UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 10-Q
(Mark One)
☑	QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

FOR THE QUARTERLY PERIOD ENDED June 25, 2022

OR
☐	TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
FOR THE TRANSITION PERIOD FROM TO

Commission File No. 001-15943

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

(Exact Name of Registrant as Specified in Its Charter)

Delaware			06-1397316
(State or Other Jurisdiction of<br>Incorporation or Organization)			(I.R.S. Employer<br>Identification No.)
251 Ballardvale Street	Wilmington	Massachusetts	01887
(Address of Principal Executive Offices)			(Zip Code)

(Registrant’s telephone number, including area code): (781) 222-6000

Securities registered pursuant to Section 12(b) of the Act:
Title of each class	Ticker symbol(s)	Name of each exchange on which registered
Common stock, $0.01 par value	CRL	New York Stock Exchange

Indicate by check mark whether the Registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the Registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ☑ No ☐

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files. Yes ☑ No ☐

Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer	☑	Accelerated filer	☐
Non-accelerated filer	☐	Smaller reporting company	☐
		Emerging growth company	☐

If an emerging growth company, indicate by a check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ☑

As of July 22, 2022, there were 50,863,307 shares of the Registrant’s common stock outstanding.

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

QUARTERLY REPORT ON FORM 10-Q

FOR THE QUARTERLY PERIOD ENDED JUNE 25, 2022

TABLE OF CONTENTS

Item		Page
PART I - FINANCIAL INFORMATION
1	Financial Statements
	Condensed Consolidated Statements of Income (Unaudited) for the three and six months ended June 25, 2022 and June 26, 2021	3
	Condensed Consolidated Statements of Comprehensive Income (Unaudited) for the three and six months ended June 25, 2022 and June 26, 2021	4
	Condensed Consolidated Balance Sheets (Unaudited) as of June 25, 2022 and December 25, 2021	5
	Condensed Consolidated Statements of Cash Flows (Unaudited) for the six months ended June 25, 2022 and June 26, 2021	6
	Condensed Consolidated Statements of Changes in Equity (Unaudited) for the three and six months ended June 25, 2022 and June 26, 2021	7
	Notes to Unaudited Condensed Consolidated Financial Statements	8
2	Management’s Discussion and Analysis of Financial Condition and Results of Operations	24
3	Quantitative and Qualitative Disclosure About Market Risk	35
4	Controls and Procedures	36
PART II - OTHER INFORMATION
1	Legal Proceedings	37
1A	Risk Factors	37
2	Unregistered Sales of Equity Securities and Use of Proceeds	37
6	Exhibits	38
Signatures		39

Special Note on Factors Affecting Future Results

This Quarterly Report on Form 10-Q contains forward-looking statements regarding future events and the future results of Charles River Laboratories International, Inc. that are based on our current expectations, estimates, forecasts and projections about the industries in which we operate and the beliefs and assumptions of our management. Words such as “expect,” “anticipate,” “target,” “goal,” “project,” “intend,” “plan,” “believe,” “seek,” “estimate,” “will,” “likely,” “may,” “designed,” “would,” “future,” “can,” “could,” and other similar expressions which are predictions of, indicate future events and trends or which do not relate to historical matters, are intended to identify such forward-looking statements. These statements are based on our current expectations and beliefs and involve a number of risks, uncertainties and assumptions that are difficult to predict.

For example, we may use forward-looking statements when addressing topics such as: the COVID-19 pandemic, its duration, its impact on our business, results of operations, financial condition, liquidity, use of our borrowings, business practices, operations, suppliers, inventory and supplies, third party service providers, customers, employees, industry, ability to meet future performance obligations, ability to timely account for assets on our balance sheet, ability to efficiently implement advisable safety precautions, and internal controls over financial reporting; the COVID-19 pandemic’s impact on demand, the global economy and financial markets, changes and uncertainties in the global economy; client demand, particularly future demand for drug discovery and development products and services, including the outsourcing of these services; our expectations regarding stock repurchases, including the number of shares to be repurchased, expected timing and duration, the amount of capital that may be expended and the treatment of repurchased shares; our ability to successfully execute our business strategy; our ability to timely build infrastructure to satisfy capacity needs and support business growth, our ability to fund our operations for the foreseeable future, the impact of unauthorized access into our information systems, including the timing and effectiveness of any enhanced security and monitoring; present spending trends and other cost reduction activities by our clients; future actions by our management; the outcome of contingencies; changes in our business strategy, business practices and methods of generating revenue; the development and performance of our services and products; market and industry conditions, including competitive and pricing trends; our strategic relationships with leading pharmaceutical and biotechnology companies, venture capital investments, and opportunities for future similar arrangements; our cost structure; the impact of acquisitions and divestitures; our expectations with respect to revenue growth and operating synergies (including the impact of specific actions intended to cause related improvements); the impact of implementing newly issued accounting pronouncements; the impact of specific actions intended to improve overall operating efficiencies and profitability (and our ability to accommodate future demand with our infrastructure), including gains and losses attributable to businesses we plan to close, consolidate, divest or repurpose; changes in our expectations regarding future stock option, restricted stock, performance share units, and other equity grants to employees and directors; expectations with respect to foreign currency exchange; assessing (or changing our assessment of) our tax positions for financial statement purposes; and our liquidity. In addition, these statements include the impact of economic and market conditions on us and our clients, the effects of our cost saving actions and the steps to optimize returns to shareholders on an effective and timely basis; and our ability to withstand the current market conditions.

Forward-looking statements are predictions and are subject to risks, uncertainties and assumptions that are difficult to predict. Therefore, actual results may differ materially and adversely from those expressed in any forward-looking statements. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this document, or in the case of statements incorporated by reference, on the date of the document incorporated by reference.

Factors that might cause or contribute to such differences include, but are not limited to, those discussed in our Annual Report on Form 10-K for the year ended December 25, 2021, under the sections entitled “Our Strategy,” “Management’s Discussion and Analysis of Financial Condition and Results of Operations,” and in this Quarterly Report on Form 10-Q, under the sections entitled “Management’s Discussion and Analysis of Financial Condition and Results of Operations” and “Risk Factors,” in our press releases, and other financial filings with the Securities and Exchange Commission. We have no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events, or risks. New information, future events, or risks may cause the forward-looking events we discuss in this report not to occur.

Item 1. Financial Statements

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

CONDENSED CONSOLIDATED STATEMENTS OF INCOME (UNAUDITED)

(in thousands, except per share amounts)

	Three Months Ended				Six Months Ended
	June 25, 2022		June 26, 2021		June 25, 2022		June 26, 2021
Service revenue	$	782,827	$	715,320	$	1,503,312	$	1,341,901
Product revenue	190,304		199,287		383,748		397,272
Total revenue	973,131		914,607		1,887,060		1,739,173
Costs and expenses:
Cost of services provided (excluding amortization of intangible assets)	522,623		476,762		1,009,487		900,737
Cost of products sold (excluding amortization of intangible assets)	93,782		95,824		184,029		188,137
Selling, general and administrative	131,711		171,501		281,744		327,234
Amortization of intangible assets	37,604		32,970		75,611		61,812
Operating income	187,411		137,550		336,189		261,253
Other income (expense):
Interest income	188		171		315		206
Interest expense	(3,703)		(16,190)		(13,137)		(45,909)
Other (expense) income, net	(39,783)		5,965		(68,408)		(21,752)
Income before income taxes	144,113		127,496		254,959		193,798
Provision for income taxes	33,449		37,580		49,069		39,947
Net income	110,664		89,916		205,890		153,851
Less: Net income attributable to noncontrolling interests	1,343		1,468		3,547		3,873
Net income attributable to common shareholders	$	109,321	$	88,448	$	202,343	$	149,978
Earnings per common share
Net income attributable to common shareholders:
Basic	$	2.15	$	1.76	$	3.99	$	2.99
Diluted	$	2.13	$	1.72	$	3.94	$	2.93
Weighted-average number of common shares outstanding:
Basic	50,823		50,297		50,732		50,138
Diluted	51,283		51,334		51,293		51,225
See Notes to Unaudited Condensed Consolidated Financial Statements.

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (UNAUDITED)

(in thousands)

	Three Months Ended				Six Months Ended
	June 25, 2022		June 26, 2021		June 25, 2022		June 26, 2021
Net income	$	110,664	$	89,916	$	205,890	$	153,851
Other comprehensive income (loss):
Foreign currency translation adjustment	(93,857)		20,827		(106,809)		30,656
Amortization of net loss and prior service benefit included in net periodic cost for pension and other post-retirement benefit plans	741		993		1,487		1,981
Comprehensive income, before income taxes related to items of other comprehensive income	17,548		111,736		100,568		186,488
Less: Income tax (benefit) expense related to items of other comprehensive income	(6,876)		2,449		(8,894)		1,424
Comprehensive income, net of income taxes	24,424		109,287		109,462		185,064
Less: Comprehensive (loss) income related to noncontrolling interests, net of income taxes	(1,275)		1,843		934		4,233
Comprehensive income attributable to common shareholders, net of income taxes	$	25,699	$	107,444	$	108,528	$	180,831
See Notes to Unaudited Condensed Consolidated Financial Statements.

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

CONDENSED CONSOLIDATED BALANCE SHEETS (UNAUDITED)

(in thousands, except per share amounts)

	June 25, 2022		December 25, 2021
Assets
Current assets:
Cash and cash equivalents	$	200,321	$	241,214
Trade receivables and contract assets, net of allowances for credit losses of $7,928 and $7,180, respectively	747,605		642,881
Inventories	256,765		199,146
Prepaid assets	80,939		93,543
Other current assets	107,456		97,311
Total current assets	1,393,086		1,274,095
Property, plant and equipment, net	1,383,422		1,291,068
Operating lease right-of-use assets, net	382,121		292,941
Goodwill	2,860,258		2,711,881
Client relationships, net	965,206		981,398
Other intangible assets, net	67,166		79,794
Deferred tax assets	42,467		40,226
Other assets	435,635		352,889
Total assets	$	7,529,361	$	7,024,292
Liabilities, Redeemable Noncontrolling Interests and Equity
Current liabilities:
Current portion of long-term debt and finance leases	$	2,364	$	2,795
Accounts payable	211,381		198,130
Accrued compensation	202,962		246,119
Deferred revenue	242,084		219,703
Accrued liabilities	199,234		228,797
Other current liabilities	190,110		137,641
Total current liabilities	1,048,135		1,033,185
Long-term debt, net and finance leases	2,997,221		2,663,564
Operating lease right-of-use liabilities	365,775		252,972
Deferred tax liabilities	230,051		239,720
Other long-term liabilities	195,075		242,859
Total liabilities	4,836,257		4,432,300
Commitments and contingencies (Notes 2, 9, 11 and 13)
Redeemable noncontrolling interests	40,177		53,010
Equity:
Preferred stock, $0.01 par value; 20,000 shares authorized; no shares issued and outstanding	—		—
Common stock, $0.01 par value; 120,000 shares authorized; 50,990 shares issued and 50,861 shares outstanding as of June 25, 2022, and 50,480 shares issued and outstanding as of December 25, 2021	510		505
Additional paid-in capital	1,761,125		1,718,304
Retained earnings	1,183,094		980,751
Treasury stock, at cost, 129 and 0 shares, as of June 25, 2022 and December 25, 2021, respectively	(38,468)		—
Accumulated other comprehensive loss	(258,555)		(164,740)
Total equity attributable to common shareholders	2,647,706		2,534,820
Noncontrolling interest	5,221		4,162
Total equity	2,652,927		2,538,982
Total liabilities, redeemable noncontrolling interests and equity	$	7,529,361	$	7,024,292
See Notes to Unaudited Condensed Consolidated Financial Statements.

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (UNAUDITED)

(in thousands)

	Six Months Ended
	June 25, 2022		June 26, 2021
Cash flows relating to operating activities
Net income	$	205,890	$	153,851
Adjustments to reconcile net income to net cash provided by operating activities:
Depreciation and amortization	151,720		129,613
Stock-based compensation	29,549		30,266
Loss on debt extinguishment and other financing costs	1,987		27,980
Deferred income taxes	(14,684)		8,891
Loss on venture capital and strategic equity investments, net	23,515		6,910
Contingent consideration, fair value changes	(15,420)		—
Other, net	13,520		(475)
Changes in assets and liabilities:
Trade receivables and contract assets, net	(117,642)		(5,224)
Inventories	(63,725)		(7,107)
Accounts payable	31,466		(13,383)
Accrued compensation	(38,173)		13,932
Deferred revenue	27,641		502
Customer contract deposits	16,100		(2,032)
Other assets and liabilities, net	360		13,095
Net cash provided by operating activities	252,104		356,819
Cash flows relating to investing activities
Acquisition of businesses and assets, net of cash acquired	(283,392)		(1,000,505)
Capital expenditures	(163,316)		(74,461)
Purchases of investments and contributions to venture capital investments	(108,842)		(23,266)
Proceeds from sale of investments	205		5,204
Other, net	(4,774)		839
Net cash used in investing activities	(560,119)		(1,092,189)
Cash flows relating to financing activities
Proceeds from long-term debt and revolving credit facility	2,180,511		4,999,942
Proceeds from exercises of stock options	15,571		35,298
Payments on long-term debt, revolving credit facility, and finance lease obligations	(1,856,262)		(4,241,772)
Purchase of treasury stock	(38,468)		(40,297)
Payment of debt extinguishment and financing costs	—		(38,166)
Payment of contingent considerations	(10,356)		—
Other, net	(32,843)		(2,330)
Net cash provided by financing activities	258,153		712,675
Effect of exchange rate changes on cash, cash equivalents, and restricted cash	10,756		17,066
Net change in cash, cash equivalents, and restricted cash	(39,106)		(5,629)
Cash, cash equivalents, and restricted cash, beginning of period	246,314		233,119
Cash, cash equivalents, and restricted cash, end of period	$	207,208	$	227,490
Supplemental cash flow information:
Cash and cash equivalents	$	200,321	$	222,969
Restricted cash included in Other current assets	5,797		3,118
Restricted cash included in Other assets	1,090		1,403
Cash, cash equivalents, and restricted cash, end of period	$	207,208	$	227,490
See Notes to Unaudited Condensed Consolidated Financial Statements.

