SR One Capital Management, LP

CIK

1910264

Location

Redwood City, CA

Portfolio Value

Small $914,169,725

Diversification

Moderately concentrated

Filing Date

Global Rank

#1,601 / 8,232 ▲ 427

Top Industry

Biotechnology 100.0%

3Y Alpha vs SPY

+1.1%

Period ended 2 months ago

Filed May 14, 2026 · 30d

18 quarters · since Dec 2021

Clone Performance

Jun 2023–Jun 2026 · vs SPY

Hypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.

Cloned portfolio

+81.6%

SPY

+76.5%

Annualised alpha

+1.1%

Max drawdown

−48.3%

Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.

Portfolio Concentration

14 positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025

Top Position

29.5%

+3.5 pts

Top 5

75.0%

−4.4 pts

Top 10

96.5%

−1.2 pts

HHI

1,535

Moderately concentrated−64

Portfolio Trend

18 quarters · across all stocks

Sector Breakdown

As of Mar 31, 2026

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$914,169,725	14

Last Quarter's Activity

Export CSV

Mar 31, 2026 vs Dec 31, 2025

Added To

Positions the filer increased

No qualifying positions this quarter.

Trimmed

Positions the filer reduced

No qualifying positions this quarter.

New Positions

Positions the filer opened this quarter

1 positions

Ticker	Company	Shares	Value	Open
MANE	Veradermics, Inc	2,401,868	$151,677,964
No positions match the current search.

Sold Out

Positions the filer fully exited

No qualifying positions this quarter.

Portfolio Positions

Compact Export CSV View 13F filing

14 positions · $914,169,725 total · as of Mar 31, 2026

All sectors Healthcare

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
ACLX	Arcellx, Inc. Healthcare	Held	2,346,630	0	$269,440,056	+76.1%	29.47%
MANE	Veradermics, Inc Healthcare	NEW	2,401,868	NEW	$151,677,964	NEW	16.59%
ZBIO	Zenas BioPharma, Inc. Healthcare	Held	5,037,854	0	$98,490,045	−46.2%	10.77%
CRSP	CRISPR Therapeutics AG Healthcare	Held	2,038,763	0	$96,983,955	−9.3%	10.61%
DSGN	Design Therapeutics, Inc. Healthcare	Held	6,526,476	0	$69,441,704	+13.4%	7.60%
ORIC	Oric Pharmaceuticals, Inc. Healthcare	Held	4,514,929	0	$57,204,150	+54.9%	6.26%
ALMS	Alumis Inc. Healthcare	Held	1,959,896	0	$43,176,508	+125.7%	4.72%
MLYS	Mineralys Therapeutics, Inc. Healthcare	Held	1,563,966	0	$42,367,838	−25.4%	4.63%
SPRY	ARS Pharmaceuticals, Inc. Healthcare	Held	4,012,903	0	$32,223,611	−31.1%	3.52%
ORKA	Oruka Therapeutics, Inc. Healthcare	Held	430,330	0	$21,107,686	+61.8%	2.31%
OCS	Oculis Holding AG Healthcare	Held	641,022	0	$17,044,774	+33.1%	1.86%
NKTX	Nkarta, Inc. Healthcare	Held	3,333,333	0	$7,033,332	+14.1%	0.77%
ENGN	enGene Therapeutics Inc. Healthcare	Held	747,750	0	$5,092,177	−24.6%	0.56%
RARE	Ultragenyx Pharmaceutical Inc. Healthcare	Held	137,753	0	$2,885,925	−8.9%	0.32%