Good day, and welcome to Amarin Corporation's conference call to discuss its first quarter 2024 financial results and business update. I would now like to turn the conference over to Mark Marmur, Vice President, Corporate Communications and Investor Relations at Amarin. Please go ahead.

Good morning, everyone, and thank you for joining us. Turning to our forward-looking statements. Please be aware that this conference call will contain forward-looking statements that are intended to be covered under the safe harbor provided under federal securities law. We may not achieve our goals, carry out our plans or intentions or meet the expectations disclosed in our forward-looking statements. Actual results or events could differ materially, so you should not place undue reliance on these statements. We assume no obligation to update these statements as circumstances change. Our forward-looking statements do not reflect the potential impact of significant transactions we may enter into, such as mergers, acquisitions, dispositions, joint ventures or any material agreements that we may enter into, amend or terminate. For additional information concerning the risk factors that could cause actual results to differ materially, please see the Risk Factors section of our annual report on Form 10-K for the year ended December 31, 2023, and our quarterly report on Form 10-Q for the quarter ended March 31, 2024, which has been filed with the SEC and is available through the Investor section of our website at www.amarincorp.com. We encourage everyone to read these documents. An archive of this call will be posted on Amarin's website in the Investor Relations section. Turning to today's agenda. Patrick Holt, Amarin's President and Chief Executive Officer, will provide a brief overview of our first quarter 2024 business update. Jonathan Provoost, Amarin's Chief Legal and Compliance Officer, will provide an intellectual property and legal update, Steve Ketchum, Amarin's President of R&D and Chief Scientific Officer, will provide an update on key data presented at ACC.24; and Tom Reilly, Amarin's Chief Financial Officer, will provide a review of our first quarter 2024 financial results. Following prepared remarks, we will open the call to your questions. I will now turn the call over to Patrick Holt, President and Chief Executive Officer of Amarin. Pat?

Thank you, Mark. Good morning, everyone, and thank you for joining us today. Turning to Slide 5. Our team at Amarin is focused on making progress to enhance the value of our business and maximize the patient uptake of VASCEPA/VAZKEPA. We firmly believe this focus is the best plan for Amarin and positions us strongly for the future. In Q1, our team continued to deliver considerable progress. In the first quarter, we were successful in both defending and extending our IP position in Europe. This effort delivered an extended IP runway in Europe until 2039. This is really important as it enhances the value of our business considerably. Jonathan will provide more details on this achievement later in the call. From a commercial perspective, in Europe, our teams delivered approximately 65% in-market sales growth in Q1 2024 versus Q4 2023, led by Spain and the United Kingdom. On the pricing and reimbursement front in Europe, we've resubmitted our dossier in Italy. In France, plans remain on track to submit our strengthened dossier in 2024. And in Germany, work is ongoing for a potential resubmission. Additionally, we remain on track to secure pricing reimbursement in five additional markets in 2024 in Europe. We expect to share pricing and reimbursement outcomes in Greece and Portugal in the near future. Our team continues to focus on prudent spending and our cash position. We ended the first quarter with a cash position of $308 million, marking a stable cash position over seven quarters. Importantly, we also secured shareholder approval for our share repurchase program of up to $50 million. Our next step is to secure U.K. High Court approval, and the share repurchases are anticipated to begin in the second quarter. So let's now dive into each of our business areas and the performance in the first quarter. Slide 6 and more specifically to Europe. Before we get into the results for the quarter, let me reiterate an important point that drives our confidence in the opportunities across Europe. Underpinning our progress and our path forward in Europe is our intellectual property position for VASCEPA, which is now being extended into 2039. This provides additional value for both patients and our company. So turning to the first quarter's commercial progress in Europe. In Spain, our team is delivering robust launch growth, and this market continues to demonstrate the value of VASCEPA for the region and globally with the new approach we have taken to the region following new leadership changes last year. As of the end of the first quarter, the number of patients on VASCEPA therapy in Spain has increased 91% in Q1 2024 versus Q4 2023. The team continues to focus on healthcare providers who are early adopters of cardiovascular products. In the United Kingdom, our team is executing against a more focused strategy and has new leadership in the form of a new country manager. At the end of the first quarter, the number of patients on VAZKEPA therapy in the U.K. has increased 28% in Q1 2024 versus Q4 2023. Turning to pricing and reimbursement progress. We've strengthened our focus on advancing our opportunities in key EU5 markets. In Italy, we have resubmitted our dossier and are engaging with authorities to potentially achieve market access for VAZKEPA by the end of 2024. In France, plans remain on track to submit our strengthened dossier in 2024. And in Germany, continued work is being done on plans for a potential resubmission. We will continue to communicate progress on France and Germany as additional steps are achieved. We are pleased to share today that we are well on track to secure positive pricing reimbursement decisions in at least five additional markets in 2024. We expect to share news on pricing reimbursement outcomes in Greece and Portugal in the near future. Turning now to the United States. In the first quarter, the team maintained IP market leadership. We have retained exclusive accounts representing more than 50% of the IP market. Market share has remained stable in the U.S. for the sixth consecutive quarter. These results are a testament to the work our managed care, trade, and medical affairs teams have done to extend VASCEPA's life cycle despite the elimination of our sales force and reduced marketing spend. While we are encouraged to start the year in a solid managed care position, the market remains highly dynamic. While our revenues in the quarter were impacted primarily by a decline in net selling price due to generic competition, the U.S. business remains highly profitable, funding our efforts in Europe. Our U.S. team is skilled at analyzing market dynamics, and we are prepared to change our approach to this business as the market continues to develop, including the potential future launch of an authorized generic, which would be bolstered by our strong supply position in order to retain IP market leadership. Moving to Slide 8. In the Rest of the World, Amarin and its partners continue to make regulatory market access and commercial launch progress across key markets. In China, the second largest cardiovascular market globally by population, Amarin's partner Edding continues to launch VASCEPA for very high triglycerides with a focused strategy. In the first quarter of 2024, Edding delivered a 100% increase in sales growth versus the fourth quarter of 2023. The NNPA review of the cardiovascular risk reduction indication remains on track. An approval for this indication would open the potential for the National Reimbursement and Drug Listing or NRDL. In Canada, HLS continues to make important progress across the market. In British Columbia, HLS recently secured public access and listing with the leading private Pacific Blue Cross and in Australia, Amarin's partner CLS Seqirus continues to advance the submission for VAZKEPA reimbursement with local health authorities, and timelines for potential reimbursement remain on track. In summary, our teams and our partners have made significant progress in the first quarter across the business, advancing the momentum needed for Amarin. Like all biopharmaceutical companies, intellectual property is a foundational element of our business and our ability to provide our product to patients. I would now like to turn the call over to Jonathan Provoost, to provide more detail on our IP extension for VAZKEPA in Europe. Jonathan?