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

CONDENSED CONSOLIDATED STATEMENTS OF CHANGES IN EQUITY (UNAUDITED)

(in thousands)

		Common Stock				Additional Paid-In Capital		Retained Earnings			Accumulated Other Comprehensive Income (Loss)			Treasury Stock			Total Equity Attributable to Common Shareholders		Noncontrolling Interest		Total Equity
	Shares		Amount							Shares			Amount
December 25, 2021		50,480		$	505	$	1,718,304	$	980,751		$	(164,740)		—	$	—	$	2,534,820	$	4,162	$	2,538,982
Net income		—		—		—		93,022			—			—	—		93,022		560		93,582
Other comprehensive loss		—		—		—		—			(10,193)			—	—		(10,193)		—		(10,193)
Adjustment of redeemable noncontrolling interest to redemption value		—		—		(1,161)		—			—			—	—		(1,161)		—		(1,161)
Issuance of stock under employee compensation plans		431		4		13,067		—			—			—	—		13,071		—		13,071
Purchase of treasury shares		—		—		—		—			—			111	(33,994)		(33,994)		—		(33,994)
Stock-based compensation		—		—		14,619		—			—			—	—		14,619		—		14,619
March 26, 2022		50,911		509		1,744,829		1,073,773			(174,933)			111	(33,994)		2,610,184		4,722		2,614,906
Net income		—		—		—		109,321			—			—	—		109,321		499		109,820
Other comprehensive income		—		—		—		—			(83,622)			—	—		(83,622)		—		(83,622)
Adjustment of redeemable noncontrolling interest to redemption value		—		—		(1,132)		—			—			—	—		(1,132)		—		(1,132)
Issuance of stock under employee compensation plans		79		1		2,498		—			—			—	—		2,499		—		2,499
Purchase of treasury shares		—		—		—		—			—			18	(4,474)		(4,474)		—		(4,474)
Stock-based compensation		—		—		14,930		—			—			—	—		14,930		—		14,930
June 25, 2022		50,990		$	510	$	1,761,125	$	1,183,094		$	(258,555)		129	$	(38,468)	$	2,647,706	$	5,221	$	2,652,927
		Common Stock				Additional Paid-In Capital		Retained Earnings			Accumulated Other Comprehensive Income (Loss)			Treasury Stock			Total Equity Attributable to Common Shareholders		Noncontrolling Interest		Total Equity
	Shares		Amount							Shares			Amount
December 26, 2020		49,767		$	498	$	1,627,564	$	625,414		$	(138,874)		—	$	—	$	2,114,602	$	3,567	$	2,118,169
Net income		—		—		—		61,530			—			—	—		61,530		690		62,220
Other comprehensive income		—		—		—		—			11,857			—	—		11,857		—		11,857
Adjustment of redeemable noncontrolling interest to redemption value		—		—		(835)		—			—			—	—		(835)		—		(835)
Issuance of stock under employee compensation plans		583		6		19,606		—			—			—	—		19,612		—		19,612
Purchase of treasury shares		—		—		—		—			—			134	(36,028)		(36,028)		—		(36,028)
Stock-based compensation		—		—		13,189		—			—			—	—		13,189		—		13,189
March 27, 2021		50,350		504		1,659,524		686,944			(127,017)			134	(36,028)		2,183,927		4,257		2,188,184
Net income		—		—		—		88,448			—			—	—		88,448		583		89,031
Other comprehensive income		—		—		—		—			18,996			—	—		18,996		—		18,996
Adjustment of redeemable noncontrolling interest to redemption value		—		—		(1,506)		—			—			—	—		(1,506)		—		(1,506)
Issuance of stock under employee compensation plans		188		1		15,766		—			—			—	—		15,767		—		15,767
Purchase of treasury shares		—		—		—		—			—			13	(4,269)		(4,269)		—		(4,269)
Stock-based compensation		—		—		17,077		—			—			—	—		17,077		—		17,077
June 26, 2021		50,538		$	505	$	1,690,861	$	775,392		$	(108,021)		147	$	(40,297)	$	2,318,440	$	4,840	$	2,323,280
See Notes to Unaudited Condensed Consolidated Financial Statements.

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

NOTES TO UNAUDITED CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

1. BASIS OF PRESENTATION

The accompanying condensed consolidated financial statements are unaudited and have been prepared by Charles River Laboratories International, Inc. (the Company) in accordance with accounting principles generally accepted in the United States (U.S. GAAP) and pursuant to the rules and regulations of the Securities and Exchange Commission (SEC). The year-end condensed consolidated balance sheet data was derived from the Company’s audited consolidated financial statements, but does not include all disclosures required by U.S. GAAP. These unaudited condensed consolidated financial statements should be read in conjunction with the Company’s Annual Report on Form 10-K for fiscal year 2021. The unaudited condensed consolidated financial statements, in the opinion of management, reflect all normal and recurring adjustments necessary for a fair statement of the Company’s financial position and results of operations.

Use of Estimates

The preparation of unaudited condensed consolidated financial statements in accordance with U.S. GAAP requires that the Company make estimates and judgments that may affect the reported amounts of assets, liabilities, revenues, expenses and related disclosure of contingent assets and liabilities. On an on-going basis, the Company evaluates its estimates, judgments, and methodologies. The Company bases its estimates on historical experience and on various other assumptions that are believed to be reasonable, the results of which form the basis for making judgments about the carrying values of assets and liabilities. Actual results may differ from these estimates under different assumptions or conditions. Changes in estimates are reflected in reported results in the period in which they become known.

Newly Issued Accounting Pronouncements

In June 2022, the FASB issued ASU 2022-03, “Fair Value Measurement (Topic 820): Fair Value Measurement of Equity Securities Subject to Contractual Sale Restrictions.” ASU 2022-03 sets disclosure requirements for equity securities subject to contractual sale restrictions that are measured at fair value. The ASU also clarifies that contractual sale restrictions should not be considered when measuring fair value of equity securities. The ASU is effective for fiscal years beginning after December 15, 2023 and will be applied on a prospective basis. The Company is currently evaluating the impact this new standard will have on the consolidated financial statements and related disclosures, but does not believe there will be a material impact.

In November 2021, the FASB issued ASU 2021-10, “Government Assistance (Topic 832): Disclosures by Business Entities About Government Assistance.” ASU 2021-10 requires disclosures about transactions with a government that have been accounted for by a grant or contribution accounting model to increase transparency about the types of transactions, the accounting for the transactions, and the effect on the financial statements. The ASU is an annual disclosure effective for fiscal years beginning after December 15, 2021 and will be applied on a prospective basis. The Company is currently evaluating the impact this new standard will have on the consolidated financial statements and related disclosures, but does not believe there will be a material impact.

Summary of Significant Accounting Policies

The Company’s significant accounting policies are described in Note 1, “Description of Business and Summary of Significant Accounting Policies” in the Company’s Annual Report on Form 10-K for fiscal year 2021.

Consolidation

The Company’s unaudited condensed consolidated financial statements reflect its financial statements and those of its subsidiaries in which the Company holds a controlling financial interest. For consolidated entities in which the Company owns or is exposed to less than 100% of the economics, the Company records net income (loss) attributable to noncontrolling interests in its consolidated statements of income equal to the percentage of the economic or ownership interest retained in such entities by the respective noncontrolling parties. Intercompany balances and transactions are eliminated in consolidation.

The Company’s fiscal year is typically based on 52-weeks, with each quarter composed of 13 weeks ending on the last Saturday on, or closest to, March 31, June 30, September 30, and December 31. A 53rd week in the fourth quarter of the fiscal year is occasionally necessary to align with a December 31 calendar year-end, which will occur in this fiscal year 2022.

Segment Reporting

The Company reports its results in three reportable segments: Research Models and Services (RMS), Discovery and Safety Assessment (DSA), and Manufacturing Solutions (Manufacturing). The Company’s RMS reportable segment includes the Research Models, Research Model Services, and Research and GMP-Compliant Cells businesses. Research Models includes the commercial production and sale of small research models, as well as the supply of large research models. Research Model Services includes: Genetically Engineered Models and Services (GEMS), which performs contract breeding and other services associated with genetically engineered models; Research Animal Diagnostic Services (RADS), which provides health monitoring and diagnostics services related to research models; Insourcing Solutions (IS), which provides colony management

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.NOTES TO UNAUDITED CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (Continued)

of its clients’ research operations (including recruitment, training, staffing, and management services); and Research and GMP-Compliant Cells, which supplies controlled, consistent, customized primary cells and blood components derived from normal and mobilized peripheral blood, bone marrow, and cord blood. The Company’s DSA reportable segment includes services required to take a drug through the early development process including discovery services, which are non-regulated services to assist clients with the identification, screening, and selection of a lead compound for drug development, and regulated and nonregulated (GLP and non-GLP) safety assessment services. The Company’s Manufacturing reportable segment includes Microbial Solutions, which provides in vitro (non-animal) lot-release testing products, microbial detection products, and species identification services; Biologics Solutions (Biologics), which performs specialized testing of biologics (Biologics Testing Solutions) as well as contract development and manufacturing products and services (CDMO); Avian Vaccine Services (Avian), which supplies specific-pathogen-free chicken eggs and chickens.

2. ACQUISITIONS AND DIVESTITURES

Fiscal 2022 Acquisition

Explora BioLabs Holdings, Inc.

On April 5, 2022, the Company acquired Explora BioLabs Holdings, Inc. (Explora BioLabs), a provider of contract vivarium research services, providing biopharmaceutical clients with turnkey in vivo vivarium facilities, management and related services to efficiently conduct their early-stage research activities. The acquisition of Explora BioLabs complements the Company’s existing Insourcing Solutions business, specifically the CRADL (Charles River Accelerator and Development Lab) footprint, and offers incremental opportunities to partner with an emerging client base, many of which are engaged in cell and gene therapy development. The preliminary purchase price of Explora BioLabs was $284.5 million, net of $6.6 million in cash. The acquisition was funded through proceeds from the Company’s credit facility (Credit Facility). This business is reported as part of the Company’s RMS reportable segment.

Fiscal 2021 Acquisitions

Vigene Biosciences, Inc.

On June 28, 2021, the Company acquired Vigene Biosciences, Inc. (Vigene), a gene therapy CDMO, providing viral vector-based gene delivery solutions. The acquisition enables clients to seamlessly conduct analytical testing, process development, and manufacturing for advanced modalities with the same scientific partner. The purchase price of Vigene was $323.9 million, net of $2.7 million in cash. Included in the purchase price are contingent payments fair valued at $34.5 million, which was estimated using a Monte Carlo Simulation model (the maximum contingent contractual payments are up to $57.5 million based on future performance). The acquisition was funded through a combination of available cash and proceeds from the Company’s Credit Facility. This business is reported as part of the Company’s Manufacturing reportable segment. As of June 25, 2022, the fair value of the contingent consideration was zero as certain financial targets have not and are not expected to be achieved.

Retrogenix Limited

On March 30, 2021, the Company acquired Retrogenix Limited (Retrogenix), an early-stage contract research organization providing specialized bioanalytical services utilizing its proprietary cell microarray technology. The acquisition of Retrogenix enhances the Company’s scientific expertise with additional large molecule and cell therapy discovery capabilities. The purchase price of Retrogenix was $53.9 million, net of $8.5 million in cash. Included in the purchase price are contingent payments fair valued at $6.9 million, which is the maximum potential payout, and was based on a probability-weighted approach. The acquisition was funded through a combination of available cash and proceeds from the Company’s Credit Facility. This business is reported as part of the Company’s DSA reportable segment.

Cognate BioServices, Inc.

On March 29, 2021, the Company acquired Cognate BioServices, Inc. (Cognate), a cell and gene therapy CDMO offering comprehensive manufacturing solutions for cell therapies, as well as for the production of plasmid DNA and other inputs in the CDMO value chain. The acquisition of Cognate establishes the Company as a scientific partner for cell and gene therapy development, testing, and manufacturing, providing clients with an integrated solution from basic research and discovery through cGMP production. The purchase price of Cognate was $877.9 million, net of $70.5 million in cash and includes $15.7 million of consideration for an approximate 2% ownership interest not acquired, which was redeemed in April 2022 with the ultimate payout tied to performance in 2021. The acquisition was funded through a combination of available cash and proceeds from the Company’s Credit Facility and senior notes (Senior Notes) issued in fiscal 2021. This business is reported as part of the Company’s Manufacturing reportable segment.

Distributed Bio, Inc.

On December 31, 2020, the Company acquired Distributed Bio, Inc. (Distributed Bio), a next-generation antibody discovery company with technologies specializing in enhancing the probability of success for delivering high-quality, readily formattable

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.NOTES TO UNAUDITED CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (Continued)

antibody fragments to support antibody and cell and gene therapy candidates to biopharmaceutical clients. The acquisition of Distributed Bio expands the Company’s capabilities with an innovative, large-molecule discovery platform, and creates an integrated, end-to-end platform for therapeutic antibody and cell and gene therapy discovery and development. The purchase price of Distributed Bio was $97.0 million, net of $0.8 million in cash. The total consideration includes $80.8 million cash paid, settlement of $3.0 million in convertible promissory notes previously issued by the Company during prior fiscal years, and $14.1 million of contingent consideration, which was estimated using a Monte Carlo Simulation model (the maximum contingent contractual payments are up to $21.0 million based on future performance and milestone achievements over a one-year period). The acquisition was funded through a combination of available cash and proceeds from the Company’s Credit Facility. This business is reported as part of the Company’s DSA reportable segment. During the three months ended June 25, 2022, $7.0 million of contingent consideration was paid as certain operational milestones were achieved. Other financial targets associated with the contingent consideration were not met and the fair value of the remaining contingent consideration is zero.

Other Acquisition

On March 3, 2021, the Company acquired certain assets from a distributor that supports the Company’s DSA reportable segment. The purchase price was $35.4 million, which includes $19.5 million in cash paid ($5.5 million of which was paid in fiscal 2020), and $15.9 million of contingent consideration, which was estimated using a Monte Carlo Simulation model (the maximum contingent contractual payments are up to $17.5 million based on future performance over a three-year period). The fair value of the net assets acquired included $17.3 million of goodwill, $15.2 million attributed to supplier relationships (to be amortized over a 4-year period), and $3.0 million of property, plant, and equipment. The business is reported as part of the Company’s DSA reportable segment. As of June 25, 2022, the fair value of the contingent consideration was zero as certain operational targets were not achieved.

