TWO SIGMA INVESTMENTS, LP

Position in SUPN — Supernus Pharmaceuticals, Inc.

CIK 1179392 NEW YORK, NY

Position in SUPN

as of Jun 30, 2026 · filed Aug 14, 2026 Compact

Position Value

$55,085,420

+$41,065,645 QoQ

Shares Held

1,184,378

+336.7% QoQ

Ownership

2.04%

of shares outstanding

% of Portfolio

0.05%

of 13F equity value

Holder Rank

#14

of 331 holders

Holding Since

Mar 2020

22 quarters on record

Voting authority Sole 99% Shared 0% None 1%

Healthcare · as of Jun 30, 2026

TWO SIGMA INVESTMENTS, LP holds $775,744,366 across 48 Drug Manufacturers - Specialty & Generic names. SUPN ranks #3 (7.1% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	NBIX	Neurocrine Biosciences Inc	2,076,260	$349,932,860
2	BCRX	Biocryst Pharmaceuticals Inc	6,775,349	$67,753,490
3	SUPN	Supernus Pharmaceuticals, Inc. This page	1,184,378	$55,085,420
4	ALKS	Alkermes plc.	1,038,311	$54,407,496
5	KNSA	Kiniksa Pharmaceuticals International, plc	561,480	$35,906,646
6	ZTS	Zoetis Inc.	386,428	$27,768,716
7	LQDA	Liquidia Corp	266,829	$21,274,276
8	IRWD	Ironwood Pharmaceuticals Inc	4,556,089	$19,181,134

22 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-06-30	$55,085,420	1,184,378	+336.7%	Shares	Sole	2026-08-14
2026-03-31	$14,019,775	271,228	+124.8%	Shares	Sole	2026-05-15
2025-12-31	$5,997,100	120,666	-53.2%	Shares	Sole	2026-02-17
2025-09-30	$12,328,673	257,976	+350.2%	Shares	Sole	2025-11-14
2025-06-30	$1,806,253	57,305	-41.1%	Shares	Sole	2025-08-14
2025-03-31	$3,184,086	97,224	+289.1%	Shares	Sole	2025-05-15
2024-12-31	$903,529	24,987	-70.5%	Shares	Sole	2025-02-14
2024-09-30	$2,636,799	84,567	+74.1%	Shares	Sole	2024-11-14
2024-06-30	$1,299,006	48,561	+107.1%	Shares	Sole	2024-08-14
2024-03-31	$799,947	23,452	-88.0%	Shares	Sole	2024-05-15
2023-12-31	$5,636,991	194,782	+190.6%	Shares	Sole	2024-02-14
2023-09-30	$1,848,044	67,031	-73.9%	Shares	Sole	2023-11-14
2023-06-30	$7,732,213	257,226	+23.2%	Shares	Sole	2023-08-14
2023-03-31	$7,564,968	208,804	+50.6%	Shares	Sole	2023-05-15
2022-12-31	$4,944,468	138,617	+34.5%	Shares	Sole	2023-02-14
2022-09-30	$3,488,174	103,048	+460.4%	Shares	Sole	2022-11-14
2022-03-31	$594,332	18,389	-52.4%	Shares	Sole	2022-05-16
2021-06-30	$1,188,247	38,592	-84.6%	Shares	Sole	2021-08-16
2021-03-31	$6,554,608	250,367	+329.8%	Shares	Sole	2021-05-17
2020-12-31	$1,465,494	58,247	-80.3%	Shares	Sole	2021-02-16
2020-06-30	$7,005,015	294,948	+42.5%	Shares	Sole	2020-08-14
2020-03-31	$3,723,246	206,962	—	Shares	Sole	2020-05-15
No filing history on record for this holder in this stock.