TWO SIGMA INVESTMENTS, LP

Position in XERS — Xeris Biopharma Holdings, Inc.

CIK 1179392 NEW YORK, NY

Position in XERS

as of Jun 30, 2026 · filed Aug 14, 2026 Compact

Position Value

$14,933,183

+$3,772,812 QoQ

Shares Held

1,885,503

-2.0% QoQ

Ownership

1.03%

of shares outstanding

% of Portfolio

0.01%

of 13F equity value

Holder Rank

#14

of 238 holders

Holding Since

Mar 2022

12 quarters on record

Voting authority Sole 99% Shared 0% None 1%

Healthcare · as of Jun 30, 2026

TWO SIGMA INVESTMENTS, LP holds $775,744,366 across 48 Drug Manufacturers - Specialty & Generic names. XERS ranks #10 (1.9% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	NBIX	Neurocrine Biosciences Inc	2,076,260	$349,932,860
2	BCRX	Biocryst Pharmaceuticals Inc	6,775,349	$67,753,490
3	SUPN	Supernus Pharmaceuticals, Inc.	1,184,378	$55,085,420
4	ALKS	Alkermes plc.	1,038,311	$54,407,496
5	KNSA	Kiniksa Pharmaceuticals International, plc	561,480	$35,906,646
6	ZTS	Zoetis Inc.	386,428	$27,768,716
7	LQDA	Liquidia Corp	266,829	$21,274,276
8	IRWD	Ironwood Pharmaceuticals Inc	4,556,089	$19,181,134

12 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-06-30	$14,933,183	1,885,503	-2.0%	Shares	Sole	2026-08-14
2026-03-31	$11,160,371	1,924,202	+11.1%	Shares	Sole	2026-05-15
2025-12-31	$13,601,435	1,732,667	+7.3%	Shares	Sole	2026-02-17
2025-09-30	$13,142,673	1,614,579	+32.9%	Shares	Sole	2025-11-14
2025-06-30	$5,672,644	1,214,699	+36.4%	Shares	Sole	2025-08-14
2025-03-31	$4,887,950	890,337	+3221.8%	Shares	Sole	2025-05-15
2024-06-30	$60,306	26,803	-79.4%	Shares	Sole	2024-08-14
2024-03-31	$286,999	129,864	+33.4%	Shares	Sole	2024-05-15
2023-12-31	$228,770	97,349	-11.4%	Shares	Sole	2024-02-14
2023-09-30	$204,462	109,926	-45.6%	Shares	Sole	2023-11-14
2023-06-30	$529,795	202,212	+34.7%	Shares	Sole	2023-08-14
2022-03-31	$384,279	150,109	—	Shares	Sole	2022-05-16
No filing history on record for this holder in this stock.