Siren, L.L.C.
Top Portfolio Positions
99 positions ·
$3,590,811,251 total
· as of Mar 31, 2026
| Ticker | Company | Shares | Value (USD) | % of Portfolio | Open |
|---|---|---|---|---|---|
| SRRK |
Scholar Rock Holding Corp
Healthcare
|
10,825,013 | $532,157,639 | 14.82% | |
| KYMR |
Kymera Therapeutics, Inc.
Healthcare
|
3,186,830 | $265,431,070 | 7.39% | |
| ERAS |
Erasca, Inc.
Healthcare
|
11,244,246 | $181,931,900 | 5.07% | |
| EWTX |
Edgewise Therapeutics, Inc.
Healthcare
|
4,430,263 | $139,553,284 | 3.89% | |
| ONC |
BeOne Medicines Ltd.
Healthcare
|
465,000 | $138,091,050 | 3.85% | |
| TNGX |
Tango Therapeutics, Inc.
Healthcare
|
5,657,105 | $118,346,636 | 3.30% | |
| BCAX |
Bicara Therapeutics Inc.
Healthcare
|
5,802,970 | $115,421,073 | 3.21% | |
| RVMD |
Revolution Medicines, Inc.
Healthcare
|
1,110,980 | $108,042,805 | 3.01% | |
| ARWR |
Arrowhead Pharmaceuticals, Inc.
Healthcare
|
1,615,476 | $101,290,345 | 2.82% | |
| MANE |
Veradermics, Inc
Healthcare
|
1,505,374 | $95,064,368 | 2.65% |
Portfolio Trend
7 quarters · across all stocks
Holdings in APLS
Shares Held
Position Value (USD)
6 quarters on record
| Report Date | Value (USD) | Shares | Type | Discretion | Filed | |
|---|---|---|---|---|---|---|
| 2025-12-31 | $64,769,307 | 2,578,396 | Shares | Defined | 2026-02-13 | |
| 2025-09-30 | $58,349,101 | 2,578,396 | Shares | Defined | 2025-11-13 | |
| 2025-06-30 | $44,632,034 | 2,578,396 | Shares | Defined | 2025-08-13 | |
| 2025-03-31 | $56,389,520 | 2,578,396 | Shares | Defined | 2025-05-23 | |
| 2024-12-31 | $89,866,792 | 2,816,258 | Shares | Defined | 2025-02-14 | |
| 2024-09-30 | $62,502,740 | 2,167,224 | Shares | Defined | 2024-11-13 | |
| No 13F history on record for this holder in this stock. | ||||||