Thank you, Pat. Good morning, everyone, and thank you for the opportunity to give a brief update on our IP progress for VAZKEPA. Turning to Slide 10. As we announced in April, we have been successful over the past few months, taking important steps to strengthen our intellectual property position for VAZKEPA in Europe. Before I go into the details, it is important to understand two key items. First, that Amarin's intellectual property for VASCEPA in this region is built upon a multilayered collection of patent and regulatory protection such that exclusivity for VASCEPA stems from a diverse portfolio of intellectual property assets. Second, the recent progress we have made extends commercial exclusivity for VAZKEPA until 2039, eight years beyond the data exclusivity period of 2031. In our announcement in April, we shared that we were successful with two separate patent outcomes. First, we were recently successful in defending a European VAZKEPA patent from third-party opposition within the European patent office or EPO. That patent expires in 2032. Following this decision, the company received a decision to grant from the EPO for a new patent covering VAZKEPA that extends the product exclusivity until April 2039. In addition to these patents, Amarin possesses additional European patents and pending patent applications that further our intellectual property protection for VAZKEPA within the European market. Taken together, these patents collectively provide us with a high level of confidence that our intellectual property position for VAZKEPA in Europe is strong and dependable, providing us exclusivity protection in Europe into the 2039 period. As stated earlier, intellectual property is a foundational element of our business and our ability to provide our product to patients. As we've done in the past, Amarin will continue to vigorously defend our intellectual property to the fullest extent possible. As we know, the data and science behind VASCEPA and VAZKEPA is critical to its commercial success in markets around the world. I would now like to turn the call over to Steve Ketchum to provide an overview of key data presented at the ACC.24 Conference. Steve?

