Inmune Bio, Inc. Q1 FY2025 Earnings Call

Greetings. And welcome to the INmune Bio First Quarter 2025 Earnings Call. At this time, all participants are in a listen-only mode. Later, you will have the opportunity to ask questions during the question-and-answer session. As a reminder, this conference is being recorded. A transcript will follow within 24 hours of this conference call. At this time, it is my pleasure to introduce Dr., excuse me, Mr. David Moss, CFO of INmune Bio. David?

Thank you, Jessie, and good afternoon, everyone. We thank you for joining us for the call for INmune Bio’s first quarter 2025 financial results. With me on the call today are Dr. RJ Tesi, CEO of INmune Bio; and Dr. Mark Lowdell, Chief Scientific Officer of INmune Bio, who will provide an update on our CORDStrom and INKmune programs. Also on the call is Dr. CJ Barnum, Head of Neuroscience, who will be here to answer questions. Before we begin, I remind everyone that except for statements of historical facts, the statements made by management in response to questions on this conference call are forward-looking statements under the Safe Harbors provisions of the Private Securities Litigation Reform Act of 1995. These statements involve risks and uncertainties that can cause actual results to differ materially from those such as forward-looking statements. Please see the forward-looking statements disclaimer on the company’s earnings press release, as well as risk factors in the company’s SEC filings, including our most recent quarterly filings with the SEC. There’s no assurance of any specific outcome. Undue reliance should not be placed on forward-looking statements, which speak only as of the date they are made, as the facts and circumstances underlying these forward-looking statements may change. Except as required by law, INmune Bio disclaims any obligation to update these forward-looking statements to reflect future information, events or circumstances. With that behind us, now it’s my pleasure to turn the call over to RJ Tesi. RJ?