Purchase price information

The purchase price allocation was as follows:

		Vigene		Retrogenix		Cognate		Distributed Bio
		June 28, 2021		March 30, 2021		March 29, 2021		December 31, 2020
Trade receivables	7,679	$	3,548	$	2,266	$	18,566	$	2,722
Other current assets (excluding cash)		1,657		209		14,128		221
Property, plant and equipment		7,649		400		52,082		2,382
Operating lease right-of-use asset, net		22,507		1,385		34,349		1,586
Goodwill (2)		239,681		34,489		611,555		71,585
Definite-lived intangible assets		93,900		22,126		270,900		24,540
Other long-term assets		694		—		6,098		469
Deferred revenue		(4,260)		(434)		(20,539)		(1,319)
Other current liabilities (3)		(6,319)		(1,141)		(45,388)		(1,504)
Operating lease right-of-use liabilities (Long-term)		(21,220)		(1,205)		(31,383)		(1,123)
Deferred tax liabilities		(13,958)		(4,174)		(32,503)		(2,529)
Other long-term liabilities		—		—		—		—
Total purchase price allocation	284,521	$	323,879	$	53,921	$	877,865	$	97,030
(1) Purchase price allocation is preliminary and subject to change as additional information becomes available concerning the fair value and tax basis of the assets acquired and liabilities assumed, including certain contracts and obligations. Any additional adjustments to the purchase price allocation will be made as soon as practicable but no later than one year from the date of acquisition.
(2) The goodwill resulting from these transactions is primarily attributable to the potential growth of the Company’s segments from new customers introduced to the acquired businesses and the assembled workforce of the acquirees, thus is not deductible for tax purposes. Explora BioLabs had 5.0 million of goodwill due to a prior asset acquisition that is not deductible for tax purposes.
(3) In connection with its acquisitions of businesses, the Company routinely records liabilities related to indirect state and local taxes for preacquisition periods when such liabilities are estimable and deemed probable. The Company may or may not be indemnified for such indirect tax liabilities under terms of the acquisitions. As these indirect tax contingencies are resolved, actual obligations, and any indemnifications, may differ from the recorded amounts and any differences are reflected in reported results in the period in which these are resolved. Specifically for Cognate, as of March 29, 2021, the Company recorded an estimated liability of 17 million pertaining to indirect state sales taxes. During the three months ended June 25, 2022, the Company received a favorable ruling from the applicable state in which the indirect state sales tax liability arose and, accordingly, this liability was reduced in full, resulting in a gain recorded through selling, general and administrative expenses in the period.

All values are in US Dollars.

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.NOTES TO UNAUDITED CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (Continued)

The definite-lived intangible assets acquired were as follows:

	Explora BioLabs		Vigene		Retrogenix		Cognate		Distributed Bio
Definite-Lived Intangible Assets	(in thousands)
Client relationships	$	64,000	$	87,500	$	17,340	$	257,200	$	16,080
Other intangible assets	6,100		6,400		4,786		13,700		8,460
Total definite-lived intangible assets	$	70,100	$	93,900	$	22,126	$	270,900	$	24,540
Weighted Average Amortization Life	(in years)
Client relationships	13		12		13		13		9
Other intangible assets	4		2		3		2		4
Total definite-lived intangible assets	12		11		11		13		7				Three Months Ended				Six Months Ended
---	---	---	---	---	---	---	---	---
	June 25, 2022		June 26, 2021		June 25, 2022		June 26, 2021
	(in thousands)
Transaction and Integration Costs
Selling, general and administrative expenses	$	4,426	$	14,694	$	11,539	$	23,411

Pro forma information

The following selected unaudited pro forma consolidated results of operations are presented as if the Cognate and Vigene acquisitions had occurred as of the beginning of the period immediately preceding the period of acquisition, which is December 29, 2019, after giving effect to certain adjustments. For the three and six months ended June 26, 2021, these adjustments included additional amortization of intangible assets and depreciation of fixed assets of $4.0 million and $13.3 million, additional interest expense on borrowing of $2.2 million and $5.6 million, elimination of intercompany activity and other one-time costs, and the tax impacts of these adjustments. All other acquisitions have not been included because that information is not material to the consolidated financial statements.

	June 26, 2021
	Three Months Ended		Six Months Ended
	(in thousands)
	(unaudited)
Revenue	$	923,859	$	1,782,659
Net income attributable to common shareholders	94,984		132,559

These unaudited pro forma results of operations have been prepared for comparative purposes only, and they do not purport to be indicative of the results of operations that actually would have resulted had the acquisition occurred on the dates indicated or that may result in the future. No effect has been given for synergies, if any, that may be realized through the acquisition.

RMS Japan Divestiture

On October 12, 2021, the Company sold its RMS Japan operations to The Jackson Laboratory for a preliminary purchase price of $70.6 million, which included $7.9 million in cash, $3.8 million pension over funding, and certain post-closing adjustments.

The RMS Japan business was reported in the Company’s RMS reportable segment. The Company determined that the RMS Japan business was not optimized within the Company’s portfolio at its current scale, and that the capital could be better deployed in other long-term growth opportunities.

CDMO Sweden Divestiture

On October 12, 2021, the Company sold its gene therapy CDMO site in Sweden to a private investor group for a preliminary purchase price of $59.6 million, net of $0.2 million in cash and other post-closing adjustments that may impact the purchase price. Included in the purchase price are contingent payments fair valued at $15.3 million, which were estimated using a probability weighted model (the maximum contingent contractual payments are up to $25.0 million based on future performance), as well as a purchase obligation of approximately $10.0 million between the parties.

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.NOTES TO UNAUDITED CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (Continued)

The CDMO Sweden business was acquired in March 2021 as part of the acquisition of Cognate and was reported in the Company’s Manufacturing reportable segment. The Company routinely evaluates the strategic fit and fundamental performance of our acquisitions integrated within our global infrastructure. As part of this assessment, the Company determined that this capital could be better deployed in other long-term growth opportunities.

The carrying amounts of the major classes of assets and liabilities associated with the divestitures of the businesses were as follows:

	October 12, 2021
	RMS Japan		CDMO Sweden
	(in thousands)
Assets
Current assets	$	26,524	$	8,187
Property, plant, and equipment, net	17,379		14,339
Operating lease right-of-use assets, net	—		19,733
Goodwill	4,129		27,764
Intangible assets, net	—		14,089
Other assets	3,695		—
Total assets	$	51,727	$	84,112
Liabilities
Current liabilities	$	8,705	$	6,386
Operating lease right-of-use liabilities	—		18,221
Long-term liabilities	94		—
Total liabilities	$	8,799	$	24,607

3. REVENUE FROM CONTRACTS WITH CUSTOMERS

Disaggregation of Revenue

The following table disaggregates the Company’s revenue by major business line and timing of transfer of products or services:

	Three Months Ended				Six Months Ended
	June 25, 2022		June 26, 2021		June 25, 2022		June 26, 2021
	(in thousands)
Timing of Revenue Recognition:
RMS
Services and products transferred over time	$	85,803	$	66,334	$	155,727	$	131,230
Services and products transferred at a point in time	100,607		110,360		207,225		222,374
Total RMS revenue	186,410		176,694		362,952		353,604
DSA
Services and products transferred over time	589,371		539,790		1,131,707		1,040,258
Services and products transferred at a point in time	2,546		304		4,469		1,014
Total DSA revenue	591,917		540,094		1,136,176		1,041,272
Manufacturing
Services and products transferred over time	92,811		95,974		187,820		146,542
Services and products transferred at a point in time	101,993		101,845		200,112		197,755
Total Manufacturing revenue	194,804		197,819		387,932		344,297
Total revenue	$	973,131	$	914,607	$	1,887,060	$	1,739,173

RMS

The RMS business generates revenue through the commercial production and sale of research models, research and GMP-compliant cells (cell supply), and the provision of services related to the maintenance and monitoring of research models and management of clients’ research operations. Revenue from the sale of research models and cell supply is recognized at a point in time when the customer obtains control of the product, which may be upon shipment or upon delivery based on the shipping

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.NOTES TO UNAUDITED CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (Continued)

terms of a contract. Revenue generated from research models services is recognized over time and is typically based on a right-to-invoice measure of progress (output method) as invoiced amounts correspond directly to the value of the Company’s performance to date.

DSA

The DSA business provides a full suite of integrated drug discovery services directed at the identification, screening and selection of a lead compound for drug development and offers a full range of safety assessment services including bioanalysis, drug metabolism, pharmacokinetics, toxicology and pathology. DSA services revenue is generally recognized over time using the cost-to-cost or right to invoice measures of progress, primarily representing fixed fee service contracts and per unit service contracts, respectively.

Manufacturing

The Manufacturing business includes Microbial Solutions, which provides in vitro (non-animal) lot-release testing products, microbial detection products, and species identification services; Biologics Solutions (Biologics), which performs specialized testing of biologics (Biologics Testing Solutions) as well as contract development and manufacturing products and services (CDMO); and Avian Vaccine Services (Avian), which supplies specific-pathogen-free chicken eggs and chickens. Species identification service revenue is generally recognized at a point in time as identifications are completed by the Company. Biologics service revenue is generally recognized over time using the cost-to-cost measure of progress. Microbial Solutions and Avian product sales are generally recognized at a point in time when the customer obtains control of the product, which may be upon shipment or upon delivery based on the contractual shipping terms of a contract.

Transaction Price Allocated to Future Performance Obligations

The Company discloses the aggregate amount of transaction price that is allocated to performance obligations that have not yet been satisfied as of June 25, 2022. Excluded from the disclosure is the value of unsatisfied performance obligations for (i) contracts with an original expected length of one year or less (ii) contracts for which revenue is recognized at the amount to which the Company has the right to invoice for services performed and (iii) service revenue recognized in accordance with ASC 842, “Leases” (see additional disclosure for Other Performance Obligations).

The following table includes estimated revenue expected to be recognized in the future related to performance obligations that are unsatisfied (or partially satisfied) as of June 25, 2022:

	Revenue Expected to be Recognized in Future Periods
	Less than 1 Year		1 to 3 Years		4 to 5 Years		Beyond 5 Years		Total
	(in thousands)
DSA	$	499,945	$	429,944	$	52,543	$	3,083	$	985,515
Manufacturing	1,621		—		—		—		1,621
Total	$	501,566	$	429,944	$	52,543	$	3,083	$	987,136

Contract Balances from Contracts with Customers

The timing of revenue recognition, billings and cash collections results in billed receivables (client receivables), contract assets (unbilled revenue), and contract liabilities (current and long-term deferred revenue and customer contract deposits) on the unaudited condensed consolidated balance sheets. The Company’s payment terms are generally 30 days in the United States and consistent with prevailing practice in international markets. A contract asset is recorded when a right to consideration in exchange for goods or services transferred to a customer is conditioned other than the passage of time. Client receivables are recorded separately from contract assets since only the passage of time is required before consideration is due. A contract liability is recorded when consideration is received, or such consideration is unconditionally due, from a customer prior to transferring goods or services to the customer under the terms of a contract. Contract liabilities are recognized as revenue after control of the products or services is transferred to the customer and all revenue recognition criteria have been met.

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.NOTES TO UNAUDITED CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (Continued)

The following table provides information about client receivables, contract assets, and contract liabilities from contracts with customers:

	June 25, 2022		December 25, 2021
	(in thousands)
Balances from contracts with customers:
Client receivables	$	564,719	$	489,452
Contract assets (unbilled revenue)	190,814		160,609
Contract liabilities (current and long-term deferred revenue)	262,850		240,281
Contract liabilities (customer contract deposits)	77,038		59,512

When the Company does not have the unconditional right to advanced billings, both advanced client payments and unpaid advanced client billings are excluded from deferred revenue, with the advanced billings also being excluded from client receivables. The Company excluded approximately $49 million and $36 million of unpaid advanced client billings from both client receivables and deferred revenue in the accompanying unaudited condensed consolidated balance sheets as of June 25, 2022 and December 25, 2021, respectively. Advanced client payments of approximately $77 million and $60 million have been presented as customer contract deposits within other current liabilities in the accompanying unaudited condensed consolidated balance sheets as of June 25, 2022 and December 25, 2021, respectively.

Other changes in the contract asset and the contract liability balances during the six months ended June 25, 2022 and June 26, 2021 were as follows:

(i) Changes due to acquisitions and divestitures:

See Note 2 “Acquisitions and Divestitures” for the Company’s recent acquisitions.

(ii) Cumulative catch-up adjustments to revenue that affect the corresponding contract asset or contract liability, including adjustments arising from a change in the measure of progress, a change in an estimate of the transaction price (including any changes in the assessment of whether an estimate of variable consideration is constrained), or a contract modification:

During the six months ended June 25, 2022 and June 26, 2021, immaterial cumulative catch-up adjustments to revenue were recorded.

(iii) A change in the time frame for a right to consideration to become unconditional (that is, for a contract asset to be recorded as a client receivable):

Approximately 75% of unbilled revenue as of December 25, 2021, which was $161 million, was billed during the six months ended June 25, 2022. Approximately 80% of unbilled revenue as of December 26, 2020, which was $135 million, was billed during the six months ended June 26, 2021.

(iv) A change in the time frame for a performance obligation to be satisfied (that is, for the recognition of revenue arising from a contract liability):

Approximately 75% of contract liabilities as of December 25, 2021, which was $240 million, were recognized as revenue during the six months ended June 25, 2022. Approximately 75% of contract liabilities as of December 26, 2020, which was $227 million, were recognized as revenue during the six months ended June 26, 2021.

Other Performance Obligations

As part of the Company’s service offerings, primarily in the Manufacturing and RMS segments, the Company has identified performance obligations related to leasing Company owned assets. In certain arrangements, customers obtain substantially all of the economic benefits of the identified assets, which may include manufacturing suites and related equipment, and have the right to direct the assets’ use over the term of the contract. The associated revenue is recognized on a straight-line basis over the term of the lease, which is generally less than one year. For the three months ended June 25, 2022 and June 26, 2021, the Company recognized lease revenue of $13.9 million and $6.3 million, which is recorded within service revenue, which is transferred over time, within the unaudited condensed consolidated statements of income. For the six months ended June 25, 2022 and June 26, 2021, the Company recognized lease revenue of $21.8 million and $6.3 million within the unaudited condensed consolidated statements of income. Due to the nature of these arrangements and timing of the contractual lease term, the remaining revenue to be recognized related to these lease performance obligations is not material to the unaudited condensed consolidated financial statements.

