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Equibles

JANUS HENDERSON GROUP PLC

Position in SYRE — Spyre Therapeutics, Inc.

CIK 1274173 LONDON, X0
Back to SYRE Full portfolio

Position in SYRE

as of Mar 31, 2026 · filed May 18, 2026
Position Value
$83,536,912
+$23,618,578 QoQ
Shares Held
1,656,164
-9.5% QoQ
Ownership
1.88%
of shares outstanding
% of Portfolio
0.04%
of 13F equity value
Holder Rank
—
not a current holder
Holding Since
Mar 2024
9 quarters on record
Voting authority Sole 0% Shared 99% None 1%

Common Shares in SYRE Over Time

Shares Held

Position Value (USD)

Position in Biotechnology

Healthcare · as of Mar 31, 2026

JANUS HENDERSON GROUP PLC holds $15,214,395,751 across 183 Biotechnology names. SYRE ranks #32 (0.5% of the industry book) .

# Ticker Company Shares Value (USD) Open
1 ARGX
Argenx SE
 2,541,732 $1,856,099,791
2 PRAX
Praxis Precision Medicines, Inc.
 3,458,863 $1,114,411,067
3 MDGL
Madrigal Pharmaceuticals, Inc.
 2,018,647 $1,056,701,142
4 BBIO
BridgeBio Pharma, Inc.
 13,179,013 $978,673,503
5 PCVX
Vaxcyte, Inc.
 16,575,875 $963,224,094
6 VRTX
Vertex Pharmaceuticals Inc / Ma
 2,131,527 $951,812,064
7 RVMD
Revolution Medicines, Inc.
 9,766,496 $949,791,733
8 MIRM
Mirum Pharmaceuticals, Inc.
 6,945,813 $641,654,204

All Filings in SYRE

Export CSV
9 filing rows on record
Report Date Value (USD) Shares
2026-03-31 $83,536,912 1,656,164
2025-12-31 $59,918,334 1,829,009
2025-09-30 $217,880 13,000
2025-06-30 $194,610 13,000
2025-03-31 $16,803,150 1,041,410
2024-12-31 $33,912,907 1,456,740
2024-09-30 $32,954,816 1,120,531
2024-06-30 $15,842,613 673,867
2024-03-31 $530,147 13,977