Thank you, David. For our first quarter 2025 call, I will review key takeaways and provide an update on our platform programs. Following my comments on recent developments, Dr. Mark Lowdell, INmune Bio CSO and inventor of both CORDstrom and INKmune, will provide an update on those programs. David Moss, INmune Bio CFO, will then conclude with a review of the first quarter financial results and update future catalysts. Then we will be happy to take your questions. I’m sure everyone on this call knows we will soon be reporting topline results from MINDFuL, that is our Phase 2 trial in patients with early Alzheimer’s disease. The results are expected mid-to-late June. In about 50 days, we will know the answer to the question, what happens in Alzheimer’s disease when you properly target neuroinflammation? Our last investor update call was just a short six weeks ago. But there have been important and I believe positive changes in the Alzheimer’s disease marketplace during that short period of time. We believe these changes will be beneficial to expose market opportunity in early Alzheimer’s disease. Last month at ADPD, which is the largest Alzheimer’s disease meeting in Europe, INmune Bio reported the biomarker profile of patients enrolled in the MINDFuL study. The data confirmed that we have been underestimating the market opportunity for XPro in patients with early AD. Historically, we stated that up to half of the early Alzheimer’s patients will qualify for XPro based on the biomarkers we used as our enrollment criteria. Based on the data INmune Bio and other companies presented at ADPD, we now believe more than two-thirds of early Alzheimer’s disease patients will be eligible for XPro based on ApoE4 status alone. I remind you that ApoE4 positivity was one of the four enrichment or enrollment criteria we used in the MINDFuL study. The ApoE4 status of patients in MINDFuL is almost identical to what is reported in recent major trials in Alzheimer’s. Patients with at least one ApoE4 allele make up more than two-thirds of the patients in these trials. This means the market opportunity for XPro in early AD has increased to nearly 70% of early AD patients, not the 40% we have previously been discussing. On the call six weeks ago, I also mentioned the safety profile of XPro in the MINDFuL trial. Nothing has changed. There are no reports of area. No patients have had unscheduled MRIs due to pNF symptoms or headaches, and there have been no deaths. So far, XPro is safe and well-tolerated in this patient population that has an average age of 73 years old, and many of them have a long list of comorbidities. The excellent safety profile of XPro in these patients provides a unique ApoE4-related market opportunity for XPro. Let me explain. Both the EU and the U.K. have approved lecanemab, the anti-amyloid drug, for patients with early Alzheimer’s disease who have none or one copy of the ApoE4 gene. The market authorizations specifically exclude patients who carry two ApoE4 alleles. In the early AD trials that report ApoE4 status, ApoE4 homozygotes, meaning patients that have two ApoE4 alleles, are 15% of the patients. This means because of labeling restrictions on lecanemab in the U.K. and EU, early Alzheimer’s patients who are ApoE4 homozygotes will not be eligible for therapy with the anti-amyloid drugs. This group now represents an important unmet need ideally suited for XPro therapy. In the U.S., recent surveys of practice patterns indicate that this population is not treated in many centers due to the risk of area. So even in the U.S., where the labeling is different than what you see in the U.K. and Europe, we believe that after approval, XPro will be the best and only treatment option available for this important subgroup of early Alzheimer’s patients. We should have an exclusively biologically based market. Finally, the biomarker landscape of Alzheimer’s disease is evolving quite quickly. And it’s evolving in a way that truly benefits our focus on these patients. Once the diagnosis of Alzheimer’s is made, p-tau217 in blood has become the biomarker of most importance to clinical teams treating these early Alzheimer’s patients. P-tau217 levels define the severity of Alzheimer’s. p-tau217 levels in the blood have prognostic value and correlate with the stage of disease. In the near future, we predict that changes in p-tau217 blood levels will be used as a pharmacodynamic blood marker of therapeutic response in these patients. As a reminder, XPro significantly decreased p-tau217 during the three-month Phase 1 study, and this biomarker is included in the package of biomarkers that we are studying in the MINDFuL’s Phase 2 program. Having a great drug is a necessary element for a successful clinical program, but it is only part of the story. Since the last patient was enrolled in November, we have been highlighting the hard work needed to report the topline data in June. These are the busiest times. For example, after the last patient has their final safety visit, but before the database is locked, a complex series of critical data management and quality assurance tasks are undertaken to ensure the data are complete, accurate, and ready for analysis. The process begins with data cleaning, where we review case report forms and entries into the electronic data capture system to resolve discrepancies, fill in missing data, and look for outliers. This is a patient-by-patient process. It is labor-intensive. Queries are issued to trial sites to clarify inconsistencies, and there is source data verification to confirm that the recorded data matches the source documents, for instance, the medical records. This phase also involves ensuring compliance with regulatory standards, such as ICH, by maintaining trial records and documenting all changes. After data cleaning is complete, the focus shifts to the final quality checks and preparation for database lock. A comprehensive review of the data is performed to confirm that all queries are resolved, deviations documented and validation checks satisfied. The statistical plan is cross-checked to ensure that all data points are present and correctly formatted, and data monitoring committees conduct final safety and efficacy reviews. We don’t lock the database until we are sure it is clean and accurate. I will also say that this is all done with blinded data. No one knows who got what during this process. We don’t run the statistical programs until the database is locked, and it’s only when that statistical package comes out that the real unblinding occurs. We remain on track for this process to be completed in mid-to-late June, and I can tell you we can hardly wait to see the fruits of our labors. This is a moment we’ve been anticipating for several years. We are confident we will report results that will change the care of patients with early Alzheimer’s disease, and this confidence is highlighted by management’s substantial share ownership. Like you, we are investors in INmune Bio. Our interests are aligned with yours. As important as MINDFuL, our Alzheimer’s trial, is to the company and our investors, it’s not our only program. Correction for the treatment of children with recessive dystrophic epidermolysis bullosa or RDEB is expected to file a BLA in 2026. The INKmune program continues to move forward in men with metastatic castration-resistant prostate cancer. The light is shining more brightly on CORDstrom these days. It is an ortho-based disease program, and after recent comments from the FDA, we are increasingly excited by its prospects. The FDA has stated their intention to move rare disease treatments through the approval process faster, with more input from patients and caregivers. In RDEB, CORDstrom provides a systemic therapy for systemic genetic disease that has the support of patients and caregivers. But enough from me. I will turn the microphone over to Mark Lowdell, the CSO and inventor of both CORDstrom and INKmune, to give you a more in-depth update on those programs. Mark?

