8-K

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

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CURRENT REPORT

Pursuant to Section 13 OR 15(d) ofThe Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): March 7, 2023

RIGEL PHARMACEUTICALS, INC.

(Exact name of registrant as specified in its charter)

Delaware

(State or other jurisdiction of incorporation)

0-29889	94-3248524
(Commission File No.)	(IRS Employer Identification No.)
611 Gateway Boulevard
Suite 900
South San Francisco, CA	94080
(Address of principal executive offices)	(Zip Code)

Registrant’s telephone number, including area code:

(650

) 624-1100

Not Applicable

(Former name or former address, if changed since last report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

¨ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

¨ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

¨ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

¨ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Title of Each Class	Trading Symbol(s)	Name of Each Exchange on Which Registered
Common Stock, par value $0.001 per share	RIGL	The Nasdaq Stock Market LLC

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company ¨

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ¨

Item 2.02.	Results of Operations and Financial Condition.

On March 7, 2023, Rigel Pharmaceuticals, Inc. (“Rigel”) announced certain financial results for its fourth quarter and year ended December 31, 2022. A copy of Rigel’s press release, titled “Rigel Reports Fourth Quarter and Full Year 2022 Financial Results and Provides Business Update,” is furnished pursuant to Item 2.02 as Exhibit 99.1 hereto.

The information in thisreport, including the exhibit hereto, shall not be deemed to be “filed” for purposes of Section 18 of the SecuritiesExchange Act of 1934, as amended, or otherwise subject to the liabilities of that section or Sections 11 and 12(a)(2) of the SecuritiesAct of 1933, as amended. The information contained herein and in the accompanying exhibit shall not be incorporated by reference intoany filing with the U.S. Securities and Exchange Commission made by Rigel, whether made before or after the date hereof, regardless ofany general incorporation language in such filing.

Item 9.01.	Financial Statements and Exhibits.
(d)	Exhibits.
Exhibit	Description
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99.1	Press<br> Release, dated March 7, 2023, titled “Rigel Reports Fourth Quarter and Full Year 2022 Financial Results and Provides Business<br> Update.”
104	Cover Page Interactive Data File (embedded within the Inline XBRL document)

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Dated: March 7, 2023	RIGEL PHARMACEUTICALS, INC.
	By:	/s/ Ray Furey, J.D.
		Ray Furey, J.D.
		Executive Vice President, General Counsel and Corporate Secretary

Exhibit 99.1

Rigel Reports Fourth Quarter and Full Year2022 Financial Results and Provides Business Update

●	Fourth quarter 2022 Total Revenue of $51.3 million which includes TAVALISSE^®^ net product sales of $21.9 million and REZLIDHIA^™^ net product sales of $0.9 million
●	REZLIDHIA U.S. commercial launch continues to progress and is supported by recent addition to NCCN Guidelines^®^ for AML
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●	Conference call and webcast scheduled today at 4:30 p.m. Eastern Time
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SOUTH SAN FRANCISCO, Calif., March 7, 2023 /PRNewswire/ -- Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL) today reported financial results for the fourth quarter and full year ended December 31, 2022, including sales of TAVALISSE^®^ (fostamatinib disodium hexahydrate) tablets for the treatment of adults with chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment and sales of REZLIDHIA^™^ (olutasidenib) capsules for the treatment of adult patients with relapsed or refractory (R/R) acute myeloid leukemia (AML) with a susceptible isocitrate dehydrogenase-1 (IDH1) mutation as detected by an FDA-approved test.

"2022 was a year of significant accomplishments for Rigel, as we expanded our commercial hematology-oncology portfolio with the approval and launch of REZLIDHIA, an important new treatment option for AML patients. We also continued to strengthen our commercial execution, with TAVALISSE net product sales reaching a record high in the fourth quarter,” said Raul Rodriguez, Rigel's president and CEO. “We are focused on continuing the successful launch of REZLIDHIA in R/R AML, driving sales growth for TAVALISSE in ITP, and advancing our development programs. In 2023, we look forward to further expanding our hematology-oncology portfolio and clinical pipeline.”

