure to successfully operate or lease acquired properties, decreased rental rates, increased vacancy rates or failure to renew or replace expiring leases, defaults on or non-renewal of leases by tenants, adverse general and local economic conditions, an unfavorable capital market environment, decreased leasing activity or lease renewals, failure to obtain LEED and other healthy building certifications and efficiencies, and other risks and uncertainties detailed in our filings with the Securities and Exchange Commission (“SEC”). Accordingly, you are cautioned not to place undue reliance on such forward-looking statements. All forward-looking statements are made as of the date of this Earnings Press Release and Supplemental Information, and unless otherwise stated, we assume no obligation to update this information and expressly disclaim any obligation to update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise. For more discussion relating to risks and uncertainties that could cause actual results to differ materially from those anticipated in our forward-looking statements, and risks to our business in general, please refer to our SEC filings, including our most recent annual report on Form 10-K and any subsequent quarterly reports on Form 10-Q.

For additional discussion of the risks and other potential impacts posed by the outbreak of the COVID-19 pandemic and uncertainties we, our tenants, and the global and national economies face as a result, see the sections entitled “Risk Factors” and “Management’s Discussion and Analysis of Financial Condition and Results of Operations” in our annual report on Form 10-K filed with the SEC on February 1, 2021.

Alexandria®, Lighthouse Design® logo, Building the Future of Life-Changing Innovation™, That’s What’s in Our DNA®, Labspace®, Alexandria Center®, Alexandria Technology Square®, Alexandria Technology Center®, and Alexandria Innovation Center® are copyrights and trademarks of Alexandria Real Estate Equities, Inc. All other company names, trademarks, and logos referenced herein are the property of their respective owners.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 7
Consolidated Statements of Operations
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September 30, 2021
(Dollars in thousands, except per share amounts) Three Months Ended Nine Months Ended
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
9/30/21 6/30/21 3/31/21 12/31/20 9/30/20 9/30/21 9/30/20
Revenues:
Income from rentals $ 546,527 $ 508,371 $ 478,695 $ 461,335 $ 543,412 (1) $ 1,533,593 $ 1,416,873
Other income 1,232 1,248 1,154 2,385 1,630 3,634 5,044
Total revenues 547,759 509,619 479,849 463,720 545,042 1,537,227 1,421,917
Expenses:
Rental operations 165,995 143,955 137,888 136,767 140,443 447,838 393,457
General and administrative 37,931 37,880 33,996 32,690 36,913 109,807 100,651
Interest 35,678 35,158 36,467 37,538 43,318 107,303 134,071
Depreciation and amortization 210,842 190,052 180,913 177,750 176,831 581,807 520,354
Impairment of real estate 42,620 (1) 4,926 5,129 25,177 7,680 52,675 (1) 22,901
Loss on early extinguishment of debt 67,253 7,898 52,770 67,253 52,770
Total expenses 493,066 411,971 461,646 417,820 457,955 1,366,683 1,224,204
Equity in earnings of unconsolidated real estate joint ventures 3,091 2,609 3,537 3,593 3,778 9,237 4,555
Investment income 67,084 304,263 1,014 255,137 3,348 372,361 166,184
(Loss) gain on sales of real estate (435) 2,779 152,503 1,586 2,344 1,586
Net income 124,433 404,520 25,533 457,133 95,799 554,486 370,038
Net income attributable to noncontrolling interests (21,286) (19,436) (17,412) (15,649) (14,743) (58,134) (40,563)
Net income attributable to Alexandria Real Estate Equities, Inc.’s stockholders 103,147 385,084 8,121 441,484 81,056 496,352 329,475
Net income attributable to unvested restricted stock awards (1,883) (4,521) (2,014) (5,561) (1,730) (5,750) (5,304)
Net income attributable to Alexandria Real Estate Equities, Inc.’s common stockholders $ 101,264 $ 380,563 $ 6,107 $ 435,923 $ 79,326 $ 490,602 $ 324,171
Net income per share attributable to Alexandria Real Estate Equities, Inc.’s common stockholders:
Basic $ 0.67 $ 2.61 $ 0.04 $ 3.26 $ 0.64 $ 3.39 $ 2.62
Diluted $ 0.67 $ 2.61 $ 0.04 $ 3.26 $ 0.63 $ 3.38 $ 2.61
Weighted-average shares of common stock outstanding:
Basic 150,854 145,825 137,319 133,688 124,901 144,716 123,561
Diluted 151,561 146,058 137,688 133,827 125,828 145,153 124,027
Dividends declared per share of common stock $ 1.12 $ 1.12 $ 1.09 $ 1.09 $ 1.06 $ 3.33 $ 3.15

(1)Refer to “Funds from operations and funds from operations per share” of this Earnings Press Release for additional details.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 8
Consolidated Balance Sheets
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September 30, 2021
(In thousands) 9/30/21 6/30/21 3/31/21 12/31/20 9/30/20
--- --- --- --- --- --- --- --- --- --- ---
Assets
Investments in real estate $ 23,071,514 $ 21,692,385 $ 20,253,418 $ 18,092,372 $ 17,600,648
Investments in unconsolidated real estate joint ventures 321,737 323,622 325,928 332,349 330,792
Cash and cash equivalents 325,872 323,876 492,184 568,532 446,255
Restricted cash 42,182 33,697 42,219 29,173 38,788
Tenant receivables 7,749 6,710 7,556 7,333 7,641
Deferred rent 816,219 781,600 751,967 722,751 719,552
Deferred leasing costs 329,952 321,005 294,328 272,673 266,440
Investments 2,046,878 1,999,283 1,641,811 1,611,114 1,330,945
Other assets 1,596,615 1,536,672 1,424,935 1,191,581 1,169,610
Total assets $ 28,558,718 $ 27,018,850 $ 25,234,346 $ 22,827,878 $ 21,910,671
Liabilities, Noncontrolling Interests, and Equity
Secured notes payable $ 198,758 $ 227,984 $ 229,406 $ 230,925 $ 342,363
Unsecured senior notes payable 8,314,851 8,313,025 8,311,512 7,232,370 7,230,819
Unsecured senior line of credit and commercial paper 749,978 299,990 99,991 249,989
Accounts payable, accrued expenses, and other liabilities 2,149,450 1,825,387 1,750,687 1,669,832 1,609,340
Dividends payable 173,560 170,647 160,779 150,982 143,040
Total liabilities 11,586,597 10,837,033 10,452,384 9,384,100 9,575,551
Commitments and contingencies
Redeemable noncontrolling interests 11,681 11,567 11,454 11,342 11,232
Alexandria Real Estate Equities, Inc.’s stockholders’ equity:
Common stock 1,532 1,507 1,457 1,367 1,333
Additional paid-in capital 14,727,735 14,194,023 12,994,748 11,730,970 10,711,119
Accumulated other comprehensive loss (6,029) (4,508) (5,799) (6,625) (10,638)
Alexandria Real Estate Equities, Inc.’s stockholders’ equity 14,723,238 14,191,022 12,990,406 11,725,712 10,701,814
Noncontrolling interests 2,237,202 1,979,228 1,780,102 1,706,724 1,622,074
Total equity 16,960,440 16,170,250 14,770,508 13,432,436 12,323,888
Total liabilities, noncontrolling interests, and equity $ 28,558,718 $ 27,018,850 $ 25,234,346 $ 22,827,878 $ 21,910,671
Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 9
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Funds From Operations and Funds From Operations per Share
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September 30, 2021
(In thousands)

The following table presents a reconciliation of net income (loss) attributable to Alexandria’s common stockholders, the most directly comparable financial measure presented in accordance with U.S. generally accepted accounting principles (“GAAP”), including our share of amounts from consolidated and unconsolidated real estate joint ventures, to funds from operations attributable to Alexandria’s common stockholders – diluted, and funds from operations attributable to Alexandria’s common stockholders – diluted, as adjusted, for the periods below:

Three Months Ended Nine Months Ended
9/30/21 6/30/21 3/31/21 12/31/20 9/30/20 9/30/21 9/30/20
Net income attributable to Alexandria’s common stockholders $ 101,264 $ 380,563 $ 6,107 $ 435,923 $ 79,326 $ 490,602 $ 324,171
Depreciation and amortization of real estate assets 205,436 186,498 177,720 173,392 173,622 569,654 511,290
Noncontrolling share of depreciation and amortization from consolidated real estate JVs (17,871) (16,301) (15,443) (15,032) (15,256) (49,615) (46,901)
Our share of depreciation and amortization from unconsolidated real estate JVs 3,465 4,135 3,076 2,976 2,936 10,676 8,437
Loss (gain) on sales of real estate 435 (2,779) (152,503) (1,586) (2,344) (1,586)
Impairment of real estate – rental properties 18,602 (1) 1,754 5,129 25,177 7,680 25,485 15,324
Allocation to unvested restricted stock awards (1,472) (2,191) (201) (420) (1,261) (6,574) (5,692)
Funds from operations attributable to Alexandria’s common stockholders – diluted(2) 309,859 554,458 173,609 469,513 245,461 1,037,884 805,043
Unrealized losses (gains) on non-real estate investments 14,432 (244,031) 46,251 (233,538) 14,013 (183,348) (140,495)
Significant realized gains on non-real estate investments (52,427) (3) (34,773) (22,919) (110,119)
Impairment of non-real estate investments 24,482
Impairment of real estate 24,018 (4) 3,172 27,190 15,221
Loss on early extinguishment of debt 67,253 7,898 52,770 67,253 52,770
Termination fee (86,179) (5) (86,179)
Acceleration of stock compensation expense due to executive officer resignation 4,499 4,499
Allocation to unvested restricted stock awards 149 3,428 (1,208) 2,774 179 2,400 1,804
Funds from operations attributable to Alexandria’s common stockholders – diluted, as adjusted $ 296,031 $ 282,254 $ 262,986 $ 246,647 $ 230,743 $ 841,260 $ 677,145

(1)Related to a property in a non-core submarket to reduce the carrying amount of the property to its estimated fair value less costs to sell, upon our review of the current local market conditions.

(2)Calculated in accordance with standards established by the Nareit Board of Governors.

(3)Includes three separate significant realized gains from the following transactions: (i) the sale of shares in an investment in a publicly traded biotechnology company, (ii) a distribution received from a limited partnership investment, and (iii) the acquisition of one of our privately held biotechnology investments by a publicly traded biotechnology company.

(4)Primarily related to an impairment charge of $22.5 million to reduce the carrying amount of an option to purchase a land parcel in our SoMa submarket for the development of an office property to its estimated fair value less costs to sell, upon our classification of the option as held for sale in September 2021.

(5)Represents termination fee of $89.5 million and related expenses of $3.3 million recognized during the three months ended September 30, 2020, upon termination of our contract with Pinterest, Inc. related to a lease at 88 Bluxome Street in our SoMa submarket.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 10
Funds From Operations and Funds From Operations per Share (continued)
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September 30, 2021
(In thousands, except per share amounts)

The following table presents a reconciliation of net income (loss) per share attributable to Alexandria’s common stockholders, the most directly comparable financial measure presented in accordance with GAAP, including our share of amounts from consolidated and unconsolidated real estate joint ventures, to funds from operations per share attributable to Alexandria’s common stockholders – diluted, and funds from operations per share attributable to Alexandria’s common stockholders – diluted, as adjusted, for the periods below. Per share amounts may not add due to rounding.

Three Months Ended Nine Months Ended
9/30/21 6/30/21 3/31/21 12/31/20 9/30/20 9/30/21 9/30/20
Net income per share attributable to Alexandria’s common stockholders – diluted $ 0.67 $ 2.61 $ 0.04 $ 3.26 $ 0.63 $ 3.38 $ 2.61
Depreciation and amortization of real estate assets 1.26 1.19 1.20 1.21 1.28 3.66 3.81
Loss (gain) on sales of real estate (0.02) (1.14) (0.01) (0.02) (0.01)
Impairment of real estate – rental properties 0.12 0.01 0.04 0.19 0.06 0.18 0.12
Allocation to unvested restricted stock awards (0.01) (0.01) (0.01) (0.01) (0.05) (0.04)
Funds from operations per share attributable to Alexandria’s common stockholders – diluted 2.04 3.80 1.26 3.51 1.95 7.15 6.49
Unrealized losses (gains) on non-real estate investments 0.10 (1.67) 0.34 (1.75) 0.11 (1.26) (1.13)
Significant realized gains on non-real estate investments (0.35) (0.24) (0.17) (0.76)
Impairment of non-real estate investments 0.20
Impairment of real estate 0.16 0.02 0.19 0.12
Loss on early extinguishment of debt 0.49 0.06 0.42 0.46 0.42
Termination fee (0.69) (0.69)
Acceleration of stock compensation expense due to executive officer resignation 0.04 0.04
Allocation to unvested restricted stock awards 0.02 (0.01) 0.02 0.02 0.01
Funds from operations per share attributable to Alexandria’s common stockholders – diluted, as adjusted $ 1.95 $ 1.93 $ 1.91 $ 1.84 $ 1.83 $ 5.80 $ 5.46
Weighted-average shares of common stock outstanding – diluted 151,561 146,058 137,688 133,827 125,828 145,153 124,027
Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 11
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SUPPLEMENTAL

INFORMATION

Company Profile
September 30, 2021

Alexandria Real Estate Equities, Inc. (NYSE:ARE), an S&P 500® urban office REIT, is the first, longest-tenured, and pioneering owner, operator, and developer uniquely focused on collaborative life science, agtech, and technology campuses in AAA innovation cluster locations, with a total market capitalization of $38.6 billion as of September 30, 2021, and an asset base in North America of 63.9 million SF. The asset base in North America includes 38.7 million RSF of operating properties and 4.3 million RSF of Class A properties undergoing construction, 8.9 million RSF of near-term and intermediate-term development and redevelopment projects, and 12.0 million SF of future development projects. Founded in 1994, Alexandria pioneered this niche and has since established a significant market presence in key locations, including Greater Boston, the San Francisco Bay Area, New York City, San Diego, Seattle, Maryland, and Research Triangle. Alexandria has a longstanding and proven track record of developing Class A properties clustered in urban life science, agtech, and technology campuses that provide our innovative tenants with highly dynamic and collaborative environments that enhance their ability to successfully recruit and retain world-class talent and inspire productivity, efficiency, creativity, and success. Alexandria also provides strategic capital to transformative life science, agtech, and technology companies through our venture capital platform. We believe our unique business model and diligent underwriting ensure a high-quality and diverse tenant base that results in higher occupancy levels, longer lease terms, higher rental income, higher returns, and greater long-term asset value. For additional information on Alexandria, please visit www.are.com.

Tenant base

Alexandria is known for our high-quality and diverse tenant base, with 53% of our annual rental revenue generated from tenants that are investment-grade rated or publicly traded large cap companies. The quality, diversity, breadth, and depth of our significant relationships with our tenants provide Alexandria with high-quality and stable cash flows. Alexandria’s underwriting team and long-term industry relationships positively distinguish us from all other publicly traded REITs and real estate companies.

Executive and senior management team

Alexandria’s executive and senior management team has unique experience and expertise in creating, owning, and operating highly dynamic and collaborative campuses in key urban life science, agtech, and technology cluster locations that inspire innovation. From the development of high-quality, sustainable real estate, to the ongoing cultivation of collaborative environments with unique amenities and events, the Alexandria team has a first-in-class reputation of excellence in our niche. Alexandria’s highly experienced management team also includes regional market directors with leading reputations and longstanding relationships within the life science, agtech, and technology communities in their respective innovation clusters. We believe that our expertise, experience, reputation, and key relationships in the real estate, life science, agtech, and technology sectors provide Alexandria significant competitive advantages in attracting new business opportunities.

Alexandria’s executive and senior management team consists of 53 individuals, averaging 25 years of real estate experience, including 12 years with Alexandria. Our executive management team alone averages 18 years of experience with Alexandria.