Thank you, Jonathan. Good morning, everyone, and thank you for the opportunity to summarize key data on VASCEPA/VAZKEPA and EPA recently presented at the American College of Cardiology's annual scientific session. Turning to Slide 12. In early April, the American College of Cardiology held its annual scientific sessions in Atlanta, Georgia. The Congress brought together more than 17,000 attendees, surpassing pre-COVID attendance levels. Data featured at ACC.24 included key abstract on REDUCE-IT subpopulations as well as mechanistic activity data on EPA. The first abstract was a post-hoc analysis of REDUCE-IT that sought to measure VASCEPA/VAZKEPA's effect on the relationship between lipoprotein A, also known as LP(a) levels, and reducing major adverse cardiovascular events, or MACE. High LP(a) concentrations are associated with increased cardiovascular event risk even when low-density lipoprotein cholesterol, or LDL-C levels are well managed. In this analysis of REDUCE-IT, VASCEPA/VAZKEPA showed a clear clinical benefit for patients with both high and low baseline LP(a) levels. The molecule provided a relative risk reduction of 21% among patients with high LP(a) levels of greater than or equal to 15 milligrams per deciliter at baseline, and a relative risk reduction of 25% among patients with a low LP(a) level of less than 50 milligrams per deciliter at baseline. These findings, which were published simultaneously in the Journal of the American College of Cardiology, reinforce VASCEPA/VAZKEPA's clinical benefit in these at-risk patient subpopulations. In a second abstract featured at ACC, investigators explored REDUCE-IT data to determine if VASCEPA/VAZKEPA reduces cardiovascular events among high-risk cardiovascular patients irrespective of baseline LDL-C. Elevated LDL-C is a well-established major cardiovascular risk factor, supported by clinical evidence showing decreased atherosclerotic disease events when LDL-C is therapeutically lowered. Findings from this analysis showed that among adults with increased cardiovascular risk and elevated triglycerides, icosapent ethyl clearly reduced the rate of cardiovascular outcomes irrespective of baseline LDL-C, including in those with very well controlled LDL-C of less than 55 milligrams per deciliter. Finally, a few comments on EPA mechanistic data that were presented at the Congress which provide new insights into the mechanism of action for VASCEPA/VAZKEPA, including the effect of EPA in combination with high-intensity statins on endothelial cell function during inflammation and EPA's effect on LP(a) levels. This latest research reaffirms Amarin's commitment to advancing cardiovascular care and helps further advance the medical community's understanding of the role, the value, and the potential mechanism of action of VASCEPA/VAZKEPA to reduce cardiovascular events in at-risk patients globally. Before I close, on behalf of the Amarin team, I would like to thank the investigators for their important work on the analyses featured at ACC. It is through their efforts that we are able to continue to better understand the science behind VASCEPA/VAZKEPA. Now I would like to hand the call over to Tom Reilly to review our first quarter 2024 financial performance. Tom?

Thank you, Steve. Good morning, everyone. Today, I am reporting details on our financial performance for the first quarter of 2024. In the first quarter of 2024, Amarin reported total net revenue of $56.5 million, including net product revenue of $55.2 million and $1.4 million of licensing and royalty revenue versus $86 million total revenue in the first quarter of 2023. The U.S. product revenue was $48.1 million in the first quarter of 2024 versus $82.3 million in the first quarter of 2023. This decline was driven largely by net selling price impact due to the generic competition in the market. Despite the revenue decline, the U.S. business continues to deliver significant profit. Revenue results include European net product revenue of $1.9 million, a 35% increase versus the fourth quarter of 2023, reflecting growth in revenue primarily from Spain and the United Kingdom. We recognized $5.2 million in Rest of World revenue in the first quarter of 2024, including product revenue related to supply shipments to our partners in Canada, China, and the Middle East. Cost of goods sold in the first quarter of 2024 was $24.6 million compared to $38 million in the first quarter of 2023. Amarin's overall gross margin on net product revenue in the first quarter of 2024 and 2023 was 55%. Excluding inventory restructuring charges in the first quarter 2023, gross margin was 70%. Moving on to operating expenses. Operating expenses were $45.5 million in the first quarter, comprised of $39.9 million in selling, general and administrative expenses, and $5.6 million in research and development expenses, which is a $20 million reduction versus Q1 2023. We are on track to deliver a $40 million reduction in operating expenses by July 2024, which we announced in Q3 2023. Amarin reported a net loss of $10 million for the first quarter of 2024, basic and diluted loss per share of $0.02. Let me now turn to our efforts and results in controlling costs and effectively managing our cash. As of March 31, 2024, Amarin reported aggregate cash and investments of $308 million, while our cash balance has been impacted by revenue shortfall over the last several quarters. We remain focused on preserving cash and have maintained a stable cash position over the last seven quarters. The team continues to focus on cash preservation currently investing in the right opportunities, particularly in Europe based on pricing and reimbursement decisions. Before I wrap up, I will provide a brief update on our share repurchase program. As announced in January, Amarin entered into a conditional share repurchase agreement with Cantor Fitzgerald to purchase up to $50 million of Amarin ordinary shares. On April 18, Amarin announced we secured shareholder approval for the program. The next step in this process is to seek U.K. High Court approval. Last week, we filed our claim for approval with the court. Expected share repurchases would commence shortly after the court approval, which we anticipate in the second quarter of 2024. With that, I will now turn back to Pat for closing remarks and to begin the Q&A portion of our call. Pat?