Business Update

●	In<br> the fourth quarter of 2022, a total of 2,417 bottles of TAVALISSE were sold in the U.S.,<br> 2,196 of which were shipped directly to patients and clinics, representing the highest number<br> of daily bottles shipped to patients and clinics in a quarter since launch. For the full<br> year ended December 31, 2022, 8,112 bottles of TAVALISSE were shipped directly to patients<br> and clinics, representing an increase of 20% compared to 2021.
●	On<br> December 1, 2022, REZLIDHIA was approved by the U.S. Food and Drug Administration (FDA)<br> for the treatment of adult patients with R/R AML with a susceptible IDH1 mutation as detected<br> by an FDA-approved test. From December 22, 2022, when REZLIDHIA became commercially<br> available in the U.S., to December 31, 2022, a total of 64 bottles of REZLIDHIA were<br> sold in the U.S. to fill initial orders from our distributors, 2 of which were shipped to<br> patients and clinics.
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●	REZLIDHIA<br> was added by the National Comprehensive Cancer Network^®^ (NCCN^®^)<br> to the latest NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines^®^)<br> for AML in January 2023. REZLIDHIA is included as a recommended targeted therapy for<br> adult patients with R/R AML with IDH1 mutation.
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●	Rigel<br> announced a peer-reviewed publication of data in Blood Advances in February 2023,<br> which summarizes clinical results from the Phase 2 registrational trial of REZLIDHIA in patients<br> with mIDH1 R/R AML. The published data demonstrate that REZLIDHIA induced durable remissions<br> and transfusion independence with a well-characterized safety profile.
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●	In<br> December 2022, Rigel's partner Kissei announced Japan's Pharmaceuticals and Medical<br> Devices Agency (PMDA) approval of TAVALISSE for the treatment of chronic ITP. During the<br> fourth quarter, Rigel recognized a $20.0 million regulatory milestone earned from Kissei<br> in connection with the approval. The payment was received during the first quarter of 2023.
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●	Rigel<br> continues to advance the open-label, Phase 1b clinical trial of R289^1^, an investigational,<br> potent, and selective IRAK1/4 inhibitor, in patients with lower-risk myeloid dysplastic syndrome<br> (LR-MDS) who are refractory/resistant to prior therapies. The first patients have been dosed<br> and enrollment is underway.
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●	R552,<br> an investigational, potent, and selective RIPK1 inhibitor, is being advanced by Rigel's partner<br> Eli Lilly (Lilly). The initial Phase 2a trial in approximately 100 patients with moderately<br> to severely active rheumatoid arthritis (RA) is anticipated to begin in the first half of<br> 2023 and will involve global recruitment. The Phase 2a trial analysis is expected by the<br> end of 2024.
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●	Data<br> was published in Transplantation and Cellular Therapy, which summarizes the<br> results of an investigational Phase 1 clinical trial of fostamatinib, Rigel's oral spleen<br> tyrosine kinase, for the treatment of chronic graft-versus-host disease (cGvHD). Highlights<br> included a promising overall response rate of 77% for fostamatinib in steroid-refractory<br> cGvHD patients with 70% of responses lasting >1 year and a manageable safety profile in<br> the post-transplant setting.
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FinancialUpdate

For the fourth quarter of 2022, Rigel reported a net income of $1.4 million, or $0.01 per basic and diluted share, compared to a net loss of $22.6 million, or $0.13 per basic and diluted share, for the same period of 2021.