EXECUTIVE MANAGEMENT TEAM
Joel S. Marcus Stephen A. Richardson
Executive Chairman & Founder Co-Chief Executive Officer
Dean A. Shigenaga Peter M. Moglia
President & Chief Financial Officer Co-Chief Executive Officer & <br>Co-Chief Investment Officer
Daniel J. Ryan Lawrence J. Diamond
Co-Chief Investment Officer & Regional Market Director – San Diego Co-Chief Operating Officer & Regional Market Director – Maryland
Vincent R. Ciruzzi John H. Cunningham
Chief Development Officer Executive Vice President – Regional Market Director – New York City
Hunter L. Kass Jackie B. Clem
Executive Vice President – Regional Market Director – Greater Boston General Counsel & Secretary
Joseph Hakman Terezia C. Nemeth
Co-Chief Operating Officer & <br>Chief Strategic Transactions Officer Executive Vice President – Regional Market Director – San Francisco <br>Bay Area
Marc E. Binda Andres R. Gavinet
Executive Vice President – <br>Finance & Treasurer Chief Accounting Officer
Gary D. Dean
Executive Vice President – <br>Real Estate Legal Affairs
Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 13
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Investor Information
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September 30, 2021 Corporate Headquarters New York Stock Exchange Trading Symbol Information Requests
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26 North Euclid Avenue Common stock: ARE Phone: (626) 578-0777
Pasadena, California 91101 Email: corporateinformation@are.com
Website: www.are.com Equity Research Coverage
--- Alexandria is currently covered by the following research analysts. This list may be incomplete and is subject to change as firms initiate or discontinue coverage of our company. Please note that any opinions, estimates, or forecasts regarding our historical or predicted performance made by these analysts are theirs alone and do not represent opinions, estimates, or forecasts of Alexandria or our management. Alexandria does not by our reference or distribution of the information below imply our endorsement of or concurrence with any opinions, estimates, or forecasts of these analysts. Interested persons may obtain copies of analysts’ reports on their own as we do not distribute these reports. Several of these firms may, from time to time, own our stock and/or hold other long or short positions in our stock and may provide compensated services to us.
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Bank of America Merrill Lynch Citigroup Global Markets Inc. JMP Securities RBC Capital Markets
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Jamie Feldman Michael Bilerman / Emmanuel Korchman Aaron Hecht Michael Carroll / Jason Idoine
(646) 855-5808 (212) 816-1383 / (212) 816-1382 (415) 835-3963 (440) 715-2649 / (440) 715-2651
Berenberg Capital Markets Evercore ISI J.P. Morgan Securities LLC Robert W. Baird & Co. Incorporated
Connor Siversky / Nate Crossett Sheila McGrath / Wendy Ma Anthony Paolone / Ray Zhong David Rodgers / Nicholas Thillman
(646) 949-9037 / (646) 949-9030 (212) 497-0882 / (212) 497-0870 (212) 622-6682 / (212) 622-5411 (216) 737-7341 / (414) 298-5053
BTIG, LLC Green Street Mizuho Securities USA LLC SMBC Nikko Securities America, Inc.
Tom Catherwood / James Sullivan Daniel Ismail / Dylan Burzinski Haendel St. Juste / Lydia Jiang Richard Anderson / Jay Kornreich
(212) 738-6140 / (212) 738-6139 (949) 640-8780 / (949) 640-8780 (212) 205-7860 / (212) 209-9379 (646) 521-2351 / (646) 424-3202
CFRA
Kenneth Leon
(646) 517-2552
Fixed Income Coverage Rating Agencies
Barclays Capital Inc. Stifel Financial Corp. Moody’s Investors Service S&P Global Ratings
Srinjoy Banerjee / Devon Zhou Thierry Perrein (212) 553-0376 Fernanda Hernandez / Michael Souers
(212) 526-3521 / (212) 526-6961 (646) 376-5303 (212) 438-1347 / (212) 438-2508
J.P. Morgan Securities LLC
Mark Streeter / Ian Snyder
(212) 834-5086 / (212) 834-3798 Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 14
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Financial and Asset Base Highlights
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September 30, 2021
(Dollars in thousands, except per share amounts)
Three Months Ended (unless stated otherwise)
--- --- --- --- --- ---
9/30/21 6/30/21 3/31/21 12/31/20 9/30/20
Selected financial data from consolidated financial statements and related information
Rental revenues
Tenant recoveries
General and administrative expenses
General and administrative expenses as a percentage of net operating income –<br><br>trailing 12 months 10.1% 9.8% 9.8% 9.8% 9.9%
Operating margin 70% 72% 71% 71% 74%
Adjusted EBITDA margin 68% 69% 69% 69% 67%
Adjusted EBITDA – quarter annualized
Adjusted EBITDA – trailing 12 months
Net debt at end of period
Net debt and preferred stock to Adjusted EBITDA – quarter annualized 5.8x 5.8x 5.8x 5.3x 5.8x
Net debt and preferred stock to Adjusted EBITDA – trailing 12 months 6.2x 6.2x 6.1x 5.5x 6.0x
Gross assets at end of period
Net debt to gross assets at end of period 28% 28% 28% 27% 30%
Fixed-charge coverage ratio – quarter annualized 5.1x 4.9x 4.7x 4.6x 4.3x
Fixed-charge coverage ratio – trailing 12 months 4.8x 4.6x 4.4x 4.4x 4.3x
Unencumbered net operating income as a percentage of total net operating income 97% 97% 97% 97% 96%
Closing stock price at end of period
Common shares outstanding (in thousands) at end of period 153,284 150,708 145,656 136,690 133,312
Total equity capitalization at end of period
Total market capitalization at end of period
Dividend per share – quarter/annualized 1.12/4.48 1.12/4.48 1.09/4.36 1.09/4.36 1.06/4.24
Dividend payout ratio for the quarter 58% 60% 60% 60% 61%
Dividend yield – annualized 2.3% 2.5% 2.7% 2.4% 2.7%
Amounts related to operating leases:
Operating lease liabilities at end of period
Rent expense
Capitalized interest
Weighted-average interest rate for capitalization of interest during the period 3.30% 3.47% 3.44% 3.66% 3.64%

All values are in US Dollars.

| Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 | 15 | | --- | --- || Financial and Asset Base Highlights (continued) | | --- | | September 30, 2021 | | (Dollars in thousands, except annual rental revenue per occupied RSF amounts) || | Three Months Ended (unless stated otherwise) | | | | | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | | 9/30/21 | | | 6/30/21 | | 3/31/21 | | 12/31/20 | | 9/30/20 | | | Amounts included in funds from operations and non-revenue-enhancing capital expenditures | | | | | | | | | | | | | Straight-line rent revenue | $ | 33,918 | | $ | 27,903 | $ | 27,382 | $ | 23,890 | $ | 28,822 | | Amortization of acquired below-market leases | $ | 13,664 | | $ | 13,267 | $ | 12,112 | $ | 13,514 | $ | 13,979 | | Straight-line rent expense on ground leases | $ | 58 | | $ | 248 | $ | 290 | $ | 348 | $ | 229 | | Stock compensation expense | $ | 9,728 | | $ | 12,242 | $ | 12,446 | $ | 11,394 | $ | 12,994 | | Amortization of loan fees | $ | 2,854 | | $ | 2,859 | $ | 2,817 | $ | 2,905 | $ | 2,605 | | Amortization of debt premiums | $ | 498 | | $ | 465 | $ | 576 | $ | 869 | $ | 910 | | Non-revenue-enhancing capital expenditures: | | | | | | | | | | | | | Building improvements | $ | 3,901 | | $ | 3,669 | $ | 3,760 | $ | 3,466 | $ | 3,358 | | Tenant improvements and leasing commissions | $ | 16,409 | | $ | 47,439 | $ | 16,035 | $ | 31,235 | $ | 34,036 | | Operating statistics and related information (at end of period) | | | | | | | | | | | | | Number of properties – North America | 407 | | | 381 | | 360 | | 338 | | 326 | | | RSF – North America (including development and redevelopment projects under construction) | 43,044,195 | | | 40,076,883 | | 37,916,882 | | 35,163,572 | | 34,071,653 | | | Total square feet – North America | 63,858,780 | | | 58,108,390 | | 52,591,039 | | 49,712,701 | | 47,389,023 | | | Annual rental revenue per occupied RSF – North America | $ | 47.73 | | $ | 48.65 | $ | 49.58 | $ | 49.08 | $ | 49.55 | | Occupancy of operating properties – North America | 94.4% | | | 94.3% | | 94.5% | | 94.6% | | 94.9% | | | Occupancy of operating properties – North America (excluding vacancy at recently acquired properties) | 98.5% | | (1) | 98.1% | | 98.0% | | 97.7% | | 97.7% | | | Occupancy of operating and redevelopment properties – North America | 89.6% | | | 90.1% | | 89.2% | | 90.0% | | 91.3% | | | Weighted-average remaining lease term (in years) | 7.4 | | | 7.5 | | 7.6 | | 7.6 | | 7.7 | | | Total leasing activity – RSF | 1,810,630 | | | 1,933,838 | | 1,677,659 | | 1,369,599 | | 1,208,382 | | | Lease renewals and re-leasing of space – change in average new rental rates over expiring rates: | | | | | | | | | | | | | Rental rate increases | 35.3% | | | 42.4% | | 36.2% | | 29.8% | | 39.9% | | | Rental rate increases (cash basis) | 19.3% | | | 25.4% | | 17.4% | | 10.7% | | 30.9% | | | RSF (included in total leasing activity above) | 671,775 | | | 1,472,713 | | 521,825 | | 699,916 | | 605,765 | | | Same property – percentage change over comparable quarter from prior year: | | | | | | | | | | | | | Net operating income increase | 3.0% | | | 3.7% | | 4.4% | | 2.7% | | 2.9% | | | Net operating income increase (cash basis) | 7.1% | | | 7.8% | | 6.1% | | 5.0% | | 4.9% | |

(1)Refer to “Occupancy” in this Supplemental Information for additional details.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 16
High-Quality, Diverse, and Innovative Tenants
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September 30, 2021

Long-Duration Cash Flows From High-Quality, Diverse, and

Innovative Tenants

Investment-Grade or<br>Publicly Traded Large Cap Tenants Tenant Mix
53%
of ARE’s Annual Rental Revenue(1)
Long-Duration Lease Terms
7.4 Years
Weighted-Average Remaining Term(2)
Percentage of ARE’s Annual Rental Revenue(1)

(1)Represents annual rental revenue in effect as of September 30, 2021.

(2)Based on aggregate annual rental revenue in effect as of September 30, 2021. Refer to “Annual rental revenue” in the “Definitions and reconciliations” of this Supplemental Information for additional details about our methodology on annual rental revenue from unconsolidated real estate joint ventures.

(3)Represents annual rental revenue currently generated from office space that is targeted for a future change in use. The weighted-average remaining term of these leases is 3.2 years.

(4)Represents annual rental revenue from publicly traded technology tenants with an average daily market capitalization greater than $200 billion for the twelve months ended September 30, 2021.

(5)Our other tenants, aggregating 5.0% of our annual rental revenue, comprise 4.0% of annual rental revenue from technology, professional services, finance, telecommunications, and construction/real estate companies and only 1.0% from retail-related tenants.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 17
Class A Properties in AAA Locations
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September 30, 2021

High-Quality Cash Flows From High-Quality Tenants and

Class A Properties in AAA Locations

Industry-Leading<br>Tenant Roster AAA Locations
89%
of ARE’s Top 20 Tenants’
Annual Rental Revenue(1)
Is From Investment-Grade
or Publicly Traded Large Cap Tenants
Percentage of ARE’s Annual Rental Revenue(1)

(1)Represents annual rental revenue in effect as of September 30, 2021.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 18
Occupancy
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September 30, 2021 Solid Historical Occupancy(1) Occupancy Across Key Locations(2)
--- ---
96%
Over 10 Years

(1)Represents average occupancy of operating properties in North America as of each December 31 for the last 10 years and as of September 30, 2021.

(2)As of September 30, 2021.

(3)Excludes 1.6 million RSF, or 4.1%, of vacancy at recently acquired properties (noted below), representing lease-up opportunities that are expected to generate incremental annual rental revenues in excess of $59 million upon full lease-up. Approximately 41% of the vacant 1.6 million RSF is currently leased/negotiating, with occupancy expected primarily over the next two quarters. Excluding acquired vacancies, occupancy of operating properties in North America was 98.5% as of September 30, 2021, up 80 bps from 97.7% as of December 31, 2020. The following table provides vacancy detail for our recent acquisitions:

Incremental Projected Annual Rental Revenue<br>Upon Full Lease-Up
As of September 30, 2021 Percentage of Vacancy Leased/Negotiating
Vacant Occupancy Impact
Property Market/Submarket RSF Region Consolidated
601, 611, and 651 Gateway Boulevard San Francisco Bay Area/South San Francisco 314,991 3.8 % 0.8 % 45 % >$59 million
275 Grove Street Greater Boston/Route 128 180,648 1.8 % 0.5 65
Alexandria Center® for Life Science – Durham Research Triangle/Research Triangle 150,337 4.7 % 0.4 94
Other Greater Boston/Other 95,501 0.9 % 0.2
SD Tech by Alexandria San Diego/Sorrento Mesa 92,768 1.2 % 0.2 13
Alexandria Center® for Life Science – Fenway Greater Boston/Fenway 81,538 0.8 % 0.2
Other acquisitions Various 674,471 N/A 1.8 36
1,590,254 4.1 % 41 % Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 19
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Key Operating Metrics
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September 30, 2021 Historical Same Property<br>Net Operating Income Growth Favorable Lease Structure(1)
--- --- --- --- --- ---
q321sampropav2a.jpg Strategic Lease Structure by Owner and Operator of Collaborative <br>Life Science, Agtech, and Technology Campuses
Increasing cash flows
Percentage of leases containing<br><br>annual rent escalations 95%
Stable cash flows
Percentage of triple<br><br>net leases 92% (2)
Lower capex burden
Percentage of leases providing for the<br><br>recapture of capital expenditures 94%
Historical Rental Rate Growth: <br>Renewed/Re-Leased Space Margins(3)
Operating Adjusted EBITDA
70% 68%

(1)Percentages calculated based on RSF as of September 30, 2021.

(2)Decline to 92% from 94% as of June 30, 2021, related to non-triple net leases in place at operating properties with future development or redevelopment opportunities acquired during the three months ended September 30, 2021. We expect to transition these properties to our triple net lease structure, in conjunction with our future development or redevelopment activities.

(3)Represents percentages for the three months ended September 30, 2021.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 20
Same Property Performance
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September 30, 2021
(Dollars in thousands) September 30, 2021 September 30, 2021
--- --- --- --- --- ---
Same Property Financial Data Three Months Ended Nine Months Ended Same Property Statistical Data Three Months Ended Nine Months Ended
Percentage change over comparable period from prior year: Number of same properties 259 249
Net operating income increase 3.0% 4.1% Rentable square feet 25,493,710 23,701,101
Net operating income increase (cash basis) 7.1% 7.3% Occupancy – current-period average 94.8% 96.5%
Operating margin 71% 72% Occupancy – same-period prior-year average 95.1% 96.2%
Three Months Ended September 30, Nine Months Ended September 30,
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
2021 2020 Change % Change 2021 2020 Change % Change
Income from rentals:
Same properties $ 323,383 $ 313,015 3.3 % $ 915,884 $ 884,359 3.6 %
Non-same properties 92,535 125,378 (1) (32,843) (26.2) (1) 267,071 233,531 (1) 33,540 14.4 (1)
Rental revenues 415,918 438,393 (22,475) (5.1) 1,182,955 1,117,890 65,065 5.8
Same properties 108,958 98,749 10,209 10.3 298,955 275,953 23,002 8.3
Non-same properties 21,651 6,270 15,381 245.3 51,683 23,030 28,653 124.4
Tenant recoveries 130,609 105,019 25,590 24.4 350,638 298,983 51,655 17.3
Income from rentals 546,527 543,412 3,115 0.6 1,533,593 1,416,873 116,720 8.2
Same properties 178 126 52 41.3 382 237 145 61.2
Non-same properties 1,054 1,504 (450) (29.9) 3,252 4,807 (1,555) (32.3)
Other income 1,232 1,630 (398) (24.4) 3,634 5,044 (1,410) (28.0)
Same properties 432,519 411,890 20,629 5.0 1,215,221 1,160,549 54,672 4.7
Non-same properties 115,240 133,152 (17,912) (13.5) 322,006 261,368 60,638 23.2
Total revenues 547,759 545,042 2,717 0.5 1,537,227 1,421,917 115,310 8.1
Same properties 125,661 113,969 11,692 10.3 336,317 316,028 20,289 6.4
Non-same properties 40,334 26,474 13,860 52.4 111,521 77,429 34,092 44.0
Rental operations 165,995 140,443 25,552 18.2 447,838 393,457 54,381 13.8
Same properties 306,858 297,921 8,937 3.0 878,904 844,521 34,383 4.1
Non-same properties 74,906 106,678 (31,772) (29.8) 210,485 183,939 26,546 14.4
Net operating income $ 381,764 $ 404,599 (5.6 %) $ 1,089,389 $ 1,028,460 5.9 %
Net operating income – same properties $ 306,858 $ 297,921 3.0 % $ 878,904 $ 844,521 4.1 %
Straight-line rent revenue (16,654) (25,852) 9,198 (35.6) (47,713) (65,899) 18,186 (27.6)
Amortization of acquired below-market leases (4,201) (4,965) 764 (15.4) (9,844) (13,166) 3,322 (25.2)
Net operating income – same properties (cash basis) $ 286,003 $ 267,104 7.1 % $ 821,347 $ 765,456 7.3 %

All values are in US Dollars.

(1)Includes the effect of a termination fee of $89.5 million recognized in 3Q20. Excluding this termination fee, growth in rental revenues for 3Q21 and YTD 3Q21 was 19.2% and 15.0%, respectively. Refer to “Funds from operations and funds from operations per share” of this Earnings Press Release for additional details.

Refer to “Same property comparisons” in the “Definitions and reconciliations” of this Supplemental Information for a reconciliation of same properties to total properties. “Definitions and reconciliations” also contains definitions of “Tenant recoveries” and “Net operating income” and their respective reconciliations from the most directly comparable financial measures presented in accordance with GAAP.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 21
Leasing Activity
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September 30, 2021
(Dollars per RSF)
Three Months Ended Nine Months Ended Year Ended
--- --- --- --- --- --- --- --- ---
September 30, 2021 September 30, 2021 December 31, 2020
Including <br>Straight-Line Rent Cash Basis
Leasing activity:
Renewed/re-leased space(1)
Rental rate changes 35.3% 19.3% 39.4% 22.3% 37.6% 18.3%
New rates 54.66 52.90 57.47 55.08 49.51 $46.53
Expiring rates 40.39 44.34 41.23 45.05 35.99 $39.32
RSF 671,775 2,666,313 2,556,833
Tenant improvements/leasing commissions 24.00 29.96 35.08
Weighted-average lease term 4.4 years 5.7 years 6.0 years
Developed/redeveloped/previously vacant space leased(2)
New rates 103.29 88.46 72.94 64.67 56.67 $53.61
RSF 1,138,855 2,755,814 1,802,013
Weighted-average lease term 11.2 years 10.4 years 9.0 years
Leasing activity summary (totals):
New rates 85.25 75.27 65.33 59.96 52.47 $49.46
RSF 1,810,630 5,422,127 4,358,846
Weighted-average lease term 8.7 years 8.1 years 7.3 years
Lease expirations(1)
Expiring rates 40.74 42.61 40.38 43.16 36.03 $39.01
RSF 870,283 3,329,865 3,560,188

All values are in US Dollars.

Leasing activity includes 100% of results for each property in which we have an investment in North America.

(1)Excludes month-to-month leases aggregating 94,202 RSF and 96,383 RSF as of September 30, 2021, and December 31, 2020, respectively.

(2)Refer to “New Class A development and redevelopment properties: summary of pipeline” of this Supplemental Information for additional information on total project costs.

(3)Represents the highest leasing activity in Company history, surpassing our record annual leasing volume of 5.1 million RSF during the year ended December 31, 2019.