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.NOTES TO UNAUDITED CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (Continued)

4. SEGMENT INFORMATION

The following table presents revenue and other financial information by reportable segment:

	Three Months Ended				Six Months Ended
	June 25, 2022		June 26, 2021		June 25, 2022		June 26, 2021
	(in thousands)
RMS
Revenue	$	186,410	$	176,694	$	362,952	$	353,604
Operating income	39,526		42,580		87,408		87,515
Depreciation and amortization	13,228		9,844		22,697		19,523
Capital expenditures	13,850		8,512		22,496		11,495
DSA
Revenue	$	591,917	$	540,094	$	1,136,176	$	1,041,272
Operating income	128,793		104,514		233,779		195,463
Depreciation and amortization	44,626		43,588		91,415		88,196
Capital expenditures	41,578		20,473		90,508		37,513
Manufacturing
Revenue	$	194,804	$	197,819	$	387,932	$	344,297
Operating income	62,503		56,717		108,871		106,154
Depreciation and amortization	18,000		13,952		36,482		20,521
Capital expenditures	24,431		13,602		47,259		20,712

The following tables present reconciliations of segment operating income, depreciation and amortization, and capital expenditures to the respective consolidated amounts:

	Operating Income				Depreciation and Amortization				Capital Expenditures
	June 25, 2022		June 26, 2021		June 25, 2022		June 26, 2021		June 25, 2022		June 26, 2021
	(in thousands)
Three Months Ended:
Total reportable segments	$	230,822	$	203,811	$	75,854	$	67,384	$	79,859	$	42,587
Unallocated corporate	(43,411)		(66,261)		567		721		2,993		3,844
Total consolidated	$	187,411	$	137,550	$	76,421	$	68,105	$	82,852	$	46,431
Six Months Ended
Total reportable segments	$	430,058	$	389,132	$	150,594	$	128,240	$	160,263	$	69,720
Unallocated corporate	(93,869)		(127,879)		1,126		1,373		3,053		4,741
Total consolidated	$	336,189	$	261,253	$	151,720	$	129,613	$	163,316	$	74,461

Revenue for each significant product or service offering is as follows:

	Three Months Ended				Six Months Ended
	June 25, 2022		June 26, 2021		June 25, 2022		June 26, 2021
	(in thousands)
RMS	$	186,410	$	176,694	$	362,952	$	353,604
DSA	591,917		540,094		1,136,176		1,041,272
Manufacturing	194,804		197,819		387,932		344,297
Total revenue	$	973,131	$	914,607	$	1,887,060	$	1,739,173

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.NOTES TO UNAUDITED CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (Continued)

A summary of unallocated corporate expense consists of the following:

	Three Months Ended				Six Months Ended
	June 25, 2022		June 26, 2021		June 25, 2022		June 26, 2021
	(in thousands)
Stock-based compensation	$	8,531	$	10,417	$	17,034	$	18,059
Compensation, benefits, and other employee-related expenses	20,507		25,924		49,143		53,286
External consulting and other service expenses	4,727		6,301		9,046		13,657
Information technology	3,079		4,117		5,553		8,212
Depreciation	567		721		1,126		1,373
Acquisition and integration	3,014		15,036		8,840		25,596
Other general unallocated corporate	2,986		3,745		3,127		7,696
Total unallocated corporate expense	$	43,411	$	66,261	$	93,869	$	127,879

Other general unallocated corporate expense consists of costs associated with departments such as senior executives, corporate accounting, legal, tax, human resources, treasury, and investor relations.

Revenue by geographic area is as follows:

	U.S.		Europe		Canada		Asia Pacific		Other		Consolidated
	(in thousands)
Three Months Ended:
June 25, 2022	$	566,917	$	263,584	$	93,694	$	46,239	$	2,697	$	973,131
June 26, 2021	491,619		275,706		90,565		55,133		1,584		914,607
Six Months Ended:
June 25, 2022	$	1,093,466	$	514,671	$	178,940	$	95,185	$	4,798	$	1,887,060
June 26, 2021	940,101		513,241		167,672		114,579		3,580		1,739,173

Included in the Other category above are operations located in Brazil and Israel. Revenue represents sales originating in entities physically located in the identified geographic area.

5. SUPPLEMENTAL BALANCE SHEET INFORMATION

The composition of trade receivables and contract assets, net is as follows:

	June 25, 2022		December 25, 2021
	(in thousands)
Client receivables	$	564,719	$	489,452
Unbilled revenue	190,814		160,609
Total	755,533		650,061
Less: Allowance for credit losses	(7,928)		(7,180)
Trade receivables and contract assets, net	$	747,605	$	642,881

The composition of inventories is as follows:

	June 25, 2022		December 25, 2021
	(in thousands)
Raw materials and supplies	$	37,237	$	33,118
Work in process	43,615		40,268
Finished products	175,913		125,760
Inventories	$	256,765	$	199,146

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.NOTES TO UNAUDITED CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (Continued)

The composition of other current assets is as follows:

	June 25, 2022		December 25, 2021
	(in thousands)
Prepaid income tax	$	92,909	$	84,725
Short-term investments	1,012		1,063
Restricted cash	5,797		4,023
Other receivables	7,738		7,500
Other current assets	$	107,456	$	97,311

The composition of other assets is as follows:

	June 25, 2022		December 25, 2021
	(in thousands)
Venture capital investments	$	127,864	$	149,640
Strategic equity investments	151,207		51,712
Life insurance policies	42,116		51,048
Other long-term income tax assets	16,412		18,690
Restricted cash	1,090		1,077
Long-term pension assets	37,357		39,582
Other	59,589		41,140
Other assets	$	435,635	$	352,889

The composition of other current liabilities is as follows:

	June 25, 2022		December 25, 2021
	(in thousands)
Current portion of operating lease right-of-use liabilities	$	48,937	$	33,267
Accrued income taxes	46,226		26,161
Customer contract deposits	77,038		59,512
Other	17,909		18,701
Other current liabilities	$	190,110	$	137,641

The composition of other long-term liabilities is as follows:

	June 25, 2022		December 25, 2021
	(in thousands)
U.S. Transition Tax	$	32,324	$	43,057
Long-term pension liability, accrued executive supplemental life insurance retirement plan and deferred compensation plans	103,245		104,944
Long-term deferred revenue	20,766		20,578
Other	38,740		74,280
Other long-term liabilities	$	195,075	$	242,859

6. VENTURE CAPITAL AND STRATEGIC EQUITY INVESTMENTS

Venture capital investments were $127.9 million and $149.6 million as of June 25, 2022 and December 25, 2021, respectively. The Company’s total commitment to the venture capital funds as of June 25, 2022 was $192.7 million, of which the Company funded $119.7 million through that date. The Company received distributions totaling $2.7 million and $18.2 million for the three months ended June 25, 2022 and June 26, 2021, respectively. The Company received distributions totaling $4.0 million and $27.5 million for the six months ended June 25, 2022 and June 26, 2021, respectively.

The Company recognized net losses on venture capital investments of $9.7 million for the three months ended June 25, 2022 and net gains of $11.1 million for the three months ended June 26, 2021, both of which were driven primarily by publicly-held investments. The Company recognized net losses on venture capital investments of $23.1 million for the six months ended June

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.NOTES TO UNAUDITED CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (Continued)

25, 2022, driven by the decrease in the fair value of publicly-held investments offset by increases from private investments, and net losses of $5.3 million for the six months ended June 26, 2021, which were driven by publicly-held and private investments.

The Company also invests, with minority positions, directly in equity of privately-held companies. Strategic equity investments were $151.2 million and $51.7 million as of June 25, 2022 and December 25, 2021, respectively. In April 2022, the Company acquired a 49% equity interest in a supplier supporting the DSA reportable segment (the Investee) for $90.0 million up front and an additional future contingent payment of up to $5.0 million based upon the Investee’s future performance. The total allocable basis of the investment exceeds the proportional interest in the Investee’s underlying net assets by $86.7 million, which has been allocated primarily to goodwill, intangible assets (client relationships and backlog), and deferred tax liabilities in the amount of $26.2 million and $71.2 million, and $10.7 million respectively. The Company recognizes its proportional share of the Investee’s earnings, adjusted for the amortization of the intangible assets over their useful lives and any intra-entity eliminations, under the equity method of accounting on a three-month lag within other income (expense), net in the accompanying consolidated statements of income. Summarized financial information for this equity method Investee is not presented as such information is not material to the Company’s financial statements. The Company purchased additional strategic equity investments of $12.2 million during the six months ended June 25, 2022 and recognized insignificant gains and losses for the three and six months ended June 25, 2022 and June 26, 2021.

Additionally, as of June 25, 2022 the Company has a $25 million commitment to purchase an additional interest in an existing strategic equity investment.

7. FAIR VALUE

The Company has certain financial assets and liabilities recorded at fair value, which have been classified as Level 1, 2, or 3 within the fair value hierarchy. Assets and liabilities measured at fair value on a recurring basis are summarized below:

	June 25, 2022
	Level 1		Level 2		Level 3		Total
Current assets measured at fair value:	(in thousands)
Cash equivalents	$	—	$	77	$	—	$	77
Other assets:
Life insurance policies	—		34,882		—		34,882
Total assets measured at fair value	$	—	$	34,959	$	—	$	34,959
Accrued liabilities measured at fair value:
Contingent consideration	$	—	$	—	$	9,550	$	9,550
Total liabilities measured at fair value	$	—	$	—	$	9,550	$	9,550

The Company recognizes transfers between levels within the fair value hierarchy, if any, at the end of each quarter. During the six months ended June 25, 2022, there were no transfers between levels.

	December 25, 2021
	Level 1		Level 2		Level 3		Total
Current assets measured at fair value:	(in thousands)
Cash equivalents	$	—	$	893	$	—	$	893
Other assets:
Life insurance policies	—		42,918		—		42,918
Total assets measured at fair value	$	—	$	43,811	$	—	$	43,811
Accrued liabilities measured at fair value:
Contingent consideration	$	—	$	—	$	11,794	$	11,794
Other long-term liabilities measured at fair value:
Contingent consideration	—		—		25,450		25,450
Total liabilities measured at fair value	$	—	$	—	$	37,244	$	37,244

During the year ended December 25, 2021, there were no transfers between levels.

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

NOTES TO UNAUDITED CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (Continued)

Contingent Consideration

The following table provides a rollforward of the contingent consideration related to the Company’s acquisitions.

	Six Months Ended
	June 25, 2022		June 26, 2021
	(in thousands)
Beginning balance	$	37,244	$	2,328
Additions	—		37,983
Payments	(11,476)		(2,889)
Total gains or losses (realized/unrealized):
Adjustment of previously recorded contingent liability	(15,340)		—
Foreign currency translation	(878)		(115)
Ending balance	$	9,550	$	37,307

The Company estimates the fair value of contingent consideration obligations through valuation models, such as probability-weighted and option pricing models, that incorporate probability adjusted assumptions and simulations related to the achievement of the milestones and the likelihood of making related payments. The unobservable inputs used in the fair value measurements include the probabilities of successful achievement of certain financial targets, forecasted results or targets, volatility, and discount rates. The remaining maximum potential payments are approximately $53 million, of which the value accrued as of June 25, 2022 is approximately $10 million. The weighted average probability of achieving the maximum target is approximately 18%. The average volatility and weighted average cost of capital are approximately 40% and 16%, respectively. Increases or decreases in these assumptions may result in a higher or lower fair value measurement, respectively.

Debt Instruments

The book value of the Company’s term and revolving loans, which are variable rate loans carried at amortized cost, approximates the fair value based on current market pricing of similar debt. As the fair value is based on significant other observable inputs, including current interest and foreign currency exchange rates, it is deemed to be Level 2 within the fair value hierarchy.

The book value of the Company’s Senior Notes are fixed rate obligations carried at amortized cost. Fair value is based on quoted market prices as well as borrowing rates available to the Company. As the fair value is based on significant other observable outputs, it is deemed to be Level 2 within the fair value hierarchy. The book value and fair value of the Company’s Senior Notes is summarized below:

	June 25, 2022				December 25, 2021
	Book Value		Fair Value		Book Value		Fair Value
4.25% Senior Notes due 2028	$	500,000	$	453,100	$	500,000	$	521,250
3.75% Senior Notes due 2029	500,000		437,500		500,000		506,700
4.0% Senior Notes due 2031	500,000		438,100		500,000		507,500

8. GOODWILL AND INTANGIBLE ASSETS

Goodwill

The following table provides a rollforward of the Company’s goodwill:

			Adjustments to Goodwill
	December 25, 2021		Acquisition Related		Foreign Exchange		June 25, 2022
	(in thousands)
RMS	$	283,524	$	216,324	$	(1,152)	$	498,696
DSA	1,472,506		—		(36,509)		1,435,997
Manufacturing	955,851		(592)		(29,694)		925,565
Goodwill	$	2,711,881	$	215,732	$	(67,355)	$	2,860,258

The increase in goodwill during the six months ended June 25, 2022 related primarily to the acquisition of Explora BioLabs in the RMS reportable segment.

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

NOTES TO UNAUDITED CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (Continued)

Intangible Assets, Net

The following table displays intangible assets, net by major class:

	June 25, 2022						December 25, 2021
	Gross		Accumulated Amortization		Net		Gross		Accumulated Amortization		Net
	(in thousands)
Backlog	$	15,295	$	(11,862)	$	3,433	$	12,577	$	(9,517)	$	3,060
Technology	130,236		(98,132)		32,104		135,764		(95,454)		40,310
Trademarks and trade names	12,680		(3,982)		8,698		13,086		(3,448)		9,638
Other	38,153		(15,222)		22,931		35,231		(8,445)		26,786
Other intangible assets	196,364		(129,198)		67,166		196,658		(116,864)		79,794
Client relationships	1,504,441		(539,235)		965,206		1,475,757		(494,359)		981,398
Intangible assets	$	1,700,805	$	(668,433)	$	1,032,372	$	1,672,415	$	(611,223)	$	1,061,192

The increase in intangible assets, net during the six months ended June 25, 2022 related primarily to the acquisition of Explora BioLabs, offset by normal amortization over the useful lives.

9. DEBT AND OTHER FINANCING ARRANGEMENTS

Long-term debt, net and finance leases consists of the following:

	June 25, 2022		December 25, 2021
	(in thousands)
Revolving facility	$	1,486,976	$	1,161,431
4.25% Senior Notes due 2028	500,000		500,000
3.75% Senior Notes due 2029	500,000		500,000
4.00% Senior Notes due 2031	500,000		500,000
Other debt	350		368
Finance leases	32,961		27,223
Total debt and finance leases	3,020,287		2,689,022
Less:
Current portion of long-term debt	95		101
Current portion of finance leases	2,269		2,694
Current portion of long-term debt and finance leases	2,364		2,795
Long-term debt and finance leases	3,017,923		2,686,227
Debt discount and debt issuance costs	(20,702)		(22,663)
Long-term debt, net and finance leases	$	2,997,221	$	2,663,564

As of June 25, 2022 and December 25, 2021, the weighted average interest rate on the Company’s debt was 3.15% and 2.78%, respectively. During the six months ended June 26, 2021, the Company prepaid $500 million of Senior Notes due in 2026 along with $21 million of related debt extinguishment costs and $13 million of accrued interest using proceeds from additional senior notes issued on the same day. The payment of the 2026 Senior Notes was accounted for as a debt extinguishment. Approximately $21 million of debt extinguishment costs and $5 million of deferred financing costs write-offs were recorded in Interest expense for the six months ended June 26, 2021.

