Position in ALNY
as of Dec 31, 2025
· filed Feb 17, 2026
Position Value
$450,362,484
+$43,382,484 QoQ
Shares Held
1,132,560
+26.9% QoQ
Ownership
0.854%
of shares outstanding
% of Portfolio
0.88%
of 13F equity value
Holder Rank
—
not a current holder
Holding Since
Jun 2020
19 quarters on record
Voting authority
Sole 94.32789432789433.ToString("F0")%
Shared 0.ToString("F0")%
None 5.672105672105672.ToString("F0")%
Common Shares in ALNY Over Time
Shares Held
Position Value (USD)
Position in Biotechnology
Healthcare · as of Dec 31, 2025TWO SIGMA ADVISERS, LP holds $2,538,392,646 across 227 Biotechnology names. ALNY ranks #2 (17.7% of the industry book) .
| # | Ticker | Company | Shares | Value (USD) | Open |
|---|---|---|---|---|---|
| 1 | REGN |
Regeneron Pharmaceuticals, Inc.
|
604,540 | $466,626,289 | |
| 2 | ALNY |
Alnylam Pharmaceuticals, Inc.
This page
|
1,132,560 | $450,362,484 | |
| 3 | IONS |
Ionis Pharmaceuticals Inc
|
3,052,111 | $241,452,501 | |
| 4 | MRNA |
Moderna, Inc.
|
7,729,700 | $227,948,853 | |
| 5 | ARGX |
Argenx SE
|
135,500 | $113,948,725 | |
| 6 | BBIO |
BridgeBio Pharma, Inc.
|
1,401,035 | $107,165,167 | |
| 7 | VKTX |
Viking Therapeutics, Inc.
|
2,129,228 | $74,906,241 | |
| 8 | INSM |
INSMED Inc
|
395,000 | $68,745,800 |
All Filings in ALNY
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19 filing rows on record
| Report Date | Value (USD) | Shares | Type | Discretion | Filed | |
|---|---|---|---|---|---|---|
| 2025-12-31 | $450,362,484 | 1,132,560 | Shares | Sole | 2026-02-17 | |
| 2025-09-30 | $406,980,000 | 892,500 | Shares | Sole | 2025-11-14 | |
| 2025-06-30 | $86,772,549 | 266,100 | Shares | Sole | 2025-08-14 | |
| 2025-03-31 | $74,471,516 | 275,800 | Shares | Sole | 2025-05-15 | |
| 2024-12-31 | $18,542,428 | 78,800 | Shares | Sole | 2025-02-14 | |
| 2024-09-30 | $28,355,593 | 103,100 | Shares | Sole | 2024-11-14 | |
| 2024-06-30 | $62,864,100 | 258,700 | Shares | Sole | 2024-08-14 | |
| 2024-03-31 | $28,335,720 | 189,600 | Shares | Sole | 2024-05-15 | |
| 2023-09-30 | $6,357,890 | 35,900 | Shares | Sole | 2023-11-14 | |
| 2023-06-30 | $36,772,384 | 193,600 | Shares | Sole | 2023-08-14 | |
| 2023-03-31 | $31,069,632 | 155,100 | Shares | Sole | 2023-05-15 | |
| 2022-12-31 | $28,518,000 | 120,000 | Shares | Sole | 2023-02-14 | |
| 2022-09-30 | $12,770,208 | 63,800 | Shares | Sole | 2022-11-14 | |
| 2022-06-30 | $1,808,540 | 12,400 | Shares | Sole | 2022-08-15 | |
| 2022-03-31 | $7,625,643 | 46,700 | Shares | Sole | 2022-05-16 | |
| 2021-12-31 | $644,404 | 3,800 | Shares | Sole | 2022-02-14 | |
| 2021-03-31 | $4,503,961 | 31,900 | Shares | Sole | 2021-05-17 | |
| 2020-12-31 | $480,889 | 3,700 | Shares | Sole | 2021-02-16 | |
| 2020-06-30 | $1,229,313 | 8,300 | Shares | Sole | 2020-09-15 | |
| No filing history on record for this holder in this stock. | ||||||