Holocene Advisors, LP

Position in XENE — Xenon Pharmaceuticals Inc.

CIK 1700574 New York, NY

Position in XENE

as of Mar 31, 2026 · filed May 15, 2026 Compact

Position Value

$88,311,590

+$30,848,720 QoQ

Shares Held

1,518,686

+18.5% QoQ

Ownership

1.57%

of shares outstanding

% of Portfolio

0.22%

of 13F equity value

Holder Rank

—

not a current holder

Holding Since

Mar 2022

11 quarters on record

Voting authority Sole 100% Shared 0% None 0%

Healthcare · as of Jun 30, 2026

Holocene Advisors, LP holds $1,266,200,483 across 29 Biotechnology names.

#	Ticker	Company	Shares	Value (USD)
1	RVMD	Revolution Medicines, Inc.	1,359,269	$254,563,898
2	DNLI	Denali Therapeutics Inc.	3,905,225	$100,442,387
3	CYTK	Cytokinetics Inc	1,144,579	$97,506,685
4	SRRK	Scholar Rock Holding Corp	1,755,978	$96,578,790
5	ARWR	Arrowhead Pharmaceuticals, Inc.	1,106,177	$90,164,487
6	SYRE	Spyre Therapeutics, Inc.	1,015,170	$90,126,792
7	MDGL	Madrigal Pharmaceuticals, Inc.	152,924	$82,112,541
8	TNGX	Tango Therapeutics, Inc.	2,410,939	$75,365,953

11 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-03-31	$88,311,590	1,518,686	+18.5%	Shares	Sole	2026-05-15
2025-12-31	$57,462,870	1,282,081	-35.1%	Shares	Sole	2026-02-17
2025-09-30	$79,358,602	1,976,553	+9.2%	Shares	Sole	2025-11-14
2025-06-30	$56,636,567	1,809,475	+913.9%	Shares	Sole	2025-08-14
2023-09-30	$6,096,535	178,470	-75.0%	Shares	Sole	2023-11-14
2023-06-30	$27,430,403	712,478	-27.8%	Shares	Sole	2023-08-14
2023-03-31	$35,295,919	986,195	-17.2%	Shares	Sole	2023-05-15
2022-12-31	$46,986,286	1,191,638	-34.9%	Shares	Sole	2023-02-14
2022-09-30	$66,032,387	1,829,152	0.0%	Shares	Sole	2022-11-14
2022-06-30	$55,642,803	1,829,152	+101.1%	Shares	Sole	2022-08-15
2022-03-31	$27,807,327	909,628	—	Shares	Sole	2022-05-16
No filing history on record for this holder in this stock.