Foreign currency transactions

During the three and six months ended June 25, 2022 and June 26, 2021 the Company had multiple U.S. dollar denominated loans borrowed by a non-U.S. Euro functional currency entity under the Credit Facility, which were approximately

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

NOTES TO UNAUDITED CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (Continued)

$400 million each. To limit this foreign currency exposure, the Company entered into foreign exchange forward contracts, which are not designated as hedging instruments. The gains and losses incurred on these transactions were as follows:

	Three Months Ended				Six Months Ended
	June 25, 2022		June 26, 2021		June 25, 2022		June 26, 2021		Affected Line Item in the Consolidated Statements of Income
	(in thousands)
Gain (loss) on foreign debt remeasurement	$	(19,423)	$	(4,907)	$	(30,523)	$	(18,263)	Other (expense) income
Gain (loss) on foreign exchange forward contract	20,522		5,355		32,306		19,332		Interest expense

Letters of Credit

As of June 25, 2022 and December 25, 2021, the Company had $17.7 million in outstanding letters of credit.

10. EQUITY AND NONCONTROLLING INTERESTS

Earnings Per Share

The following table reconciles the numerator and denominator in the computations of basic and diluted earnings per share:

	Three Months Ended				Six Months Ended
	June 25, 2022		June 26, 2021		June 25, 2022		June 26, 2021
	(in thousands)
Numerator:
Net income	$	110,664	$	89,916	$	205,890	$	153,851
Less: Net income attributable to noncontrolling interests	1,343		1,468		3,547		3,873
Net income attributable to common shareholders	$	109,321	$	88,448	$	202,343	$	149,978
Denominator:
Weighted-average shares outstanding - Basic	50,823		50,297		50,732		50,138
Effect of dilutive securities:
Stock options, restricted stock units and performance share units	460		1,037		561		1,087
Weighted-average shares outstanding - Diluted	51,283		51,334		51,293		51,225
Anti-dilutive common stock equivalents(1)	597		159		550		159
(1) These common stock equivalents were outstanding for the periods presented, but were not included in the computation of diluted EPS for those periods because their inclusion would have had an anti-dilutive effect.

Treasury Shares

During the six months ended June 25, 2022 and June 26, 2021, the Company did not repurchase any shares under its authorized stock repurchase program. As of June 25, 2022, the Company had $129.1 million remaining on the authorized stock repurchase program. The Company’s stock-based compensation plans permit the netting of common stock upon vesting of RSUs and PSUs in order to satisfy individual statutory tax withholding requirements. During the six months ended June 25, 2022 and June 26, 2021, the Company acquired 0.1 million shares for $38.5 million and 0.1 million shares for $40.3 million, respectively, from such netting.

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

NOTES TO UNAUDITED CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (Continued)

Accumulated Other Comprehensive Income (Loss)

Changes to each component of accumulated other comprehensive income (loss), net of income taxes, are as follows:

	Foreign Currency Translation Adjustment<br>and Other		Pension and Other Post-Retirement Benefit Plans		Total
	(in thousands)
December 25, 2021	$	(98,173)	$	(66,567)	$	(164,740)
Other comprehensive loss before reclassifications	(104,196)		—		(104,196)
Amounts reclassified from accumulated other comprehensive income	—		1,487		1,487
Net current period other comprehensive (loss) income	(104,196)		1,487		(102,709)
Income tax (benefit) expense	(9,264)		370		(8,894)
June 25, 2022	$	(193,105)	$	(65,450)	$	(258,555)

Nonredeemable Noncontrolling Interest

The Company has an investment in an entity whose financial results are consolidated in the Company’s unaudited condensed consolidated financial statements, as it has the ability to exercise control over this entity. The interest of the noncontrolling party in this entity has been recorded as noncontrolling interest within Equity in the accompanying unaudited condensed consolidated balance sheets. The activity within the nonredeemable noncontrolling interest was not significant during the three and six months ended June 25, 2022 and June 26, 2021.

Redeemable Noncontrolling Interests

The Company has a 92% equity interest in Vital River with an 8% redeemable noncontrolling interest. The Company has the right to purchase, and the noncontrolling interest holders have the right to sell, the remaining 8% equity interest at a contractually defined redemption value, subject to a redemption floor, which represents a derivative embedded within the equity instrument. The redeemable noncontrolling interest is measured at the greater of the amount that would be paid if settlement occurred as of the balance sheet date based on the contractually defined redemption value ($24.3 million as of June 25, 2022) and the carrying amount adjusted for net income (loss) attributable to the noncontrolling interest. As the noncontrolling interest holders have the ability to require the Company to purchase the remaining 8% interest, the noncontrolling interest is classified in the mezzanine section of the unaudited condensed consolidated balance sheets, which is presented above the equity section and below liabilities. The amount that the Company could be required to pay to purchase the remaining 8% equity interest is not limited.

Prior to June 2022, the Company had an 80% equity interest in a subsidiary with a 20% redeemable noncontrolling interest. In June 2022, the Company purchased an additional 10% interest in the subsidiary for $15.0 million. Beginning in 2024, the Company has the right to purchase, and the noncontrolling interest holders have the right to sell (Put/call option), the remaining 10% equity interest at its appraised value ($15.9 million as of June 25, 2022). The redeemable noncontrolling interest is measured at the greater of the amount that would be paid if settlement occurred as of the balance sheet date based on the appraised value and the carrying amount adjusted for net income (loss) attributable to the noncontrolling interest or a predetermined floor value. As the noncontrolling interest holders have the ability to require the Company to purchase the remaining 10% interest, the noncontrolling interest is classified in the mezzanine section of the unaudited condensed consolidated balance sheets, which is presented above the equity section and below liabilities. The amount that the Company could be required to pay to purchase the remaining 10% equity interest is not limited.

The following table provides a rollforward of the activity related to the Company’s redeemable noncontrolling interests:

	Six Months Ended
	June 25, 2022		June 26, 2021
	(in thousands)
Beginning balance	$	53,010	$	25,499
Purchase of a 10% redeemable noncontrolling interest	(15,000)		—
Adjustments of noncontrolling interests to redemption values	2,293		2,341
Net income attributable to noncontrolling interests	2,487		2,599
Foreign currency translation	(2,613)		360
Ending balance	$	40,177	$	30,799

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

NOTES TO UNAUDITED CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (Continued)

11. INCOME TAXES

The Company’s effective tax rates for the three months ended June 25, 2022 and June 26, 2021 were 23.2% and 29.5%, respectively. The Company’s effective tax rates for the six months ended June 25, 2022 and June 26, 2021 were 19.2% and 20.6%, respectively. The decrease in the effective tax rates from the prior year period was primarily attributable to the deferred tax impact of tax law changes enacted during the three months ended June 26, 2021, partially offset by a decreased tax benefit from stock-based compensation deductions in the six months ended June 25, 2022.

For the three months ended June 25, 2022, the Company’s unrecognized tax benefits increased by $0.3 million to $34.5 million, primarily due to increases in research & development tax credit reserves. For the three months ended June 25, 2022, the amount of unrecognized income tax benefits that would impact the effective tax rate increased by $0.1 million to $31.1 million for the same reasons discussed above. The accrued interest on unrecognized tax benefits was $0.9 million as of June 25, 2022. The Company estimates that it is reasonably possible that the unrecognized tax benefits will decrease by approximately $11.4 million over the next twelve-month period, primarily due to audit settlements and expiring statutes of limitations.

The Company conducts business in a number of tax jurisdictions. As a result, it is subject to tax audits on a regular basis including, but not limited to, such major jurisdictions as the U.S., the U.K., China, France, Germany, and Canada. With few exceptions, the Company is no longer subject to U.S. and international income tax examinations for years before 2018.

The Company and certain of its subsidiaries have ongoing tax controversies in the U.S., Canada, France, the Netherlands, and India. The Company does not anticipate resolution of these audits will have a material impact on its consolidated financial statements.

12. RESTRUCTURING AND ASSET IMPAIRMENTS

In recent fiscal years, the Company has undertaken productivity improvement initiatives within all reportable segments at various locations across the U.S., Canada, and Europe. This includes workforce right-sizing and scalability initiatives, resulting in severance and transition costs; and cost related to the consolidation of facilities, resulting in asset impairment and accelerated depreciation charges. The Company does not have any significant remaining lease obligations for facilities associated with restructuring activities. The following table presents a summary of restructuring costs related to these initiatives within the unaudited condensed consolidated statements of income:

	Three Months Ended				Six Months Ended
	June 25, 2022		June 26, 2021		June 25, 2022		June 26, 2021
					(in Thousands)
RMS	$	453	$	—	$	1,127	$	7
DSA	473		1,074		616		1,633
Manufacturing	271		535		378		869
Unallocated corporate	167		—		1,254		(151)
Total	$	1,364	$	1,609	$	3,375	$	2,358

As of June 25, 2022 and June 26, 2021, $3.3 million and $2.8 million, respectively, of severance and other personnel related costs liabilities and lease obligation liabilities were included in accrued compensation and accrued liabilities within the Company’s unaudited condensed consolidated balance sheets.

13. COMMITMENTS AND CONTINGENCIES

Litigation

Various lawsuits, claims and proceedings are pending against the Company. While the outcome of any of these proceedings cannot be accurately predicted, the Company does not believe the ultimate resolution of any of these existing matters would have a material adverse effect on the Company’s business or financial condition.

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations

The following discussion should be read in conjunction with our unaudited condensed consolidated financial statements and related notes of this Quarterly Report on Form 10-Q and our audited consolidated financial statements and related notes included in our Annual Report on Form 10-K for fiscal year 2021. The following discussion contains forward-looking statements. Actual results may differ significantly from those projected in the forward-looking statements. Factors that might cause future results to differ materially from those projected in the forward-looking statements include, but are not limited to, those discussed in Item 1A, “Risk Factors” included elsewhere within this Form 10-Q. Certain percentage changes may not recalculate due to rounding.

Overview

We are a full service, non-clinical contract research organization (CRO). We have built upon our original core competency of laboratory animal medicine and science (research model technologies) to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, which is able to support our clients from target identification through non-clinical development. We also provide a suite of products and services to support our clients’ manufacturing activities, including our recently acquired contract development and manufacturing organization (CDMO) business. Utilizing our broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness, and increases speed to market.

Our client base includes major global biopharmaceutical companies, many biotechnology companies; agricultural and industrial chemical, life science, veterinary medicine, medical device, diagnostic and consumer product companies; contract research and contract manufacturing organizations; and other commercial entities, as well as leading hospitals, academic institutions, and government agencies around the world.

Segment Reporting

Our three reportable segments are Research Models and Services (RMS), Discovery and Safety Assessment (DSA), and Manufacturing Solutions (Manufacturing). Our RMS reportable segment includes the Research Models, Research Model Services, and Research and GMP-Compliant Cells businesses. Research Models includes the commercial production and sale of small research models, as well as the supply of large research models. Research Model Services includes: Genetically Engineered Models and Services (GEMS), which performs contract breeding and other services associated with genetically engineered models; Research Animal Diagnostic Services (RADS), which provides health monitoring and diagnostics services related to research models; and Insourcing Solutions (IS), which provides colony management of our clients’ research operations (including recruitment, training, staffing, and management services). Research and GMP-Compliant Cells supplies controlled, consistent, customized primary cells and blood components derived from normal and mobilized peripheral blood, bone marrow, and cord blood. Our DSA reportable segment includes services required to take a drug through the early development process including discovery services, which are non-regulated services to assist clients with the identification, screening, and selection of a lead compound for drug development, and regulated and non-regulated (GLP and non-GLP) safety assessment services. Our Manufacturing reportable segment includes Microbial Solutions, which provides in vitro (non-animal) lot-release testing products, microbial detection products, and species identification services; Biologics Solutions (Biologics), which performs specialized testing of biologics (Biologics Testing Solutions) as well as contract development and manufacturing products and services (CDMO); and Avian Vaccine Services (Avian), which supplies specific-pathogen-free chicken eggs and chickens.

Russia-Ukraine Conflict

In February 2022, the Russian Federation launched an invasion of the country of Ukraine resulting in conflict in the region and a variety of sanctions against the Russian Federation enacted by several governments, including the U.S, United Kingdom, Canada and European Union. The conflict has had and continues to have, direct and indirect adverse effects on financial markets and global supply chain disruptions. We do not have any direct operations in either Russia or Ukraine and there were no material impacts to our financial statements for the three and six months ended June 25, 2022 as a result of the situation. We will continue to monitor the situation as it evolves for potential impacts to our operating and financial results such as increased inflationary, supply chain, or cybersecurity risks in subsequent periods. Refer to Item 1A, Risk Factors disclosed herein and in our Annual Report on Form 10-K for fiscal 2021 for our assessment of risk factors surrounding inflationary, supply chain and cybersecurity risks.

Recent Acquisitions

Our strategy is to augment internal growth of existing businesses with complementary acquisitions. Our recent acquisitions are described below.

Fiscal Year 2022 Acquisition

On April 5, 2022, we acquired Explora BioLabs Holdings, Inc. (Explora BioLabs), a provider of contract vivarium research

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

services, providing biopharmaceutical clients with turnkey in vivo vivarium facilities, management and related services to efficiently conduct their early-stage research activities. The acquisition of Explora BioLabs complements our existing IS business, specifically our CRADL (Charles River Accelerator and Development Lab) footprint, and offers incremental opportunities to partner with an emerging client base, many of which are engaged in cell and gene therapy development. The preliminary purchase price of Explora BioLabs was $284.5 million, net of $6.6 million in cash. The acquisition was funded through proceeds from our Credit Facility. This business is reported as part of our RMS reportable segment.

Fiscal Year 2021 Acquisitions

On June 28, 2021, we acquired Vigene Biosciences, Inc. (Vigene), a gene therapy CDMO, providing viral vector-based gene delivery solutions. The acquisition enables clients to seamlessly conduct analytical testing, process development, and manufacturing for advanced modalities with the same scientific partner. The purchase price of Vigene was $323.9 million, net of $2.7 million in cash, and included $34.5 million of contingent consideration (maximum contingent payments of up to $57.5 million based on future performance). The acquisition was funded through a combination of available cash and proceeds from our Credit Facility. This business is reported as part of our Manufacturing reportable segment. As of June 25, 2022, the fair value of the contingent consideration was zero as certain financial targets have not and are not expected to be achieved.

On March 30, 2021, we acquired Retrogenix Limited (Retrogenix), an early-stage CRO providing specialized bioanalytical services utilizing its proprietary cell microarray technology. The acquisition of Retrogenix enhances our scientific expertise with additional large molecule and cell therapy discovery capabilities. The purchase price of Retrogenix was $53.9 million, net of $8.5 million in cash. Included in the purchase price are additional payments up to $6.9 million, which are contingent on future performance. The acquisition was funded through a combination of available cash and proceeds from our Credit Facility. This business is reported as part of our DSA reportable segment.