Thanks, RJ, and good afternoon, everyone, and thank you for joining us. So, with regard to the latest developments with INKmune, the CaRe PC trial in prostate cancer completed the Phase 1 dose escalation cohorts in December, which allowed us to open the Phase 2 extensions of both the high-dose and intermediate-dose cohorts in parallel, and we reported that in our last call. We saw no adverse events in any of the patients treated during Phase 1, which thus met the primary endpoint of the entire trial, and similarly, none of the patients treated in Phase 2 to date have shown any adverse events, and INKmune remains extremely well-tolerated in this challenging elderly group of patients who’ve had lots of previous treatments and a lot of comorbidities. At the end of March, we reported that INKmune infusions had led to increased NK cell potency in the patients treated at the lowest dose, and the blood samples from patients at the intermediate and high-dose cohorts of Phase 1 and Phase 2 are being received in the INmune Bio labs in London and are being prepared for testing. We will share those results as soon as they’re available. But in parallel, we’re receiving the independent reports of the PSMA PET screening of the Phase 1 patients who’ve completed follow-up. This is a very precise assay of the sizes of individual tumor lesions in each patient before treatment and at three months after the completion of INKmune treatment. This very complex data set is being reviewed by the lead clinician for CaRe PC, but we can already see from subjects in the lowest dose cohort that some lesions have resolved completely following INKmune treatment. We eagerly await the data from the intermediate and high-dose patients, which we’ll share as soon as they become available. The CaRe PC trial continues to recruit Phase 2 subjects and remains on track to complete enrollment this year. The INmune Bio team has manufactured all doses of INKmune for the completion of the trial, and we’ve successfully transitioned the U.S. drug supply logistics from our previous contractor into a U.S. company called Cryoport, so we’re set up for the successful conclusion of the trial. In line with our ambitions for INKmune in prostate cancer and other solid tumors, we’re transitioning our manufacturing into a U.K. Government incubator facility where we can manufacture future drug batches for clinical trial and a successful commercial manufacture and global supply. But while CaRe PC is ongoing, in February, as RJ has said, we announced the development of our CORDstrom asset towards a BLA filing next year, 2026, for the treatment of the extremely debilitating disease, recessive dystrophic epidermolysis bullosa or RDEB. Epidermolysis bullosa, of which RDEB is the most severe form, is an inherited disease that manifests in the first two years of life. The outer layer of the skin, the epidermis, doesn’t anchor properly to the underlying dermis, and children suffer horrific skin blisters over their whole bodies. Worse still is that EB is a systemic disease, as RJ said, so children suffer with lesions behind their eyes, down their esophagus, and throughout their gastrointestinal tract. There’s no systemic treatment for RDEB. CORDstrom is an off-the-shelf, allogeneic mesenchymal stromal cell drug from pooled donors, which INmune Bio has owned since 2019. It was developed by me and some colleagues with academic funding in the U.K., and is a platform that can be used to treat multiple clinical indications by specific selection of the individual donor products used to formulate the final pooled drug. We’ve been selling one formulation of CORDstrom into the U.K. multi-center trial led by pediatricians from Great Ormond Street Children’s Hospital in London to treat children with RDEB. This was a double-blind, placebo-controlled crossover trial which treated all of the eligible children in England with RDEB. The results, when they were unblinded, led to the clinicians and the U.K. National Institute of Health Research asking INmune Bio to develop CORDstrom as a licensed medicine for this disease. We presented the trial data to the U.S. FDA in December, as RJ said. The FDA data review led to the award of rare pediatric disease and orphan drug status for the treatment of epidermolysis bullosa. Following a type C meeting with the FDA in February, we have a clear route to submission of a BLA in 2026 and parallel submissions to the U.K. MHRA and the European Medicines Agency. On our last call, we said that clinical trials are the poster children of drug development. But moving from trials to market requires much more, not least a full development of the drug manufacturing pathway, which meets regulatory requirements, is cost-effective at scale, and meets likely global demand. We’ve taken this on board with respect to CORDstrom in the same way we have with INKmune, and in fact, have developed parallel processes for both drugs, which can share the same manufacturing platforms at all stages of manufacture. It not only simplifies manufacturing facility setup and design, but it allows us to maximize the use of manufacturing space we rent by being able to switch between INKmune production and CORDstrom manufacture, thus controlling our production costs as we move towards commercial supply. Having used the income from selling CORDstrom into the U.K. trial in EB to subsidize the supply of INKmune into CaRe PC, the equipment we’ve been using to manufacture INKmune is now subsidizing the development of CORDstrom, which is a nice, very circular situation. Having completed all manufacture of INKmune for CaRe PC, the U.K. team is dedicated to providing all of the data needed for the BLA submission next year for CORDstrom and transitioning into the new production space to allow CORDstrom as a commercial product and INKmune as an investigational product for our next clinical trials. So that ends my update on the INKmune and CORDstrom platforms. I’d like to turn the call over to David Moss, our CFO, to discuss financials. David?

