BRNS · Barinthus Biotherapeutics plc.

The shares underlying this option shall vest in full on the earlier of (i) June 10, 2026 or (ii) the next annual meeting of shareholders of the Issuer, subject to the Reporting Person's continued service as a director through the applicable vesting date.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The shares underlying this option shall vest in full on the earlier of (i) June 10, 2026 or (ii) the next annual meeting of shareholders of the Issuer, subject to the Reporting Person's continued service as a director through the applicable vesting date.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The shares underlying this option shall vest in full on the earlier of (i) June 10, 2026 or (ii) the next annual meeting of shareholders of the Issuer, subject to the Reporting Person's continued service as a director through the applicable vesting date.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The shares underlying this option shall vest in full on the earlier of (i) June 10, 2026 or (ii) the next annual meeting of shareholders of the Issuer, subject to the Reporting Person's continued service as a director through the applicable vesting date.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The shares underlying this option shall vest in full on the earlier of (i) June 10, 2026 or (ii) the next annual meeting of shareholders of the Issuer, subject to the Reporting Person's continued service as a director through the applicable vesting date.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The shares underlying this option shall vest in full on the earlier of (i) June 10, 2026 or (ii) the next annual meeting of shareholders of the Issuer, subject to the Reporting Person's continued service as a director through the applicable vesting date.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The shares underlying this option shall vest and become exercisable in three equal annual installments, with the first installment vesting on February 3, 2026.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The shares underlying this option shall vest and become exercisable in three equal annual installments, with the first installment vesting on February 3, 2026.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The shares underlying this option shall vest and become exercisable in three equal annual installments, with the first installment vesting on February 3, 2026.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The shares underlying this option shall vest and become exercisable in three equal annual installments, with the first installment vesting on February 3, 2026.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The shares underlying this option shall vest and become exercisable in three equal annual installments, with the first installment vesting on June 3, 2025.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The shares underlying this option shall vest in full on the earlier of (i) May 10, 2025 or (ii) the next annual meeting of shareholders of the Issuer, subject to the Reporting Person's continued service as a director through the applicable vesting date.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The shares underlying this option shall vest in full on the earlier of (i) May 10, 2025 or (ii) the next annual meeting of shareholders of the Issuer, subject to the Reporting Person's continued service as a director through the applicable vesting date.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The shares underlying this option shall vest in full on the earlier of (i) May 10, 2025 or (ii) the next annual meeting of shareholders of the Issuer, subject to the Reporting Person's continued service as a director through the applicable vesting date.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The shares underlying this option shall vest in full on the earlier of (i) May 10, 2025 or (ii) the next annual meeting of shareholders of the Issuer, subject to the Reporting Person's continued service as a director through the applicable vesting date.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The shares underlying this option shall vest in full on the earlier of (i) May 10, 2025 or (ii) the next annual meeting of shareholders of the Issuer, subject to the Reporting Person's continued service as a director through the applicable vesting date.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The shares underlying this option shall vest in full on the earlier of (i) May 10, 2025 or (ii) the next annual meeting of shareholders of the Issuer, subject to the Reporting Person's continued service as a director through the applicable vesting date.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The shares underlying this option shall vest and become exercisable in three equal annual installments, with the first installment vesting on January 2, 2025.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The shares underlying this option shall vest and become exercisable in three equal annual installments, with the first installment vesting on January 2, 2025.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The shares underlying this option shall vest and become exercisable in three equal annual installments, with the first installment vesting on January 2, 2025.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The shares underlying this option shall vest and become exercisable in three equal annual installments, with the first installment vesting on January 2, 2025.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.48 to $2.70, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range.

The shares underlying this option shall vest in full on the earlier of (i) May 11, 2024 or (ii) the next annual meeting of shareholders of the Issuer, subject to the Reporting Person's continued service as a director through the applicable vesting date.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The shares underlying this option shall vest in full on the earlier of (i) May 11, 2024 or (ii) the next annual meeting of shareholders of the Issuer, subject to the Reporting Person's continued service as a director through the applicable vesting date.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The shares underlying this option shall vest in full on the earlier of (i) May 11, 2024 or (ii) the next annual meeting of shareholders of the Issuer, subject to the Reporting Person's continued service as a director through the applicable vesting date.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The shares underlying this option shall vest in full on the earlier of (i) May 11, 2024 or (ii) the next annual meeting of shareholders of the Issuer, subject to the Reporting Person's continued service as a director through the applicable vesting date.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The shares underlying this option shall vest in full on the earlier of (i) May 11, 2024 or (ii) the next annual meeting of shareholders of the Issuer, subject to the Reporting Person's continued service as a director through the applicable vesting date.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The shares underlying this option shall vest in full on the earlier of (i) May 11, 2024 or (ii) the next annual meeting of shareholders of the Issuer, subject to the Reporting Person's continued service as a director through the applicable vesting date.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $2.40 - $2.47. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Shares held by William J Enright TR UA Dated 03/04/2021 Enright Family 2021 Irrevocable Trust, of which the Reporting Person serves as trustee. The Reporting Person disclaims beneficial ownership of the shares held by such trust for purposes of Section 16 of the Exchange Act, except to the extent of his pecuniary interest therein, if any.

This option shall vest and become exercisable in three equal annual installments, with the first installment vesting on February 1, 2024.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

This option shall vest and become exercisable in three equal annual installments, with the first installment vesting on January 3, 2024.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

This option shall vest and become exercisable in three equal annual installments, with the first installment vesting on January 3, 2024.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

This option shall vest and become exercisable in three equal annual installments, with the first installment vesting on January 3, 2024.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

This option shall vest and become exercisable in three equal annual installments, with the first installment vesting on January 3, 2024.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

This option shall vest and become exercisable in three equal annual installments, with the first installment vesting on January 3, 2024.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

This option shall vest and become exercisable in three equal annual installments, with the first installment vesting on January 3, 2024.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

Each share representing one ordinary share.

The reported securities were held directly by Prudential Credit Opportunities SCSP, advised by M&G Alternatives Investment Management Limited. The reported securities may be deemed beneficially owned for the purposes of Section 13(d) of the Securities Exchange Act 1934 by M&G Alternatives Investment Management Limited as investment manager to these funds. The Reporting Person disclaims beneficial ownership of the securities for purposes of Rule 16a-1(a)(2) and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

Each share representing one ordinary share.

The reported securities are held directly by M&G ACS, advised by M&G Investment Management Limited. The reported securities may be deemed beneficially owned for the purposes of Section 13(d) of the Securities Exchange Act 1934 by M&G Investment Management Limited as investment manager to these funds. The Reporting Person disclaims beneficial ownership of the securities for purposes of Rule 16a-1(a)(2) and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

The shares underlying this option shall vest and become exercisable in three equal annual installments, with the first installment vesting on September 15, 2023.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $5.46 - $5.93. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $7.34 - $7.44. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

This option is fully vested and exercisable as of the date hereof. The exercise price of this option is GBP 0.000324 per share and has been converted from pounds sterling to U.S. dollars using an average exchange rate of $1.3269 to GBP 1.00 on December 31, 2019.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $7.04 - $7.12. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $4.75 - $4.96. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.