For the fourth quarter of 2022, total revenues were $51.3 million, consisting of $21.9 million in TAVALISSE net product sales, $0.9 million in REZLIDHIA net product sales, $26.5 million in contract revenues from collaborations and $2.0 million in government contract revenue. TAVALISSE net product sales of $21.9 million represents an increase of 25% from $17.6 million in the fourth quarter of 2021. Following the approval of REZLIDHIA in December 2022, Rigel initiated the commercialization of REZLIDHIA in the U.S. and recognized net product sales of $0.9 million in the fourth quarter of 2022. Contract revenues from collaborations for the fourth quarter of 2022 consisted of $20.0 million in revenue from Kissei related to a milestone payment earned upon Japan’s PMDA approval of TAVALISSE for the treatment of chronic ITP, $5.7 million in non-cash revenue from the collaboration agreement with Medison Pharma Trading AG (Medison), $0.6 million in royalty revenue from Grifols S.A. (Grifols), and $0.2 million in revenue related to its license agreement with Lilly. Government contract revenue for the fourth quarter of 2022 was related to the income recognized pursuant to the agreement with the U.S. Department of Defense (DOD) to support Rigel’s ongoing Phase 3 clinical trial of fostamatinib in hospitalized patients with COVID-19.

For the fourth quarter of 2022, total costs and expenses were $49.2 million, compared to $41.8 million for the same period of 2021. The increase in costs and expenses was primarily due to an increase in personnel-related costs and commercial expenses, and higher research and development costs related to the IRAK 1/4 inhibitor program. These increases were partially offset by decreased research and development costs related to the Phase 3 clinical trial for wAIHA and the Phase 3 clinical trial in high-risk hospitalized patients with COVID-19.

For the full year 2022, Rigel reported a net loss of $58.6 million, or $0.34 per basic and diluted share, compared to a net loss of $17.9 million, or $0.11 per basic and diluted share, for the same period of 2021.

For the full year 2022, total revenues were $120.2 million, consisting of $75.8 million in TAVALISSE net product sales, $0.9 million in REZLIDHIA net product sales, $39.0 million in contract revenues from collaborations and $4.5 million in government contract revenue. TAVALISSE net product sales of $75.8 million increased by 20% compared to $63.0 million in the same period of 2021. REZLIDHIA net product sales were related to shipments of products to customers following the FDA approval after commercial launch in December 2022. Contract revenues from collaborations for the full year 2022 consisted of $27.6 million in revenue from Kissei primarily related to milestones earned and delivery of fostamatinib supply, $5.7 million in non-cash revenue from the collaboration agreement with Medison, $3.0 million in revenue from Grifols related to the delivery of fostamatinib supply, performance of certain research and development services pursuant to the collaboration agreement and royalty revenue, $2.0 million in revenue related to the license agreement with Knight, and $0.7 million in revenue related to the license agreement with Lilly. Government contract revenue for the full year 2022 was related to the income recognized pursuant to the agreement with DOD.

For the full year 2022, total costs and expenses were $175.8 million, compared to $161.7 million for the same period of 2021. The increase in costs and expenses was primarily due to an increase in personnel-related costs and commercial expenses, and higher research and development costs related to the IRAK 1/4 inhibitor program. These increases were partially offset by decreased research and development costs related to the Phase 3 clinical trial for wAIHA and Phase 3 clinical trial in high-risk hospitalized patients with COVID-19.

As of December 31, 2022, Rigel had cash, cash equivalents and short-term investments of $58.2 million, compared to $125.0 million as of December 31, 2021.

Conference Calland Webcast with Slides Today at 4:30pm Eastern Time

Rigel will hold a live conference call and webcast today at 4:30pm Eastern Time (1:30pm Pacific Time).

Participants can access the live conference call by dialing (877) 407-3088 (domestic) or (201) 389-0927 (international). The conference call will also be webcast live and can be accessed from the Investor Relations section of the company's website at www.rigel.com. The webcast will be archived and available for replay after the call via the Rigel website.

About ITP

In patients with ITP (immune thrombocytopenia), the immune system attacks and destroys the body's own blood platelets, which play an active role in blood clotting and healing. Common symptoms of ITP are excessive bruising and bleeding. People suffering with chronic ITP may live with an increased risk of severe bleeding events that can result in serious medical complications or even death. Current therapies for ITP include steroids, blood platelet production boosters (TPO-RAs), and splenectomy. However, not all patients respond to existing therapies. As a result, there remains a significant medical need for additional treatment options for patients with ITP.