Thank you, Mark. As usual, I’ll provide a brief overview of our financial results and upcoming milestones before we head to our Q&A session. Net loss attributable to common stockholders for the quarter ended March 31, 2025, was approximately $9.7 million, compared with approximately $11 million for the comparable period in 2024. Research and development expenses totaled approximately $7.6 million for the quarter ended March 2025, compared with approximately $8.7 million for the comparable period in 2024. General and administrative expenses were approximately $2.3 million for the quarter ended March 31, 2025, compared with approximately $2.3 million for the comparable period in 2024. At March 31, 2025, the company had cash and cash equivalents of approximately $19.3 million. Based on our current operating plan, we believe our cash is sufficient to fund our operations through Q3 of 2025. As of May 8, 2025, the company had approximately 23.2 million shares of common stock outstanding. Subsequent to the end of the quarter, the company raised gross proceeds of approximately $2.1 million from the sale of common stock on the ATM. Now I’d like to focus on some key upcoming milestones. As everybody is well aware, we expect to have topline cognitive data from our phase 2 trial on Alzheimer’s disease in the second half of June. As already stated, everyone at the company is looking forward to this event. We anticipate an end of phase 2 meeting with the FDA in the fourth quarter of 2026 to agree on the design of a phase 3 trial. We expect to complete enrollment in the phase 2 portion of the INKmune trial this year, as Mark mentioned earlier, with periodic updates on immunologic and therapeutic responses to INKmune as data becomes available. We anticipate filing a BLA for CORDstrom in RDEB in the first half of 2026. Finally, we will initiate a phase 2 trial of XPro in patients with treatment-resistant depression once NIH funding is made available. At this point, Jessie, I’d like to now poll for questions and open it up to Q&A.

Thank you. We’ll go first to Gary Nachman with Raymond James.

Hey, guys. This is Denis Reznik on for Gary Nachman. Thank you for taking our questions and congrats on all the progress. So, just assuming a positive readout in June, can you just continue walking us through the exact next steps for the program? You mentioned you can meet with the FDA at the end of this year, but what’s a realistic timeline as to when you can initiate the Phase 3? And then can you provide maybe some metrics as to what’s reasonable as to how many sites you can get online and how many patients could be enrolled each month? And then I’ve got a couple follow-ups.

Yeah. Well, this is RJ. So, thank you, Gary. But I think expecting us to really design the trial before we have the results and before we talk to the FDA, we would like to defer that opportunity. Our goal, as David mentioned in his milestones, is to, as quickly as possible, get to the FDA for an end of Phase 2 meeting. It is classified as a Type A/B meeting by the FDA process, so there’s a 70-day clock. So, hopefully, as we said, it will be completed in the fourth quarter. Then we will move as quickly as possible to getting sites open and those first patients enrolled. We are lucky that we’ve got a lot of sites ready to go in Europe. So and we know there’s considerable enthusiasm for this program in the U.S. So, we anticipate being able to get the sites. But I don’t want to put a date on it. We don’t want to put a size on it. And because we can’t put a size on it, we don’t want to really predict what the capital needs will be at this point. But suffice it to say that we believe that it will look very much like the Phase 2 trial, although we expect it will be larger and there may be a fewer set of biomarkers. But we won’t know until we talk to the FDA.

Totally understand that. And that’s helpful color. Just a couple quick follow-ups. Just because there’s been a lot of turnover and uncertainty at the FDA recently, can you comment on if the people who will be reviewing your program are also there? Everyone who’s previously signed off on the EMAC is also there? And then with the post-presentation you guys had at ADPD last month, maybe can you just talk a little bit more about the receptivity you’ve received at the conference and then overall the level of interest the company has been receiving recently as we approach its June readouts?

