TWO SIGMA SECURITIES, LLC
Broker-DealerPosition in VRTX — Vertex Pharmaceuticals Inc / Ma
CIK 1450144
NEW YORK, NY
Position in VRTX
as of Jun 30, 2026
· filed Aug 14, 2026
Position Value
$458,481
+$196,363 QoQ
Shares Held
923
+57.2% QoQ
Ownership
0.000%
of shares outstanding
% of Portfolio
0.06%
of 13F equity value
Holder Rank
#1,099
of 1,735 holders
Holding Since
Mar 2020
23 quarters on record
Voting authority
Sole 100%
Shared 0%
None 0%
Common Shares in VRTX Over Time
Shares Held
Position Value (USD)
Derivatives in VRTX
reported options exposure · as of Sep 30, 2024CallValue
$3,906,672
CallShares
8,400
PutValue
$2,092,860
PutShares
4,500
Notional value of option positions as reported on Form 13F. Calls and puts are disclosed separately and do not net against the common-share stake above.
Position in Biotechnology
Healthcare · as of Jun 30, 2026TWO SIGMA SECURITIES, LLC holds $22,488,370 across 103 Biotechnology names. VRTX ranks #13 (2.0% of the industry book) .
| # | Ticker | Company | Shares | Value (USD) | Open |
|---|---|---|---|---|---|
| 1 | REGN |
Regeneron Pharmaceuticals, Inc.
|
5,761 | $3,592,213 | |
| 2 | ALNY |
Alnylam Pharmaceuticals, Inc.
|
5,585 | $1,681,252 | |
| 3 | BBIO |
BridgeBio Pharma, Inc.
|
17,689 | $1,317,476 | |
| 4 | MDGL |
Madrigal Pharmaceuticals, Inc.
|
2,219 | $1,191,492 | |
| 5 | INSM |
INSMED Inc
|
10,338 | $1,102,237 | |
| 6 | HALO |
Halozyme Therapeutics, Inc.
|
12,525 | $980,331 | |
| 7 | ARWR |
Arrowhead Pharmaceuticals, Inc.
|
11,256 | $917,476 | |
| 8 | AXSM |
Axsome Therapeutics, Inc.
|
3,708 | $907,607 |
All Filings in VRTX
Export CSV
47 filing rows on record
| Report Date | Value (USD) | Shares | Type | Discretion | Filed | |
|---|---|---|---|---|---|---|
| 2026-06-30 | $458,481 | 923 | Shares | Sole | 2026-08-14 | |
| 2026-03-31 | $262,118 | 587 | Shares | Sole | 2026-05-15 | |
| 2025-06-30 | $2,288,773 | 5,141 | Shares | Sole | 2025-08-14 | |
| 2025-03-31 | $626,872 | 1,293 | Shares | Sole | 2025-05-15 | |
| 2024-09-30 | $1,955,661 | 4,205 | Shares | Sole | 2024-11-14 | |
| 2024-09-30 | $3,906,672 | 8,400 | Call | Sole | 2024-11-14 | |
| 2024-09-30 | $2,092,860 | 4,500 | Put | Sole | 2024-11-14 | |
| 2024-06-30 | $2,296,728 | 4,900 | Call | Sole | 2024-08-14 | |
| 2024-06-30 | $3,984,120 | 8,500 | Put | Sole | 2024-08-14 | |
| 2024-06-30 | $2,447,187 | 5,221 | Shares | Sole | 2024-08-14 | |
| 2024-03-31 | $1,755,642 | 4,200 | Call | Sole | 2024-05-15 | |
| 2024-03-31 | $1,651,975 | 3,952 | Shares | Sole | 2024-05-15 | |
| 2024-03-31 | $4,012,896 | 9,600 | Put | Sole | 2024-05-15 | |
| 2023-12-31 | $1,505,493 | 3,700 | Call | Sole | 2024-02-14 | |
| 2023-12-31 | $14,610,606 | 35,908 | Shares | Sole | 2024-02-14 | |
| 2023-12-31 | $2,929,608 | 7,200 | Put | Sole | 2024-02-14 | |
| 2023-09-30 | $4,485,846 | 12,900 | Put | Sole | 2023-11-14 | |
| 2023-09-30 | $2,016,892 | 5,800 | Call | Sole | 2023-11-14 | |
| 2023-09-30 | $2,063,836 | 5,935 | Shares | Sole | 2023-11-14 | |
| 2023-06-30 | $2,674,516 | 7,600 | Call | Sole | 2023-08-14 | |
| 2023-06-30 | $453,260 | 1,288 | Shares | Sole | 2023-08-14 | |
| 2023-06-30 | $1,231,685 | 3,500 | Put | Sole | 2023-08-14 | |
| 2023-03-31 | $1,732,885 | 5,500 | Call | Sole | 2023-05-15 | |
| 2023-03-31 | $850,689 | 2,700 | Put | Sole | 2023-05-15 | |
| 2022-12-31 | $1,732,680 | 6,000 | Put | Sole | 2023-02-14 | |
| 2022-12-31 | $1,328,388 | 4,600 | Call | Sole | 2023-02-14 | |
| 2022-12-31 | $260,768 | 903 | Shares | Sole | 2023-02-14 | |
| 2022-09-30 | $665,942 | 2,300 | Put | Sole | 2022-11-14 | |
| 2022-09-30 | $318,494 | 1,100 | Call | Sole | 2022-11-14 | |
| 2022-06-30 | $368,863 | 1,309 | Shares | Sole | 2022-08-15 | |
| 2022-03-31 | $6,342,353 | 24,303 | Shares | Sole | 2022-05-16 | |
| 2021-12-31 | $1,261,821 | 5,746 | Shares | Sole | 2022-02-14 | |
| 2021-12-31 | $1,910,520 | 8,700 | Put | Sole | 2022-02-14 | |
| 2021-09-30 | $234,174 | 1,291 | Shares | Sole | 2021-11-15 | |
| 2021-06-30 | $302,445 | 1,500 | Put | Sole | 2021-08-16 | |
| 2021-03-31 | $328,566 | 1,529 | Shares | Sole | 2021-05-17 | |
| 2020-12-31 | $668,369 | 2,828 | Shares | Sole | 2021-02-16 | |
| 2020-12-31 | $732,654 | 3,100 | Put | Sole | 2021-02-16 | |
| 2020-12-31 | $1,559,844 | 6,600 | Call | Sole | 2021-02-16 | |
| 2020-09-30 | $598,664 | 2,200 | Put | Sole | 2020-11-16 | |
| 2020-09-30 | $544,240 | 2,000 | Call | Sole | 2020-11-16 | |
| 2020-09-30 | $262,051 | 963 | Shares | Sole | 2020-11-16 | |
| 2020-06-30 | $1,393,488 | 4,800 | Call | Sole | 2020-09-10 | |
| 2020-06-30 | $464,786 | 1,601 | Shares | Sole | 2020-09-10 | |
| 2020-06-30 | $812,868 | 2,800 | Put | Sole | 2020-09-10 | |
| 2020-03-31 | $428,310 | 1,800 | Put | Sole | 2020-05-15 | |
| 2020-03-31 | $951,800 | 4,000 | Call | Sole | 2020-05-15 | |
| No filing history on record for this holder in this stock. | ||||||