TWO SIGMA INVESTMENTS, LP

Position in ESTA — Establishment Labs Holdings Inc.

CIK 1179392 NEW YORK, NY

Position in ESTA

as of Jun 30, 2026 · filed Aug 14, 2026 Compact

Position Value

$38,479,349

+$13,979,631 QoQ

Shares Held

448,425

+3.9% QoQ

Ownership

1.50%

of shares outstanding

% of Portfolio

0.03%

of 13F equity value

Holder Rank

#20

of 197 holders

Holding Since

Mar 2020

14 quarters on record

Voting authority Sole 99% Shared 0% None 1%

Healthcare · as of Jun 30, 2026

TWO SIGMA INVESTMENTS, LP holds $2,671,988,741 across 67 Medical Devices names. ESTA ranks #8 (1.4% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	BSX	Boston Scientific Corp	19,359,023	$826,243,101
2	ABT	Abbott Laboratories	8,126,315	$737,381,823
3	PODD	Insulet Corp	1,903,734	$289,843,501
4	MDT	Medtronic plc	3,240,847	$253,531,460
5	EW	Edwards Lifesciences Corp	1,521,899	$137,670,983
6	PEN	Penumbra Inc	428,128	$135,181,416
7	BRKR	Bruker Corp	200,091	$45,941,097
8	ESTA	Establishment Labs Holdings Inc. This page	448,425	$38,479,349

14 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-06-30	$38,479,349	448,425	+3.9%	Shares	Sole	2026-08-14
2026-03-31	$24,499,718	431,485	+47.6%	Shares	Sole	2026-05-15
2025-12-31	$21,301,002	292,275	+605.1%	Shares	Sole	2026-02-17
2025-09-30	$1,699,158	41,453	+17.3%	Shares	Sole	2025-11-14
2023-12-31	$914,590	35,326	-46.3%	Shares	Sole	2024-02-14
2023-06-30	$4,511,038	65,749	-37.9%	Shares	Sole	2023-08-14
2023-03-31	$7,175,969	105,934	-14.1%	Shares	Sole	2023-05-15
2022-12-31	$8,091,428	123,251	+195.4%	Shares	Sole	2023-02-14
2022-09-30	$2,278,165	41,717	-51.8%	Shares	Sole	2022-11-14
2021-09-30	$6,198,326	86,593	-8.2%	Shares	Sole	2021-11-15
2021-06-30	$8,242,013	94,367	+28.4%	Shares	Sole	2021-08-16
2021-03-31	$4,596,455	73,508	+317.4%	Shares	Sole	2021-05-17
2020-06-30	$329,010	17,613	-17.9%	Shares	Sole	2020-08-14
2020-03-31	$310,010	21,454	—	Shares	Sole	2020-05-15
No filing history on record for this holder in this stock.