Yeah. I’ll let CJ answer the ADPD call. But we’ve obviously, like any biotech, have been watching what’s going on at the FDA quite closely. Our intelligence, which is pretty good, we believe suggests that when it comes to drug development, the FDA has remained on track. Delays appear to not be developing as everyone feared. We can’t predict the future, but everything we hear so far is okay. I remind you that the FDA has not yet completely signed off on EMAC. Our goal is and CJ can add more color to this, our goal is to present them EMAC data side-by-side with the CDR data. One of the major questions we’ll be asking them at the end of Phase 2 meeting is, can we use EMAC as the primary endpoint for the registration trial? Remember, and we’ve been saying this forever, that we believe that it’s our superior metric of cognitive function in these patients. But it’s the FDA’s sandbox. And if they say no, we’re not happy, but we will move ahead with CDR. In fact, the trial that we are currently doing will allow us to perfectly design the study to get the kind of result we need. CJ, do you want to add any color to that and also comment on his ADPD question?

Yeah. Yeah. Sure. Just to sort of give you, clarify a little bit about what we’ve communicated with the FDA is we’ve given them the plans and what we intend to do with EMAC. What they’ve done is they’ve responded to that in a way that really says that outlines their guidelines on how you validate a measure, really thinking about it more like a checklist, which is what we’ve done in this trial. They’re not going to comment on that until they see the data. That’s just a standard response. But we think we’ve done everything. We’ve hit all those bullets in those checklists and I think we’re in a good position. ADPD was pretty interesting. I think there are two things that I think really came out of it as it relates to feedback we got from the poster. One is I think people are excited for an anti-amyloid or a therapy that’s not targeting anti-amyloid. And I would say even more so, we’ve got a lot of traffic and interest in EMAC. One of the comments that we received, especially from neuropsychs that work with big companies or work in the space and measuring cognition, were really excited that there’s a company that’s driving the appropriate measures moving forward. So, there’s a lot of excitement and interest around the outcome there.

Great. Thanks so much. We’re looking forward to the readout.

We’ll move next to George Farmer with Scotiabank.

Hi. Good afternoon. Thank you for taking my questions. I have a couple regarding XPro. With the upcoming trial and data, how do you expect investors to respond if you achieve success with EMAC but the CDR results are somewhat unclear? Also, RJ, you mentioned the potential advantages of XPro for patients who cannot receive anti-amyloid therapy, particularly ApoE homozygotes. Do you have an estimate of how many ApoE homozygotes are participating in your trial?

Yeah. So, CJ, why don’t you address the specific question about hitting on EMAC and what CDR will look like? Because it will be more correlative than not.

So, yeah, I’m not sure where you’re going with that, RJ. But let me just, to answer the question about how investors feel, I actually would ask you that question. From a scientific standpoint, what I can tell you is that the EMAC is the tool that’s actually capturing cognitive changes that occur in early AD. It’s identifying those patients. It’s the ability to measure cognitive decline. It’s the right tool. The CDR is a more blunt instrument. I think what RJ is saying is, one of the things that we’re seeing is it correlates very well. So we’re seeing correlations between EMAC and CDR, which is a good sign. But the CDR is inherently more noisy because it’s a blunt tool. So I would say, while I can’t answer how investors would think, I’m hopeful that we’ve talked with enough of you so that you understand how we think in the scientific validity and rationale for using the EMAC. For us, the EMAC is really the primary driver and we’ll understand what if the EMAC, for example, is fuzzy. We’ll have a clear understanding. The most likely scenario is just it’s a power issue due to noise. But we won’t know until we see the data.

Yeah. To provide some additional context, we believe that professionals in the field, including academics and potential biopharma partners, will be able to recognize that neither option is perfect. As CJ mentioned, CDR isn't heading in a different direction; the issue lies in the power and size of the study, which can be easily addressed in the Phase 3 trial. Now, regarding the ApoE4 homozygotes, they comprised 15% of the patients in both the lecanemab and donanemab trials, while our trial shows 9%. These are smaller studies, and I don't see a significant difference between 15% and 9%. I anticipate that it will be around 15%. Notably, aducanumab did not specify the number of homozygotes, at least I don't recall it doing so. From my review of the literature and clinical data, that seems to be the case. This population is significant in Europe, and as you know, in Europe and the U.K., off-label prescribing is not common. Therefore, I believe this group is poised and ready for XPro.