About AML

Acute myeloid leukemia (AML) is a rapidly progressing cancer of the blood and bone marrow that affects myeloid cells, which normally develop into various types of mature blood cells. AML occurs primarily in adults and accounts for about 1 percent of all adult cancers. The American Cancer Society estimates that in the United States alone, there will be about 20,380 new cases, most in adults, in 2023.^2^

Relapsed AML affects about half of all patients who, following treatment and remission, experience a return of leukemia cells in the bone marrow.^3^ Refractory AML, which affects between 10 and 40 percent of newly diagnosed patients, occurs when a patient fails to achieve remission even after intensive treatment.^4^ Quality of life declines for patients with each successive line of treatment for AML, and well-tolerated treatments in relapsed or refractory disease remain an unmet need.

About TAVALISSE^®^

Indication

TAVALISSE (fostamatinib disodium hexahydrate) tablets is indicated for the treatment of thrombocytopenia in adult patients with chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment.

Important SafetyInformation

Warnings and Precautions

●	Hypertension<br> can occur with TAVALISSE treatment. Patients with pre-existing hypertension may be more susceptible<br> to the hypertensive effects. Monitor blood pressure every 2 weeks until stable, then monthly,<br> and adjust or initiate antihypertensive therapy for blood pressure control maintenance during<br> therapy. If increased blood pressure persists, TAVALISSE interruption, reduction, or discontinuation<br> may be required.
●	Elevated<br> liver function tests (LFTs), mainly ALT and AST, can occur with TAVALISSE. Monitor LFTs monthly<br> during treatment. If ALT or AST increase to ≥3 x upper limit of normal, manage hepatotoxicity<br> using TAVALISSE interruption, reduction, or discontinuation.
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●	Diarrhea<br> occurred in 31% of patients and severe diarrhea occurred in 1% of patients treated with TAVALISSE.<br> Monitor patients for the development of diarrhea and manage using supportive care measures<br> early after the onset of symptoms. If diarrhea becomes severe (≥Grade 3), interrupt, reduce<br> dose or discontinue TAVALISSE.
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●	Neutropenia<br> occurred in 6% of patients treated with TAVALISSE; febrile neutropenia occurred in 1% of<br> patients. Monitor the ANC monthly and for infection during treatment. Manage toxicity with<br> TAVALISSE interruption, reduction, or discontinuation.
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●	TAVALISSE<br> can cause fetal harm when administered to pregnant women. Advise pregnant women the potential<br> risk to a fetus. Advise females of reproductive potential to use effective contraception<br> during treatment and for at least 1 month after the last dose. Verify pregnancy status prior<br> to initiating TAVALISSE. It is unknown if TAVALISSE or its metabolite is present in human<br> milk. Because of the potential for serious adverse reactions in a breastfed child, advise<br> a lactating woman not to breastfeed during TAVALISSE treatment and for at least 1 month after<br> the last dose.
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Drug Interactions

●	Concomitant<br> use of TAVALISSE with strong CYP3A4 inhibitors increases exposure to the major active metabolite<br> of TAVALISSE (R406), which may increase the risk of adverse reactions. Monitor for toxicities<br> that may require a reduction in TAVALISSE dose.
●	It<br> is not recommended to use TAVALISSE with strong CYP3A4 inducers, as concomitant use reduces<br> exposure to R406.
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●	Concomitant<br> use of TAVALISSE may increase concentrations of some CYP3A4 substrate drugs and may require<br> a dose reduction of the CYP3A4 substrate drug.
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●	Concomitant<br> use of TAVALISSE may increase concentrations of BCRP substrate drugs (eg, rosuvastatin) and<br> P-Glycoprotein (P-gp) substrate drugs (eg, digoxin), which may require a dose reduction of<br> the BCRP and P-gp substrate drug.
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Adverse Reactions

●	Serious<br> adverse drug reactions in the ITP double-blind studies were febrile neutropenia, diarrhea,<br> pneumonia, and hypertensive crisis, which occurred in 1% of TAVALISSE patients. In addition,<br> severe adverse reactions occurred including dyspnea and hypertension (both 2%), neutropenia,<br> arthralgia, chest pain, diarrhea, dizziness, nephrolithiasis, pain in extremity, toothache,<br> syncope, and hypoxia (all 1%).
●	Common<br> adverse reactions (≥5% and more common than placebo) from FIT-1 and FIT-2 included: diarrhea,<br> hypertension, nausea, dizziness, ALT and AST increased, respiratory infection, rash, abdominal<br> pain, fatigue, chest pain, and neutropenia.
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Please see www.TAVALISSEUSPI.comfor full Prescribing Information.