On March 29, 2021, we acquired Cognate BioServices, Inc. (Cognate), a cell and gene therapy CDMO offering comprehensive manufacturing solutions for cell therapies, as well as for the production of plasmid DNA and other inputs in the CDMO value chain. The acquisition of Cognate establishes us as a scientific partner for cell and gene therapy development, testing, and manufacturing, providing clients with an integrated solution from basic research and discovery through cGMP production. The purchase price of Cognate was $877.9 million, net of $70.5 million in cash, subject to certain post-closing adjustments and includes $15.7 million of consideration for an approximate 2% ownership interest not acquired, which was redeemed in April 2022 with the ultimate payout tied to performance in 2021. The acquisition was funded through a combination of available cash and proceeds from our Credit Facility and Senior Notes issued in fiscal 2021. This business is reported as part of our Manufacturing reportable segment.

On March 3, 2021, we acquired certain assets from a distributor that supports our DSA reportable segment. The purchase price was $35.4 million, which includes $19.5 million in cash paid ($5.5 million of which was paid in fiscal 2020), and $15.9 million of contingent consideration (the maximum contingent contractual payments are up to $17.5 million). The business is reported as part of our DSA reportable segment. As of June 25, 2022, the fair value of the contingent consideration was zero as certain operational targets were not achieved.

On December 31, 2020, we acquired Distributed Bio, Inc. (Distributed Bio), a next-generation antibody discovery company with technologies specializing in enhancing the probability of success for delivering high-quality, readily formattable antibody fragments to support antibody and cell and gene therapy candidates to biopharmaceutical clients. The acquisition of Distributed Bio expands our capabilities with an innovative, large-molecule discovery platform, and creates an integrated, end-to-end platform for therapeutic antibody and cell and gene therapy discovery and development. The purchase price of Distributed Bio was $97.0 million, net of $0.8 million in cash. The total consideration includes $80.8 million cash paid, settlement of $3.0 million in convertible promissory notes previously issued by us during prior fiscal years, and $14.1 million of contingent consideration (the maximum contingent contractual payments are up to $21.0 million). The acquisition was funded through a combination of available cash and proceeds from our Credit Facility. This business is reported as part of our DSA reportable segment. During the three months ended June 25, 2022, $7 million of contingent consideration was paid as certain operational milestones were achieved. Other financial targets associated with the contingent consideration were not met and the fair value of the remaining contingent consideration is zero as of June 25, 2022.

Recent Divestitures

On October 12, 2021, we completed two separate divestitures. We sold our RMS Japan operations to The Jackson Laboratory for a preliminary purchase price of $70.6 million, which included $7.9 million in cash, $3.8 million pension over funding, and certain post-closing adjustments. We also sold our gene therapy CDMO site in Sweden to a private investor group for a preliminary purchase price of $59.6 million, net of $0.2 million in cash and certain post-closing adjustments. Included in the purchase price are contingent payments fair valued at $15.3 million, (the maximum contingent contractual payments are up to $25.0 million based on future performance), as well as a purchase obligation of approximately $10 million between the parties. We routinely evaluate the strategic fit and fundamental performance of our businesses. As part of this assessment, we determined that the above capital could be better deployed in other long-term growth opportunities.

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

Fiscal Quarters

Our fiscal year is typically based on 52-weeks, with each quarter composed of 13 weeks ending on the last Saturday on, or closest to, March 31, June 30, September 30, and December 31. A 53rd week in the fourth quarter of the fiscal year is occasionally necessary to align with a December 31 calendar year-end, which will occur in this fiscal year 2022.

Overview of Results of Operations and Liquidity

Revenue for the three months ended June 25, 2022 increased $58.5 million, or 6.4%, to $973.1 million compared to $914.6 million in the corresponding period in 2021. Revenue for the six months ended June 25, 2022 increased $147.9 million, or 8.5%, to $1,887.1 million compared to $1,739.2 million in the corresponding period in 2021. The increase in revenue in both periods was primarily due to increased demand within our DSA and RMS segments; partially offset by the divestitures of RMS Japan and CDMO Sweden and the negative effect of changes in foreign currency exchange rates when compared to the corresponding three and six month periods in 2021.

In the three months ended June 25, 2022, our operating income and operating income margin were $187.4 million and 19.3%, respectively, compared with $137.6 million and 15.0%, respectively, in the corresponding period of 2021. In the six months ended June 25, 2022, our operating income and operating income margin were $336.2 million and 17.8%, respectively, compared with $261.3 million and 15.0%, respectively, in the corresponding period of 2021. The increases in operating income and operating income margin for the three and six months ended June 25, 2022 was primarily due to the contribution of higher revenue described above, lower acquisition related costs, changes in contingent consideration, and a favorable ruling from tax authorities on certain indirect tax positions.

Net income attributable to common shareholders increased to $109.3 million in the three months ended June 25, 2022, from $88.4 million in the corresponding period of 2021. The increase in Net income attributable to common shareholders was primarily due to the increase in operating income described above, partially offset by losses on our investments compared to gains in the corresponding period in 2021.

Net income attributable to common shareholders increased to $202.3 million in the six months ended June 25, 2022, from $150.0 million in the corresponding period of 2021. The increase in Net income attributable to common shareholders was primarily due to the increase in operating income described above and by the absence of debt extinguishment costs associated with the repayment of the 2026 Senior Notes and related write-off of deferred financing costs incurred in 2021; partially offset by higher losses on our investments in the corresponding period in 2021.

During the six months ended June 25, 2022, our cash flows from operations was $252.1 million compared with $356.8 million for the same period in 2021. The decrease was driven by timing and amounts of our working capital balances, principally collections of net contract balances from customers (collectively trade receivables and contract assets, net; deferred revenue; and customer contract deposits), inventory purchases, and variable compensation payments; partially offset by favorable timing of our vendor and supplier payments compared to the same period in 2021.

Results of Operations

Three Months Ended June 25, 2022 Compared to the Three Months Ended June 26, 2021

Revenue and Operating Income

The following tables present consolidated revenue by type and by reportable segment:

	Three Months Ended
	June 25, 2022		June 26, 2021		change	% change
	(in millions, except percentages)
Service revenue	$	782.8	$	715.3		9.4	%
Product revenue	190.3		199.3		(9.0)	(4.5)	%
Total revenue	$	973.1	$	914.6		6.4	%

All values are in US Dollars.

	Three Months Ended
	June 25, 2022		June 26, 2021		change	% change		Impact of FX
	(in millions, except percentages)
RMS	$	186.4	$	176.7		5.5	%	(3.0)	%
DSA	591.9		540.1		51.8	9.6	%	(3.3)	%
Manufacturing	194.8		197.8		(3.0)	(1.5)	%	(4.1)	%
Total revenue	$	973.1	$	914.6		6.4	%	(3.4)	%

All values are in US Dollars.

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

The following table presents operating income by reportable segment:

	Three Months Ended
	June 25, 2022			June 26, 2021			change	% change
	(in millions, except percentages)
RMS	$	39.5		$	42.6			(7.2)	%
DSA	128.8			104.5			24.3	23.2	%
Manufacturing	62.5			56.7			5.8	10.2	%
Unallocated corporate	(43.4)			(66.3)			22.9	(34.5)	%
Total operating income	$	187.4		$	137.5			36.2	%
Operating income % of revenue	19.3		%	15.0		%		430 bps

All values are in US Dollars.

The following presents and discusses our consolidated financial results by each of our reportable segments:

RMS

	Three Months Ended
	June 25, 2022			June 26, 2021			change	% change		Impact of FX
	(in millions, except percentages)
Revenue	$	186.4		$	176.7			5.5	%	(3.0)	%
Cost of revenue (excluding amortization of intangible assets)	114.8			106.0			8.8	8.3	%
Selling, general and administrative	26.6			24.0			2.6	10.8	%
Amortization of intangible assets	5.5			4.1			1.4	34.3	%
Operating income	$	39.5		$	42.6			(7.2)	%
Operating income % of revenue	21.2		%	24.1		%		(290) bps

All values are in US Dollars.

RMS revenue increased $9.7 million due primarily to higher research model product revenue in North America and China, however China was negatively impacted by COVID-related restrictions that affected client order activity, higher research model services revenue, specifically Insourcing Solutions, which included the acquisition of Explora BioLabs contributing $12.7 million, and our GEMS business; partially offset by the divestiture of RMS Japan, which decreased revenue by $11.7 million and the effect of changes in foreign currency exchange rates.

RMS operating income decreased $3.1 million compared to the corresponding period in 2021. RMS operating income as a percentage of revenue for the three months ended June 25, 2022 was 21.2%, a decrease of (290) bps from 24.1% for the corresponding period in 2021. Operating income and operating income as a percentage of revenue decreased primarily due to the divestiture of RMS Japan and the COVID-related revenue impact in China.

DSA

	Three Months Ended
	June 25, 2022			June 26, 2021			change	% change		Impact of FX
	(in millions, except percentages)
Revenue	$	591.9		$	540.1			9.6	%	(3.3)	%
Cost of revenue (excluding amortization of intangible assets)	391.2			365.9			25.3	6.9	%
Selling, general and administrative	51.1			48.6			2.5	5.3	%
Amortization of intangible assets	20.8			21.1			(0.3)	(1.5)	%
Operating income	$	128.8		$	104.5			23.2	%
Operating income % of revenue	21.8		%	19.4		%		240 bps

All values are in US Dollars.

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

DSA revenue increased $51.8 million due primarily to service revenue which increased in both the Safety Assessment and Discovery Services businesses due principally to increased demand and pricing of services; partially offset by the effect of changes in foreign currency exchange rates.

DSA operating income increased $24.3 million during the three months ended June 25, 2022 compared to the corresponding period in 2021. DSA operating income as a percentage of revenue for the three months ended June 25, 2022 was 21.8%, an increase of 240 bps from 19.4% for the corresponding period in 2021. Operating income and operating income as a percentage of revenue increased primarily due to the contribution of higher revenue described above as well as lower acquisition related costs and adjustments to contingent consideration arrangements related to certain acquisitions; partially offset by higher staffing costs and modest inflationary pressures compared to the same period in 2021.

Manufacturing

	Three Months Ended
	June 25, 2022			June 26, 2021			change	% change		Impact of FX
	(in millions, except percentages)
Revenue	$	194.8		$	197.8			(1.5)	%	(4.1)	%
Cost of revenue (excluding amortization of intangible assets)	110.4			100.6			9.8	9.7	%
Selling, general and administrative	10.5			32.7			(22.2)	(67.8)	%
Amortization of intangible assets	11.4			7.8			3.6	45.6	%
Operating income	$	62.5		$	56.7			10.2	%
Operating income % of revenue	32.1		%	28.7		%		340 bps

All values are in US Dollars.

Manufacturing revenue decreased $3.0 million due primarily to the divestiture of the CDMO Sweden business, which decreased revenue by $4.8 million, a slight reduction within our CDMO business related to reduction in COVID-19 testing services, and the effect of changes in foreign currency exchange rates; partially offset by the acquisition of Vigene, which contributed $7.6 million, higher service revenue within our Biologics Testing Solutions business, and increased demand for endotoxin products in our Microbial Solutions business.

Manufacturing operating income increased $5.8 million during the three months ended June 25, 2022 compared to the corresponding period in 2021. Manufacturing operating income as a percentage of revenue for the three months ended June 25, 2022 was 32.1%, an increase of 340 bps from 28.7% for the corresponding period in 2021. The increase in operating income and operating income as a percentage of revenue was due primarily to a favorable adjustment related to a contingent consideration arrangement and a favorable ruling from tax authorities on certain indirect tax positions recorded within selling, general and administrative expenses; partially offset by higher amortization of intangible assets costs as compared to the same period in 2021 and higher operating costs associated with our CDMO business.

Unallocated Corporate

	Three Months Ended
	June 25, 2022			June 26, 2021			change	% change
	(in millions, except percentages)
Unallocated corporate	$	43.4		$	66.3			(34.5)	%
Unallocated corporate % of revenue	4.5		%	7.2		%		(270) bps

All values are in US Dollars.

Unallocated corporate costs consist of selling, general and administrative expenses that are not directly related or allocated to the reportable segments. The decrease in unallocated corporate costs of $22.9 million, or 34.5%, compared to the corresponding period in 2021 is primarily related to decreased costs associated with the evaluation and integration of our recent acquisition activity and lower variable compensation. Costs as a percentage of revenue for the three months ended June 25, 2022 was 4.5%, a decrease of 270 bps from 7.2% for the corresponding period in 2021.

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

Interest Income

Interest income, which represents earnings on cash, cash equivalents, and time deposits was $0.2 million for both the three months ended June 25, 2022 and the corresponding period in 2021.

Interest Expense

Interest expense for the three months ended June 25, 2022 was $3.7 million, a decrease of $12.5 million, or 77.1%, compared to $16.2 million for the corresponding period in 2021. The decrease was due primarily to a higher foreign currency gain recognized in connection with a debt-related foreign exchange forward contract in the three months ended June 25, 2022, partially offset by higher interest rates on our variable debt as compared to the corresponding period in 2021.

Other (Expense) Income, Net

Other expense, net, was $39.8 million for the three months ended June 25, 2022, a decrease of $45.8 million compared to Other income, net of $6.0 million for the corresponding period in 2021. The decrease in the three months ended June 25, 2022 was due primarily to venture capital and life insurance investment losses compared to gains incurred for the corresponding period in 2021, and higher foreign currency losses recognized in connection with a U.S. dollar denominated loan borrowed by a non-U.S. entity with a different functional currency as compared to the corresponding period in 2021.

Income Taxes

Income tax expense for the three months ended June 25, 2022 was $33.4 million, a decrease of $4.2 million compared to $37.6 million for the corresponding period in 2021. Our effective tax rate was 23.2% for the three months ended June 25, 2022, compared to 29.5% for the corresponding period in 2021. The decrease in our effective tax rate in the 2022 period compared to the 2021 period was primarily attributable to the deferred tax impact of tax law changes enacted during the three months ended June 26, 2021, partially offset by a decreased tax benefit from stock-based compensation deductions.

Six Months Ended June 25, 2022 Compared to the Six Months Ended June 26, 2021

Revenue and Operating Income

The following tables present consolidated revenue by type and by reportable segment:

	Six Months Ended
	June 25, 2022		June 26, 2021		change	% change
	(in millions, except percentages)
Service revenue	$	1,503.3	$	1,341.9		12.0	%
Product revenue	383.8		397.3		(13.5)	(3.4)	%
Total revenue	$	1,887.1	$	1,739.2		8.5	%

All values are in US Dollars.