(4)During the nine months ended September 30, 2021, we granted tenant concessions/free rent averaging 2.5 months with respect to the 5,422,127 RSF leased. Approximately 52% of the leases executed during the nine months ended September 30, 2021, did not include concessions for free rent.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 22
Contractual Lease Expirations
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September 30, 2021 Year RSF Percentage of<br>Occupied RSF Annual Rental Revenue (per RSF)(1) Percentage of Total<br>Annual Rental Revenue
--- --- --- --- --- --- --- --- --- --- --- --- --- ---
2021 (2) 669,501 1.8 % $ 42.01 1.6 %
2022 2,514,927 6.9 % $ 43.75 6.4 %
2023 3,593,276 9.9 % $ 40.09 8.4 %
2024 3,220,392 8.9 % $ 43.27 8.1 %
2025 2,894,465 8.0 % $ 50.51 8.5 %
2026 2,282,272 6.3 % $ 45.40 6.0 %
2027 2,264,684 6.2 % $ 48.00 6.3 %
2028 3,046,238 8.4 % $ 49.97 8.9 %
2029 2,333,448 6.4 % $ 53.34 7.3 %
2030 2,282,456 6.3 % $ 53.32 7.1 %
Thereafter 11,285,360 30.9 % $ 47.44 31.4 %
Market 2021 Contractual Lease Expirations (in RSF) Annual Rental Revenue<br><br>(per RSF)(1) 2022 Contractual Lease Expirations (in RSF) Annual Rental Revenue<br><br>(per RSF)(1)
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Leased Negotiating/<br>Anticipating Targeted for<br>Development/<br>Redevelopment Remaining<br>Expiring<br>Leases Total(2) Leased Negotiating/<br>Anticipating Targeted for<br><br>Development/<br><br>Redevelopment(3) Remaining<br><br>Expiring Leases(4) Total
Greater Boston 91,284 16,674 202,428 5,807 316,193 $ 37.23 57,663 158,561 267,256 483,480 $ 57.99
San Francisco Bay Area 63,831 18,223 60,904 142,958 63.31 60,075 490,127 180,190 730,392 51.78
New York City 130 1,191 1,321 N/A 14,891 3,464 18,355 N/A
San Diego 38,201 32,774 62,175 133,150 29.54 103,730 6,196 354,123 160,226 624,275 35.26
Seattle 17,883 17,883 16.09 15,177 51,255 124,951 191,383 32.79
Maryland 7,268 3,125 10,393 37.63 35,789 35,144 9,966 80,899 26.81
Research Triangle 21,215 6,871 10,747 38,833 37.78 7,591 62,490 149,202 219,283 24.76
Canada 26,426 2,197 28,623 22.49
Non-cluster/other markets 8,770 8,770 104.46 10,430 127,807 138,237 35.21
Total 221,799 41,898 235,202 170,602 669,501 $ 42.01 212,073 319,600 957,995 1,025,259 2,514,927 $ 43.75
Percentage of expiring leases 33 % 6 % 35 % 26 % 100 % 8 % 13 % 38 % 41 % 100 %

(1)Represents amounts in effect as of September 30, 2021.

(2)Excludes month-to-month leases aggregating 94,202 RSF as of September 30, 2021.

(3)Represents RSF targeted for development or redevelopment upon expiration of existing in-place leases primarily related to recently acquired properties with an average contractual lease expiration date, weighted by annual rental revenue, of April 26, 2022. Refer to “Investments in real estate” in the “Definitions and reconciliations” of this Supplemental Information for additional details on value-creation square feet currently included in rental properties.

(4)The largest remaining contractual expiration is 113,555 RSF in our Cambridge/Inner Suburbs submarket.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 23
Top 20 Tenants
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September 30, 2021
(Dollars in thousands, except average market cap amounts)

89% of Top 20 Annual Rental Revenue From Investment-Grade

or Publicly Traded Large Cap Tenants(1)

Tenant Remaining Lease Term(1) (in years) Aggregate <br>RSF Annual Rental Revenue(1) Percentage of Aggregate Annual Rental Revenue(1) Investment-Grade <br>Credit Ratings Average Market Cap(1)<br><br>(in billions)
Moody’s S&P
1 Bristol-Myers Squibb Company 7.0 916,234 $ 53,085 3.1 % A2 A+ $ 142.8
2 Takeda Pharmaceutical Company Ltd. 7.9 606,249 39,416 2.3 Baa2 BBB+ $ 54.7
3 Moderna, Inc. 11.0 855,458 39,341 2.3 $ 79.5
4 Facebook, Inc. 10.3 903,786 38,795 2.3 $ 869.2
5 Eli Lilly and Company 7.5 602,874 37,755 2.2 A2 A+ $ 189.7
6 Sanofi 7.7 553,693 36,952 2.2 A1 AA $ 126.3
7 Illumina, Inc. 8.9 891,495 36,141 2.1 Baa3 BBB $ 60.2
8 Novartis AG 6.8 447,820 30,595 1.8 A1 AA- $ 219.2
9 Uber Technologies, Inc. 61.2 (2) 1,009,188 27,477 1.6 $ 91.0
10 Roche 2.5 (3) 546,893 26,077 1.5 Aa3 AA $ 308.2
11 bluebird bio, Inc. 5.7 312,805 23,140 1.4 $ 2.3
12 Maxar Technologies 4.0 (4) 478,000 21,803 1.3 $ 2.4
13 Massachusetts Institute of Technology 7.2 257,626 21,165 1.2 Aaa AAA $
14 United States Government 13.5 918,516 20,276 1.2 Aaa AA+ $
15 The Children’s Hospital Corporation 15.1 269,816 20,066 1.2 Aa2 AA $
16 New York University 10.0 204,691 19,531 1.2 Aa2 AA- $
17 Merck & Co., Inc. 12.4 311,015 19,392 1.1 A1 AA- $ 196.5
18 Pfizer Inc. 3.4 416,896 17,760 1.0 A2 A+ $ 218.2
19 FibroGen, Inc. 7.2 234,249 16,896 1.0 $ 2.8
20 Amgen Inc. 2.5 407,369 16,838 1.0 Baa1 A- $ 136.3
Total/weighted-average 10.6 (2) 11,144,673 $ 562,501 33.0 %

(1)Based on aggregate annual rental revenue in effect as of September 30, 2021. Refer to “Annual rental revenue” and “Investment-grade or publicly traded large cap tenants” in the “Definitions and reconciliations” of this Supplemental Information for additional details about our methodology on annual rental revenue from unconsolidated real estate joint ventures and average daily market capitalization.

(2)Includes (i) ground leases for land at 1455 and 1515 Third Street (two buildings aggregating 422,980 RSF) and (ii) leases at 1655 and 1725 Third Street (two buildings aggregating 586,208 RSF) owned by our unconsolidated real estate joint venture in which we have an ownership interest of 10%. Annual rental revenue is presented using 100% of the annual rental revenue of our consolidated properties and our share of annual rental revenue for our unconsolidated real estate joint ventures. Refer to footnote 1 for additional details. Excluding the ground lease, the weighted-average remaining lease term for our top 20 tenants was 8.1 years as of September 30, 2021.

(3)Includes 197,787 RSF expiring in 2022 at our recently acquired property at 651 Gateway Boulevard in our South San Francisco submarket. Upon expiration of the lease, 651 Gateway Boulevard will be redeveloped into a Class A office/laboratory building. Excluding this 197,787 RSF, the weighted-average remaining term of space leased to Roche is 3.1 years.

(4)Represents remaining lease term at two recently acquired properties with future redevelopment and development opportunities. The leases with this tenant were in place when we acquired the properties in 2019.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 24
Summary of Properties and Occupancy
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September 30, 2021
(Dollars in thousands, except per RSF amounts)

Summary of properties

Market RSF Number of Properties Annual Rental Revenue
Operating Development Redevelopment Total % of Total Total % of Total Per RSF
Greater Boston 10,163,050 972,216 885,001 12,020,267 28 % 82 $ 590,125 35 % $ 61.58
San Francisco Bay Area 8,385,438 535,373 48,722 8,969,533 21 68 419,550 25 59.92
New York City 1,165,060 104,959 1,270,019 3 5 82,964 5 72.43
San Diego 7,932,982 341,891 117,212 8,392,085 19 103 284,665 17 38.23
Seattle 2,734,010 213,976 2,947,986 7 42 109,681 6 41.70
Maryland 3,594,657 84,264 344,226 4,023,147 9 50 96,652 6 26.97
Research Triangle 3,202,145 363,688 325,936 3,891,769 9 36 77,270 5 25.64
Canada 322,159 322,159 1 4 6,638 24.90
Non-cluster/other markets 1,128,223 1,128,223 3 16 28,311 1 32.95
Properties held for sale 79,007 79,007 1 707 24.12
North America 38,706,731 2,297,432 2,040,032 43,044,195 100 % 407 $ 1,696,563 100 % $ 47.73
4,337,464

Summary of occupancy

Operating Properties Operating and Redevelopment Properties
Market 9/30/21 6/30/21 9/30/20 9/30/21 6/30/21 9/30/20
Greater Boston 94.3 % (1) 95.5 % 98.3 % 86.7 % 91.0 % 95.0 %
San Francisco Bay Area 94.5 (1) 94.0 95.3 94.0 92.9 94.2
New York City 98.3 99.4 95.5 90.2 90.1 84.8
San Diego 93.9 (1) 93.8 93.7 92.5 92.3 92.7
Seattle 96.2 97.6 91.0 89.2 90.2 91.0
Maryland 99.7 98.9 96.0 91.0 90.3 96.0
Research Triangle 94.1 (1) 92.8 90.5 85.4 84.1 73.4
Subtotal 95.0 95.2 95.2 90.1 90.9 91.5
Canada 82.8 77.0 90.0 82.8 77.0 90.0
Non-cluster/other markets 76.2 46.0 69.8 76.2 46.0 69.8
North America 94.4 % (1) 94.3 % 94.9 % 89.6 % 90.1 % 91.3 %

(1)Refer to “Occupancy” of this Supplemental Information for additional details on vacancy at recently acquired properties.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 25
Property Listing
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September 30, 2021
(Dollars in thousands) Market / Submarket / Address RSF Number of Properties Annual Rental Revenue Occupancy Percentage
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Operating Operating and Redevelopment
Operating Development Redevelopment Total
Greater Boston
Cambridge/Inner Suburbs
Alexandria Center® at Kendall Square 2,365,487 2,365,487 10 $ 171,131 98.9 % 98.9 %
50, 60, 75/125(1), 100, and 225(1) Binney Street, 161 and 215 First Street, 150 Second Street, 300 Third Street, and 11 Hurley Street
Alexandria Technology Square® 1,181,635 1,181,635 7 105,158 100.0 100.0
100, 200, 300, 400, 500, 600, and 700 Technology Square
The Arsenal on the Charles 571,533 301,132 872,665 11 25,429 88.9 58.2
311, 321, and 343 Arsenal Street, 300 and 400 North Beacon Street,<br>     1, 2, and 3 Kingsbury Avenue, and 100, 200, and 400 Talcott Avenue
Alexandria Center® at One Kendall Square 814,779 462,100 1,276,879 11 66,902 93.4 93.4
One Kendall Square – Buildings 100, 200, 300, 400, 500, 600/700, 1400, 1800, and 2000 and 325 and 399 Binney Street
480 Arsenal Way and 500 and 550 Arsenal Street 495,127 495,127 3 20,644 98.3 98.3
640 Memorial Drive 225,504 225,504 1 13,861 100.0 100.0
780 and 790 Memorial Drive 99,658 99,658 2 8,800 100.0 100.0
167 Sidney Street and 99 Erie Street 54,549 54,549 2 4,026 100.0 100.0
79/96 13th Street (Charlestown Navy Yard) 25,309 25,309 1 620 100.0 100.0
Cambridge/Inner Suburbs 5,833,581 462,100 301,132 6,596,813 48 416,571 97.4 92.6
Fenway
Alexandria Center® for Life Science – Fenway 973,145 510,116 1,483,261 2 58,119 91.6 91.6
401 Park Drive and 201 Brookline Avenue(1)
Seaport Innovation District
380 and 420 E Street 195,506 195,506 2 3,914 100.0 100.0
5 Necco Street 87,163 87,163 1 5,819 86.6 86.6
Seaport Innovation District 282,669 282,669 3 9,733 95.9 95.9
Route 128
Reservoir Woods 515,273 515,273 3 21,808 100.0 100.0
40, 50, and 60 Sylvan Road
275 Grove Street 509,702 509,702 1 16,501 64.6 64.6
One Upland Road, 100 Tech Drive, and One Investors Way 683,513 683,513 3 25,202 100.0 100.0
Alexandria Park at 128 343,882 343,882 8 12,544 100.0 100.0
3 and 6/8 Preston Court, 29, 35, and 44 Hartwell Avenue, 35 and 45/47 Wiggins Avenue, and 60 Westview Street
225, 266, and 275 Second Avenue 317,617 317,617 3 13,515 84.8 84.8
19 Presidential Way 144,892 144,892 1 5,063 94.7 94.7
840 Winter Street 30,009 130,000 160,009 1 1,239 95.1 17.8
100 Beaver Street 82,330 82,330 1 4,886 100.0 100.0
285 Bear Hill Road 26,270 26,270 1 1,167 100.0 100.0
Route 128 2,653,488 130,000 2,783,488 22 $ 101,925 91.0 % 86.8 %
(1)We own a partial interest in this property through a real estate joint venture. Refer to “Joint venture financial information” of this Supplemental Information for additional details. Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 26
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September 30, 2021
(Dollars in thousands) Market / Submarket / Address RSF Number of Properties Annual Rental Revenue Occupancy Percentage
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Operating Operating and Redevelopment
Operating Development Redevelopment Total
Greater Boston (continued)
Route 495
111 and 130 Forbes Boulevard 155,846 155,846 2 $ 1,735 100.0 % 100.0 %
20 Walkup Drive 91,045 91,045 1 649 100.0 100.0
Route 495 246,891 246,891 3 2,384 100.0 100.0
Other 173,276 453,869 627,145 4 1,393 44.9 12.4
Greater Boston 10,163,050 972,216 885,001 12,020,267 82 590,125 94.3 86.7
San Francisco Bay Area
Mission Bay
Alexandria Center® for Science and Technology – Mission Bay 1,990,262 1,990,262 9 95,177 99.8 99.9
1455, 1515, 1655(1), and 1725(1) Third Street, 409 and 499 Illinois Street(1), 1500(1) and 1700 Owens Street, and 455 Mission Bay Boulevard South
Mission Bay 1,990,262 1,990,262 9 95,177 99.8 99.8
South San Francisco
Alexandria Technology Center® – Gateway 1,415,020 229,000 1,644,020 12 57,160 76.3 76.3
600, 601(1), 611(1), 630, 650, 651(1), 681(1), 685(1), 701(1), 751(1), 901, and 951<br><br>Gateway Boulevard
213(1), 249, 259, 269, and 279 East Grand Avenue 919,704 919,704 5 48,951 100.0 100.0
Alexandria Center® for Life Science – South San Francisco 398,968 96,790 495,758 3 24,760 87.8 87.8
201 Haskins Way and 400 and 450 East Jamie Court
1122 El Camino Real 223,232 223,232 1 443 100.0 100.0
500 Forbes Boulevard(1) 155,685 155,685 1 6,619 100.0 100.0
7000 Shoreline Court 139,709 139,709 1 8,632 100.0 100.0
341 and 343 Oyster Point Boulevard 108,208 108,208 2 6,443 100.0 100.0
849/863 Mitten Road/866 Malcolm Road 103,857 103,857 1 4,582 97.7 97.7
South San Francisco 3,464,383 325,790 3,790,173 26 157,590 88.8 88.8
Greater Stanford
Menlo Gateway(1) 772,983 772,983 3 29,779 100.0 100.0
100 Independence Drive and 125 and 135 Constitution Drive
Alexandria Center® for Life Science – San Carlos 529,609 209,583 739,192 9 32,155 97.6 97.6
825, 835, 960, and 1501-1599 Industrial Road
3825 and 3875 Fabian Way 478,000 478,000 2 21,802 100.0 100.0
Alexandria Stanford Life Science District 333,263 48,722 381,985 4 27,815 100.0 87.2
3160, 3165, 3170, and 3181 Porter Drive
Alexandria PARC 197,498 197,498 4 9,302 78.1 78.1
2100, 2200, 2300, and 2400 Geng Road
3330, 3412, 3450, and 3460 Hillview Avenue 183,267 183,267 4 15,180 100.0 100.0
2475 and 2625/2627/2631 Hanover Street 116,869 116,869 2 9,972 100.0 100.0
2425 Garcia Avenue/2400/2450 Bayshore Parkway 99,208 99,208 1 $ 4,257 100.0 % 100.0 %
(1)We own a partial interest in this property through a real estate joint venture. Refer to “Joint venture financial information” of this Supplemental Information for additional details. Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 27
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September 30, 2021
(Dollars in thousands) Market / Submarket / Address RSF Number of Properties Annual Rental Revenue Occupancy Percentage
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Operating Operating and Redevelopment
Operating Development Redevelopment Total
San Francisco Bay Area (continued)
Greater Stanford (continued)
Shoreway Science Center 82,462 82,462 2 $ 5,422 100.0 % 100.0 %
75 and 125 Shoreway Road
1450 Page Mill Road 77,634 77,634 1 8,009 100.0 100.0
3350 West Bayshore Road 60,000 60,000 1 3,090 74.3 74.3
Greater Stanford 2,930,793 209,583 48,722 3,189,098 33 166,783 97.6 96.0
San Francisco Bay Area 8,385,438 535,373 48,722 8,969,533 68 419,550 94.5 94.0
New York City
New York City
Alexandria Center® for Life Science – New York City 740,972 740,972 3 65,744 97.4 97.4
430 and 450 East 29th Street
219 East 42nd Street 349,947 349,947 1 14,006 100.0 100.0
Alexandria Center® for Life Science – Long Island City 74,141 104,959 179,100 1 3,214 100.0 41.4
30-02 48th Avenue
New York City 1,165,060 104,959 1,270,019 5 82,964 98.3 90.2
San Diego
Torrey Pines
One Alexandria Square 776,150 146,456 922,606 10 33,432 90.3 90.4
3115 and 3215 Merryfield Row, 3010, 3013, and 3033 Science Park Road, 10931/10933 and 10975 North Torrey Pines Road, 10975, 10995, and 10996 Torreyana Road, and 3545 Cray Court
ARE Torrey Ridge 298,863 298,863 3 12,836 83.3 83.3
10578, 10618, and 10628 Science Center Drive
ARE Nautilus 213,900 213,900 4 12,323 100.0 100.0
3530 and 3550 John Hopkins Court and 3535 and 3565 General Atomics Court
11119, 11255, and 11355 North Torrey Pines Road 211,641 211,641 3 9,103 100.0 100.0
Torrey Pines 1,500,554 146,456 1,647,010 20 $ 67,694 91.7 % 91.7 % Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 28
--- --- Property Listing (continued)
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September 30, 2021
(Dollars in thousands) Market / Submarket / Address RSF Number of Properties Annual Rental Revenue Occupancy Percentage
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Operating Operating and Redevelopment
Operating Development Redevelopment Total
San Diego (continued)
University Town Center
Alexandria Point(1) 1,435,916 1,435,916 8 $ 61,734 98.8 % 98.8 %
9880(2), 10210, 10260, 10290, and 10300 Campus Point Drive and 4161, 4224, and 4242 Campus Point Court
5200 Illumina Way(1) 792,687 792,687 6 29,978 100.0 100.0
University District 406,732 406,732 5 17,621 100.0 100.0
9625 Towne Centre Drive(1), 4755, 4757, and 4767 Nexus Center Drive, and 4796 Executive Drive
University Town Center 2,635,335 2,635,335 19 109,333 99.3 99.3
Sorrento Mesa
SD Tech by Alexandria(1) 782,193 195,435 79,945 1,057,573 14 23,698 84.9 77.0
9605, 9645, 9675, 9685, 9725, 9735, 9808, 9855, and 9868 Scranton Road, 5505 Morehouse Drive(2), and 10055, 10065, 10121(2), and 10151(2) Barnes Canyon Road
Sequence District by Alexandria 805,223 805,223 7 26,544 92.5 92.5
6260, 6290, 6310, 6340, 6350, 6420, and 6450 Sequence Drive
Pacific Technology Park(1) 632,732 632,732 6 9,711 93.1 93.1
9389, 9393, 9401, 9444, 9455, and 9477 Waples Street
Summers Ridge Science Park 316,531 316,531 4 11,077 100.0 100.0
9965, 9975, 9985, and 9995 Summers Ridge Road
ARE Portola 101,857 101,857 3 3,603 100.0 100.0
6175, 6225, and 6275 Nancy Ridge Drive
7330 and 7360 Carroll Road 84,441 84,441 2 2,743 100.0 100.0
5810/5820 Nancy Ridge Drive 82,272 82,272 1 1,031 41.4 41.4
9877 Waples Street 63,774 63,774 1 2,374 100.0 100.0
5871 Oberlin Drive 33,842 33,842 1 1,710 100.0 100.0
Sorrento Mesa 2,902,865 195,435 79,945 3,178,245 39 82,491 90.7 88.2
Sorrento Valley
3911, 3931, 3985, 4025, 4031, 4045, and 4075 Sorrento Valley Boulevard 191,406 191,406 7 6,483 100.0 100.0
11025, 11035, 11045, 11055, 11065, and 11075 Roselle Street 121,655 121,655 6 3,306 97.1 97.1
Sorrento Valley 313,061 313,061 13 9,789 98.9 98.9
Other 581,167 37,267 618,434 12 15,358 88.0 82.7
San Diego 7,932,982 341,891 117,212 8,392,085 103 $ 284,665 93.9 % 92.5 %
(1)We own a partial interest in this property through a real estate joint venture. Refer to “Joint venture financial information” of this Supplemental Information for additional details.<br><br>(2)We own 100% of this property. Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 29
--- --- Property Listing (continued)
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September 30, 2021
(Dollars in thousands) Market / Submarket / Address RSF Number of Properties Annual Rental Revenue Occupancy Percentage
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Operating Operating and Redevelopment
Operating Development Redevelopment Total
Seattle
Lake Union
The Eastlake Life Science Campus by Alexandria 937,290 937,290 8 $ 56,253 100.0 % 100.0 %
1165, 1201(1), 1208(1), 1551, and 1616 Eastlake Avenue East, 188 and 199(1) East Blaine Street, and 1600 Fairview Avenue East
400 Dexter Avenue North(1) 290,111 290,111 1 14,603 100.0 100.0
2301 5th Avenue 197,135 197,135 1 9,239 99.0 99.0
219 Terry Avenue North 30,705 30,705 1 1,852 100.0 100.0
601 Dexter Avenue North 18,680 18,680 1 449 100.0 100.0
Lake Union 1,473,921 1,473,921 12 82,396 99.9 99.9
SoDo
830 4th Avenue South 42,380 42,380 1 1,538 70.5 70.5
Elliott Bay
3000/3018 Western Avenue 47,746 47,746 1 1,839 100.0 100.0
410 West Harrison Street and 410 Elliott Avenue West 36,849 36,849 2 1,362 100.0 100.0
Elliott Bay 84,595 84,595 3 3,201 100.0 100.0
Other 1,133,114 213,976 1,347,090 26 22,546 92.1 77.5
Seattle 2,734,010 213,976 2,947,986 42 109,681 96.2 89.2
Maryland
Rockville
9601, 9603, 9605, 9609, 9613, and 9615 Medical Center Drive 711,072 94,256 805,328 6 5,406 100.0 88.3
9800, 9804, 9900, 9920, and 9950 Medical Center Drive 560,788 84,264 645,052 8 24,280 100.0 100.0
9704, 9708, 9712, and 9714 Medical Center Drive 215,619 215,619 4 7,936 100.0 100.0
1330 Piccard Drive 131,511 131,511 1 4,021 100.0 100.0
1500 and 1550 East Gude Drive 91,359 91,359 2 1,844 100.0 100.0
14920 and 15010 Broschart Road 86,703 86,703 2 2,364 100.0 100.0
1405 Research Boulevard 72,170 72,170 1 2,478 100.0 100.0
5 Research Place 63,852 63,852 1 2,719 100.0 100.0
5 Research Court 51,520 51,520 1 1,788 100.0 100.0
9920 Belward Campus Drive 51,181 51,181 1 1,966 100.0 100.0
12301 Parklawn Drive 49,185 49,185 1 1,329 100.0 100.0
Rockville 2,084,960 84,264 94,256 2,263,480 28 56,131 100.0 95.7
Gaithersburg
Alexandria Technology Center® – Gaithersburg I 613,438 613,438 9 17,107 99.7 99.7
9, 25, 35, 45, 50, and 55 West Watkins Mill Road and 910, 930, and 940 Clopper Road
Alexandria Technology Center® – Gaithersburg II 315,085 169,420 484,505 7 $ 10,409 99.0 % 64.4 %
700, 704, and 708 Quince Orchard Road and 19, 20, 21, and 22 Firstfield Road
(1)We own a partial interest in this property through a real estate joint venture. Refer to “Joint venture financial information” of this Supplemental Information for additional details. Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 30
--- --- Property Listing (continued)
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September 30, 2021
(Dollars in thousands) Market / Submarket / Address RSF Number of Properties Annual Rental Revenue Occupancy Percentage
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Operating Operating and Redevelopment
Operating Development Redevelopment Total
Maryland (continued)
Gaithersburg (Continued)
20400 Century Boulevard 80,550 80,550 1 $ N/A %
401 Professional Drive 63,154 63,154 1 1,899 100.0 % 100.0
950 Wind River Lane 50,000 50,000 1 1,004 100.0 100.0
620 Professional Drive 27,950 27,950 1 1,207 100.0 100.0
Gaithersburg 1,069,627 249,970 1,319,597 20 31,626 99.5 80.7
Beltsville
8000/9000/10000 Virginia Manor Road 191,884 191,884 1 2,768 96.7 96.7
Northern Virginia
14225 Newbrook Drive 248,186 248,186 1 6,127 100.0 100.0
Maryland 3,594,657 84,264 344,226 4,023,147 50 96,652 99.7 91.0
Research Triangle
Research Triangle
Alexandria Center® for Life Science – Durham 1,912,211 325,936 2,238,147 16 36,839 92.1 78.7
6, 8, 10, 12, 14, 40, 41, 42, and 65 Moore Drive, 21, 25, 27, 29, and 31<br><br>Parmer Way, 2400 Ellis Road, and 14 TW Alexander Drive
Alexandria Center® for Advanced Technologies 137,740 229,500 367,240 4 3,837 85.1 85.1
6, 8, 10, and 12 Davis Drive
Alexandria Center® for AgTech 206,212 134,188 340,400 2 8,787 98.3 98.3
5 and 9 Laboratory Drive
Alexandria Technology Center® – Alston 186,870 186,870 3 4,125 92.4 92.4
100, 800, and 801 Capitola Drive
108/110/112/114 TW Alexander Drive 158,417 158,417 1 5,416 100.0 100.0
Alexandria Innovation Center® – Research Triangle 136,455 136,455 3 4,417 100.0 100.0
7010, 7020, and 7030 Kit Creek Road
7 Triangle Drive 96,626 96,626 1 3,156 100.0 100.0
2525 East NC Highway 54 82,996 82,996 1 3,651 100.0 100.0
407 Davis Drive 81,956 81,956 1 1,644 100.0 100.0
601 Keystone Park Drive 77,395 77,395 1 1,375 100.0 100.0
6040 George Watts Hill Drive 61,547 61,547 1 2,148 100.0 100.0
5 Triangle Drive 32,120 32,120 1 1,147 100.0 100.0
6101 Quadrangle Drive 31,600 31,600 1 728 100.0 100.0
Research Triangle 3,202,145 363,688 325,936 3,891,769 36 77,270 94.1 85.4
Canada 322,159 322,159 4 6,638 82.8 82.8
Non-cluster/other markets 1,128,223 1,128,223 16 28,311 76.2 76.2
North America, excluding properties held for sale 38,627,724 2,297,432 2,040,032 42,965,188 406 1,695,856 94.4 % 89.6 %
Properties held for sale 79,007 79,007 1 707 37.1 % 37.1 %
Total – North America 38,706,731 2,297,432 2,040,032 43,044,195 407 $ 1,696,563
Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 31
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Investments in Real Estate
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September 30, 2021