Thank you, Tom, for the overview of our financial results and update on our share repurchase programs. Our team continues to remain focused on advancing goals across Amarin. In the first quarter of 2024, we delivered an enhanced European IP position, European growth led by the United Kingdom and Spain, a stable cash position of $308 million, and advanced our share repurchase program. Our fundamentals continue to provide the foundation for our progress, best-in-class science supporting VASCEPA/VAZKEPA, a large global opportunity to impact cardiovascular patients, a team dedicated to driving results, and a strong balance sheet. Before we turn to Q&A, I would like to thank our colleagues for their ongoing commitment and dedication. I look forward to continuing to advance our priorities in order to deliver shareholder value together. And with that, Mark, let's begin the Q&A portion of the call.

Thank you, Pat. As we previously shared, to enhance engagement with the company's shareholder base and facilitate connections with its investors, Amarin is partnering with Safe Technologies to allow retail and institutional shareholders to submit and upload questions, a selection of which will be answered by Amarin management during today's earnings call. Let's begin the Q&A. Pat, we received a question from an investor regarding when can we expect to see revenue from China?

Thanks very much for the question. Firstly, it's important to remember that China is a really large market with substantial unmet needs. In fact, it's the second largest cardiovascular market globally by population and quite frankly, it's a market that I'm particularly bullish about. In China, our partner Edding launched VASCEPA for very high triglycerides in Q3 2023. And in this quarter, Q1 2024, they delivered 100% sales growth versus Q4 2023. In addition, cardiovascular risk reduction, which has been submitted and accepted by the NNPA, would open the potential for the National Drug and Reimbursement Listing or NRDL, which would therefore increase royalties to Amarin over time. As a reminder of our deal, the structure of our agreement provides us immediate profitability, tiered double-digit royalty payments on net sales as well as development, regulatory, and revenue-based milestone payments. The cardiovascular risk reduction filing remains on track.

Thanks, Pat. Our second set of questions focuses on the share buyback program. What can you tell us on progress? When can we expect the U.K. High Court to approve it? When will the purchase begin and when will it be completed? Finally, in addition, how much does the company plan to purchase?

This is progressing well, and it's really aligned to our view of the business and the needs that business has. So firstly, we've achieved a very critical step, which is shareholder approval. At our recent AGM, shareholders approved a share repurchase program overwhelmingly with 91% approval. We sincerely appreciate the support and engagement from our shareholders on this. The next step is to secure approval from the U.K. High Court for the program. Last week, we filed a claim for approval with the U.K. High Court. Importantly, commencement of share repurchases will follow U.K. High Court approval and will be conducted based on SEC and U.K. corporate law. Broadly, we continue to believe this is a prudent use of capital to deliver value back to shareholders, given our cash position. We continue to show a strong balance sheet with $308 million in cash, stable over the past seven quarters, and no debt.

Thanks, Pat. Turning to EU/U.K. sales, why has Amarin struggled with U.K. and EU product adoption? What are the main strategic issues and your confidence in addressing them?

Thanks very much for the question. Well, firstly, I am confident about our progress in Europe. As we've noted previously, in Europe, the process for reimbursement pricing and launch is both complicated and varies country by country. It's important to remember that last year, we installed new leadership across the region with a new strategy for Europe. That had some really key focus areas: firstly, targeted patient and customer segmentation at launch, focusing on the highest risk patients, where the urgency to treat is the highest. Secondly, really prioritizing and optimizing our resources, aggressively focused on where we see the near-term significant opportunities, and thirdly, enhancing and being flexible with our value proposition to address specific country payer needs. While we would all like to see faster uptake, we're encouraged by the progress we're making in Europe with 35% revenue growth and 65% in-market sales growth in Q1 versus Q4 2023. At a country level, we can see that our new strategy is working, albeit at a different pace aligned to each market dynamic. Specifically in Spain, this is really an excellent case study demonstrating the value of VASCEPA in Spain as well as across the region, and we're seeing a fast uptake—91% in patients on therapy in Q1 2024 versus Q4 2023. In the U.K., we are also seeing our new strategy work, albeit in a slower uptake market. With the team focused on building momentum in key accounts, we see a 28% increase in patients on therapy in Q1 2024 versus Q4 2023. Again, taking a step back, underpinning all of this, looking at our long term, we've successfully secured additional patent protection until 2039, which gives us the confidence to invest in our belief around future uptake and enhances the value of our business.

