TWO SIGMA SECURITIES, LLC

Broker-Dealer

Position in PALI — Palisade Bio, Inc.

CIK 1450144 NEW YORK, NY

Position in PALI

as of Jun 30, 2026 · filed Aug 14, 2026 Compact

Position Value

$57,370

+$32,081 QoQ

Shares Held

27,450

-6.7% QoQ

Ownership

0.016%

of shares outstanding

% of Portfolio

0.01%

of 13F equity value

Holder Rank

#92

of 124 holders

Holding Since

Dec 2021

11 quarters on record

Voting authority Sole 100% Shared 0% None 0%

Healthcare · as of Jun 30, 2026

TWO SIGMA SECURITIES, LLC holds $22,805,438 across 104 Biotechnology names. PALI ranks #53 (0.3% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	REGN	Regeneron Pharmaceuticals, Inc.	5,761	$3,592,213
2	ALNY	Alnylam Pharmaceuticals, Inc.	5,585	$1,681,252
3	BBIO	BridgeBio Pharma, Inc.	17,689	$1,317,476
4	MDGL	Madrigal Pharmaceuticals, Inc.	2,219	$1,191,492
5	INSM	INSMED Inc	10,338	$1,102,237
6	HALO	Halozyme Therapeutics, Inc.	12,525	$980,331
7	ARWR	Arrowhead Pharmaceuticals, Inc.	11,256	$917,476
8	AXSM	Axsome Therapeutics, Inc.	3,708	$907,607

11 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-06-30	$57,370	27,450	-6.7%	Shares	Sole	2026-08-14
2025-09-30	$25,289	29,406	+84.1%	Shares	Sole	2025-11-14
2025-06-30	$10,858	15,969	+12.8%	Shares	Sole	2025-08-14
2025-03-31	$9,624	14,153	-49.8%	Shares	Sole	2025-05-15
2024-03-31	$11,283	28,208	+43.5%	Shares	Sole	2024-05-15
2023-12-31	$11,594	19,652	-0.2%	Shares	Sole	2024-02-14
2022-12-31	$102,398	19,692	-75.9%	Shares	Sole	2023-02-14
2022-09-30	$8,163	81,638	+167.6%	Shares	Sole	2022-11-14
2022-06-30	$12,510	30,513	-10.7%	Shares	Sole	2022-08-15
2022-03-31	$36,227	34,177	+135.8%	Shares	Sole	2022-05-16
2021-12-31	$18,840	14,493	—	Shares	Sole	2022-02-14
No filing history on record for this holder in this stock.