We continue to execute our unique and differentiated life science strategy at an accelerated pace and expand our collaborative campuses and asset base in each of our key life science cluster submarkets, and we remain strategically positioned to take maximum advantage of historic tenant demand.

Demand for our value-creation development and redevelopment projects of high-quality office/laboratory space, as well as continued operational excellence at our world-class, sophisticated laboratory facilities and strong execution by our team, has translated into record leasing activity.

Under Construction Key Projects Expected to Commence Construction in the Next Six Quarters(1) Incremental<br>Projected Annual Rental Revenues
4.3 Million RSF 3.4 Million RSF > $615 Million
37 Properties + 20 Properties =
79% Leased/Negotiating 80% Leased/Negotiating

(1)We also expect other projects to commence construction in 2022.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 32
Investments in Real Estate
---
September 30, 2021
(Dollars in thousands)
Development and Redevelopment
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Operating Under Construction Near<br>Term Intermediate<br>Term Future Subtotal Total
Investments in real estate
Book value as of September 30, 2021(1) $ 21,499,872 $ 2,240,891 $ 1,190,570 $ 605,848 $ 1,130,464 $ 5,167,773 $ 26,667,645
Square footage
Operating 38,706,731 38,706,731
New Class A development and redevelopment properties 4,337,464 6,392,194 (2) 4,047,611 14,790,048 29,567,317 29,567,317
Value-creation square feet currently included in rental properties(3) (1,235,727) (372,991) (2,806,550) (4,415,268) (4,415,268)
Total square footage 38,706,731 4,337,464 5,156,467 3,674,620 11,983,498 25,152,049 63,858,780

(1)Balances exclude our share of the cost basis associated with our properties held by our unconsolidated real estate joint ventures, which is classified as investments in unconsolidated real estate joint ventures in our consolidated balance sheets. Refer to “Investments in real estate” in the “Definitions and reconciliations” of this Supplemental Information for reconciliation detail of investments in real estate.

(2)Includes 3,366,117 RSF, currently 80% leased/negotiating, expected to commence construction in the next six quarters. Refer to “New Class A development and redevelopment properties: current projects” for additional details.

(3)Refer to “Investments in real estate” in the “Definitions and reconciliations” of this Supplemental Information for additional details on value-creation square feet currently included in rental properties.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 33
New Class A Development and Redevelopment Properties: Recent Deliveries
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September 30, 2021 The Arsenal on the Charles Alexandria Center® for Life Science –<br><br>South San Francisco(1) Alexandria Center® for Life Science –<br><br>San Carlos(2) 3160 Porter Drive Alexandria Center® for Life Science –<br><br>Long Island City(3)
--- --- --- --- ---
Greater Boston/<br>Cambridge/Inner Suburbs San Francisco Bay Area/<br>South San Francisco San Francisco Bay Area/<br>Greater Stanford San Francisco Bay Area/<br>Greater Stanford New York City/New York City
86,546 RSF 226,400 RSF 316,546 RSF 43,578 RSF 32,892 RSF
100% Occupancy 100% Occupancy 100% Occupancy 100% Occupancy 100% Occupancy
1165 Eastlake Avenue East 9804 Medical Center Drive Alexandria Center® for Life Science – Durham(4) Alexandria Center® for AgTech(5) Alexandria Center® for<br><br>Advanced Technologies(6)
--- --- --- --- ---
Seattle/Lake Union Maryland/Rockville Research Triangle/Research Triangle Research Triangle/Research Triangle Research Triangle/Research Triangle
100,086 RSF 176,832 RSF 326,445 RSF 25,812 RSF 20,500 RSF
100% Occupancy 100% Occupancy 100% Occupancy 100% Occupancy 100% Occupancy

(1)Image represents 201 Haskins Way in our Alexandria Center® for Life Science – South San Francisco campus.

(2)Image represents 825 and 835 Industrial Road in our Alexandria Center® for Life Science – San Carlos campus.

(3)Image represents 30-02 48th Avenue in our Alexandria Center® for Life Science – Long Island City campus.

(4)Image represents 2400 Ellis Road in our Alexandria Center® for Life Science – Durham campus.

(5)Image represents 9 Laboratory Drive in our Alexandria Center® for AgTech campus.

(6)Image represents 10 Davis Drive in our Alexandria Center® for Advanced Technologies campus.

| Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 | 34 | | --- | --- || New Class A Development and Redevelopment Properties: Recent Deliveries (continued) | | --- | | September 30, 2021 | | (Dollars in thousands) | | Property/Market/Submarket | | | Our Ownership Interest | | RSF Placed in Service | | | | | | | | | | | Occupancy Percentage(2) | | Total Project | | | | Unlevered Yields | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | | 3Q21 Delivery Date(1) | | | 4Q20 | | 1Q21 | | 2Q21 | | 3Q21 | | | Total | | | | Initial Stabilized | | Initial Stabilized (Cash Basis) | | | | | | | | | | | | | | | | RSF | | | Investment | | | | | Development projects | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Alexandria Center® for Life Science – South San Francisco/San Francisco Bay Area/South San Francisco | | 8/4/21 | 100% | | — | | — | | 171,042 | | | 55,358 | | | 226,400 | | 100% | 323,190 | | $ | 370,000 | | 6.4 | % | | 6.2 | % | | | Alexandria Center® for Life Science – San Carlos/San Francisco Bay Area/Greater Stanford | | 7/9/21 | 100% | | 96,463 | | 99,557 | | 114,157 | | | 6,369 | | | 316,546 | | 100% | 526,129 | | 630,000 | | | 6.4 | | | 6.1 | | | | 1165 Eastlake Avenue East/Seattle/Lake Union | | N/A | 100% | | — | | 100,086 | | — | | | — | | | 100,086 | | 100% | 100,086 | | 138,000 | | | 6.3 | | (3) | 6.4 | | (3) | | 9804 Medical Center Drive/Maryland/Rockville | | N/A | 100% | | — | | 176,832 | | — | | | — | | | 176,832 | | 100% | 176,832 | | 89,300 | | | 8.3 | | | 8.0 | | | | Alexandria Center® for AgTech/Research Triangle/Research Triangle | | 7/22/21 | 100% | | — | | — | | — | | | 25,812 | | | 25,812 | | 100% | 340,400 | | 193,000 | | | 7.1 | | | 7.0 | | | | Alexandria Center® for Advanced Technologies/Research Triangle/Research Triangle | | 9/24/21 | 100% | | — | | — | | — | | | 20,500 | | | 20,500 | | 100% | 250,000 | | 151,000 | | | 7.5 | | | 7.3 | | | | Redevelopment projects | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | The Arsenal on the Charles/Greater Boston/Cambridge/Inner Suburbs | | 9/4/21 | 100% | | — | | — | | — | | | 86,546 | | | 86,546 | | 100% | 872,665 | | 772,000 | | | 6.2 | | | 5.5 | | | | 3160 Porter Drive/San Francisco Bay Area/<br><br>Greater Stanford | | 8/19/21 | 100% | | — | | — | | — | | | 43,578 | | | 43,578 | | 100% | 92,300 | | 107,000 | | | 5.2 | | | 5.0 | | | | Alexandria Center® for Life Science – Long Island City/New York City/New York City | | N/A | 100% | | 17,716 | | — | | 15,176 | | | — | | | 32,892 | | 100% | 179,100 | | 224,000 | | | 5.8 | | | 5.8 | | | | 9877 Waples Street/San Diego/Sorrento Mesa | | N/A | 100% | | 63,774 | | — | | — | | | — | | | 63,774 | | 100% | 63,774 | | 31,000 | | | 8.8 | | | 8.1 | | | | Other/San Diego | | N/A | 100% | | — | | — | | 128,745 | | | — | | | 128,745 | | 100% | 128,745 | | 47,000 | | | 8.0 | | (4) | 8.0 | | (4) | | Alexandria Center® for Life Science – Durham/Research Triangle/Research Triangle | | N/A | 100% | | — | | — | | 326,445 | | | — | | | 326,445 | | 100% | 652,381 | | 245,000 | | | 7.5 | | | 6.7 | | | | Total | | 8/22/21 | | | 177,953 | | 376,475 | | 755,565 | | | 238,163 | | | 1,548,156 | | | 3,705,602 | | $ | 2,997,300 | | 6.6 | % | | 6.2 | % | |

Refer to “New Class A development and redevelopment properties: current projects” of this Supplemental Information for details on the RSF in service and under construction, if applicable.

(1)Represents the average delivery date during the current quarter, weighted by annual rental revenue.

(2)Relates to total operating RSF placed in service as of the most recent delivery.

(3)Unlevered yields represent aggregate returns for 1165 Eastlake Avenue East, an amenity-rich research headquarters for Adaptive Biotechnologies Corporation, and 1208 Eastlake Avenue East, an adjacent multi-tenant office/laboratory building.

(4)We achieved yields greater than 8.0%.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 35
New Class A Development and Redevelopment Properties: Current Projects
---
September 30, 2021
325 Binney Street The Arsenal on the Charles 201 Brookline Avenue 840 Winter Street Alexandria Center® for Life Science –<br><br>South San Francisco(1)
--- --- --- --- ---
Greater Boston/Cambridge Greater Boston/<br>Cambridge/Inner Suburbs Greater Boston/Fenway Greater Boston/Route 128 San Francisco Bay Area/<br>South San Francisco
462,100 RSF 301,132 RSF 510,116 RSF 130,000 RSF 96,790 RSF
100% Leased 92% Leased/Negotiating 96% Leased/Negotiating 18% Leased/Negotiating 100% Leased
751 Gateway Boulevard Alexandria Center® for Life Science –<br><br>San Carlos(2) 3160 Porter Drive Alexandria Center® for Life Science –<br><br>Long Island City(3) 3115 Merryfield Row
--- --- --- --- ---
San Francisco Bay Area/<br>South San Francisco San Francisco Bay Area/<br>Greater Stanford San Francisco Bay Area/<br>Greater Stanford New York City/New York City San Diego/Torrey Pines
229,000 RSF 209,583 RSF 48,722 RSF 104,959 RSF 146,456 RSF
100% Leased/Negotiating 100% Leased 88% Leased/Negotiating 52% Leased/Negotiating 100% Leased

(1)Image represents 201 Haskins Way in our Alexandria Center® for Life Science – South San Francisco campus.

(2)Image represents 825 and 835 Industrial Road in our Alexandria Center® for Life Science – San Carlos campus.

