Position in IONS
as of Dec 31, 2025
· filed Feb 17, 2026
Position Value
$241,452,501
+$105,829,580 QoQ
Shares Held
3,052,111
+47.2% QoQ
Ownership
1.85%
of shares outstanding
% of Portfolio
0.47%
of 13F equity value
Holder Rank
—
not a current holder
Holding Since
Mar 2020
24 quarters on record
Voting authority
Sole 96.39266068632497.ToString("F0")%
Shared 0.ToString("F0")%
None 3.6073393136750265.ToString("F0")%
Common Shares in IONS Over Time
Shares Held
Position Value (USD)
Position in Biotechnology
Healthcare · as of Dec 31, 2025TWO SIGMA ADVISERS, LP holds $2,538,392,646 across 227 Biotechnology names. IONS ranks #3 (9.5% of the industry book) .
| # | Ticker | Company | Shares | Value (USD) | Open |
|---|---|---|---|---|---|
| 1 | REGN |
Regeneron Pharmaceuticals, Inc.
|
604,540 | $466,626,289 | |
| 2 | ALNY |
Alnylam Pharmaceuticals, Inc.
|
1,132,560 | $450,362,484 | |
| 3 | IONS |
Ionis Pharmaceuticals Inc
This page
|
3,052,111 | $241,452,501 | |
| 4 | MRNA |
Moderna, Inc.
|
7,729,700 | $227,948,853 | |
| 5 | ARGX |
Argenx SE
|
135,500 | $113,948,725 | |
| 6 | BBIO |
BridgeBio Pharma, Inc.
|
1,401,035 | $107,165,167 | |
| 7 | VKTX |
Viking Therapeutics, Inc.
|
2,129,228 | $74,906,241 | |
| 8 | INSM |
INSMED Inc
|
395,000 | $68,745,800 |
All Filings in IONS
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24 filing rows on record
| Report Date | Value (USD) | Shares | Type | Discretion | Filed | |
|---|---|---|---|---|---|---|
| 2025-12-31 | $241,452,501 | 3,052,111 | Shares | Sole | 2026-02-17 | |
| 2025-09-30 | $135,622,921 | 2,073,111 | Shares | Sole | 2025-11-14 | |
| 2025-06-30 | $105,397,310 | 2,667,611 | Shares | Sole | 2025-08-14 | |
| 2025-03-31 | $63,115,971 | 2,092,011 | Shares | Sole | 2025-05-15 | |
| 2024-12-31 | $47,168,416 | 1,349,211 | Shares | Sole | 2025-02-14 | |
| 2024-09-30 | $53,376,384 | 1,332,411 | Shares | Sole | 2024-11-14 | |
| 2024-06-30 | $61,343,710 | 1,287,111 | Shares | Sole | 2024-08-14 | |
| 2024-03-31 | $45,088,811 | 1,040,111 | Shares | Sole | 2024-05-15 | |
| 2023-12-31 | $39,308,986 | 777,011 | Shares | Sole | 2024-02-14 | |
| 2023-09-30 | $27,411,546 | 604,311 | Shares | Sole | 2023-11-14 | |
| 2023-06-30 | $14,122,977 | 344,211 | Shares | Sole | 2023-08-14 | |
| 2023-03-31 | $12,359,285 | 345,811 | Shares | Sole | 2023-05-15 | |
| 2022-12-31 | $23,980,588 | 634,911 | Shares | Sole | 2023-02-14 | |
| 2022-09-30 | $29,081,711 | 657,511 | Shares | Sole | 2022-11-14 | |
| 2022-06-30 | $26,129,123 | 705,811 | Shares | Sole | 2022-08-15 | |
| 2022-03-31 | $22,654,071 | 611,611 | Shares | Sole | 2022-05-16 | |
| 2021-12-31 | $15,136,216 | 497,411 | Shares | Sole | 2022-02-14 | |
| 2021-09-30 | $14,496,356 | 432,211 | Shares | Sole | 2021-11-15 | |
| 2021-06-30 | $20,974,600 | 525,811 | Shares | Sole | 2021-08-16 | |
| 2021-03-31 | $32,119,918 | 714,411 | Shares | Sole | 2021-05-17 | |
| 2020-12-31 | $45,243,929 | 800,211 | Shares | Sole | 2021-02-16 | |
| 2020-09-30 | $51,725,766 | 1,090,111 | Shares | Sole | 2020-11-16 | |
| 2020-06-30 | $69,084,080 | 1,171,711 | Shares | Sole | 2020-09-15 | |
| 2020-03-31 | $56,131,336 | 1,187,211 | Shares | Sole | 2020-05-15 | |
| No filing history on record for this holder in this stock. | ||||||