TWO SIGMA INVESTMENTS, LP

Position in IRWD — Ironwood Pharmaceuticals Inc

CIK 1179392 NEW YORK, NY

Position in IRWD

as of Mar 31, 2026 · filed May 15, 2026 Compact

Position Value

$20,527,448

+$10,912,148 QoQ

Shares Held

5,848,276

+105.0% QoQ

Ownership

3.55%

of shares outstanding

% of Portfolio

0.02%

of 13F equity value

Holder Rank

—

not a current holder

Holding Since

Mar 2020

23 quarters on record

Voting authority Sole 98.21656843828848.ToString("F0")% Shared 0.ToString("F0")% None 1.78343156171152.ToString("F0")%

Healthcare · as of Mar 31, 2026

TWO SIGMA INVESTMENTS, LP holds $750,878,580 across 46 Drug Manufacturers - Specialty & Generic names. IRWD ranks #6 (2.7% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	NBIX	Neurocrine Biosciences Inc	3,060,570	$403,199,491
2	BCRX	Biocryst Pharmaceuticals Inc	6,392,628	$60,857,818
3	ALKS	Alkermes plc.	780,683	$27,604,950
4	ESPR	Esperion Therapeutics, Inc.	9,458,779	$25,917,054
5	LQDA	Liquidia Corp	563,233	$21,256,413
6	IRWD	Ironwood Pharmaceuticals Inc This page	5,848,276	$20,527,448
7	KNSA	Kiniksa Pharmaceuticals International, plc	420,914	$20,267,009
8	COLL	Collegium Pharmaceutical, Inc	590,116	$19,515,136

23 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-03-31	$20,527,448	5,848,276	+105.0%	Shares	Sole	2026-05-15
2025-12-31	$9,615,300	2,853,205	+12.6%	Shares	Sole	2026-02-17
2025-09-30	$3,320,209	2,534,511	-7.9%	Shares	Sole	2025-11-14
2025-06-30	$1,980,412	2,750,573	+124.1%	Shares	Sole	2025-08-14
2025-03-31	$1,803,978	1,227,196	+42.1%	Shares	Sole	2025-05-15
2024-12-31	$3,824,986	863,428	-3.1%	Shares	Sole	2025-02-14
2024-09-30	$3,670,767	890,963	-2.9%	Shares	Sole	2024-11-14
2024-06-30	$5,982,712	917,594	-22.8%	Shares	Sole	2024-08-14
2024-03-31	$10,349,509	1,188,233	+102.8%	Shares	Sole	2024-05-15
2023-12-31	$6,702,089	585,847	-58.0%	Shares	Sole	2024-02-14
2023-09-30	$13,425,789	1,394,163	-47.4%	Shares	Sole	2023-11-14
2023-06-30	$28,192,276	2,649,650	+73.8%	Shares	Sole	2023-08-14
2023-03-31	$16,034,804	1,524,221	-3.8%	Shares	Sole	2023-05-15
2022-12-31	$19,634,259	1,584,686	+853.2%	Shares	Sole	2023-02-14
2022-09-30	$1,722,422	166,257	-80.7%	Shares	Sole	2022-11-14
2022-06-30	$9,909,965	859,494	-3.3%	Shares	Sole	2022-08-15
2022-03-31	$11,182,211	888,888	+162.5%	Shares	Sole	2022-05-16
2021-09-30	$4,422,560	338,634	+34.4%	Shares	Sole	2021-11-15
2021-06-30	$3,242,158	251,916	-45.4%	Shares	Sole	2021-08-16
2021-03-31	$5,160,542	461,587	-33.4%	Shares	Sole	2021-05-17
2020-12-31	$7,892,757	692,955	+401.2%	Shares	Sole	2021-02-16
2020-09-30	$1,243,011	138,266	-47.1%	Shares	Sole	2020-11-16
2020-03-31	$2,638,020	261,449	—	Shares	Sole	2020-05-15
No filing history on record for this holder in this stock.