To report side effectsof prescription drugs to the FDA, visit www.fda.gov/medwatch or call 1-800-FDA-1088 (800-332-1088).

TAVALISSE and TAVLESSE are registered trademarks of Rigel Pharmaceuticals, Inc.

About REZLIDHIA^™^

INDICATION

REZLIDHIA is indicated for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with a susceptible isocitrate dehydrogenase-1 (IDH1) mutation as detected by an FDA-approved test.

IMPORTANT SAFETY INFORMATION

WARNING: DIFFERENTIATION SYNDROME

Differentiation syndrome, which can be fatal,can occur with REZLIDHIA treatment. Symptoms may include dyspnea, pulmonary infiltrates/pleuropericardial effusion, kidney injury, hypotension,fever, and weight gain. If differentiation syndrome is suspected, withhold REZLIDHIA and initiate treatment with corticosteroids andhemodynamic monitoring until symptom resolution.

WARNINGS AND PRECAUTIONS

Differentiation Syndrome

REZLIDHIA can cause differentiation syndrome. In the clinical trial of REZLIDHIA in patients with relapsed or refractory AML, differentiation syndrome occurred in 16% of patients, with grade 3 or 4 differentiation syndrome occurring in 8% of patients treated, and fatalities in 1% of patients. Differentiation syndrome is associated with rapid proliferation and differentiation of myeloid cells and may be life-threatening or fatal. Symptoms of differentiation syndrome in patients treated with REZLIDHIA included leukocytosis, dyspnea, pulmonary infiltrates/pleuropericardial effusion, kidney injury, fever, edema, pyrexia, and weight gain. Of the 25 patients who experienced differentiation syndrome, 19 (76%) recovered after treatment or after dose interruption of REZLIDHIA. Differentiation syndrome occurred as early as 1 day and up to 18 months after REZLIDHIA initiation and has been observed with or without concomitant leukocytosis.

If differentiation syndrome is suspected, temporarily withhold REZLIDHIA and initiate systemic corticosteroids (e.g., dexamethasone 10 mg IV every 12 hours) for a minimum of 3 days and until resolution of signs and symptoms. If concomitant leukocytosis is observed, initiate treatment with hydroxyurea, as clinically indicated. Taper corticosteroids and hydroxyurea after resolution of symptoms. Differentiation syndrome may recur with premature discontinuation of corticosteroids and/or hydroxyurea treatment. Institute supportive measures and hemodynamic monitoring until improvement; withhold dose of REZLIDHIA and consider dose reduction based on recurrence.

Hepatotoxicity

REZLIDHIA can cause hepatotoxicity, presenting as increased alanine aminotransferase (ALT), increased aspartate aminotransferase (AST), increased blood alkaline phosphatase, and/or elevated bilirubin. Of 153 patients with relapsed or refractory AML who received REZLIDHIA, hepatotoxicity occurred in 23% of patients; 13% experienced grade 3 or 4 hepatotoxicity. One patient treated with REZLIDHIA in combination with azacitidine in the clinical trial, a combination for which REZLIDHIA is not indicated, died from complications of drug-induced liver injury. The median time to onset of hepatotoxicity in patients with relapsed or refractory AML treated with REZLIDHIA was 1.2 months (range: 1 day to 17.5 months) after REZLIDHIA initiation, and the median time to resolution was 12 days (range: 1 day to 17 months). The most common hepatotoxicities were elevations of ALT, AST, blood alkaline phosphatase, and blood bilirubin.