(3)Image represents 30-02 48th Avenue in our Alexandria Center® for Life Science – Long Island City campus.

| Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 | 36 | | --- | --- || New Class A Development and Redevelopment Properties: Current Projects (continued) | | --- | | September 30, 2021 || SD Tech by Alexandria(1) | 5505 Morehouse Drive | 10277 Scripps Ranch Boulevard | 9601 and 9603 Medical Center Drive | 9950 Medical Center Drive | | --- | --- | --- | --- | --- | | San Diego/Sorrento Mesa | San Diego/Sorrento Mesa | San Diego/Other | Maryland/Rockville | Maryland/Rockville | | 195,435 RSF | 79,945 RSF | 37,267 RSF | 94,256 RSF | 84,264 RSF | | 100% Leased | 100% Leased | 47% Leased/Negotiating | 51% Leased/Negotiating | 100% Leased | | 700 Quince Orchard Road | 20400 Century Boulevard | Alexandria Center® for Life Science – Durham(2) | Alexandria Center® for AgTech(3) | Alexandria Center® for<br><br>Advanced Technologies(4) | | --- | --- | --- | --- | --- | | Maryland/Gaithersburg | Maryland/Gaithersburg | Research Triangle/Research Triangle | Research Triangle/Research Triangle | Research Triangle/Research Triangle | | 169,420 RSF | 80,550 RSF | 325,936 RSF | 134,188 RSF | 229,500 RSF | | 100% Leased | 40% Leased/Negotiating | 77% Leased/Negotiating | 87% Leased/Negotiating | 83% Leased/Negotiating |

(1)Image represents 10055 Barnes Canyon Road in our SD Tech by Alexandria campus.

(2)Image represents 14 TW Alexander Drive in our Alexandria Center® for Life Science – Durham campus.

(3)Image represents 9 Laboratory Drive in our Alexandria Center® for AgTech campus.

(4)Image represents 10 Davis Drive in our Alexandria Center® for Advanced Technologies campus.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 37
New Class A Development and Redevelopment Properties: Current Projects (continued)
---
September 30, 2021 Market<br><br>Property/Submarket Square Footage Percentage
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Dev/Redev In Service CIP Total Leased Leased/Negotiating Initial<br><br>Occupancy(1)
Under construction
Greater Boston
325 Binney Street/Cambridge Dev 462,100 462,100 100 % 100 % 2023
The Arsenal on the Charles/Cambridge/Inner Suburbs Redev 571,533 301,132 872,665 85 92 3Q21
201 Brookline Avenue/Fenway Dev 510,116 510,116 59 96 2022
840 Winter Street/Route 128 Redev 30,009 130,000 160,009 18 18 2022
Other Redev 453,869 453,869 2023/2024
San Francisco Bay Area
Alexandria Center® for Life Science – South San Francisco/South San Francisco Dev 226,400 96,790 323,190 100 100 2Q21
751 Gateway Boulevard/South San Francisco Dev 229,000 229,000 100 2023
Alexandria Center® for Life Science – San Carlos/Greater Stanford Dev 316,546 209,583 526,129 100 100 4Q20
3160 Porter Drive/Greater Stanford Redev 43,578 48,722 92,300 86 88 3Q21
New York City
Alexandria Center® for Life Science – Long Island City/New York City Redev 74,141 104,959 179,100 49 52 4Q20
San Diego
3115 Merryfield Row/Torrey Pines Dev 146,456 146,456 100 100 2022
SD Tech by Alexandria/Sorrento Mesa Dev 195,435 195,435 100 100 2022
5505 Morehouse Drive/Sorrento Mesa Redev 79,945 79,945 100 100 2021
10277 Scripps Ranch Boulevard/Other Redev 32,774 37,267 70,041 47 47 2022
Seattle
Other Redev 246,647 213,976 460,623 53 61 2022
Maryland
9601 and 9603 Medical Center Drive/Rockville Redev 94,256 94,256 51 2022
9950 Medical Center Drive/Rockville Dev 84,264 84,264 100 100 1H22
700 Quince Orchard Road/Gaithersburg Redev 169,420 169,420 100 100 2021
20400 Century Boulevard/Gaithersburg Redev 80,550 80,550 27 40 2022
Research Triangle
Alexandria Center® for Life Science – Durham/Research Triangle(2) Redev 326,445 325,936 652,381 77 77 2Q21/2022
Alexandria Center® for AgTech/Research Triangle(3) Redev/Dev 206,212 134,188 340,400 83 87 3Q21
Alexandria Center® for Advanced Technologies/Research Triangle Dev 20,500 229,500 250,000 (4) 80 (4) 83 (4) 3Q21/2022
2,094,785 4,337,464 6,432,249 70 79
Pre-leased/negotiating near-term projects and key pending acquisition
Charles Park/Greater Boston/Cambridge(5) Redev 400,000 400,000 100
4150 Campus Point Court/San Diego/University Town Center Dev 171,102 171,102 100 100
Other near-term projects expected to commence construction in the next six quarters<br><br>(17 properties) Dev/Redev 2,795,015 2,795,015 4 76
3,366,117 3,366,117 9 % 80 %
2,094,785 7,703,581 9,798,366

(1)Initial occupancy dates are subject to leasing and/or market conditions. Multi-tenant projects may have occupancy by tenants over a period of time. Stabilized occupancy may vary depending on single tenancy versus multi-tenancy.

(2)The recently acquired Alexandria Center® for Life Science – Durham campus redevelopment project includes three properties at 40 Moore Drive, 2400 Ellis Road, and 14 TW Alexander Drive. 2400 Ellis Road is 100% leased and was delivered in 2Q21. We expect stabilized occupancy for the remaining buildings in 2022.

(3)The strategic collaborative agtech campus consists of Phase I at 5 Laboratory Drive, including campus amenities, which was previously delivered, and Phase II at 9 Laboratory Drive.

(4)Represents 150,000 RSF that is 71% leased/negotiating at 8 Davis Drive and 100,000 RSF that is 100% leased at 10 Davis Drive.

(5)We expect to complete this acquisition in December 2021.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 38
New Class A Development and Redevelopment Properties: Current Projects (continued)
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September 30, 2021
(Dollars in thousands)
Our Ownership Interest Unlevered Yields
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Market<br><br>Property/Submarket In Service CIP Cost to Complete Total at<br>Completion Initial Stabilized Initial Stabilized (Cash Basis)
Under construction
Greater Boston
325 Binney Street/Cambridge 100 % $ $ 198,031 $ 582,969 $ 781,000 8.6 % 7.2 %
The Arsenal on the Charles/Cambridge/Inner Suburbs 100 % 454,061 236,242 81,697 772,000 6.2 % 5.5 %
201 Brookline Avenue/Fenway 98.2 % 446,219 287,781 734,000 6.8 % 6.0 %
840 Winter Street/Route 128 100 % 12,981 56,926 TBD
Other 100 % 113,389
San Francisco Bay Area
Alexandria Center® for Life Science – South San Francisco/South San Francisco 100 % 254,933 92,551 22,516 370,000 6.4 % 6.2 %
751 Gateway Boulevard/South San Francisco 48.1 % 59,657 TBD
Alexandria Center® for Life Science – San Carlos/Greater Stanford 100 % 391,681 202,346 35,973 630,000 6.4 % 6.1 %
3160 Porter Drive/Greater Stanford 100 % 44,537 50,469 11,994 107,000 5.2 % 5.0 %
New York City
Alexandria Center® for Life Science – Long Island City/New York City 100 % 52,470 120,664 50,866 224,000 5.8 % 5.8 %
San Diego
3115 Merryfield Row/Torrey Pines 100 % 104,535 47,465 152,000 6.2 % 6.2 %
SD Tech by Alexandria/Sorrento Mesa 50.0 % 71,291 109,709 181,000 7.2 % 6.6 %
5505 Morehouse Drive/Sorrento Mesa 100 % 41,784 25,216 67,000 6.9 % 7.0 %
10277 Scripps Ranch Boulevard/Other 100 % 11,850 13,727 TBD
Seattle
Other 100 % 54,500 68,259 TBD
Maryland
9601 and 9603 Medical Center Drive/Rockville 100 % 28,724 TBD
9950 Medical Center Drive/Rockville 100 % 41,813 17,787 59,600 8.6 % 7.7 %
700 Quince Orchard Road/Gaithersburg 100 % 62,156 17,344 79,500 8.6 % 7.3 %
20400 Century Boulevard/Gaithersburg 100 % 12,391 TBD
Research Triangle
Alexandria Center® for Life Science – Durham/Research Triangle 100 % 89,443 74,138 81,419 245,000 7.5 % 6.7 %
Alexandria Center® for AgTech/Research Triangle 100 % 111,803 73,184 8,013 193,000 7.1 % 7.0 %
Alexandria Center® for Advanced Technologies/Research Triangle 100 % 10,622 72,395 67,983 151,000 7.5 % 7.3 %
$ 1,488,881 $ 2,240,891 $ 2,210,000 (1)(2) $ 5,940,000 (1)

(1)Amounts rounded to the nearest $10 million.

(2)Based on our current target of net debt and preferred stock to adjusted EBITDA of less than or equal to 5.2x, we expect the net operating income to be generated upon stabilization of these projects will require $1.6 billion of debt and approximately $600 million of incremental equity funding on a leverage-neutral basis. Actual debt and equity capital funding until stabilization of these projects will vary from these estimates.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 39
New Class A Development and Redevelopment Properties: Summary of Pipeline
---
September 30, 2021
(Dollars in thousands)
Market<br><br>Property/Submarket Our Ownership Interest Book Value Square Footage
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Development and Redevelopment
Under Construction Near<br>Term Intermediate<br>Term Future Total(1)
Greater Boston
325 Binney Street/Cambridge 100 % $ 198,031 462,100 462,100
The Arsenal on the Charles/Cambridge/Inner Suburbs 100 % 269,802 301,132 200,000 12,502 513,634
Alexandria Center® for Life Science – Fenway/Fenway (2) 572,449 510,116 450,000 960,116
840 Winter Street/Route 128 100 % 56,926 130,000 130,000
99 Coolidge Avenue/Cambridge/Inner Suburbs 75.0 % 56,152 275,000 275,000
15 Necco Street/Seaport Innovation District 90.0 % 211,324 350,000 350,000
Reservoir Woods/Route 128 100 % 47,762 515,273 440,000 955,273
10 Necco Street/Seaport Innovation District 100 % 93,586 175,000 175,000
215 Presidential Way/Route 128 100 % 6,808 112,000 112,000
Alexandria Technology Square®/Cambridge 100 % 7,881 100,000 100,000
550 Arsenal Street/Cambridge/Inner Suburbs 100 % 54,853 775,000 775,000
380 and 420 E Street/Seaport Innovation District 100 % 119,517 1,000,000 1,000,000
99 A Street/Seaport Innovation District 94.8 % 46,597 235,000 235,000
One Upland Road, 100 Tech Drive, and One Investors Way/Route 128 100 % 14,081 1,100,000 1,100,000
231 Second Avenue/Route 128 100 % 1,093 32,000 32,000
Other value-creation projects 100 % 161,182 453,869 190,992 434,504 1,079,365
1,918,044 1,857,217 1,531,265 737,000 4,129,006 8,254,488
San Francisco Bay Area
Alexandria Technology Center® – Gateway/South San Francisco 48.1 % 82,176 229,000 300,010 291,000 820,010
Alexandria Center® for Life Science – South San Francisco/<br><br>South San Francisco 100 % 92,551 96,790 96,790
Alexandria Center® for Life Science – San Carlos/Greater Stanford 100 % 481,720 209,583 700,000 587,000 1,496,583
3160 Porter Drive/Greater Stanford 100 % 50,469 48,722 48,722
1450 Owens Street/Mission Bay 100 % 65,685 191,000 191,000
901 California Avenue/Greater Stanford 100 % 2,694 56,924 56,924
3450 and 3460 Hillview Avenue/Greater Stanford 100 % 42,340 34,611 76,951
88 Bluxome Street/SoMa 100 % 318,656 1,070,925 1,070,925
3825 and 3875 Fabian Way/Greater Stanford 100 % 250,000 228,000 478,000
1122 El Camino Real/South San Francisco 100 % 105,053 700,000 700,000
East Grand Avenue/South San Francisco 30.0 % 6,113 90,000 90,000
2475 Hanover Street/Greater Stanford 100 % 83,980 83,980
Other value-creation projects 100 % (3) 38,137 223,188 223,188
$ 1,243,254 584,095 1,661,199 984,611 2,203,168 5,433,073
(1)Represents total square footage upon completion of development or redevelopment of a new Class A property. Square footage presented includes RSF of buildings currently in operation at properties that also have inherent future development or redevelopment opportunities. Upon expiration of existing in-place leases, we have the intent to demolish or redevelop the existing property and commence future construction. Refer to “Definitions and reconciliations” of this Supplemental Information for additional details on value-creation square feet currently included in rental properties.<br><br>(2)We have a 98.2% ownership interest in 201 Brookline Avenue, aggregating 510,116 RSF, and is currently under construction. We have a 100% ownership interest in the intermediate-term development project, aggregating 450,000 RSF.<br><br>(3)Includes a future development project at Alexandria Center® for Life Science – Millbrae Station where we have a 37.6% ownership interest. Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 40
--- ---
New Class A Development and Redevelopment Properties: Summary of Pipeline (continued)
---
September 30, 2021
(Dollars in thousands)
Market<br><br>Property/Submarket Our Ownership Interest Book Value Square Footage
--- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Development and Redevelopment
Under Construction Near<br>Term Intermediate<br>Term Future Total(1)
New York City
Alexandria Center® for Life Science – Long Island City/New York City 100 % $ 120,664 104,959 104,959
47-50 30th Street/New York City 100 % 30,639 135,938 135,938
Alexandria Center® for Life Science – New York City/New York City 100 % 74,894 550,000 (2) 550,000
219 East 42nd Street/New York City 100 % 579,947 579,947
226,197 104,959 135,938 550,000 579,947 1,370,844
San Diego
3115 Merryfield Row/Torrey Pines 100 % 104,535 146,456 146,456
SD Tech by Alexandria/Sorrento Mesa 50.0 % 159,088 195,435 190,074 160,000 333,845 879,354
5505 Morehouse Drive/Sorrento Mesa 100 % 41,784 79,945 79,945
10277 Scripps Ranch Boulevard/Other 100 % 13,727 37,267 32,774 70,041
11255 and 11355 North Torrey Pines Road/Torrey Pines 100 % 111,760 288,956 288,956
10931 and 10933 North Torrey Pines Road/Torrey Pines 100 % 242,000 242,000
Alexandria Point/University Town Center 55.0 % 112,895 596,102 324,445 920,547
Sequence District by Alexandria/Sorrento Mesa 100 % 37,758 200,000 509,000 1,089,915 1,798,915
University District/University Town Center 100 % 66,108 600,000 (3) 600,000
9444 Waples Street/Sorrento Mesa 50.0 % 18,809 149,000 149,000
10975 and 10995 Torreyana Road/Torrey Pines 100 % 49,009 125,280 125,280
5200 Illumina Way/University Town Center 51.0 % 13,313 451,832 451,832
4025, 4031, 4045, and 4075 Sorrento Valley Boulevard/Sorrento Valley 100 % 7,765 247,000 247,000
Other value-creation projects 100 % 13,734 54,000 114,235 168,235
750,285 459,103 1,603,906 1,418,000 2,686,552 6,167,561
Seattle
1150 Eastlake Avenue East/Lake Union 100 % 102,305 311,631 311,631
701 Dexter Avenue North/Lake Union 100 % 67,509 217,000 217,000
601 Dexter Avenue North/Lake Union 100 % 37,827 188,400 188,400
1010 4th Avenue South/SoDo 100 % 50,969 544,825 544,825
830 4th Avenue South/SoDo 100 % 52,488 52,488
Other value-creation projects 100 % 80,172 213,976 51,255 230,000 495,231
$ 338,782 213,976 579,886 1,015,713 1,809,575
(1)Represents total square footage upon completion of development or redevelopment of a new Class A property. Square footage presented includes RSF of buildings currently in operation at properties that also have inherent future development or redevelopment opportunities. Upon expiration of existing in-place leases, we have the intent to demolish or redevelop the existing property and commence future construction. Refer to “Definitions and reconciliations” of this Supplemental Information for additional details on value-creation square feet currently included in rental properties.<br><br>(2)Pursuant to an option agreement, we are currently negotiating a long-term ground lease with the City of New York for the future site of a new building approximating 550,000 RSF.<br><br>(3)Includes our recently acquired property at 4555 Executive Drive and 9363, 9373, and 9393 Towne Centre Drive in our University Town Center submarket, which are currently under evaluation for development, subject to future market conditions. Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 41
--- ---
New Class A Development and Redevelopment Properties: Summary of Pipeline (continued)
---
September 30, 2021
(Dollars in thousands)
Market<br><br>Property/Submarket Our Ownership Interest Book Value Square Footage
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Development and Redevelopment
Under Construction Near<br>Term Intermediate<br>Term Future Total(1)
Maryland
9601 and 9603 Medical Center Drive and Excess Land/Rockville 100 % $ 43,073 94,256 258,000 352,256
9950 Medical Center Drive/Rockville 100 % 41,813 84,264 84,264
700 Quince Orchard Road/Gaithersburg 100 % 62,156 169,420 169,420
20400 Century Boulevard/Gaithersburg 100 % 12,391 80,550 80,550
Alexandria Center® at Traville Gateway/Rockville 100 % 33,091 410,000 70,000 480,000
9808 Medical Center Drive/Rockville 100 % 9,986 90,000 90,000
202,510 428,490 500,000 258,000 70,000 1,256,490
Research Triangle
Alexandria Center® for Life Science – Durham/Research Triangle 100 % 117,469 325,936 100,000 885,000 1,310,936
Alexandria Center® for Advanced Technologies/Research Triangle 100 % 112,762 229,500 180,000 990,000 1,399,500
Alexandria Center® for AgTech, Phase II/Research Triangle 100 % 73,184 134,188 134,188
3029 East Cornwallis Road/Research Triangle 100 % 94,958 100,000 100,000 855,000 1,055,000
Other value-creation projects 100 % 4,185 76,262 76,262
402,558 689,624 380,000 100,000 2,806,262 3,975,886
Other value-creation projects 100 % 86,143 1,299,400 1,299,400
Total pipeline as of September 30, 2021 $ 5,167,773 (2) 4,337,464 6,392,194 4,047,611 14,790,048 29,567,317 (1)
Key pending acquisitions
Charles Park/Cambridge(3) 400,000 400,000
Mercer Mega Block/Lake Union 800,000 800,000
4,337,464 7,592,194 4,047,611 14,790,048 30,767,317

(1)Total square footage includes 4,415,268 RSF of buildings currently in operation that will be redeveloped or replaced with new development RSF upon commencement of future construction. Refer to “Definitions and reconciliations” of this Supplemental Information for additional details on value-creation square feet currently included in rental properties.

