TWO SIGMA INVESTMENTS, LP

Position in ESTA — Establishment Labs Holdings Inc.

CIK 1179392 NEW YORK, NY

Position in ESTA

as of Mar 31, 2026 · filed May 15, 2026 Compact

Position Value

$24,499,718

+$3,198,716 QoQ

Shares Held

431,485

+47.6% QoQ

Ownership

1.47%

of shares outstanding

% of Portfolio

0.02%

of 13F equity value

Holder Rank

—

not a current holder

Holding Since

Mar 2020

13 quarters on record

Voting authority Sole 99% Shared 0% None 1%

Healthcare · as of Mar 31, 2026

TWO SIGMA INVESTMENTS, LP holds $2,221,263,395 across 63 Medical Devices names. ESTA ranks #13 (1.1% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	ABT	Abbott Laboratories	6,388,828	$655,940,970
2	BSX	Boston Scientific Corp	9,411,231	$590,554,745
3	PODD	Insulet Corp	762,349	$159,971,314
4	SYK	Stryker Corp	469,215	$154,179,356
5	STE	STERIS plc	479,146	$105,953,554
6	EW	Edwards Lifesciences Corp	1,051,535	$84,206,922
7	DXCM	Dexcom Inc	1,114,948	$70,018,734
8	MDT	Medtronic plc	605,568	$52,472,467

13 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-03-31	$24,499,718	431,485	+47.6%	Shares	Sole	2026-05-15
2025-12-31	$21,301,002	292,275	+605.1%	Shares	Sole	2026-02-17
2025-09-30	$1,699,158	41,453	+17.3%	Shares	Sole	2025-11-14
2023-12-31	$914,590	35,326	-46.3%	Shares	Sole	2024-02-14
2023-06-30	$4,511,038	65,749	-37.9%	Shares	Sole	2023-08-14
2023-03-31	$7,175,969	105,934	-14.1%	Shares	Sole	2023-05-15
2022-12-31	$8,091,428	123,251	+195.4%	Shares	Sole	2023-02-14
2022-09-30	$2,278,165	41,717	-51.8%	Shares	Sole	2022-11-14
2021-09-30	$6,198,326	86,593	-8.2%	Shares	Sole	2021-11-15
2021-06-30	$8,242,013	94,367	+28.4%	Shares	Sole	2021-08-16
2021-03-31	$4,596,455	73,508	+317.4%	Shares	Sole	2021-05-17
2020-06-30	$329,010	17,613	-17.9%	Shares	Sole	2020-08-14
2020-03-31	$310,010	21,454	—	Shares	Sole	2020-05-15
No filing history on record for this holder in this stock.