5AM Venture Management, LLC

CIK

1799883

City

SAN FRANCISCO

State / Country

CA

Stock

TYRA — Tyra Biosciences, Inc.

Top Portfolio Positions

20 positions · $360,212,474 total · as of Mar 31, 2026

Ticker	Company	Shares	Value (USD)	% of Portfolio	Open
ERAS	Erasca, Inc. Healthcare	3,485,971	$56,403,010	15.66%
TRDA	Entrada Therapeutics, Inc. Healthcare	4,056,379	$51,191,502	14.21%
TYRA	Tyra Biosciences, Inc. Healthcare	1,029,298	$39,422,113	10.94%
CAMP	Camp4 Therapeutics Corp Healthcare	5,869,091	$25,882,691	7.19%
CNTA	Centessa Pharmaceuticals plc Healthcare	580,945	$23,075,135	6.41%
PHVS	Pharvaris N.V. Healthcare	797,600	$22,532,200	6.26%
MPLT	MapLight Therapeutics, Inc. Healthcare	950,011	$19,313,723	5.36%
TECX	Tectonic Therapeutic, Inc. Healthcare	606,660	$18,751,860	5.21%
CLDX	Celldex Therapeutics, Inc. Healthcare	497,270	$15,773,404	4.38%
ARTV	Artiva Biotherapeutics, Inc. Healthcare	2,353,304	$15,155,277	4.21%

Portfolio Trend

25 quarters · across all stocks

Holdings in TYRA

Compact Export CSV

Shares Held

Position Value (USD)

11 quarters on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-03-31	$39,422,113	1,029,298	0.0%	Shares	Sole	2026-05-15
2025-12-31	$27,060,244	1,029,298	+9.6%	Shares	Sole	2026-02-17
2025-09-30	$13,140,779	939,298	0.0%	Shares	Sole	2025-11-14
2025-06-30	$8,989,081	939,298	0.0%	Shares	Sole	2025-08-14
2025-03-31	$8,735,471	939,298	0.0%	Shares	Sole	2025-05-15
2024-12-31	$13,056,242	939,298	0.0%	Shares	Sole	2025-02-14
2024-09-30	$22,082,895	939,298	0.0%	Shares	Sole	2024-11-14
2024-06-30	$15,019,375	939,298	0.0%	Shares	Sole	2024-08-14
2024-03-31	$15,404,487	939,298	+69.2%	Shares	Sole	2024-05-15
2023-12-31	$7,686,459	554,979	+34.9%	Shares	Sole	2024-02-14
2023-09-30	$5,665,666	411,450	—	Shares	Sole	2023-11-14
No 13F history on record for this holder in this stock.