TWO SIGMA ADVISERS, LP

Position in INSM — INSMED Inc

CIK 1478735 NEW YORK, NY

Position in INSM

as of Dec 31, 2025 · filed Feb 17, 2026 Compact

Position Value

$68,745,800

+$61,358,087 QoQ

Shares Held

395,000

+670.0% QoQ

Ownership

0.182%

of shares outstanding

% of Portfolio

0.13%

of 13F equity value

Holder Rank

—

not a current holder

Holding Since

Mar 2020

24 quarters on record

Voting authority Sole 95.56962025316456.ToString("F0")% Shared 0.ToString("F0")% None 4.430379746835443.ToString("F0")%

Healthcare · as of Dec 31, 2025

TWO SIGMA ADVISERS, LP holds $2,538,392,646 across 227 Biotechnology names. INSM ranks #8 (2.7% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	REGN	Regeneron Pharmaceuticals, Inc.	604,540	$466,626,289
2	ALNY	Alnylam Pharmaceuticals, Inc.	1,132,560	$450,362,484
3	IONS	Ionis Pharmaceuticals Inc	3,052,111	$241,452,501
4	MRNA	Moderna, Inc.	7,729,700	$227,948,853
5	ARGX	Argenx SE	135,500	$113,948,725
6	BBIO	BridgeBio Pharma, Inc.	1,401,035	$107,165,167
7	VKTX	Viking Therapeutics, Inc.	2,129,228	$74,906,241
8	INSM	INSMED Inc This page	395,000	$68,745,800

24 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2025-12-31	$68,745,800	395,000	+670.0%	Shares	Sole	2026-02-17
2025-09-30	$7,387,713	51,300	+193.1%	Shares	Sole	2025-11-14
2025-06-30	$1,761,200	17,500	-88.9%	Shares	Sole	2025-08-14
2025-03-31	$11,992,788	157,200	-51.9%	Shares	Sole	2025-05-15
2024-12-31	$22,541,560	326,500	-16.9%	Shares	Sole	2025-02-14
2024-09-30	$28,667,100	392,700	+32.9%	Shares	Sole	2024-11-14
2024-06-30	$19,791,800	295,400	-58.8%	Shares	Sole	2024-08-14
2024-03-31	$19,435,932	716,400	+13.9%	Shares	Sole	2024-05-15
2023-12-31	$19,498,908	629,200	-23.8%	Shares	Sole	2024-02-14
2023-09-30	$20,841,350	825,400	+45.0%	Shares	Sole	2023-11-14
2023-06-30	$12,008,010	569,100	+26.7%	Shares	Sole	2023-08-14
2023-03-31	$7,655,450	449,000	+45.3%	Shares	Sole	2023-05-15
2022-12-31	$6,173,820	309,000	+63.1%	Shares	Sole	2023-02-14
2022-09-30	$4,081,830	189,500	+80.8%	Shares	Sole	2022-11-14
2022-06-30	$2,066,656	104,800	-42.0%	Shares	Sole	2022-08-15
2022-03-31	$4,246,450	180,700	-11.0%	Shares	Sole	2022-05-16
2021-12-31	$5,529,720	203,000	-52.9%	Shares	Sole	2022-02-14
2021-09-30	$11,861,478	430,700	+79.9%	Shares	Sole	2021-11-15
2021-06-30	$6,813,324	239,400	+90.6%	Shares	Sole	2021-08-16
2021-03-31	$4,277,936	125,600	+70.0%	Shares	Sole	2021-05-17
2020-12-31	$2,460,131	73,900	-58.2%	Shares	Sole	2021-02-16
2020-09-30	$5,675,924	176,600	+45.5%	Shares	Sole	2020-11-16
2020-06-30	$3,343,356	121,400	+26.5%	Shares	Sole	2020-09-15
2020-03-31	$1,538,880	96,000	—	Shares	Sole	2020-05-15
No filing history on record for this holder in this stock.