Monitor patients frequently for clinical symptoms of hepatic dysfunction such as fatigue, anorexia, right upper abdominal discomfort, dark urine, or jaundice. Obtain baseline liver function tests prior to initiation of REZLIDHIA, at least once weekly for the first two months, once every other week for the third month, once in the fourth month, and once every other month for the duration of therapy. If hepatic dysfunction occurs, withhold, reduce, or permanently discontinue REZLIDHIA based on recurrence/severity.

ADVERSE REACTIONS

The most common (≥20%) adverse reactions, including laboratory abnormalities, were aspartate aminotransferase increased, alanine aminotransferase increased, potassium decreased, sodium decreased, alkaline phosphatase increased, nausea, creatinine increased, fatigue/malaise, arthralgia, constipation, lymphocytes increased, bilirubin increased, leukocytosis, uric acid increased, dyspnea, pyrexia, rash, lipase increased, mucositis, diarrhea and transaminitis.

DRUG INTERACTIONS

●	Avoid<br> concomitant use of REZLIDHIA with strong or moderate CYP3A inducers.
●	Avoid<br> concomitant use of REZLIDHIA with sensitive CYP3A substrates unless otherwise instructed<br> in the substrates prescribing information. If concomitant use is unavoidable, monitor patients<br> for loss of therapeutic effect of these drugs.
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LACTATION

Advise women not to breastfeed during treatment with REZLIDHIA and for 2 weeks after the last dose.

GERIATRIC USE

No overall differences in effectiveness were observed between patients 65 years and older and younger patients. Compared to patients younger than 65 years of age, an increase in incidence of hepatotoxicity and hypertension was observed in patients ≥65 years of age.

HEPATIC IMPAIRMENT

In patients with mild or moderate hepatic impairment, closely monitor for increased probability of differentiation syndrome.

Click here for Full Prescribing Information, including Boxed WARNING.

To report side effects of prescription drugs to the FDA, visit www.fda.gov/medwatch or call 1-800-FDA-1088 (800-332-1088).

REZLIDHIA is a trademark of Rigel Pharmaceuticals, Inc.

About Rigel

Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL) is a biotechnology company dedicated to discovering, developing and providing novel therapies that significantly improve the lives of patients with hematologic disorders and cancer. Founded in 1996, Rigel is based in South San Francisco, California. For more information on Rigel, the Company's marketed products and pipeline of potential products, visit www.rigel.com.

1.	R289 is an investigational compound not approved<br> by the FDA
2.	The American Cancer Society. Key Statistics<br> for Acute Myeloid Leukemia (AML). Revised January 12, 2023. Accessed Feb. 15, 2023:<br> https://www.cancer.org/cancer/acute-myeloid-leukemia/about/key-statistics.html
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3.	Leukaemia Care. Relapse in Acute Myeloid Leukaemia<br> (AML). Version 3. Reviewed October 2021. Accessed Feb 15, 2023: https://media.leukaemiacare.org.uk/wp-content/uploads/Relapse-in-Acute-Myeloid-Leukaemia-AML-Web-Version.pdf
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4.	Thol F, Schlenk RF, Heuser M, Ganser A. How<br> I treat refractory and early relapsed acute myeloid leukemia. Blood. 2015 Jul 16;126(3):319-27.<br> doi: https://doi.org/10.1182/blood-2014-10-551911
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Forward LookingStatements