Thanks, Pat. Investors would like to know the long-term future of the company. What can you tell us about this?

Yes. Great question. Management and the Board are really discussing often and remain incredibly focused on building value for shareholders. Firstly, in Europe, we continue to see growth in our key EU5 markets, especially the U.K. and Spain, and we’re on track to deliver positive pricing reimbursement in at least five additional markets in 2024. That's underpinned by the confidence of our intellectual property for VAZKEPA extending to 2039, which adds value to the company and for patients. In the U.S., it’s all about driving profitability. In the Rest of the World, our partners are progressing regulatory market access and commercial launches to advance our success. Additionally, we've taken critical steps to reduce operating expenses which aids profitability and our cash position. All of this strengthens Amarin for today as well as for the future.

One final question. We saw that Amarin issued a press release regarding Healthy Women's citizens petition regarding fibrates in the U.S. Can you tell us a bit more about that and why Amarin has weighed in on this issue?

Yes. Thanks very much. That's a great question. Look, fundamentally, this is about patient care and ensuring that patients are being prescribed proven effective therapies that will reduce their cardiovascular risk. Specifically to fibrates. Fibrates are an old class of drugs studied over many years through a number of clinical studies, most recently the PROMINENT trial, and they do not reduce cardiovascular risk when prescribed in combination with statins. Unfortunately, this clinical evidence has not translated to a significant change in prescribing for many patients. It is estimated that in the United States, more than one million patients are being prescribed fibrates and a statin together to reduce cardiovascular risk. This means that more than one million patients are being treated with a combination of products that has no benefit in reducing cardiovascular disease, and that is why we have continued to come out strongly in support of this issue. We will be filing additional comments to the docket on the citizens petition during the current open comment period. Before we take additional questions, I would like to thank those shareholders who submitted questions via the Say Technologies platform. We are committed to continuing open and transparent dialogue with our shareholders, and the Say Technologies platform is one of the ways we are trying to increase shareholder engagement and a two-way dialogue with you all. We look forward to continuing to hear from you and answering your questions on this platform and other opportunities as we move forward.

Thank you for those updates, Pat. We'll now open the Q&A up for additional questions.

Our first question is from Roanna Ruiz with Leerink Partners.

A couple for me. First one in the U.S. So I was curious, are there any new strategies that you're implementing to help preserve the exclusive business? And do you have any updates on your outlook on possibly launching an authorized generic in the U.S.?

Roanna, thanks so much for the question. So when we consider the U.S., obviously, we see a decline in revenues this quarter. With that said, we see that our exclusive strategy continues to yield the expected results. We start the year and continue to have significant progress with our exclusive accounts, which is yielding market leadership. And that is, therefore, delivering the profits that we expect that drives our investments in Europe and protects our cash. With that said, it really is about the profitability that the U.S. drives. So we continue to monitor that dynamic market very closely. We have the option of an authorized generic strategy, particularly given our supply position, and we continue to monitor as to whether that time would eventuate that we would shift to that strategy. But as it stands right now, our focus is on extending the branded life cycle of VASCEPA in the U.S. through the excellent capabilities that we have in managed care, trade, and medical affairs that are experts in navigating particularly those contracting with our counterparts. Tom, would you like to add anything there?

No. I mean just other than related to—I think you mentioned on the authorized generic, if and when we get to that point, we are prepared and focused on the profitability that we're gathering today.

Yes. Understood. And one on Europe too, could you talk a bit about the rate of new prescriber growth that you're seeing across some of the different European countries for your launch, especially if you're seeing any important trends, particularly in the U.K. and countries like that?

