Position in APLS
as of Mar 31, 2026
· filed May 15, 2026
Position Value
$0
+$0 QoQ
Shares Held
186,853
-58.4% QoQ
Ownership
0.146%
of shares outstanding
% of Portfolio
0.00%
of 13F equity value
Holder Rank
—
not a current holder
Holding Since
Mar 2020
25 quarters on record
Voting authority
Sole 93%
Shared 0%
None 7%
Common Shares in APLS Over Time
Shares Held
Position Value (USD)
Derivatives in APLS
reported options exposure · as of Dec 31, 2025CallValue
$0
CallShares
13,900
PutValue
$0
PutShares
15,000
Notional value of option positions as reported on Form 13F. Calls and puts are disclosed separately and do not net against the common-share stake above.
Position in Biotechnology
Healthcare · as of Jun 30, 2026D. E. Shaw & Co., Inc. holds $5,017,559,982 across 217 Biotechnology names.
| # | Ticker | Company | Shares | Value (USD) | Open |
|---|---|---|---|---|---|
| 1 | INSM |
INSMED Inc
|
5,877,959 | $626,707,987 | |
| 2 | ALNY |
Alnylam Pharmaceuticals, Inc.
|
1,104,109 | $332,369,932 | |
| 3 | EXEL |
Exelixis, Inc.
|
5,551,747 | $302,070,554 | |
| 4 | BBIO |
BridgeBio Pharma, Inc.
|
3,633,007 | $270,586,360 | |
| 5 | TGTX |
Tg Therapeutics, Inc.
|
3,400,808 | $186,840,390 | |
| 6 | HALO |
Halozyme Therapeutics, Inc.
|
2,006,479 | $157,047,110 | |
| 7 | AXSM |
Axsome Therapeutics, Inc.
|
604,753 | $148,025,391 | |
| 8 | PTCT |
Ptc Therapeutics, Inc.
|
1,548,919 | $126,345,322 |
All Filings in APLS
Export CSV
37 filing rows on record
| Report Date | Value (USD) | Shares | Type | Discretion | Filed | |
|---|---|---|---|---|---|---|
| 2026-03-31 | — | 186,853 | Shares | Defined | 2026-05-15 | |
| 2025-12-31 | — | 15,000 | Put | Defined | 2026-02-17 | |
| 2025-12-31 | — | 449,676 | Shares | Defined | 2026-02-17 | |
| 2025-12-31 | — | 13,900 | Call | Defined | 2026-02-17 | |
| 2025-09-30 | — | 456,791 | Shares | Defined | 2025-11-14 | |
| 2025-09-30 | — | 13,900 | Call | Defined | 2025-11-14 | |
| 2025-09-30 | — | 15,000 | Put | Defined | 2025-11-14 | |
| 2025-06-30 | — | 22,700 | Put | Defined | 2025-08-14 | |
| 2025-06-30 | — | 251,069 | Shares | Defined | 2025-08-14 | |
| 2025-06-30 | — | 13,900 | Call | Defined | 2025-08-14 | |
| 2025-03-31 | — | 38,100 | Put | Defined | 2025-05-15 | |
| 2025-03-31 | — | 18,200 | Call | Defined | 2025-05-15 | |
| 2024-12-31 | — | 31,000 | Put | Defined | 2025-02-14 | |
| 2024-12-31 | — | 20,000 | Shares | Defined | 2025-02-14 | |
| 2024-12-31 | — | 31,700 | Call | Defined | 2025-02-14 | |
| 2024-09-30 | — | 31,700 | Call | Defined | 2024-11-14 | |
| 2024-06-30 | — | 34,900 | Call | Defined | 2024-08-14 | |
| 2024-03-31 | — | 37,700 | Call | Defined | 2024-05-15 | |
| 2023-12-31 | — | 33,086 | Shares | Defined | 2024-02-14 | |
| 2023-12-31 | — | 29,500 | Call | Defined | 2024-02-14 | |
| 2023-09-30 | — | 39,473 | Shares | Defined | 2023-11-14 | |
| 2023-09-30 | — | 29,500 | Call | Defined | 2023-11-14 | |
| 2023-06-30 | — | 527,811 | Shares | Defined | 2023-08-14 | |
| 2023-06-30 | — | 29,500 | Call | Defined | 2023-08-14 | |
| 2023-03-31 | — | 412,853 | Shares | Defined | 2023-05-15 | |
| 2022-12-31 | — | 12,898 | Shares | Defined | 2023-02-14 | |
| 2022-09-30 | — | 197,364 | Shares | Defined | 2022-11-14 | |
| 2022-06-30 | — | 4,570 | Shares | Defined | 2022-08-15 | |
| 2022-03-31 | — | 33,034 | Shares | Defined | 2022-05-16 | |
| 2021-12-31 | — | 37,890 | Shares | Defined | 2022-02-14 | |
| 2021-09-30 | — | 75,522 | Shares | Defined | 2021-11-15 | |
| 2021-06-30 | — | 245,029 | Shares | Defined | 2021-08-16 | |
| 2021-03-31 | — | 336,643 | Shares | Defined | 2021-05-17 | |
| 2020-12-31 | — | 414,062 | Shares | Defined | 2021-02-16 | |
| 2020-09-30 | — | 385,866 | Shares | Defined | 2020-11-16 | |
| 2020-06-30 | — | 531,761 | Shares | Defined | 2020-08-14 | |
| 2020-03-31 | — | 369,733 | Shares | Defined | 2020-05-15 | |
| No filing history on record for this holder in this stock. | ||||||