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ADPT · Adaptive Biotechnologies Corp

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$24.74 +0.28 (+1.14%) At close · Aug 14
Market Cap
$3.95B
Shares
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All earnings calls

Earnings call · FY2025 Q4

Adaptive Biotechnologies Corp Q4 FY2025 Earnings Call

Adaptive Biotechnologies Corp Q4 FY2025 Earnings Call

Concluded Feb 5, 2026
Feb 5, 2026 42 turns
Period
FY2025 Q4
Runtime
Sources
3 artifacts

Executive readout · one minute

What matters this quarter

Adaptive Biotechnologies reported strong Q4 and full-year 2025 results, with total revenue up 55% for the year to $277 million and MRD revenue up 46%, while cutting cash burn by 68% and ending with $227 million in cash.

MRD business growth and profitability 53 ClonoSEQ volume and test growth 33 ASP expansion and payer contracts 28 Immune Medicine data licensing strategy 22 EMR integrations and community expansion 20 Execution risk on 2026 guidance 20

Management tone

Confident

Net tone +75 · moderate hedging

Grounding quotes
  • “2025 was a remarkable year for Adaptive, marked by strong execution and meaningful progress across the business.”
  • “we achieved profitability ahead of expectations”
  • “instilling confidence that we can achieve or surpass our goals”
  • “we are quite confident in the ASP guidance, and we have multiple strategies to achieve it”

Forward guidance

1 guided metrics

Management's latest ranges and targets are included below.

Research coverage

3 live sources

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Revenue · derived Q4 $71.68M +51% YoY
Net income · derived Q4 -$13.58M

Research materials

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Key takeaways

What improved, and what deserves a closer read.

Constructive signals

  • Full-year 2025 total revenue grew 55% to $277 million, with Q4 revenue up 51% to ~$72 million
  • MRD revenue grew 46% for the year and 54% in Q4 to ~$62 million, with MRD adjusted EBITDA turning positive at $15.2 million vs. a $41.2 million loss in 2024
  • clonoSEQ test volume hit a record 30,038 tests in Q4, up 43% YoY, with full-year volumes of ~105,600 tests up 39%
  • Average U.S. ASP exited Q4 at ~$1,350 per test, up 17% YoY, supported by renegotiated payer contracts and 74% YoY growth in commercial payer cash collections
  • Full-year adjusted EBITDA improved to $12.2 million from a loss of $80.4 million in 2024, and cash burn declined 68%
  • Immune Medicine revenue rose to $9.8 million in Q4 from $3.8 million a year ago, driven by a Pfizer data licensing deal

Risks & pressure points

  • Full-year net loss of $59.5 million and Q4 net loss of $13.6 million
  • Immune Medicine adjusted EBITDA loss of $31 million in 2025, with an expected $15–20 million net burn in 2026
  • $1,400 targeted ASP for 2026 relies on closing two additional large national payer contracts, with execution risk acknowledged by management
  • Orbimed interest expense was $11.8 million for the year ($3 million in Q4)

Key moments

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“Additionally, we expect to achieve positive adjusted EBITDA and positive free cash flow for the entire company by the end of 2026.” Kyle Piskel, CFO

Guidance from the call

Stated verbally and extracted from the transcript.

Metric Guided
Average ASP per test
2026
$1,400
Full-screen source Call document