Thanks very much for the question. Look, Roanna, as you understand really well, the data we get from Europe is not the same as we get from the U.S. So it's important to caveat that we don't have exactly the precise data that we come to expect in the United States. With that said, we are buoyed by our IP position extending out to 2039. When we look at those different markets in Europe, each has different dynamics around market access and launch. So we then click into the EU5, we're pleased with our progress in Spain. So if you look at Spain, we launched in, I think, October or September. It's completely on track. It's really demonstrating an excellent case study of a launch of VAZKEPA in the region. To the best of our data, we see that in Q1, we see about a 91% increase in the number of patients on therapy that approximates about 3,800 patients, which demonstrates a breadth of prescribing across the various parts of the country, and we're pleased with those dynamics. In the U.K., it's important to note that with new leadership coming in last July, we shifted our strategy in the U.K. much more as I previously disclosed. We're seeing early signs of that starting to take traction. We've also strengthened the U.K. organization with a new country leader who has just started. Our focused strategy in the U.K. is starting to gain early traction. We have excellent market access in the U.K. So our focus is on driving depth of prescribing in key accounts. As a result of that, to the best of our estimates, we see a 28% increase in Q1 versus Q4 in the number of patients on therapy, which approximates about 1,750 patients. I would say Spain's at the top of the league table, and the U.K. is improving. My time and the management team's time are focused on driving our success there.

Our next question is coming from Paul Choi with Goldman Sachs.

Maybe just to follow up on the question regarding a potential generic here in the U.S. Can you maybe just comment on what other mechanics would be required with regard to the FDA before you could launch that? And just how—roughly how quickly could that process be completed? Should you decide to go forward with that? And my second question is with regard to the cash position, excluding the pending U.K. court decision on that, your cash position has been relatively stable and consistent for the past few quarters. So I'm just curious, as you survey the landscape, just where you see the best potential opportunity for business development.

Thanks very much for the question. So to your first part of your question regarding the authorized generic, we have a well-established plan in place. That plan has been developed in detail over a period of time. So our number one goal continues to be to extend the profitable branded life cycle of VASCEPA in the U.S., given the world-class capabilities we have. With that said, we are genuinely ready to pivot to an authorized generic strategy should we need to, which is really a matter of us doing that with the partner that we have selected. So that's ready to go if needed. Obviously, that's bolstered by the very strong supply position we have that underpins that strategy. Regarding your second question, as a management team with the Board, we continue to assess opportunities in the marketplace concerning business development. We have a strong balance sheet with $308 million and no debt, and we continue to demonstrate our cash position stable over the last seven quarters. We continue to believe that in the immediate term, advancing our opportunities in Europe, our runway out to 2039, our key launches in EU5, continuing to drive significant profits in the U.S. and advancing our business in the Rest of the World via our partners, is the most important focus area for Amarin. This strengthens the company for today and enhances the company's options in the future.

Our next question is coming from Jessica— with JPMorgan.

This is Nick on for Jessica. Maybe just one from us. Spain is contributing a pretty robust uptake, maybe more focused approach in the U.K. Can you compare and contrast those dynamics there a bit more? And how should we think about Portugal's increase in terms of the launch uptake?

Thanks for your question. Each of the European markets has different dynamics. We previously signaled that we did expect Spain to be a fast uptake market, and we are proving that for VAZKEPA, which is encouraging as it’s a good case study for our success in Europe. The U.K., conversely, is typically a slower uptake market for a variety of reasons, not least of which is the complexity of the National Health System in the U.K. Our uptake is consistent with that expectation. Given the focus we have right now, we are seeing that we're making greater traction, as I noted before. Regarding Portugal and Greece, time will tell. Greece is via a partner, whereas we are directly involved in Portugal. We do broadly expect, when considering the scale between the U.K. and Spain, that Portugal and Greece will lean more towards faster uptake rather than slower as we look ahead to those markets.

Thank you. We have reached the end of our question-and-answer session. I will now turn the call back over to Mr. Holt for any closing remarks you may have.

Thank you all for your support this morning. I appreciate your time. As you can hear from our results this morning, we are encouraged by our results, particularly we’re pleased with the runway we have out to 2039 in Europe. We're pleased with the growth we are demonstrating, albeit from an early stage in Europe with 35% revenue growth, and 65% in-market sales growth. To be very clear, the U.S. is declining. This is not unexpected given our continued market leadership in IP as well as the expense management steps that we have taken. The U.S. continues to drive significant profits for us, enabling our investments in Europe and supporting our cash position. We closed the quarter with $308 million in cash and no debt. We are pleased that we secured shareholder approval for our share repurchase of up to $50 million, and we're on track for U.K. High Court approval, which is the next step towards triggering our share repurchases in Q2, all subject to U.K. and SEC laws. So thank you for your support. We look forward to continuing to update you as the business progresses. Thank you for your time.

Thank you. This concludes today's conference, and you may disconnect your lines at this time. We thank you for your participation.