All right. Great. And then one more from me. The impact of XPro on Phospho-tau 217 looks pretty compelling. Went back and looked at your presentation. How do you think that magnitude compares to other Alzheimer’s disease treatment approaches that have been published?

CJ, I’m going to leave that one to you.

I think that’s tough to answer. I think the only thing that I can say is you don’t rarely, I can’t think of another study where you saw changes in the CSF that early quite robustly. I think this is one of those things that holds a lot of promise. But we’ll see what it looks like when we have the full data set.

We are the only company that has data on a drug designed to treat neuroinflammation. While anti-amyloid drugs do reduce tau levels, I believe when neurons stop dying, there is a corresponding decrease in tau. We prefer p-tau217, which is well-received by our clinical teams. I anticipate that most regulatory agencies will be very open to considering this biomarker as part of our data package.

Okay. Thanks very much.

Thank you.

We’ll go next to Tom Shrader with BTIG.

Good afternoon. I appreciate the opportunity to ask questions. You mentioned something I hadn't considered before, and I’d like to clarify if it's accurate. Are ApoE4 patients inherently inflammatory? Additionally, I would like to follow up on George’s question regarding the CDR. How much does it need to decline for a trial involving 300 patients over six months to be successful? Is that a realistic expectation or unrealistic? What do you think the required reduction in decline would be for a trial of this size to show positive results? Thank you.

Okay. Yeah. I can take that. I can take the first one…

CJ?

...or the second one. So, Tom, what’s interesting is when we powered the study, which was powered on CDR, by the way, the assumptions that we had in terms of our expectations for decline over six months, and the effect size of that decline was somewhat conservative based on the ADME group that was used to power the study. What’s interesting is, a few years later, when lecanemab and donanemab came out, what we saw was the assumptions that we used were exactly what happened. So, within a six-month period, both aducanumab or lecanemab and donanemab were statistically significant at six months. Their decline was about the exact same number that we used to estimate the decline for six months. I think that gives us a lot of confidence that our assumptions were right on. I think the other thing that I want to point out is, is this for a cohort of patients that weren’t enriched for inflammation. And of course, we expect that we’re going to get a little bit faster decline with inflammation. So, I think that gives us even a little more confidence.

Can I?

ApoE4 is known as an inflammation gene. Having ApoE4 indicates a higher risk for issues. As mentioned, individuals with ApoE4, whether they have one or two copies, experience an earlier onset of conditions, with those having one copy seeing onset at a later age compared to those with two copies. The progression of the disease, such as moving from mild cognitive impairment to early mild Alzheimer's disease, happens more quickly. Moreover, those with two copies of ApoE4 face a higher mortality rate, surviving about five to seven years less compared to other groups. Therefore, carrying the ApoE4 gene is unfavorable. If you have done 23andMe and they ask if you want to know your Alzheimer's risk, the main outcome will indicate whether you are ApoE4 positive. Personally, I never wanted to find out.

If I can follow up with CJ, how much of the other two trials hitting, they’re bigger trials, right? There’s something like, I don’t know, there’s a few fold more patients. Is that the reason they separated in six months, or do you still think you’re powered correctly to see it if you have a similar type effect?

I believe we are close to the answer, although there are variables we are uncertain about. I don’t think our projections will be significantly off. It's challenging to provide a definitive answer, but the data we have shows that even with an increase in patients, the standard deviation in the trials was around 1, which aligns closely with what we used in our projections, and the decline was quite similar. Therefore, I feel confident that we will be fine and closely aligned with our expectations.

And Tom, remember we…

We bragged about the quality control that we’ve had in this trial.

Yeah.

The procedure involving the type of patients we enrolled is a significant advantage. When enrolling 1,600 patients across approximately 42 countries, the quality control can lead to a more complicated patient population. It's not due to a lack of effort; it's just a challenging situation. We have dedicated a substantial amount of time and resources to our quality control, and since our trial was much smaller, with 208 patients across eight or nine countries, I believe the quality will be evident in the results.

All right. Great. Thanks for all the color.

Our final question will come from James Molloy with Alliance Global Partners.