This press releasecontains forward-looking statements relating to, among other things, the potential and market opportunity of olutasidenib as therapeuticsfor R/R AML and other conditions, the commercialization of fostamatinib in the U.S. and international markets including Japan, and Rigel'sability to further develop its clinical stage and early-stage product candidates and Rigel's partnering effort, including the progressof Phase 1b clinical trial of R289 for the treatment of lower-risk myeloid dysplastic syndrome, the advancement of Phase 2a clinicaltrial of R552 for the treatment of rheumatoid arthritis, and the results of Phase 1 clinical trial of fostamatinib for the treatmentof chronic graft-versus-host disease. Any statements contained in this press release that are not statements of historical fact may bedeemed to be forward-looking statements. Forward-looking statements can be identified by words such as "plan", "potential", "may", "expects", "will" and similar expressions in reference to future periods. Forward-looking statementsare neither historical facts nor assurances of future performance. Instead, they are based on Rigel's current beliefs, expectations,and assumptions and hence they inherently involve significant risks, uncertainties and changes in circumstances that aredifficult to predict and many of which are outside of our control. Therefore, you should not rely on any of these forward-lookingstatements. Actual results and the timing of events could differ materially from those anticipated in such forward looking statementsas a result of these risks and uncertainties, which include, without limitation, risks and uncertainties associated with the commercializationand marketing of TAVALISSE or REZLIDHIA; risks that the FDA, European Medicines Agency, PMDA or other regulatory authorities may makeadverse decisions regarding fostamatinib or olutasidenib; risks that clinical trials may not be predictive of real-world results or ofresults in subsequent clinical trials; risks that fostamatinib or olutasidenib may have unintended side effects, adverse reactions orincidents of misuses; the availability of resources to develop Rigel's product candidates; market competition; as well as other risksdetailed from time to time in Rigel's reports filed with the Securities and Exchange Commission, including its Quarterly Report on Form 10-Qfor the quarter ended September 30, 2022 and subsequent filings. Any forward-looking statement made by us in this press release isbased only on information currently available to us and speaks only as of the date on which it is made. Rigel does not undertake anyobligation to update forward-looking statements, whether written or oral, that may be made from time to time, whether as a result ofnew information, future developments or otherwise, and expressly disclaims any obligation or undertaking to release publicly any updatesor revisions to any forward-looking statements contained herein, except as required by law.

Contact for Investors &Media:

Investors:

Rigel Pharmaceuticals, Inc.

650.624.1232

ir@rigel.com

Media:

David Rosen

Argot Partners

212.600.1902

david.rosen@argotpartners.com

RIGELPHARMACEUTICALS, INC.

STATEMENTSOF OPERATIONS

(in thousands, exceptper share amounts)

	Three Months Ended<br> December 31,						Year Ended December 31,
	2022			2021			2022			2021
	(unaudited)
Revenues:
Product sales, net	$	22,783		$	17,569		$	76,718		$	63,010
Contract revenues from collaborations		26,495			1,840			39,024			75,726
Government contract		2,000			1,000			4,500			10,500
Total revenues		51,278			20,409			120,242			149,236
Costs and expenses:
Cost of product sales		342			487			1,749			1,083
Research and development (see Note A)		15,365			13,304			60,272			65,237
Selling, general and administrative (see Note A)		32,172			24,515			112,451			91,891
Restructuring charges (see Note A)		1,320			3,521			1,320			3,521
Total costs<br> and expenses		49,199			41,827			175,792			161,732
Income (loss) from operations		2,079			(21,418	)		(55,550	)		(12,496	)
Interest income		429			16			684			47
Interest expense		(1,107	)		(1,299	)		(3,707	)		(4,860	)
Income (loss) before income taxes		1,401			(22,701	)		(58,573	)		(17,309	)
Provision for (benefit from) income taxes		-			(60	)		-			605
Net income (loss)	$	1,401		$	(22,641	)	$	(58,573	)	$	(17,914	)
Net income (loss) per share, basic and diluted
Basic	$	0.01		$	(0.13	)	$	(0.34	)	$	(0.11	)
Diluted	$	0.01		$	(0.13	)	$	(0.34	)	$	(0.11	)
Weighted average shares used in computing net income (loss) per<br> share, basic and diluted
Basic		172,851			171,071			172,406			170,492
Diluted		172,856			170,071			172,406			170,492
Note A
Stock-based compensation expense included in:
Selling, general and administrative	$	3,426		$	1,712		$	10,217		$	7,337
Research and development		654			178			2,168			1,700
Restructuring charges		-			449			-			449
	$	4,080		$	2,339		$	12,385		$	9,486

SUMMARY BALANCE SHEET DATA

(in thousands)

	As of December 31,
	2022			2021
Cash,<br> cash equivalents and short-term investments	$	58,206		$	124,967
Total assets		134,279			167,328
Stockholders'<br> equity (deficit)		(13,616	)		30,374