(2)Total book value includes $2.2 billion of projects currently under construction that are 79% leased/negotiating. We also expect to commence construction on pre-leased/negotiating near-term projects and a key pending acquisition aggregating $624.5 million in the next six quarters that are 80% leased/negotiating.

(3)We expect to complete this acquisition in December 2021.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 42
Construction Spending
---
September 30, 2021
(In thousands)
Nine Months Ended
--- --- ---
Construction Spending September 30, 2021
Additions to real estate – consolidated projects $ 1,542,210
Investments in unconsolidated real estate joint ventures 739
Contributions from noncontrolling interests (56,669)
Construction spending (cash basis) 1,486,280
Change in accrued construction 69,551
Construction spending 1,555,831
Projected construction spending for the three months ending December 31, 2021 554,169
Guidance midpoint $ 2,110,000 Year Ending
--- --- ---
Projected Construction Spending December 31, 2021
Development, redevelopment, and pre-construction projects $ 1,990,000
Contributions from noncontrolling interests (consolidated real estate joint ventures) (100,000)
Revenue-enhancing and repositioning capital expenditures 155,000
Non-revenue-enhancing capital expenditures 65,000
Guidance midpoint $ 2,110,000
Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 43
--- ---
Joint Venture Financial Information
---
September 30, 2021 Consolidated Real Estate Joint Ventures
--- --- --- --- --- --- --- --- --- ---
Property Market Submarket Noncontrolling<br><br>Interest Share(1) Operating RSF<br><br>at 100%
75/125 Binney Street Greater Boston Cambridge/Inner Suburbs 60.0% 388,270
225 Binney Street Greater Boston Cambridge/Inner Suburbs 70.0% 305,212
99 Coolidge Avenue Greater Boston Cambridge/Inner Suburbs 25.0% (2)
409 and 499 Illinois Street San Francisco Bay Area Mission Bay 40.0% (3) 455,069
1500 Owens Street San Francisco Bay Area Mission Bay 49.9% (3) 158,267
Alexandria Technology Center® – Gateway(4) San Francisco Bay Area South San Francisco 51.9% 1,089,852
213 East Grand Avenue San Francisco Bay Area South San Francisco 70.0% 300,930
500 Forbes Boulevard San Francisco Bay Area South San Francisco 90.0% 155,685
Alexandria Center® for Life Science – Millbrae Station San Francisco Bay Area South San Francisco 62.4%
Alexandria Point(5) San Diego University Town Center 45.0% 1,337,916
5200 Illumina Way San Diego University Town Center 49.0% 792,687
9625 Towne Centre Drive San Diego University Town Center 49.9% 163,648
SD Tech by Alexandria(6) San Diego Sorrento Mesa 50.0% 679,801
Pacific Technology Park San Diego Sorrento Mesa 50.0% 632,732
The Eastlake Life Science Campus by Alexandria(7) Seattle Lake Union 70.0% 321,218
400 Dexter Avenue North Seattle Lake Union 70.0% 290,111
Unconsolidated Real Estate Joint Ventures
Property Market Submarket Our Ownership Share(8) Operating RSF<br><br>at 100%
1655 and 1725 Third Street San Francisco Bay Area Mission Bay 10.0 % 586,208
Menlo Gateway San Francisco Bay Area Greater Stanford 49.0 % 772,983
1401/1413 Research Boulevard Maryland Rockville 65.0 % (9) (10)

(1)In addition to the consolidated real estate joint ventures listed, various partners hold insignificant noncontrolling interests in five other real estate joint ventures in North America.

(2)We expect to commence vertical construction of 275,000 RSF during 2021.

(3)Refer to “Dispositions and sales of partial interests” in our Earnings Press Release for additional information on the partial interest sale of these consolidated joint ventures in October 2021.

(4)Includes 601, 611, 651, 681, 685, 701, and 751 Gateway Boulevard in our South San Francisco submarket. Noncontrolling interest share is anticipated to be 49% as we make further contributions into the joint venture over time.

(5)Includes 10210, 10260, 10290, and 10300 Campus Point Drive and 4161, 4224, and 4242 Campus Point Court in our University Town Center submarket.

(6)Includes 9605, 9645, 9675, 9685, 9725, 9735, 9808, 9855, and 9868 Scranton Road and 10055 and 10065 Barnes Canyon Road in our Sorrento Mesa submarket.

(7)Includes 1201 and 1208 Eastlake Avenue East and 199 East Blaine Street in our Lake Union submarket.

(8)In addition to the unconsolidated real estate joint ventures listed, we hold an interest in one other insignificant unconsolidated real estate joint venture in North America.

(9)Represents our ownership interest; our voting interest is limited to 50%.

(10)Represents a joint venture with a distinguished retail real estate developer for an approximate 90,000 RSF retail shopping center.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 44
Joint Venture Financial Information (continued)
---
September 30, 2021
(Dollars in thousands)
As of September 30, 2021
--- --- --- --- ---
Noncontrolling Interest <br>Share of Consolidated <br>Real Estate JVs Our Share of <br>Unconsolidated Real <br>Estate JVs
Investments in real estate $ 2,048,838 $ 475,982
Cash, cash equivalents, and restricted cash 70,786 9,492
Other assets 235,407 63,397
Secured notes payable (refer to page 49) (219,245)
Other liabilities (106,148) (7,889)
Redeemable noncontrolling interests (11,681)
$ 2,237,202 $ 321,737
Noncontrolling Interest Share of <br>Consolidated Real Estate JVs Our Share of Unconsolidated <br>Real Estate JVs
--- --- --- --- --- --- --- --- ---
September 30, 2021 September 30, 2021
Three Months Ended Nine Months Ended Three Months Ended Nine Months Ended
Total revenues $ 54,419 $ 147,534 $ 10,876 $ 33,595
Rental operations (15,217) (39,845) (1,785) (5,610)
39,202 107,689 9,091 27,985
General and administrative (267) (599) (31) (185)
Interest (2,504) (7,887)
Depreciation and amortization (17,871) (49,615) (3,465) (10,676)
Fixed returns allocated to redeemable noncontrolling interests(1) 222 659
$ 21,286 $ 58,134 $ 3,091 $ 9,237
Straight-line rent and below-market lease revenue $ 1,377 $ 3,459 $ 809 $ 2,924
Funds from operations(2) $ 39,157 $ 107,749 $ 6,556 $ 19,913

(1)Represents an allocation of joint venture earnings to redeemable noncontrolling interests primarily in one property in our South San Francisco submarket. These redeemable noncontrolling interests earn a fixed return on their investment rather than participate in the operating results of the property.

(2)Refer to “Funds from operations and funds from operations per share” in our Earnings Press Release and “Funds from operations and funds from operations, as adjusted, attributable to Alexandria’s common stockholders” in “Definitions and reconciliations” of this Supplemental Information for the definition and reconciliation from the most directly comparable financial measure presented in accordance with GAAP.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 45
Investments
---
September 30, 2021
(Dollars in thousands)

We hold investments in publicly traded companies and privately held entities primarily involved in the life science, agtech, and technology industries. The tables below summarize components of our non-real estate investments and investment income. For additional details, refer to “Investments” in the “Definitions and reconciliations” of this Supplemental Information.

September 30, 2021
Three Months Ended Nine Months Ended Year Ended December 31, 2020
Realized gains $ 81,516 (1) $ 189,013 (2) $ 47,288 (3)
Unrealized (losses) gains (14,432) 183,348 374,033
Investment income $ 67,084 $ 372,361 $ 421,321
September 30, 2021
--- --- --- --- --- --- --- --- ---
Investments Cost Unrealized<br>Gains Carrying Amount
Publicly traded companies $ 282,816 $ 374,515 (4) $ 657,331
Entities that report NAV 355,400 480,412 835,812
Entities that do not report NAV:
Entities with observable price changes 54,562 74,906 129,468
Entities without observable price changes 349,100 349,100
$ 1,041,878 (5) $ 929,833 1,971,711
Investments accounted for under the equity method of accounting 75,167
Total investments $ 2,046,878

(1)Includes three separate significant realized gains aggregating $52.4 million related to the following transactions: (i) the sale of shares in an investment in a publicly traded biotechnology company, (ii) a distribution received from a limited partnership investment, and (iii) the acquisition of one of our privately held biotechnology investments by a publicly traded biotechnology company.

(2)Includes six separate significant realized gains aggregating $110.1 million related to the following transactions: (i) the sales of investments in three publicly traded biotechnology companies, (ii) a distribution received from a limited partnership investment, and (iii) the acquisition of two of our privately held non-real estate investments in a biopharmaceutical company and biotechnology company.

(3)Includes impairments of $24.5 million related to investments in privately held entities that do not report NAV.

(4)Includes gross unrealized gains and losses of $400.0 million and $25.5 million, respectively, as of September 30, 2021.

(5)Represents 3.2% of gross assets as of September 30, 2021.

Public/Private<br>Mix (Cost)
Tenant/Non-Tenant<br>Mix (Cost)
Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 46
--- ---
Key Credit Metrics
---
September 30, 2021
Liquidity Minimal Outstanding Borrowings and Significant Availability on Unsecured Senior Line of Credit
--- --- ---
(in millions)
4.0B q321lineofcredita.jpg
(in millions)
Availability under our unsecured senior line of credit, net of amounts outstanding under our commercial paper program 2,250
Outstanding forward equity sales agreements(1)
Cash, cash equivalents, and restricted cash
Investments in publicly traded companies
Liquidity as of September 30, 2021 4,047
Net Debt and Preferred Stock to Adjusted EBITDA(2) Fixed-Charge Coverage Ratio(2)

All values are in US Dollars.

(1)Represents expected net proceeds from the future settlement of the remaining 4.6 million shares outstanding under our forward equity sales agreements as of September 30, 2021.

(2)Quarter annualized. Refer to “Fixed-charge coverage ratio” and “Net debt and preferred stock to Adjusted EBITDA” in the “Definitions and reconciliations” of this Supplemental Information for additional details.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 47
Summary of Debt
---
September 30, 2021
(in millions)

Weighted-Average Remaining Term of 11.9 Years

(1)Refer to footnote 2 on the next page under “Fixed-rate and variable-rate debt” for additional details.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 48
Summary of Debt (continued)
---
September 30, 2021
(Dollars in thousands)
Fixed-rate and variable-rate debt Fixed-Rate<br>Debt Variable-Rate Debt Total Percentage Weighted-Average
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
Interest Rate(1) Remaining Term<br>(in years)
Secured notes payable $ 198,758 $ $ 198,758 2.1 % 3.41 % 2.4
Unsecured senior notes payable 8,314,851 8,314,851 89.8 3.54 12.8
Unsecured senior line of credit N/A 4.3
Commercial paper program 749,978 749,978 8.1 0.23 (2)
Total/weighted average $ 8,513,609 $ 749,978 $ 9,263,587 100.0 % 3.27 % 11.9 (2)
Percentage of total debt 92 % 8 % 100 %

(1)Represents the weighted-average interest rate as of the end of the applicable period, including expense/income related to the amortization of loan fees, amortization of debt premiums (discounts), and other bank fees.

(2)The commercial paper notes bear interest at short-term fixed rates and can generally be issued with a maturity of 30 days or less and with a maximum maturity of 397 days from the date of issuance. Borrowings under the program are used to fund short-term capital needs and are backed by our unsecured senior line of credit. The commercial paper outstanding as of September 30, 2021, matured on October 6, 2021. In the event we are unable to issue commercial paper notes or refinance outstanding borrowings under terms equal to or more favorable than those under our unsecured senior line of credit, we expect to borrow under the unsecured senior line of credit at L+0.815%. As such, we calculate the weighted-average remaining term of our commercial paper by using the maturity date of our unsecured senior line of credit. Using the maturity date of our outstanding commercial paper, the consolidated weighted-average maturity of our debt is 11.6 years. The commercial paper notes sold during the three months ended September 30, 2021, were issued at a weighted-average yield to maturity of 0.21% and had a weighted-average maturity term of 9 days.

Debt covenants Unsecured Senior Notes Payable Unsecured Senior Line of Credit
Debt Covenant Ratios(1) Requirement September 30, 2021 Requirement September 30, 2021
Total Debt to Total Assets ≤ 60% 31% ≤ 60.0% 28.7%
Secured Debt to Total Assets ≤ 40% 1% ≤ 45.0% 0.6%
Consolidated EBITDA to Interest Expense ≥ 1.5x 11.5x ≥ 1.50x 4.34x
Unencumbered Total Asset Value to Unsecured Debt ≥ 150% 299% N/A N/A
Unsecured Interest Coverage Ratio N/A N/A ≥ 1.75x 9.15x

(1)All covenant ratio titles utilize terms as defined in the respective debt and credit agreements. The calculation of consolidated EBITDA is based on the definitions contained in our loan agreements and is not directly comparable to the computation of EBITDA as described in Exchange Act Release No. 47226.

Unconsolidated real estate joint ventures’ debt
Unconsolidated Joint Venture Our Share Maturity Date Stated Rate Interest Rate(1) Debt Balance at 100%(2)
1401/1413 Research Boulevard 65.0% 5/17/22 L+2.50% 3.50% (3) $ 27,145
1655 and 1725 Third Street 10.0% 3/10/25 4.50% 4.57% 598,550
Menlo Gateway, Phase II 49.0% 5/1/35 4.53% 4.59% 154,992
Menlo Gateway, Phase I 49.0% 8/10/35 4.15% 4.18% 137,578
$ 918,265

(1)Includes interest expense and amortization of loan fees.

(2)Represents outstanding principal, net of unamortized deferred financing costs, as of September 30, 2021.

(3)This loan is subject to a fixed floor rate of 3.50%.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 49
Summary of Debt (continued)
---
September 30, 2021
(Dollars in thousands)
Debt Stated <br>Rate Interest<br><br>Rate(1) Maturity<br><br>Date(2) Principal Payments Remaining for the Periods Ending December 31, Principal Unamortized (Deferred Financing Cost), (Discount)/Premium Total
--- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
2021 2022 2023 2024 2025 Thereafter
Secured notes payable
Greater Boston 4.82 % 3.40 % 2/6/24 $ 870 $ 3,564 $ 3,742 $ 183,527 $ $ $ 191,703 $ 6,377 $ 198,080
San Francisco Bay Area 6.50 % 6.50 7/1/36 28 30 32 34 554 678 678
Secured debt weighted-average interest rate/subtotal 4.83 % 3.41 870 3,592 3,772 183,559 34 554 192,381 6,377 198,758
Commercial paper program(3) 0.23 % (3) 0.23 (3) (3) (3) 750,000 750,000 (22) 749,978
Unsecured senior line of credit L+0.815 % (4) N/A 1/6/26
Unsecured senior notes payable 3.45 % 3.62 4/30/25 600,000 600,000 (3,151) 596,849
Unsecured senior notes payable 4.30 % 4.50 1/15/26 300,000 300,000 (2,106) 297,894
Unsecured senior notes payable – green bond 3.80 % 3.96 4/15/26 350,000 350,000 (2,237) 347,763
Unsecured senior notes payable 3.95 % 4.13 1/15/27 350,000 350,000 (2,693) 347,307
Unsecured senior notes payable 3.95 % 4.07 1/15/28 425,000 425,000 (2,673) 422,327
Unsecured senior notes payable 4.50 % 4.60 7/30/29 300,000 300,000 (1,744) 298,256
Unsecured senior notes payable 2.75 % 2.87 12/15/29 400,000 400,000 (3,385) 396,615
Unsecured senior notes payable 4.70 % 4.81 7/1/30 450,000 450,000 (3,259) 446,741
Unsecured senior notes payable 4.90 % 5.05 12/15/30 700,000 700,000 (7,261) 692,739
Unsecured senior notes payable 3.375 % 3.48 8/15/31 750,000 750,000 (6,422) 743,578
Unsecured senior notes payable – green bond 2.00 % 2.12 5/18/32 900,000 900,000 (9,939) 890,061
Unsecured senior notes payable 1.875 % 1.97 2/1/33 1,000,000 1,000,000 (9,916) 990,084
Unsecured senior notes payable 4.85 % 4.93 4/15/49 300,000 300,000 (3,246) 296,754
Unsecured senior notes payable 4.00 % 3.91 2/1/50 700,000 700,000 10,342 710,342
Unsecured senior notes payable 3.00 % 3.08 5/18/51 850,000 850,000 (12,459) 837,541
Unsecured debt weighted average/subtotal 3.27 600,000 8,525,000 9,125,000 (60,171) 9,064,829
Weighted-average interest rate/total 3.27 % $ 870 $ 3,592 $ 3,772 $ 183,559 $ 600,034 $ 8,525,554 $ 9,317,381 $ (53,794) $ 9,263,587
Balloon payments $ $ $ $ 183,221 $ 600,000 $ 8,525,000 $ 9,308,221 $ $ 9,308,221
Principal amortization 870 3,592 3,772 338 34 554 9,160 (53,794) (44,634)
Total debt $ 870 $ 3,592 $ 3,772 $ 183,559 $ 600,034 $ 8,525,554 $ 9,317,381 $ (53,794) $ 9,263,587
Fixed-rate debt $ 870 $ 3,592 $ 3,772 $ 183,559 $ 600,034 $ 7,775,554 $ 8,567,381 $ (53,772) $ 8,513,609
Variable-rate debt 750,000 750,000 (22) 749,978
Total debt $ 870 $ 3,592 $ 3,772 $ 183,559 $ 600,034 $ 8,525,554 $ 9,317,381 $ (53,794) $ 9,263,587
Weighted-average stated rate on maturing debt N/A N/A N/A 4.82% 3.45% 3.15%

(1)Represents the weighted-average interest rate as of the end of the applicable period, including amortization of loan fees, amortization of debt premiums (discounts), and other bank fees.

(2)Reflects any extension options that we control.

(3)Refer to footnote 2 on the prior page under “Fixed-rate and variable-rate debt.”

(4)During the year ended December 31, 2020, we achieved certain sustainability measures, as described in our unsecured senior line of credit agreement, which reduced the borrowing rate by one basis point for one year ending December 31, 2021.

Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 50
Definitions and Reconciliations
---
September 30, 2021

This section contains additional details for sections throughout this Supplemental Information and the accompanying Earnings Press Release, as well as explanations and reconciliations of certain non-GAAP financial measures and the reasons why we use these supplemental measures of performance and believe they provide useful information to investors. Additional detail can be found in our most recent annual report on Form 10-K and subsequent quarterly reports on Form 10-Q, as well as other documents filed with or furnished to the SEC from time to time.

