RTW INVESTMENTS, LP

Position in ORKA — Oruka Therapeutics, Inc.

CIK 1493215 NEW YORK, NY

Position in ORKA

as of Jun 30, 2026 · filed Aug 14, 2026 Compact

Position Value

$298,741,485

+$197,789,326 QoQ

Shares Held

3,139,030

+52.5% QoQ

Ownership

4.74%

of shares outstanding

% of Portfolio

2.55%

of 13F equity value

Holder Rank

of 254 holders

Holding Since

Jun 2024

9 quarters on record

Voting authority Sole 100% Shared 0% None 0%

Healthcare · as of Jun 30, 2026

RTW INVESTMENTS, LP holds $9,530,420,260 across 63 Biotechnology names. ORKA ranks #11 (3.1% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	MDGL	Madrigal Pharmaceuticals, Inc.	1,993,687	$1,070,510,234
2	ARGX	Argenx SE	709,446	$658,202,715
3	PTCT	Ptc Therapeutics, Inc.	7,746,415	$631,875,071
4	PTGX	Protagonist Therapeutics, Inc	5,061,175	$620,398,831
5	CGON	CG Oncology, Inc.	8,514,590	$604,961,619
6	INSM	INSMED Inc	4,842,880	$516,347,865
7	TNGX	Tango Therapeutics, Inc.	13,900,620	$434,533,381
8	SYRE	Spyre Therapeutics, Inc.	4,251,996	$377,492,204

10 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-06-30	$298,741,485	3,139,030	+52.5%	Shares	Sole	2026-08-14
2026-06-30	$298,741,485	3,139,030	—	Shares	Sole	2026-08-14
2026-03-31	$100,952,159	2,058,148	0.0%	Shares	Sole	2026-05-15
2025-12-31	$62,382,465	2,058,148	+5.8%	Shares	Sole	2026-02-17
2025-09-30	$37,414,830	1,945,649	0.0%	Shares	Sole	2025-11-14
2025-06-30	$21,810,725	1,945,649	0.0%	Shares	Sole	2025-08-14
2025-03-31	$19,962,358	1,945,649	0.0%	Shares	Sole	2025-05-15
2024-12-31	$37,726,134	1,945,649	+5.1%	Shares	Sole	2025-02-14
2024-09-30	$45,359,382	1,850,648	—	Shares	Sole	2024-11-14
2024-06-30 ABIO	—	1,400,000	—	Shares	Sole	2024-08-14
No filing history on record for this holder in this stock.