TWO SIGMA SECURITIES, LLC
Broker-DealerPosition in SPRO — Spero Therapeutics, Inc.
CIK 1450144
NEW YORK, NY
Position in SPRO
as of Jun 30, 2026
· filed Aug 14, 2026
Position Value
$23,372
-$64,674 QoQ
Shares Held
10,576
-84.4% QoQ
Ownership
0.018%
of shares outstanding
% of Portfolio
0.00%
of 13F equity value
Holder Rank
#45
of 59 holders
Holding Since
Dec 2022
4 quarters on record
Voting authority
Sole 100%
Shared 0%
None 0%
Common Shares in SPRO Over Time
Shares Held
Position Value (USD)
Position in Biotechnology
Healthcare · as of Jun 30, 2026TWO SIGMA SECURITIES, LLC holds $22,805,438 across 104 Biotechnology names. SPRO ranks #71 (0.1% of the industry book) .
| # | Ticker | Company | Shares | Value (USD) | Open |
|---|---|---|---|---|---|
| 1 | REGN |
Regeneron Pharmaceuticals, Inc.
|
5,761 | $3,592,213 | |
| 2 | ALNY |
Alnylam Pharmaceuticals, Inc.
|
5,585 | $1,681,252 | |
| 3 | BBIO |
BridgeBio Pharma, Inc.
|
17,689 | $1,317,476 | |
| 4 | MDGL |
Madrigal Pharmaceuticals, Inc.
|
2,219 | $1,191,492 | |
| 5 | INSM |
INSMED Inc
|
10,338 | $1,102,237 | |
| 6 | HALO |
Halozyme Therapeutics, Inc.
|
12,525 | $980,331 | |
| 7 | ARWR |
Arrowhead Pharmaceuticals, Inc.
|
11,256 | $917,476 | |
| 8 | AXSM |
Axsome Therapeutics, Inc.
|
3,708 | $907,607 |
All Filings in SPRO
Export CSV
4 filing rows on record
| Report Date | Value (USD) | Shares | Type | Discretion | Filed | |
|---|---|---|---|---|---|---|
| 2026-06-30 | $23,372 | 10,576 | Shares | Sole | 2026-08-14 | |
| 2024-06-30 | $88,046 | 67,728 | Shares | Sole | 2024-08-14 | |
| 2023-12-31 | $15,142 | 10,301 | Shares | Sole | 2024-02-14 | |
| 2022-12-31 | $40,694 | 23,523 | Shares | Sole | 2023-02-14 | |
| No filing history on record for this holder in this stock. | ||||||