Hello. This is Laura Suriel on for Jim Molloy. Thank you for taking the questions. So, for CORDstrom, are you still on track to initiate the 12-month open-label trial with this year? And I also see that U.S. patients are expected to be enrolled later on. So, what’s the enrollment aim here, and how many sites do you expect to have open in the U.S.?

Mark?

Yeah. Great. Thanks very much for that question. What we’re doing at the moment is following the guidance from the FDA about how to make the U.K.-manufactured CORDstrom usable in the U.S., and we’re starting a manufacturing program later this week, actually, of a new batch of products using U.S.-approved cord donors. This allows us, once we have those data, to draft the IND. We’re expecting to submit an IND later this year. We’ve been delayed by various factors, including the funding situation. But we’re still on track to or still planning an IND in the U.S. for CORDstrom. But the BLA is not dependent upon the U.S. IND, or indeed, the open-label in the U.K. We’re going to submit for the BLA with the data we already have from the double-blind placebo-controlled crossover trial, and then we will run a follow-on trial in the U.S. opening next year, in parallel with trials in the U.K., in which we will further explore the dosing of the drug and the periodicity of dosing. Does that answer your question?

Yes. It does. Thank you. And just as a follow-up, with the BLA finally coming up, how would you describe the overall regulatory space for RDEB treatments? Like, Abeona, for instance, just got approval for their gene therapy for RDEB. So, do you consider this a positive for where you’re at with CORDstrom?

Yeah.

...for CORDstrom?

There are two things about that. That’s a very good question. So, the synthetic skin gene-modified product, which has just been licensed, it’s a great product. The challenge is that it’s applicable to open wounds on the skin and that’s its only indication, and it requires a surgical intervention to apply it. One of the known side effects is itch, and obviously, one of our principal clinical outcomes from the first trial has been the reduction in itch. So, even in the presence of the gene-modified product, we have a window to treat the same patients with CORDstrom. But more importantly, CORDstrom is a systemic therapy, and as I said in the presentation just a few minutes ago, RDEB, and indeed all EB, is actually a systemic disease, and these kids, and indeed when they get through to adulthood, they suffer the condition throughout their esophageal tract, and they’re more widespread than just the dermis. We see a role for CORDstrom in treating those patients with systemic disease, as well as skin lesions. Indeed, a trial of a similar MSC product that’s not going through to license in South Korea showed improvement in skin scores after treatment as well when the children were followed up long enough. So we do see a really good opportunity for CORDstrom, even in the presence of the current licensed alternatives.

Understood. Thank you for taking the questions.

And now that will conclude the Q&A portion. I will turn the program back over to Dr. Tesi for any additional or closing remarks.

Thank you all for joining today's call. I want to take a moment for some closing remarks because we are thrilled about reaching a major milestone in our company's history. When we founded INmune Bio and developed XPro in 2017, we dedicated ourselves to addressing Alzheimer’s disease, a condition that was not widely recognized as having an immunological component at the time. The prevailing focus was on amyloid and tau. However, with the introduction of two anti-amyloid drugs into the market, the perception of Alzheimer’s disease has evolved significantly. It is now considered by many to be a central nervous system disease heavily influenced by immune dysfunction. Neuroinflammation is no longer seen merely as a byproduct of Alzheimer’s pathology; it is recognized as a key factor contributing to this condition. INmune Bio has established itself as a leader in addressing the immune dysfunction that leads to harmful neuroinflammation. We are intentional and precise in how we discuss this. There is a crucial difference between halting neuroinflammation through immunosuppression and glial suppression versus stopping harmful neuroinflammation by repolarizing glial cells to support the central nervous system and facilitate repair. The aim of effective Alzheimer’s therapy is to restore normal glial homeostasis. The concept that the brains of elderly individuals with dementia can undergo remodeling and repair is groundbreaking. We anticipate that data from the MINDFuL trial will significantly influence the direction of scientific research and discovery within neurology and CNS drug development. I have previously mentioned that we are on the brink of a golden age in CNS development, and we are eager to lead this movement. Thank you again, and we look forward to communicating with you all soon when the data is released. Thank you very much.

Thank you. Ladies and gentlemen, this does conclude today’s program. Thank you for your participation. You may disconnect at any time.