Adjusted EBITDA and Adjusted EBITDA margin

The following table reconciles net income (loss) and revenues, the most directly comparable financial measures calculated and presented in accordance with GAAP, to Adjusted EBITDA and revenues, as adjusted, respectively:

Three Months Ended
(Dollars in thousands) 9/30/21 6/30/21 3/31/21 12/31/20 9/30/20
Net income $ 124,433 $ 404,520 $ 25,533 $ 457,133 $ 95,799
Interest expense 35,678 35,158 36,467 37,538 43,318
Income taxes 3,672 2,800 1,426 2,053 2,430
Depreciation and amortization 210,842 190,052 180,913 177,750 176,831
Stock compensation expense 9,728 12,242 12,446 11,394 12,994
Loss on early extinguishment of debt 67,253 7,898 52,770
Loss (gain) on sales of real estate 435 (2,779) (152,503) (1,586)
Significant realized gains on non-real estate investments (52,427) (1) (34,773) (22,919)
Unrealized losses (gains) on non-real estate investments 14,432 (244,031) 46,251 (233,538) 14,013
Impairment of real estate 42,620 4,926 5,129 25,177 7,680
Termination fee (86,179)
Adjusted EBITDA $ 389,413 $ 370,894 $ 349,720 $ 332,902 $ 318,070
Revenues $ 547,759 $ 509,619 $ 479,849 $ 463,720 $ 545,042
Total realized gains on non-real estate investments 81,516 (1) 60,232 47,265 21,599 17,361
Significant realized gains on non-real estate investments (52,427) (34,773) (22,919)
Termination fee (86,179)
Revenues, as adjusted $ 576,848 $ 535,078 $ 504,195 $ 485,319 $ 476,224
Adjusted EBITDA margin 68% 69% 69% 69% 67%

(1)Refer to “Investments” in our Supplemental Information for additional information.

We use Adjusted EBITDA as a supplemental performance measure of our operations, for financial and operational decision-making, and as a supplemental means of evaluating period-to-period comparisons on a consistent basis. Adjusted EBITDA is calculated as earnings before interest, taxes, depreciation, and amortization (“EBITDA”), excluding stock compensation expense, gains or losses on early extinguishment of debt, gains or losses on sales of real estate, impairments of real estate, and significant termination fees. Adjusted EBITDA also excludes unrealized gains or losses and significant realized gains or losses and impairments that result from our non-real estate investments. These non-real estate investment amounts are classified in our consolidated statements of operations outside of total revenues.

We believe Adjusted EBITDA provides investors with relevant and useful information as it allows investors to evaluate the operating performance of our business activities without having to account for differences recognized because of investing and financing decisions related to our real estate and non-real estate investments, our capital structure, capital market transactions, and variances resulting from the volatility of market conditions outside of our control. For example, we exclude gains or losses on the early extinguishment of debt to allow investors to measure our performance independent of our indebtedness and capital structure. We believe that adjusting for the effects of impairments and gains or losses on sales of real estate, significant impairments and realized gains or losses on non-real estate investments, and significant termination fees allows investors to evaluate performance from period to period on a consistent basis without having to account for differences recognized because of investing and financing decisions related to our real estate and non-real estate investments or other corporate activities that may not be representative of the operating performance of our properties.

In addition, we believe that excluding charges related to stock compensation and unrealized gains or losses facilitates for investors a comparison of our business activities across periods without the volatility resulting from market forces outside of our control. Adjusted EBITDA has limitations as a measure of our performance. Adjusted EBITDA does not reflect our historical expenditures or future requirements for capital expenditures or contractual commitments. While Adjusted EBITDA is a relevant measure of performance, it does not represent net income (loss) or cash flows from operations calculated and presented in accordance with GAAP, and it should not be considered as an alternative to those indicators in evaluating performance or liquidity.

In order to calculate Adjusted EBITDA margin, we also make comparable adjustments to our revenues. We adjust our total revenues by realized gains, losses, and impairments related to our non-real estate investments and significant termination fees to arrive at revenues, as adjusted. Our calculation of Adjusted EBITDA margin divides Adjusted EBITDA by our revenues, as adjusted. We believe that consistent application of these comparable adjustments to both components of Adjusted EBITDA margin provides a more useful calculation for the comparison across periods.

Annual rental revenue

Annual rental revenue represents the annualized fixed base rental obligations, calculated in accordance with GAAP, for leases in effect as of the end of the period, related to our operating RSF. Annual rental revenue is presented using 100% of the annual rental revenue of our consolidated properties and our share of annual rental revenue for our unconsolidated real estate joint ventures. Annual rental revenue per RSF is computed by dividing annual rental revenue by the sum of 100% of the RSF of our consolidated properties and our share of the RSF of properties held in unconsolidated real estate joint ventures. As of September 30, 2021, approximately 92% of our leases (on an RSF basis) were triple net leases, which require tenants to pay substantially all real estate taxes, insurance, utilities, repairs and maintenance, common area expenses, and other operating expenses (including increases thereto) in addition to base rent. Annual rental revenue excludes these operating expenses recovered from our tenants. Amounts recovered from our tenants related to these operating expenses, along with base rent, are classified in income from rentals in our consolidated statements of operations.

Capitalization Rates

Capitalization rates are calculated based upon net operating income and net operating income (cash basis) annualized for the quarter preceding the date on which the property is sold, or near term prospective net operating income.

| Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 | 51 | | --- | --- || Definitions and Reconciliations (continued) | | --- | | September 30, 2021 |

Cash interest

Cash interest is equal to interest expense calculated in accordance with GAAP plus capitalized interest, less amortization of loan fees and debt premiums (discounts). Refer to the definition of fixed-charge coverage ratio for a reconciliation of interest expense, the most directly comparable financial measure calculated and presented in accordance with GAAP, to cash interest.

Class A properties and AAA locations

Class A properties are properties clustered in AAA locations that provide innovative tenants with highly dynamic and collaborative environments that enhance their ability to successfully recruit and retain world-class talent and inspire productivity, efficiency, creativity, and success. Class A properties generally command higher annual rental rates than other classes of similar properties.

AAA locations are in close proximity to concentrations of specialized skills, knowledge, institutions, and related businesses. Such locations are generally characterized by high barriers to entry for new landlords, high barriers to exit for tenants, and a limited supply of available space.

Development, redevelopment, and pre-construction

A key component of our business model is our disciplined allocation of capital to the development and redevelopment of new Class A properties, and property enhancements identified during the underwriting of certain acquired properties, located in collaborative life science, agtech, and technology campuses in AAA innovation clusters. These projects are generally focused on providing high-quality, generic, and reusable spaces that meet the real estate requirements of, and are reusable by, a wide range of tenants. Upon completion, each value-creation project is expected to generate a significant increase in rental income, net operating income, and cash flows. Our development and redevelopment projects are generally in locations that are highly desirable to high-quality entities, which we believe results in higher occupancy levels, longer lease terms, higher rental income, higher returns, and greater long-term asset value.

Development projects generally consist of the ground-up development of generic and reusable facilities. Redevelopment projects consist of the permanent change in use of office, warehouse, and shell space into office/laboratory, agtech, or tech office space. We generally will not commence new development projects for aboveground construction of new Class A office/laboratory, agtech, and tech office space without first securing significant pre-leasing for such space, except when there is solid market demand for high-quality Class A properties.

Pre-construction activities include entitlements, permitting, design, site work, and other activities preceding commencement of construction of aboveground building improvements. The advancement of pre-construction efforts is focused on reducing the time required to deliver projects to prospective tenants. These critical activities add significant value for future ground-up development and are required for the vertical construction of buildings. Ultimately, these projects will provide high-quality facilities and are expected to generate significant revenue and cash flows.

Development, redevelopment, and pre-construction spending also includes the following costs: (i) certain tenant improvements and renovations that will be reimbursed, (ii) amounts to bring certain acquired properties up to market standard and/or other costs identified during the acquisition process (generally within two years of acquisition), and (iii) permanent conversion of space for highly flexible, move-in-ready office/laboratory space to foster the growth of promising early- and growth-stage life science companies.

Revenue-enhancing and repositioning capital expenditures represent spending to reposition or significantly change the use of a property, including through improvement in the asset quality from Class B to Class A.

Non-revenue-enhancing capital expenditures represent costs required to maintain the current revenues of a stabilized property, including the associated costs for renewed and re-leased space.

Dividend payout ratio (common stock)

Dividend payout ratio (common stock) is the ratio of the absolute dollar amount of dividends on our common stock (shares of common stock outstanding on the respective record dates multiplied by the related dividend per share) to funds from operations attributable to Alexandria’s common stockholders – diluted, as adjusted.

Dividend yield

Dividend yield for the quarter represents the annualized quarter dividend divided by the closing common stock price at the end of the quarter.

Fixed-charge coverage ratio

Fixed-charge coverage ratio is a non-GAAP financial measure representing the ratio of Adjusted EBITDA to fixed charges. We believe this ratio is useful to investors as a supplemental measure of our ability to satisfy fixed financing obligations and preferred stock dividends. Cash interest is equal to interest expense calculated in accordance with GAAP plus capitalized interest, less amortization of loan fees and debt premiums (discounts).

The following table reconciles interest expense, the most directly comparable financial measure calculated and presented in accordance with GAAP, to cash interest and fixed charges:

Three Months Ended
(Dollars in thousands) 9/30/21 6/30/21 3/31/21 12/31/20 9/30/20
Adjusted EBITDA $ 389,413 $ 370,894 $ 349,720 $ 332,902 $ 318,070
Interest expense $ 35,678 $ 35,158 $ 36,467 $ 37,538 $ 43,318
Capitalized interest 43,185 43,492 39,886 37,589 32,556
Amortization of loan fees (2,854) (2,859) (2,817) (2,905) (2,605)
Amortization of debt premiums 498 465 576 869 910
Cash interest and fixed charges $ 76,507 $ 76,256 $ 74,112 $ 73,091 $ 74,179
Fixed-charge coverage ratio:
– quarter annualized 5.1x 4.9x 4.7x 4.6x 4.3x
– trailing 12 months 4.8x 4.6x 4.4x 4.4x 4.3x
Alexandria Real Estate Equities, Inc. All Rights Reserved. © 2021 52
--- --- Definitions and Reconciliations (continued)
---
September 30, 2021

Funds from operations and funds from operations, as adjusted, attributable to Alexandria’s common stockholders

GAAP-basis accounting for real estate assets utilizes historical cost accounting and assumes that real estate values diminish over time. In an effort to overcome the difference between real estate values and historical cost accounting for real estate assets, the Nareit Board of Governors established funds from operations as an improved measurement tool. Since its introduction, funds from operations has become a widely used non-GAAP financial measure among equity REITs. We believe that funds from operations is helpful to investors as an additional measure of the performance of an equity REIT. Moreover, we believe that funds from operations, as adjusted, allows investors to compare our performance to the performance of other real estate companies on a consistent basis, without having to account for differences recognized because of real estate acquisition and disposition decisions, financing decisions, capital structure, capital market transactions, variances resulting from the volatility of market conditions outside of our control, or other corporate activities that may not be representative of the operating performance of our properties.

The 2018 White Paper published by the Nareit Board of Governors (the “Nareit White Paper”) defines funds from operations as net income (computed in accordance with GAAP), excluding gains or losses on sales of real estate, and impairments of real estate, plus depreciation and amortization of operating real estate assets, and after adjustments for our share of consolidated and unconsolidated partnerships and real estate joint ventures. Impairments represent the write-down of assets when fair value over the recoverability period is less than the carrying value due to changes in general market conditions and do not necessarily reflect the operating performance of the properties during the corresponding period.

We compute funds from operations, as adjusted, as funds from operations calculated in accordance with the Nareit White Paper, excluding significant gains, losses, and impairments realized on non-real estate investments, unrealized gains or losses on non-real estate investments, gains or losses on early extinguishment of debt, significant termination fees, acceleration of stock compensation expense due to the resignation of an executive officer, deal costs, the income tax effect related to such items, and the amount of such items that is allocable to our unvested restricted stock awards. Neither funds from operations nor funds from operations, as adjusted, should be considered as alternatives to net income (determined in accordance with GAAP) as indications of financial performance, or to cash flows from operating activities (determined in accordance with GAAP) as measures of liquidity, nor are they indicative of the availability of funds for our cash needs, including our ability to make distributions.

The following table reconciles net income to funds from operations for the share of consolidated real estate joint ventures attributable to noncontrolling interests and our share of unconsolidated real estate joint ventures:

(In thousands) Noncontrolling Interest Share of Consolidated Real Estate JVs Our Share of Unconsolidated <br>Real Estate JVs
September 30, 2021 September 30, 2021
Three Months Ended Nine Months Ended Three Months Ended Nine Months Ended
Net income $ 21,286 $ 58,134 $ 3,091 $ 9,237
Depreciation and amortization 17,871 49,615 3,465 10,676
Funds from operations $ 39,157 $ 107,749 $ 6,556 $ 19,913

Gross assets

Gross assets is calculated as total assets plus accumulated depreciation:

(in thousands) 9/30/21 6/30/21 3/31/21 12/31/20 9/30/20
Total assets $ 28,558,718 $ 27,018,850 $ 25,234,346 $ 22,827,878 $ 21,910,671
Accumulated depreciation 3,614,440 3,461,780 3,319,597 3,182,438 3,079,077
Gross assets $ 32,173,158 $ 30,480,630 $ 28,553,943 $ 26,010,316 $ 24,989,748

Initial stabilized yield (unlevered)

Initial stabilized yield is calculated as the estimated amounts of net operating income at stabilization divided by our investment in the property. Our initial stabilized yield excludes the benefit of leverage. Our cash rents related to our value-creation projects are generally expected to increase over time due to contractual annual rent escalations. Our estimates for initial stabilized yields, initial stabilized yields (cash basis), and total costs at completion represent our initial estimates at the commencement of the project. We expect to update this information upon completion of the project, or sooner if there are significant changes to the expected project yields or costs.

•Initial stabilized yield reflects rental income, including contractual rent escalations and any rent concessions over the term(s) of the lease(s), calculated on a straight-line basis.

•Initial stabilized yield (cash basis) reflects cash rents at the stabilization date after initial rental concessions, if any, have elapsed and our total cash investment in the property.

Investment-grade or publicly traded large cap tenants

Investment-grade or publicly traded large cap tenants represent tenants that are investment-grade rated or publicly traded companies with an average daily market capitalization greater than $10 billion for the twelve months ended September 30, 2021, as reported by Bloomberg Professional Services. Credit ratings from Moody’s Investors Service and S&P Global Ratings reflect credit ratings of the tenant’s parent entity, and there can be no assurance that a tenant’s parent entity will satisfy the tenant’s lease obligation upon such tenant’s default. We monitor the credit quality and related material changes of our tenants. Material changes that cause a tenant’s market capitalization to decrease below $10 billion, which are not immediately reflected in the twelve-month average, may result in their exclusion from this measure.

Space Intentionally Blank
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Investments

We hold investments in publicly traded companies and privately held entities primarily

involved in the life science, agtech, and technology industries. We recognize, measure, present, and

disclose these investments as follows:

Statements of Operations
Balance Sheet Gains and Losses
Carrying Amount Unrealized Realized
Difference between proceeds received upon disposition and historical cost
Publicly traded companies Fair value Changes in fair value
Privately held entities without readily determinable fair values that:
Report NAV Fair value, using NAV as a practical expedient Changes in NAV, as a practical expedient to fair value
Do not report NAV Cost, adjusted for observable price changes and impairments(1) Observable price changes(1) Impairments to reduce costs to fair value, which result in an adjusted cost basis and the differences between proceeds received upon disposition and adjusted or historical cost
Equity method investments Contributions, adjusted for our share of the investee’s earnings or losses, less distributions received, reduced by other-than-temporary impairments Our share of unrealized gains or losses reported by the investee Our share of realized gains or losses reported by the investee, and other-than-temporary impairments

(1)An observable price is a price observed in an orderly transaction for an identical or similar investment of the same issuer. Observable price changes result from, among other things, equity transactions for the same issuer with similar rights and obligations executed during the reporting period, including subsequent equity offerings or other reported equity transactions related to the same issuer.

Investments in real estate

The following table reconciles our investments in real estate as of September 30, 2021:

(In thousands) Investments in <br>Real Estate
Gross investments in real estate $ 26,667,645
Less: accumulated depreciation (3,609,994)
Net investments in real estate – North America 23,057,651
Net investments in real estate – Asia 13,863
Investments in real estate $ 23,071,514

The square footage presented in the table below includes RSF of buildings in operation as of September 30, 2021, primarily representing lease expirations at recently acquired properties that also have inherent future development or redevelopment opportunities, for which we have the intent to demolish or redevelop the existing property upon expiration of the existing in-place leases and commencement of future construction:

Dev/<br>Redev RSF of Lease Expirations Targeted for<br>Development and Redevelopment
Property/Submarket 2021 2022 Thereafter Total
Near-term projects:
Reservoir Woods/Route 128 Redev 202,428 312,845 515,273
651 Gateway Boulevard/South San Francisco Redev 197,787 102,223 (1) 300,010
3450 Hillview Avenue/Greater Stanford Redev 42,340 42,340
11255 and 11355 North Torrey Pines Road/<br>   Torrey Pines Dev 139,135 139,135
10931 and 10933 North Torrey Pines Road/<br>   Torrey Pines Dev 92,450 92,450
10277 Scripps Ranch Boulevard/Other San Diego Redev 32,774 32,774
Other/Seattle Redev 51,255 51,255
41 Moore Drive/Research Triangle Redev 62,490 62,490
235,202 585,457 415,068 1,235,727
Intermediate-term projects:
3825 Fabian Way/Greater Stanford Redev 250,000 250,000
3460 Hillview Avenue/Greater Stanford Redev 34,611 34,611
9444 Waples Street/Sorrento Mesa Dev 39,944 48,436 (2) 88,380
289,944 83,047 372,991
Future projects:
550 Arsenal Street/Cambridge/Inner Suburbs Dev 260,867 260,867
380 and 420 E Street/Seaport Innovation District Dev 195,506 195,506
Other/Greater Boston Redev 167,549 (3) 167,549
1122 El Camino Real/South San Francisco Dev 223,232 223,232
3875 Fabian Way/Greater Stanford Redev 228,000 228,000
960 Industrial Road/Greater Stanford Dev 110,000 110,000
2475 Hanover Street/Greater Stanford Redev 83,980 83,980
219 East 42nd Street/New York City Dev 349,947 349,947
10975 and 10995 Torreyana Road/Torrey Pines Dev 84,829 84,829
4161 Campus Point Court/University Town Center Dev 159,884 159,884
10260 Campus Point Drive/University Town Center Dev 109,164 109,164
Sequence District by Alexandria/Sorrento Mesa Dev/Redev 689,938 689,938
4025, 4031, 4045, and 4075 Sorrento Valley<br><br>Boulevard/Sorrento Valley Dev 82,594 82,594
601 Dexter Avenue North/Lake Union Dev 18,680 18,680
830 4th Avenue South/SoDo Dev 42,380 42,380
82,594 2,723,956 2,806,550
235,202 957,995 3,222,071 4,415,268

(1)Represents vacant square footage as of September 30, 2021.