	Six Months Ended
	June 25, 2022		June 26, 2021		change	% change		Impact of FX
	(in millions, except percentages)
RMS	$	363.0	$	353.6		2.6	%	(2.1)	%
DSA	1,136.2		1,041.3		94.9	9.1	%	(2.5)	%
Manufacturing	387.9		344.3		43.6	12.7	%	(3.5)	%
Total revenue	$	1,887.1	$	1,739.2		8.5	%	(2.6)	%

All values are in US Dollars.

The following table presents operating income by reportable segment:

	Six Months Ended
	June 25, 2022			June 26, 2021			change	% change
	(in millions, except percentages)
RMS	$	87.4		$	87.5			(0.1)	%
DSA	233.8			195.5			38.3	19.6	%
Manufacturing	108.9			106.2			2.7	2.6	%
Unallocated corporate	(93.9)			(127.9)			34.0	(26.6)	%
Total operating income	$	336.2		$	261.3			28.7	%
Operating income % of revenue	17.8		%	15.0		%		280 bps

All values are in US Dollars.

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

The following presents and discusses our consolidated financial results by each of our reportable segments:

RMS

	Six Months Ended
	June 25, 2022			June 26, 2021			change	% change		Impact of FX
	(in millions, except percentages)
Revenue	$	363.0		$	353.6			2.6	%	(2.1)	%
Cost of revenue (excluding amortization of intangible assets)	217.2			211.4			5.8	2.8	%
Selling, general and administrative	49.0			46.6			2.4	5.1	%
Amortization of intangible assets	9.4			8.1			1.3	14.3	%
Operating income	$	87.4		$	87.5			(0.1)	%
Operating income % of revenue	24.1		%	24.7		%		(60) bps

All values are in US Dollars.

RMS revenue increased $9.4 million due primarily to higher research model product revenue in North America and China, however China was negatively impacted by COVID-related restrictions that affected client order activity, higher research model services revenue, specifically Insourcing Solutions, which included the acquisition of Explora BioLabs contributing $12.7 million, and our GEMS business; partially offset by the divestiture of RMS Japan, which decreased revenue by $24.4 million and the effect of changes in foreign currency exchange rates.

RMS operating income decreased $0.1 million compared to the corresponding period in 2021. RMS operating income as a percentage of revenue for the six months ended June 25, 2022 was 24.1%, a decrease of 60 bps from 24.7% for the corresponding period in 2021. Operating income and operating income as a percentage of revenue decreased primarily due to the divestiture of RMS Japan and the COVID-related revenue impact in China.

DSA

	Six Months Ended
	June 25, 2022			June 26, 2021			change	% change		Impact of FX
	(in millions, except percentages)
Revenue	$	1,136.2		$	1,041.3			9.1	%	(2.5)	%
Cost of revenue (excluding amortization of intangible assets)	764.4			706.0			58.4	8.3	%
Selling, general and administrative	95.0			96.2			(1.2)	(1.2)	%
Amortization of intangible assets	43.0			43.6			(0.6)	(1.4)	%
Operating income	$	233.8		$	195.5			19.6	%
Operating income % of revenue	20.6		%	18.8		%		180 bps

All values are in US Dollars.

DSA revenue increased $94.9 million due primarily to service revenue which increased in both the Safety Assessment and Discovery Services businesses due principally to increased demand and pricing of services; and the acquisition of Retrogenix which contributed $3.3 million to Discovery Services revenue; partially offset by the effect of changes in foreign currency exchange rates.

DSA operating income increased $38.3 million during the six months ended June 25, 2022 compared to the corresponding period in 2021. DSA operating income as a percentage of revenue for the six months ended June 25, 2022 was 20.6%, an increase of 180 bps from 18.8% for the corresponding period in 2021. Operating income and operating income as a percentage of revenue increased primarily due to the contribution of higher revenue described above as well as lower acquisition related costs and adjustments to contingent consideration arrangements related to certain acquisitions; partially offset by higher staffing costs and modest inflationary pressures compared to the same period in 2021.

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

Manufacturing

	Six Months Ended
	June 25, 2022			June 26, 2021			change	% change		Impact of FX
	(in millions, except percentages)
Revenue	$	387.9		$	344.3			12.7	%	(3.5)	%
Cost of revenue (excluding amortization of intangible assets)	211.9			171.3			40.6	23.5	%
Selling, general and administrative	43.8			56.8			(13.0)	(22.7)	%
Amortization of intangible assets	23.3			10.0			13.3	132.1	%
Operating income	$	108.9		$	106.2			2.6	%
Operating income % of revenue	28.1		%	30.8		%		(270) bps

All values are in US Dollars.

Manufacturing revenue increased $43.6 million due primarily to our Biologics Solutions business, which includes the CDMO business acquisitions of Cognate and Vigene, which collectively contributed $43.8 million prior to the one year anniversaries of the acquisitions, and higher service revenue within our Biologics Testing Solutions business, as well as increased revenue in our Microbial Solutions business; partially offset by the divestiture of the CDMO Sweden business, which decreased revenue by $4.8 million, and the effect of changes in foreign currency exchange rates.

Manufacturing operating income increased $2.7 million during the six months ended June 25, 2022 compared to the corresponding period in 2021, which was primarily due to a favorable adjustment related to a contingent consideration arrangement and a favorable ruling from tax authorities on certain indirect tax positions recorded within selling, general and administrative expense; partially offset by higher amortization of intangible assets costs. Manufacturing operating income as a percentage of revenue for the six months ended June 25, 2022 was 28.1%, a decrease of 270 bps from 30.8% for the corresponding period in 2021, primarily due to higher operating costs associated with our CDMO acquisitions.

Unallocated Corporate

	Six Months Ended
	June 25, 2022			June 26, 2021			change	% change
	(in millions, except percentages)
Unallocated corporate	$	93.9		$	127.9			(26.6)	%
Unallocated corporate % of revenue	5.0		%	7.3		%		(230) bps

All values are in US Dollars.

Unallocated corporate costs consist of selling, general and administrative expenses that are not directly related or allocated to the reportable segments. The decrease in unallocated corporate costs of $34.0 million, or 26.6%, compared to the corresponding period in 2021 is primarily related to decreased costs associated with the evaluation and integration of our acquisition activity and lower variable compensation costs. Costs as a percentage of revenue for the six months ended June 25, 2022 was 5.0%, a decrease of 230 bps from 7.3% for the corresponding period in 2021.

Interest Income

Interest income, which represents earnings on cash, cash equivalents, and time deposits was $0.3 million and $0.2 million for the six months ended June 25, 2022 and the corresponding period in 2021, respectively.

Interest Expense

Interest expense for the six months ended June 25, 2022 was $13.1 million, a decrease of $32.8 million, or 71.4%, compared to $45.9 million for the corresponding period in 2021. The decrease was due primarily to the absence of $26 million of debt extinguishment costs associated with the repayment of the 2026 Senior Notes and related write-off of deferred financing costs incurred in the six months ended June 26, 2021, higher foreign currency gains recognized in connection with a debt-related foreign exchange forward contract, partially offset by higher interest rates on our variable debt in the six months ended June 25, 2022 compared to the corresponding period in 2021.

Other Expense, Net

Other expense, net, was $68.4 million for the six months ended June 25, 2022, an increase of $46.6 million compared to $21.8 million for the corresponding period in 2021. The increase was due primarily to increased net losses on our venture capital investments, strategic equity investments, and life insurance investments for the six months ended June 25, 2022 as compared to the corresponding period in 2021 and higher foreign currency losses recognized in connection with a U.S. dollar denominated loan borrowed by a non-U.S. entity with a different functional currency in the six months ended June 25, 2022 as compared to the corresponding period in 2021.

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

Income Taxes

Income tax expense for the six months ended June 25, 2022 was $49.1 million, an increase of $9.2 million compared to $39.9 million for the corresponding period in 2021. Our effective tax rate was 19.2% for the six months ended June 25, 2022 compared to 20.6% for the corresponding period in 2021. The decrease in our effective tax rate in the 2022 period compared to the 2021 period was primarily attributable to the deferred tax impact of tax law changes enacted during the six months ended June 26, 2021, partially offset by a decreased tax benefit from stock-based compensation deductions in the six months ended June 25, 2022.

Liquidity and Capital Resources

We currently require cash to fund our working capital needs, capital expansion, acquisitions, and to pay our debt, lease, venture capital investment, and pension obligations. Our principal sources of liquidity have been our cash flows from operations, supplemented by long-term borrowings. Based on our current business plan, we believe that our existing funds, when combined with cash generated from operations and our access to financing resources, are sufficient to fund our operations for the foreseeable future.

The following table presents our cash, cash equivalents and short-term investments:

	June 25, 2022		December 25, 2021
	(in millions)
Cash and cash equivalents:
Held in U.S. entities	$	8.1	$	28.2
Held in non-U.S. entities	192.2		213.0
Total cash and cash equivalents	200.3		241.2
Short-term investments:
Held in non-U.S. entities	1.0		1.1
Total cash, cash equivalents and short-term investments	$	201.3	$	242.3

Borrowings

Amounts outstanding under our Credit Facility and our Senior Notes were as follows:

	June 25, 2022		December 25, 2021
	(in millions)
Revolving facility	$	1,487.0	$	1,161.4
4.25% Senior Notes due 2028	500.0		500.0
3.75% Senior Notes due 2029	500.0		500.0
4.00% Senior Notes due 2031	500.0		500.0
Total	$	2,987.0	$	2,661.4

The interest rates applicable to the Credit Facility are equal to (A) for revolving loans denominated in U.S. dollars, at our option, either the base rate (which is the higher of (1) the prime rate, (2) the federal funds rate plus 0.50%, or (3) the one-month adjusted LIBOR rate plus 1%) or the adjusted LIBOR rate, (B) for revolving loans denominated in euros, the adjusted EURIBOR rate and (C) for revolving loans denominated in sterling, the daily simple SONIA rate, in each case, plus an interest rate margin based upon our leverage ratio.

Our off-balance sheet commitments related to our outstanding letters of credit as of June 25, 2022 were $17.7 million.

Repurchases of Common Stock

During the six months ended June 25, 2022, we did not repurchase any shares under our authorized stock repurchase program. As of June 25, 2022, we had $129.1 million remaining on the authorized $1.3 billion stock repurchase program and we do not intend to repurchase shares for the remainder of 2022. Our stock-based compensation plans permit the netting of common stock upon vesting of restricted stock, restricted stock units, and performance share units in order to satisfy individual statutory tax withholding requirements. During the six months ended June 25, 2022, we acquired 0.1 million shares for $38.5 million through such netting.

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

Cash Flows

The following table presents our net cash provided by operating activities:

	Six Months Ended
	June 25, 2022		June 26, 2021
	(in millions)
Net income	$	205.9	$	153.9
Adjustments to reconcile net income to net cash provided by operating activities	190.2		203.2
Changes in assets and liabilities	(144.0)		(0.3)
Net cash provided by operating activities	$	252.1	$	356.8

Net cash provided by cash flows from operating activities represents the cash receipts and disbursements related to all of our activities other than investing and financing activities. Operating cash flow is derived by adjusting our net income for (1) non-cash operating items such as depreciation and amortization, stock-based compensation, loss on debt extinguishment and other financing costs, deferred income taxes, gains and/or losses on venture capital and strategic equity investments, gains and/or losses on divestitures, contingent consideration, as well as (2) changes in operating assets and liabilities, which reflect timing differences between the receipt and payment of cash associated with transactions and when they are recognized in our results of operations. For the six months ended June 25, 2022, compared to the six months ended June 26, 2021, the decrease in net cash provided by operating activities was driven by timing and amount of our working capital balances, principally collections of net contract balances from customers (collectively trade receivables and contract assets, net; deferred revenue; and customer contract deposits), inventory purchases, and variable compensation payments; partially offset by favorable timing of our vendor and supplier payments compared to the same period in 2021.

The following table presents our net cash used in investing activities:

	Six Months Ended
	June 25, 2022		June 26, 2021
	(in millions)
Acquisition of businesses and assets, net of cash acquired	$	(283.4)	$	(1,000.5)
Capital expenditures	(163.3)		(74.5)
Investments, net	(108.6)		(18.1)
Other, net	(4.8)		0.9
Net cash used in investing activities	$	(560.1)	$	(1,092.2)

For the six months ended June 25, 2022, the primary use of cash used in investing activities related to the acquisition of Explora BioLabs, capital expenditures to support the growth of the business and investments in certain venture capital and strategic equity investments. For the six months ended June 26, 2021, the primary use of cash used in investing activities related to the acquisitions of Cognate, Distributed Bio, Retrogenix, and certain assets from a distributor, capital expenditures to support the growth of the business, and investments in certain venture capital and strategic equity investments.

The following table presents our net cash provided by financing activities:

	Six Months Ended
	June 25, 2022		June 26, 2021
	(in millions)
Proceeds from long-term debt and revolving credit facility	$	2,180.5	$	4,999.9
Payments on long-term debt, revolving credit facility, and finance lease obligations	(1,856.3)		(4,241.8)
Proceeds from exercises of stock options	15.6		35.3
Purchase of treasury stock	(38.5)		(40.3)
Payment of debt extinguishment and financing costs	—		(38.2)
Payment of contingent considerations	(10.4)		—
Other, net	(32.7)		(2.2)
Net cash provided by financing activities	$	258.2	$	712.7

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

For the six months ended June 25, 2022, net cash provided by financing activities reflected the net proceeds of $324.2 million on our Credit Facility, Senior Notes, and finance lease obligations. Included in the net proceeds are the following amounts:

•Borrowings under our Credit Facility of $300 million, which were used primarily for the acquisition of Explora BioLabs;

•Net borrowings of $153 million made to our Credit Facility throughout the six months ended June 25, 2022;

•Payments of $1.5 billion partially offset by $1.4 billion of proceeds in connection with a non-U.S. Euro functional currency entity repaying Euro loans and replacing the Euro loans with U.S. dollar denominated loans. A series of forward currency contracts were executed to mitigate any foreign currency gains or losses on the U.S. dollar denominated loans. These proceeds and payments are presented as gross financing activities.

Net cash used in financing activities also reflected treasury stock purchases of $38.5 million made due to the netting of common stock upon vesting of stock-based awards in order to satisfy individual statutory tax withholding requirements, approximately $15 million payment to purchase an additional 10% interest in a subsidiary, $15.7 million payment to acquire the remaining 2% ownership interest in Cognate, and $10.4 million of contingent consideration payments; partially offset by proceeds from exercises of employee stock options of $15.6 million.

