Holocene Advisors, LP

Position in DNLI — Denali Therapeutics Inc.

CIK 1700574 New York, NY

Position in DNLI

as of Jun 30, 2026 · filed Aug 14, 2026 Compact

Position Value

$100,442,387

+$39,090,151 QoQ

Shares Held

3,905,225

+22.2% QoQ

Ownership

2.44%

of shares outstanding

% of Portfolio

0.23%

of 13F equity value

Holder Rank

#11

of 290 holders

Holding Since

Mar 2024

9 quarters on record

Voting authority Sole 100% Shared 0% None 0%

Healthcare · as of Jun 30, 2026

Holocene Advisors, LP holds $1,266,200,483 across 29 Biotechnology names. DNLI ranks #2 (7.9% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	RVMD	Revolution Medicines, Inc.	1,359,269	$254,563,898
2	DNLI	Denali Therapeutics Inc. This page	3,905,225	$100,442,387
3	CYTK	Cytokinetics Inc	1,144,579	$97,506,685
4	SRRK	Scholar Rock Holding Corp	1,755,978	$96,578,790
5	ARWR	Arrowhead Pharmaceuticals, Inc.	1,106,177	$90,164,487
6	SYRE	Spyre Therapeutics, Inc.	1,015,170	$90,126,792
7	MDGL	Madrigal Pharmaceuticals, Inc.	152,924	$82,112,541
8	TNGX	Tango Therapeutics, Inc.	2,410,939	$75,365,953

9 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-06-30	$100,442,387	3,905,225	+22.2%	Shares	Sole	2026-08-14
2026-03-31	$61,352,236	3,195,429	+1.4%	Shares	Sole	2026-05-15
2025-12-31	$52,051,638	3,152,734	+0.5%	Shares	Sole	2026-02-17
2025-09-30	$45,530,538	3,135,712	+677.8%	Shares	Sole	2025-11-14
2025-06-30	$5,640,376	403,172	+102.5%	Shares	Sole	2025-08-14
2024-12-31	$4,057,087	199,072	+104.3%	Shares	Sole	2025-02-14
2024-09-30	$2,838,631	97,447	+65.0%	Shares	Sole	2024-11-14
2024-06-30	$1,370,955	59,042	-93.1%	Shares	Sole	2024-08-14
2024-03-31	$17,666,652	860,948	—	Shares	Sole	2024-05-15
No filing history on record for this holder in this stock.