(2)Includes 43,690 of vacant square footage as of September 30, 2021.

(3)Includes 89,774 of vacant square footage as of September 30, 2021.

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Joint venture financial information

We present components of balance sheet and operating results information related to our real estate joint ventures, which are not presented, or intended to be presented, in accordance with GAAP. We present the proportionate share of certain financial line items as follows: (i) for each real estate joint venture that we consolidate in our financial statements, which are controlled by us through contractual rights or majority voting rights, but of which we own less than 100%, we apply the noncontrolling interest economic ownership percentage to each financial item to arrive at the amount of such cumulative noncontrolling interest share of each component presented; and (ii) for each real estate joint venture that we do not control and do not consolidate, and are instead controlled jointly or by our joint venture partners through contractual rights or majority voting rights, we apply our economic ownership percentage to each financial item to arrive at our proportionate share of each component presented.

The components of balance sheet and operating results information related to our real estate joint ventures do not represent our legal claim to those items. For each entity that we do not wholly own, the joint venture agreement generally determines what equity holders can receive upon capital events, such as sales or refinancing, or in the event of a liquidation. Equity holders are normally entitled to their respective legal ownership of any residual cash from a joint venture only after all liabilities, priority distributions, and claims have been repaid or satisfied.

We believe this information can help investors estimate the balance sheet and operating results information related to our partially owned entities. Presenting this information provides a perspective not immediately available from consolidated financial statements and one that can supplement an understanding of the joint venture assets, liabilities, revenues, and expenses included in our consolidated results.

The components of balance sheet and operating results information related to our real estate joint ventures are limited as an analytical tool as the overall economic ownership interest does not represent our legal claim to each of our joint ventures’ assets, liabilities, or results of operations. In addition, joint venture financial information may include financial information related to the unconsolidated real estate joint ventures that we do not control. We believe that in order to facilitate for investors a clear understanding of our operating results and our total assets and liabilities, joint venture financial information should be examined in conjunction with our consolidated statements of operations and balance sheets. Joint venture financial information should not be considered an alternative to our consolidated financial statements, which are presented and prepared in accordance with GAAP.

Key items included in net income attributable to Alexandria’s common stockholders

We present a tabular comparison of items, whether gain or loss, that may facilitate a high-level understanding of our results and provide context for the disclosures included in this Supplemental Information, our most recent annual report on Form 10-K, and our subsequent quarterly reports on Form 10-Q. We believe such tabular presentation promotes a better understanding for investors of the corporate-level decisions made and activities performed that significantly affect comparison of our operating results from period to period. We also believe this tabular presentation will supplement for investors an understanding of our disclosures and real estate operating results. Gains or losses on sales of real estate and impairments of held for sale assets are related to corporate-level decisions to dispose of real estate. Gains or losses on early extinguishment of debt are related to corporate-level financing decisions focused on our capital structure strategy. Significant realized and unrealized gains or losses on non-real estate investments and impairments of real estate and non-real estate investments are not related to the operating performance of our real estate assets as they result from strategic, corporate-level non-real estate investment decisions and external market conditions. Impairments of non-real estate investments are not related to the operating performance of our real estate as they represent the write-down of non-real estate investments when their fair values decrease below their respective

carrying values due to changes in general market or other conditions outside of our control. Significant items, whether a gain or loss, included in the tabular disclosure for current periods are described in further detail in this Supplemental Information and accompanying Earnings Press Release.

Net cash provided by operating activities after dividends

Net cash provided by operating activities after dividends includes the deduction for distributions to noncontrolling interests. For purposes of this calculation, changes in operating assets and liabilities are excluded as they represent timing differences.

Net debt and preferred stock to Adjusted EBITDA

Net debt and preferred stock to Adjusted EBITDA is a non-GAAP financial measure that we believe is useful to investors as a supplemental measure of evaluating our balance sheet leverage. Net debt and preferred stock is equal to the sum of total consolidated debt less cash, cash equivalents, and restricted cash, plus preferred stock outstanding as of the end of the period. Refer to the definition of Adjusted EBITDA and Adjusted EBITDA margin for further information on the calculation of Adjusted EBITDA.

The following table reconciles debt to net debt and preferred stock and computes the ratio to Adjusted EBITDA:

(Dollars in thousands) 9/30/21 6/30/21 3/31/21 12/31/20 9/30/20
Secured notes payable $ 198,758 $ 227,984 $ 229,406 $ 230,925 $ 342,363
Unsecured senior notes payable 8,314,851 8,313,025 8,311,512 7,232,370 7,230,819
Unsecured senior line of credit and commercial paper 749,978 299,990 99,991 249,989
Unamortized deferred financing costs 65,112 66,913 68,293 56,312 58,284
Cash and cash equivalents (325,872) (323,876) (492,184) (568,532) (446,255)
Restricted cash (42,182) (33,697) (42,219) (29,173) (38,788)
Preferred stock
Net debt and preferred stock $ 8,960,645 $ 8,550,339 $ 8,074,808 $ 7,021,893 $ 7,396,412
Adjusted EBITDA:
– quarter annualized $ 1,557,652 $ 1,483,576 $ 1,398,880 $ 1,331,608 $ 1,272,280
– trailing 12 months $ 1,442,929 $ 1,371,586 $ 1,314,153 $ 1,274,187 $ 1,228,440
Net debt and preferred stock to Adjusted EBITDA:
– quarter annualized 5.8 x 5.8 x 5.8 x 5.3 x 5.8 x
– trailing 12 months 6.2 x 6.2 x 6.1 x 5.5 x 6.0 x
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Net operating income, net operating income (cash basis), and operating margin

The following table reconciles net income to net operating income and to net operating income (cash basis):

Three Months Ended Nine Months Ended
(Dollars in thousands) 9/30/21 9/30/20 9/30/21 9/30/20
Net income $ 124,433 $ 95,799 $ 554,486 $ 370,038
Equity in earnings of unconsolidated real estate joint ventures (3,091) (3,778) (9,237) (4,555)
General and administrative expenses 37,931 36,913 109,807 100,651
Interest expense 35,678 43,318 107,303 134,071
Depreciation and amortization 210,842 176,831 581,807 520,354
Impairment of real estate 42,620 7,680 52,675 22,901
Loss on early extinguishment of debt 52,770 67,253 52,770
Loss (gain) on sales of real estate 435 (1,586) (2,344) (1,586)
Investment income (67,084) (3,348) (372,361) (166,184)
Net operating income 381,764 404,599 1,089,389 1,028,460
Straight-line rent revenue (33,918) (28,822) (89,203) (72,786)
Amortization of acquired below-market leases (13,664) (13,979) (39,043) (43,730)
Net operating income (cash basis) $ 334,182 $ 361,798 $ 961,143 $ 911,944
Net operating income (cash basis) – annualized $ 1,336,728 $ 1,447,192 $ 1,281,524 $ 1,215,925
Net operating income (from above) $ 381,764 $ 404,599 $ 1,089,389 $ 1,028,460
Total revenues $ 547,759 $ 545,042 $ 1,537,227 $ 1,421,917
Operating margin(1) 70% 74% 71% 72%

(1)Includes the effect of a termination fee recognized during 3Q20. Refer to “Funds from operation and funds from operations per share” in our Earnings Press Release for additional details. Excluding this effect, our operating margin for the three and nine months ended September 30, 2020, would have been 70% and 71%, respectively.

Net operating income is a non-GAAP financial measure calculated as net income, the most directly comparable financial measure calculated and presented in accordance with GAAP, excluding equity in the earnings of our unconsolidated real estate joint ventures, general and administrative expenses, interest expense, depreciation and amortization, impairments of real estate, gains or losses on early extinguishment of debt, gains or losses on sales of real estate, and investment income or loss. We believe net operating income provides useful information to investors regarding our financial condition and results of operations because it primarily reflects those income and expense items that are incurred at the property level. Therefore, we believe net operating income is a useful measure for investors to evaluate the operating performance of our consolidated real estate assets. Net operating income on a cash basis is net operating income adjusted to exclude the effect of straight-line rent and amortization of acquired above- and below-market lease revenue adjustments required by GAAP. We believe that net operating income on a cash basis is helpful to investors as an additional measure of operating performance because it eliminates straight-line rent revenue and the amortization of acquired above- and below-market leases.

Furthermore, we believe net operating income is useful to investors as a performance measure of our consolidated properties because, when compared across periods, net operating income reflects trends in occupancy rates, rental rates, and operating costs, which provide a perspective not immediately apparent from net income or loss. Net operating income can be used to measure the initial stabilized yields of our properties by calculating net operating income generated by a property divided by our investment in the property. Net operating income excludes certain components from net income in order to provide results that are more closely related to the results of operations of our properties. For example, interest expense is not necessarily linked to the operating performance of a real estate asset and is often incurred at the corporate level rather than at the property level. In addition, depreciation and amortization, because of historical cost accounting and useful life estimates, may distort comparability of operating performance at the property level. Impairments of real estate have been excluded in deriving net operating income because we do not consider impairments of real estate to be property-level operating expenses. Impairments of real estate relate to changes in the values of our assets and do not reflect the current operating performance with respect to related revenues or expenses. Our impairments of real estate represent the write-down in the value of the assets to the estimated fair value less cost to sell. These impairments result from investing decisions or a deterioration in market conditions. We also exclude realized and unrealized investment gain or loss, which results from investment decisions that occur at the corporate level related to non-real estate investments in publicly traded companies and certain privately held entities. Therefore, we do not consider these activities to be an indication of operating performance of our real estate assets at the property level. Our calculation of net operating income also excludes charges incurred from changes in certain financing decisions, such as losses on early extinguishment of debt, as these charges often relate to corporate strategy. Property operating expenses included in determining net operating income primarily consist of costs that are related to our operating properties, such as utilities, repairs, and maintenance; rental expense related to ground leases; contracted services, such as janitorial, engineering, and landscaping; property taxes and insurance; and property-level salaries. General and administrative expenses consist primarily of accounting and corporate compensation, corporate insurance, professional fees, office rent, and office supplies that are incurred as part of corporate office management. We calculate operating margin as net operating income divided by total revenues.

We believe that in order to facilitate for investors a clear understanding of our operating results, net operating income should be examined in conjunction with net income or loss as presented in our consolidated statements of operations. Net operating income should not be considered as an alternative to net income or loss as an indication of our performance, nor as an alternative to cash flows as a measure of our liquidity or our ability to make distributions.

Operating statistics

We present certain operating statistics related to our properties, including number of properties, RSF, occupancy percentage, leasing activity, and contractual lease expirations as of the end of the period. We believe these measures are useful to investors because they facilitate an understanding of certain trends for our properties. We compute the number of properties, RSF, occupancy percentage, leasing activity, and contractual lease expirations at 100% for all properties in which we have an investment, including properties owned by our consolidated and unconsolidated real estate joint ventures. For operating metrics based on annual rental revenue, refer to our discussion of annual rental revenue herein.

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Same property comparisons

As a result of changes within our total property portfolio during the comparative periods presented, including changes from assets acquired or sold, properties placed into development or redevelopment, and development or redevelopment properties recently placed into service, the consolidated total income from rentals, as well as rental operating expenses in our operating results, can show significant changes from period to period. In order to supplement an evaluation of our results of operations over a given quarterly or annual period, we analyze the operating performance for all consolidated properties that were fully operating for the entirety of the comparative periods presented, referred to as same properties. We separately present quarterly and year-to-date same property results to align with the interim financial information required by the SEC in our management’s discussion and analysis of our financial condition and results of operations. These same properties are analyzed separately from properties acquired subsequent to the first day in the earliest comparable quarterly or year-to-date period presented, properties that underwent development or redevelopment at any time during the comparative periods, unconsolidated real estate joint ventures, properties classified as held for sale, and corporate entities (legal entities performing general and administrative functions), which are excluded from same property results. Additionally, termination fees, if any, are excluded from the results of same properties.

Space Intentionally Blank

The following table reconciles the number of same properties to total properties for the nine months ended September 30, 2021:

Development – under construction Properties Acquisitions after January 1, 2020 Properties
9950 Medical Center Drive 1 3181 Porter Drive 1
Alexandria Center® for Life Science – San Carlos 2 275 Grove Street 1
601, 611, and 651 Gateway Boulevard 3
3115 Merryfield Row 1 3330, 3412, 3450, and 3460 Hillview Avenue 4
Alexandria Center® for Life Science – South San Francisco 1
9605, 9609, 9613, and 9615 Medical Center Drive 4
Alexandria Center® for AgTech 2
Alexandria Center® for Advanced Technologies 2 9808 and 9868 Scranton Road 2
Alexandria Center® for Life Science – Durham
201 Brookline Avenue 1 13
SD Tech by Alexandria 1 Reservoir Woods 3
751 Gateway Boulevard 1 One Upland Road 1
325 Binney Street 1 830 4th Avenue South 1
13 11255 and 11355 North Torrey Pines Road 2
Development – placed into
service after January 1, 2020 Properties Sequence District by Alexandria 7
9804 Medical Center Drive 1 380 and 420 E Street 2
1165 Eastlake Avenue East 1 Alexandria Center® for Life Science – Fenway 1
2
Redevelopment – under construction Properties 550 Arsenal Street 1
5505 Morehouse Drive 1 1501-1599 Industrial Road 6
Alexandria Center® for Life Science – Long Island City 1 One Investors Way 1
2475 Hanover Street 1
3160 Porter Drive 1 10975 and 10995 Torreyana Road 2
The Arsenal on the Charles 11 Pacific Technology Park 6
700 Quince Orchard Road 1 1122 El Camino Real 1
Alexandria Center® for Life Science – Durham 3 12 Davis Drive 1
7360 Carroll Road 1
840 Winter Street 1 Other 39
20400 Century Boulevard 1 104
10277 Scripps Ranch Boulevard 1 Unconsolidated real estate JVs 5
9601 and 9603 Medical Center Drive 2 Properties held for sale 1
Other 8
31 Total properties excluded from same properties 158
Redevelopment – placed into
service after January 1, 2020 Properties Same properties 249
9877 Waples Street 1 Total properties in North America as of September 30, 2021 407
Other 1
2
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Stabilized occupancy date

The stabilized occupancy date represents the estimated date on which the project is expected to reach occupancy of 95% or greater.

Tenant recoveries

Tenant recoveries represent revenues comprising reimbursement of real estate taxes, insurance, utilities, repairs and maintenance, common area expenses, and other operating expenses and earned in the period during which the applicable expenses are incurred and the tenant’s obligation to reimburse us arises.

We classify rental revenues and tenant recoveries generated through the leasing of real estate assets within revenue in income from rentals in our consolidated statements of operations. We provide investors with a separate presentation of rental revenues and tenant recoveries in “Same Property Performance” of this Supplemental Information because we believe it promotes investors’ understanding of our operating results. We believe that the presentation of tenant recoveries is useful to investors as a supplemental measure of our ability to recover operating expenses under our triple net leases, including recoveries of utilities, repairs and maintenance, insurance, property taxes, common area expenses, and other operating expenses, and of our ability to mitigate the effect to net income for any significant variability to components of our operating expenses.

The following table reconciles income from rentals to tenant recoveries:

Three Months Ended Nine Months Ended
(In thousands) 9/30/21 6/30/21 3/31/21 12/31/20 9/30/20 9/30/21 9/30/20
Income from rentals $ 546,527 $ 508,371 $ 478,695 $ 461,335 $ 543,412 $ 1,533,593 $ 1,416,873
Rental revenues (415,918) (396,804) (370,233) (353,950) (438,393) (1,182,955) (1,117,890)
Tenant recoveries $ 130,609 $ 111,567 $ 108,462 $ 107,385 $ 105,019 $ 350,638 $ 298,983

Total equity capitalization

Total equity capitalization is equal to the outstanding shares of common stock multiplied by the closing price on the last trading day at the end of each period presented.

Total market capitalization

Total market capitalization is equal to the sum of total equity capitalization and total debt.

Unencumbered net operating income as a percentage of total net operating income

Unencumbered net operating income as a percentage of total net operating income is a non-GAAP financial measure that we believe is useful to investors as a performance measure of the results of operations of our unencumbered real estate assets as it reflects those income and expense items that are incurred at the unencumbered property level. Unencumbered net operating income is derived from assets classified in continuing operations, which are not subject to any mortgage, deed of trust, lien, or other security interest, as of the period for which income is presented.

The following table summarizes unencumbered net operating income as a percentage of total net operating income:

Three Months Ended
(Dollars in thousands) 9/30/21 6/30/21 3/31/21 12/31/20 9/30/20
Unencumbered net operating income $ 371,026 $ 353,104 $ 330,160 $ 315,586 $ 388,575
Encumbered net operating income 10,738 12,560 11,801 11,367 16,024
Total net operating income $ 381,764 $ 365,664 $ 341,961 $ 326,953 $ 404,599
Unencumbered net operating income as a percentage of total net operating income 97% 97% 97% 97% 96%

Weighted-average interest rate for capitalization of interest

The weighted-average interest rate required for calculating capitalization of interest pursuant to GAAP represents a weighted-average rate based on the rates applicable to borrowings outstanding during the period, including expense/income related to interest rate hedge agreements, amortization of loan fees, amortization of debt premiums (discounts), and other bank fees. A separate calculation is performed to determine our weighted-average interest rate for capitalization for each month. The rate will vary each month due to changes in variable interest rates, outstanding debt balances, the proportion of variable-rate debt to fixed-rate debt, the amount and terms of interest rate hedge agreements, and the amount of loan fee and premium (discount) amortization.

Weighted-average shares of common stock outstanding – diluted

From time to time, we enter into capital market transactions, including forward equity sales agreements (“Forward Agreements”), to fund acquisitions, to fund construction of our highly leased development and redevelopment projects, and for general working capital purposes. We are required to consider the potential dilutive effect of our forward equity sales agreements under the treasury stock method while the forward equity sales agreements are outstanding. As of September 30, 2021, we had Forward Agreements outstanding to sell an aggregate of 4.6 million shares of common stock.

The weighted-average shares of common stock outstanding used in calculating EPS – diluted, FFO per share – diluted, and FFO per share – diluted, as adjusted, during each period are calculated as follows:

Three Months Ended Nine Months Ended
(In thousands) 9/30/21 6/30/21 3/31/21 12/31/20 9/30/20 9/30/21 9/30/20
Weighted-average of common stock outstanding – basic 150,854 145,825 137,319 133,688 124,901 144,716 123,561
Forward Agreements 707 233 369 139 927 437 466
Weighted-average of common stock outstanding – diluted 151,561 146,058 137,688 133,827 125,828 145,153 124,027
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