For the six months ended June 26, 2021, net cash provided by financing activities reflected the net proceeds of $758.1 million our Credit Facility, Senior Notes, and finance lease obligations. Included in the net proceeds are the following amounts:

•Payments of approximately $147 million on our term loan;

•Proceeds of $1 billion from the issuance of the 2029 and 2031 Senior Notes, which were used to prepay our $500 million 2026 Senior Notes;

•Borrowings under our Credit Facility of $0.9 billion, which were used primarily for the acquisitions of Cognate, Distributed Bio, Retrogenix and certain assets from a distributor;

•Payments of $439 million made to our Credit Facility throughout the six months ended June 26, 2021;

•Gross proceeds and borrowings of $1.5 billion, but having a net impact of zero, were incurred as part of amending and restating our Credit Facility;

•Gross proceeds and payments of approximately $1.5 billion in connection with a non-U.S. Euro functional currency entity repaying Euro loans and replacing the Euro loans with U.S. dollar denominated loans. A series of forward currency contracts were executed to mitigate any foreign currency gains or losses on the U.S. dollar denominated loans. These proceeds and payments are presented as gross financing activities.

Net cash provided by financing activities also reflected proceeds from exercises of employee stock options of $35.3 million, offset by treasury stock purchases of $40.3 million made due to the netting of common stock upon vesting of stock-based awards in order to satisfy individual statutory tax withholding requirements. Additionally we paid $21 million of debt extinguishment costs associated with the 2026 Senior Notes repayment and $17 million of debt financing costs associated with the 2029 and 2031 Senior Notes issuances.

Off-Balance Sheet and Other Arrangements

There have been no material changes from the off-balance sheet and other arrangements previously disclosed in our Annual Report on Form 10-K for fiscal 2021 other than the changes described in Note 2, “Acquisitions and Divestitures,” Note 7, “Fair Value,” Note 9, “Debt and Other Financing Arrangements,”, and Note 13, “Commitments and Contingencies,” in our notes to the unaudited condensed consolidated financial statements in this Quarterly Report on Form 10-Q.

Venture Capital Investments

We invest in several venture capital funds that invest in start-up companies, primarily in the life sciences industry. Our total commitment to the funds as of June 25, 2022 was $192.7 million, of which we funded $119.7 million through June 25, 2022. Refer to Note 6, “Venture Capital and Strategic Equity Investments” in this Quarterly Report on Form 10-Q for additional information.

Critical Accounting Policies and Estimates

Our discussion and analysis of our financial condition and results of operations is based upon our consolidated financial statements prepared in accordance with generally accepted accounting principles in the U.S. The preparation of these financial statements requires us to make certain estimates and assumptions that may affect the reported amounts of assets and liabilities, the reported amounts of revenues and expenses during the reported periods and related disclosures. These estimates and assumptions are monitored and analyzed by us for changes in facts and circumstances, and material changes in these estimates could occur in the future. We base our estimates on our historical experience, trends in the industry, and various other factors

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

that are believed to be reasonable under the circumstances. Actual results may differ from our estimates under different assumptions or conditions.

We believe that the application of our accounting policies, each of which require significant judgments and estimates on the part of management, are the most critical to aid in fully understanding and evaluating our reported financial results. Our significant accounting policies are more fully described in Note 1, “Description of Business and Summary of Significant Accounting Policies” to our Annual Report on Form 10-K for fiscal year 2021.

Recent Accounting Pronouncements

For a discussion of recent accounting pronouncements please refer to Note 1, “Basis of Presentation,” in this Quarterly Report on Form 10-Q. Other than as discussed in Note 1, “Basis of Presentation,” we did not adopt any other new accounting pronouncements during the six months ended June 25, 2022 that had a significant effect on our unaudited condensed consolidated financial statements included in this Quarterly Report on Form 10-Q.

Item 3. Quantitative and Qualitative Disclosures about Market Risk

We are exposed to market risk from changes in interest rates and currency exchange rates, which could affect our future results of operations and financial condition. We manage our exposure to these risks through our regular operating and financing activities.

Interest Rate Risk

We are exposed to changes in interest rates while conducting normal business operations as a result of ongoing financing activities. As of June 25, 2022, our debt portfolio was comprised primarily of floating interest rate borrowings. A 100-basis point increase in interest rates would increase our annual pre-tax interest expense by $14.9 million.

Foreign Currency Exchange Rate Risk

We operate on a global basis and have exposure to some foreign currency exchange rate fluctuations for our financial position, results of operations, and cash flows.

While the financial results of our global activities are reported in U.S. dollars, our foreign subsidiaries typically conduct their operations in their respective local currency. The principal functional currencies of the Company’s foreign subsidiaries are the Euro, British Pound and Canadian Dollar. During the six months ended June 25, 2022, the most significant drivers of foreign currency translation adjustment the Company recorded as part of Other comprehensive income (loss) were the Euro, British Pound, Hungarian Forint, and Chinese Yuan.

Fluctuations in the foreign currency exchange rates of the countries in which we do business will affect our financial position, results of operations, and cash flows. As the U.S. dollar strengthens against other currencies, the value of our non-U.S. revenue, expenses, assets, liabilities, and cash flows will generally decline when reported in U.S. dollars. The impact to net income as a result of a U.S. dollar strengthening will be partially mitigated by the value of non-U.S. expenses, which will decline when reported in U.S. dollars. As the U.S. dollar weakens versus other currencies, the value of the non-U.S. revenue, expenses, assets, liabilities, and cash flows will generally increase when reported in U.S. dollars. For the six months ended June 25, 2022, our revenue would have decreased by $58.5 million and our operating income would have decreased by $1.0 million, if the U.S. dollar exchange rate had strengthened by 10%, with all other variables held constant.

We attempt to minimize this exposure by using certain financial instruments in accordance with our overall risk management and our hedge policy. We do not enter into speculative derivative agreements.

During the six months ended June 25, 2022, we entered into foreign exchange forward contracts to limit our foreign currency exposure related to both intercompany loans and a U.S. dollar denominated loan borrowed by a non-U.S. Euro functional currency entity under our Credit Facility. Refer to Note 9, “Debt and Other Financing Arrangements” in this Quarterly Report on Form 10-Q for additional information regarding these types of forward contracts.

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

Item 4. Controls and Procedures

(a)  Evaluation of Disclosure Controls and Procedures

Based on their evaluation, required by paragraph (b) of Rules 13a-15 or 15d-15, promulgated by the Securities Exchange Act of 1934, as amended (Exchange Act), the Company’s principal executive officer and principal financial officer have concluded that the Company’s disclosure controls and procedures, as defined in Rules 13a-15(e) and 15d-15(e) of the Exchange Act, are effective, at a reasonable assurance level, as of June 25, 2022, to ensure that information required to be disclosed by the Company in reports that it files or submits under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in Securities and Exchange Commission rules and forms. Disclosure controls and procedures include, without limitation, controls and procedures designed to ensure that information required to be disclosed by the Company in the reports that it files or submits under the Exchange Act is accumulated and communicated to the Company’s management, including its principal executive and principal financial officers, or persons performing similar functions, as appropriate to allow timely decisions regarding required disclosure. In designing and evaluating the disclosure controls and procedures, our management recognizes that any controls and procedures, no matter how well designed and operated, can provide only reasonable assurances of achieving the desired control objectives, and management necessarily was required to apply its judgment in designing and evaluating the controls and procedures.

(b) Changes in Internal Controls Over Financial Reporting

The Company continued to execute a plan to centralize certain accounting transaction processing functions to internal shared service centers during the three months ended June 25, 2022. There were no other material changes in the Company’s internal control over financial reporting identified in connection with the evaluation required by paragraph (d) of the Exchange Act Rules 13a-15 or 15d-15 that occurred during the quarter ended June 25, 2022 that materially affected, or were reasonably likely to materially affect, the Company’s internal control over financial reporting.

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

PART II. OTHER INFORMATION

Item 1. Legal Proceedings

Please refer to Note 13 “Commitments and Contingencies” in our notes to the unaudited condensed consolidated financial statements in this Quarterly Report on Form 10-Q.

Item 1A. Risk Factors

In addition to the other information set forth in this report, you should carefully consider the factors discussed in Part I, “Item 1A. Risk Factors” in our Annual Report on Form 10-K for fiscal year 2021, which could materially affect our business, financial condition, and/or future results. The risks described in our Annual Report on Form 10-K are not the only risks we face. Additional risks and uncertainties not currently known to us or that we currently deem to be immaterial also may materially adversely affect our business, financial condition, and/or operating results. There have been no material changes to the risk factors set forth in our Annual Report on Form 10-K for fiscal year 2021, except as disclosed below.

Our business, results of operations, or financial condition could be adversely affected by disruptions in the global economy caused by the ongoing conflict between the Russian Federation and Ukraine.

In February 2022, the Russian Federation launched an invasion of the country of Ukraine, resulting in negative impacts to the global economy. Furthermore, governments in the U.S., Canada, the United Kingdom, and European Union have each imposed export controls on certain products and financial and economic sanctions on certain industry sectors and parties in Russia. Although we have no operations in Russia or Ukraine, we have ceased doing business with our Russian customers and distributors. Additional risks to our business that may emerge as a result of the armed conflict include, among others, shortages in materials; increased costs for transportation, energy, and raw materials; increased trade barriers or restrictions on global trade; cyberattacks; supply disruptions; lower consumer demand; and changes to foreign exchange rates and financial markets, any of which may adversely affect our business and supply chain.

Item 2. Unregistered Sales of Equity Securities and Use of Proceeds

The following table provides information relating to the purchases of shares of our common stock during the three months ended June 25, 2022.

	Total Number<br>of Shares<br>Purchased	Average<br>Price Paid<br>per Share		Total Number of<br>Shares Purchased<br>as Part of Publicly<br>Announced Plans<br>or Programs	Approximate Dollar<br>Value of Shares<br>That May Yet Be<br>Purchased Under<br>the Plans or Programs
					(in thousands)
March 27, 2022 to April 23, 2022	—	$	—	—	$	129,105
April 24, 2022 to May 21, 2022	20	245.91		—	129,105
May 22, 2022 to June 25, 2022	18,250	244.38		—	129,105
Total	18,270			—

Our Board of Directors have authorized up to an aggregate amount of $1.3 billion for our stock repurchase program. During the three months ended June 25, 2022, we did not repurchase any shares of common stock under our stock repurchase program or in open market trading. As of June 25, 2022, we had $129.1 million remaining on the authorized stock repurchase program.

Additionally, our stock-based compensation plans permit the netting of common stock upon vesting of restricted stock, restricted stock units, and performance share units in order to satisfy individual statutory tax withholding requirements.

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

Item 6. Exhibits

(a) Exhibits	Description of Exhibits
31.1+	Rule 13a-14(a)/15d-14(a) Certification of Chief Executive Officer
31.2+	Rule 13a-14(a)/15d-14(a) Certification of Chief Financial Officer
32.1+	Certification of the Principal Executive Officer and the Principal Financial Officer required by Rule 13a-14(a) of 15d-14(a) of the Exchange Act
101.INS	eXtensible Business Reporting Language (XBRL) Instance Document - the instance document does not appear in the Interactive Data File because its XBRL tags are embedded within the Inline XBRL document
101.SCH	XBRL Taxonomy Extension Schema Document
101.CAL	XBRL Taxonomy Calculation Linkbase Document
101.DEF	XBRL Taxonomy Definition Linkbase Document
101.LAB	XBRL Taxonomy Label Linkbase Document
101.PRE	XBRL Taxonomy Presentation Linkbase Document
+ Furnished herein.

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

	CHARLES RIVER LABORATORIES INTERNATIONAL, INC.
August 3, 2022	/s/ JAMES C. FOSTER
	James C. Foster<br><br>Chairman, President and Chief Executive Officer
August 3, 2022	/s/ FLAVIA H. PEASE
	Flavia H. Pease<br><br>Corporate Executive Vice President and Chief Financial Officer

39

Document

Exhibit 31.1

CERTIFICATION PURSUANT TO

SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

AND RULE 13a-14(a)/15d-14(a) OF THE EXCHANGE ACT OF 1934

I, James C. Foster, Chairman, President and Chief Executive Officer of Charles River Laboratories International, Inc. (the registrant) certify that:

1.    I have reviewed this quarterly report on Form 10-Q for the quarter ended June 25, 2022 of the registrant;

2.    Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3.    Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4.    The registrant's other certifying officers and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

a.    designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

b.    designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

c.    evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures as of the end of the period covered by this report based on such evaluation; and

d.    disclosed in this report any change in the registrant's internal control over financial reporting that occurred during the registrant's most recent fiscal quarter (the registrant's fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant's internal control over financial reporting; and

5.    The registrant's other certifying officers and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions):

a.    all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and

b.    any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting.

	/s/ James C. Foster
August 3, 2022	James C. Foster<br><br>Chairman, President and Chief Executive Officer<br><br>Charles River Laboratories International, Inc.

Document

Exhibit 31.2

CERTIFICATION PURSUANT TO

SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

AND RULE 13a-14(a)/15d-14(a) OF THE EXCHANGE ACT OF 1934

I, Flavia H. Pease, Corporate Executive Vice President and Chief Financial Officer of Charles River Laboratories International, Inc. (the registrant) certify that:

1.    I have reviewed this quarterly report on Form 10-Q for the quarter ended June 25, 2022 of the registrant;

2.    Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3.    Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4.    The registrant's other certifying officers and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

a.    designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

b.    designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

c.    evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures as of the end of the period covered by this report based on such evaluation; and

d.    disclosed in this report any change in the registrant's internal control over financial reporting that occurred during the registrant's most recent fiscal quarter (the registrant's fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant's internal control over financial reporting; and

5.    The registrant's other certifying officers and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions):

a.    all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and

b.    any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting.

	/s/ Flavia H. Pease
August 3, 2022	Flavia H. Pease<br><br>Corporate Executive Vice President and Chief Financial Officer<br><br>Charles River Laboratories International, Inc.

Document

Exhibit 32.1

CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350,

AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the quarterly report on Form 10-Q for the quarter ended June 25, 2022 of Charles River Laboratories International, Inc. (the “Company”) as filed with the Securities and Exchange Commission on the date hereof (the “Report”), the undersigned, James C. Foster, Chairman, President and Chief Executive Officer of the Company, and Flavia H. Pease, Corporate Executive Vice President and Chief Financial Officer of the Company, each hereby certifies, to the best of his knowledge and pursuant to 18 U.S.C. Section 1350, that:

(1)    the Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934 (the “Exchange Act”); and

(2)    the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

	/s/ James C. Foster
August 3, 2022	James C. Foster<br><br>Chairman, President and Chief Executive Officer<br><br>Charles River Laboratories International, Inc.
	/s/ Flavia H. Pease
August 3, 2022	Flavia H. Pease<br><br>Corporate Executive Vice President and Chief Financial Officer<br><br>Charles River Laboratories International, Inc.

This certification shall not be deemed "filed" for any purpose, nor shall it be deemed to be incorporated by reference into any filing under the Securities Act of 1933 or the Exchange Act.