TWO SIGMA SECURITIES, LLC

Broker-Dealer

Position in JAGX — Jaguar Health, Inc.

CIK 1450144 NEW YORK, NY

Position in JAGX

as of Mar 31, 2026 · filed May 15, 2026 Compact

Position Value

$4,656

-$12,059 QoQ

Shares Held

359

+2464.3% QoQ

Ownership

0.007%

of shares outstanding

% of Portfolio

0.00%

of 13F equity value

Holder Rank

—

not a current holder

Holding Since

Jun 2020

10 quarters on record

Voting authority Sole 100% Shared 0% None 0%

Healthcare · as of Jun 30, 2026

TWO SIGMA SECURITIES, LLC holds $22,805,438 across 104 Biotechnology names.

#	Ticker	Company	Shares	Value (USD)
1	REGN	Regeneron Pharmaceuticals, Inc.	5,761	$3,592,213
2	ALNY	Alnylam Pharmaceuticals, Inc.	5,585	$1,681,252
3	BBIO	BridgeBio Pharma, Inc.	17,689	$1,317,476
4	MDGL	Madrigal Pharmaceuticals, Inc.	2,219	$1,191,492
5	INSM	INSMED Inc	10,338	$1,102,237
6	HALO	Halozyme Therapeutics, Inc.	12,525	$980,331
7	ARWR	Arrowhead Pharmaceuticals, Inc.	11,256	$917,476
8	AXSM	Axsome Therapeutics, Inc.	3,708	$907,607

10 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-03-31	$4,656	12,551	+1.4%	Shares	Sole	2026-05-15
2024-09-30	$16,715	12,382	-80.1%	Shares	Sole	2024-11-14
2023-12-31	$9,400	62,255	+109.6%	Shares	Sole	2024-02-14
2023-06-30	$15,324	29,698	-42.8%	Shares	Sole	2023-08-14
2023-03-31	$32,612	51,931	-19.4%	Shares	Sole	2023-05-15
2022-12-31	$5,608	64,470	+506.4%	Shares	Sole	2023-02-14
2022-03-31	—	10,631	-77.9%	Shares	Sole	2022-05-16
2021-12-31	—	48,180	-48.2%	Shares	Sole	2022-02-14
2020-12-31	—	92,940	+448.8%	Shares	Sole	2021-02-16
2020-06-30	—	16,936	—	Shares	Sole	2020-09-10
No filing history on record for this holder in this stock.