TWO SIGMA ADVISERS, LP

Position in CRBU — Caribou Biosciences, Inc.

CIK 1478735 NEW YORK, NY

Position in CRBU

as of Dec 31, 2025 · filed Feb 17, 2026 Compact

Position Value

$1,773,963

-$1,085,879 QoQ

Shares Held

1,115,700

-9.1% QoQ

Ownership

1.12%

of shares outstanding

% of Portfolio

0.00%

of 13F equity value

Holder Rank

—

not a current holder

Holding Since

Sep 2023

10 quarters on record

Voting authority Sole 95.55436049117147.ToString("F0")% Shared 0.ToString("F0")% None 4.445639508828538.ToString("F0")%

Healthcare · as of Dec 31, 2025

TWO SIGMA ADVISERS, LP holds $2,538,392,646 across 227 Biotechnology names. CRBU ranks #82 (0.1% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	REGN	Regeneron Pharmaceuticals, Inc.	604,540	$466,626,289
2	ALNY	Alnylam Pharmaceuticals, Inc.	1,132,560	$450,362,484
3	IONS	Ionis Pharmaceuticals Inc	3,052,111	$241,452,501
4	MRNA	Moderna, Inc.	7,729,700	$227,948,853
5	ARGX	Argenx SE	135,500	$113,948,725
6	BBIO	BridgeBio Pharma, Inc.	1,401,035	$107,165,167
7	VKTX	Viking Therapeutics, Inc.	2,129,228	$74,906,241
8	INSM	INSMED Inc	395,000	$68,745,800

10 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2025-12-31	$1,773,963	1,115,700	-9.1%	Shares	Sole	2026-02-17
2025-09-30	$2,859,842	1,227,400	-15.2%	Shares	Sole	2025-11-14
2025-06-30	$1,824,228	1,447,800	-3.9%	Shares	Sole	2025-08-14
2025-03-31	$1,376,073	1,507,200	+2.5%	Shares	Sole	2025-05-15
2024-12-31	$2,338,413	1,470,700	+39.5%	Shares	Sole	2025-02-14
2024-09-30	$2,066,036	1,054,100	+1.8%	Shares	Sole	2024-11-14
2024-06-30	$1,698,548	1,035,700	+2132.1%	Shares	Sole	2024-08-14
2024-03-31	$238,496	46,400	-32.6%	Shares	Sole	2024-05-15
2023-12-31	$394,224	68,800	+391.4%	Shares	Sole	2024-02-14
2023-09-30	$66,920	14,000	—	Shares	Sole	2023-11-14
No filing history on record for this holder in this stock.