TWO SIGMA INVESTMENTS, LP

CIK

1179392

City

NEW YORK

State / Country

Stock

CDNA — CareDx, Inc.

Top Portfolio Positions

3,307 positions · $112,062,244,503 total · as of Mar 31, 2026

Ticker	Company	Shares	Value (USD)	% of Portfolio
NVDA	Nvidia Corp Technology	12,053,545	$2,102,138,248	1.88%
AAPL	Apple Inc. Technology	6,085,143	$1,544,348,441	1.38%
GOOGL	Alphabet Inc. Communication Services	4,810,528	$1,383,315,431	1.23%
AMZN	Amazon Com Inc Consumer Cyclical	6,454,567	$1,344,292,669	1.20%
TSLA	Tesla, Inc. Consumer Cyclical	3,116,099	$1,158,409,803	1.03%
JPM	Jpmorgan Chase & Co Financial Services	3,523,588	$1,036,498,646	0.92%
PLTR	Palantir Technologies Inc. Technology	6,809,802	$996,137,836	0.89%
COST	Costco Wholesale Corp /New Consumer Defensive	891,093	$887,911,797	0.79%
TJX	Tjx Companies Inc /De/ Consumer Cyclical	5,277,968	$842,891,489	0.75%
MA	Mastercard Inc Financial Services	1,682,998	$840,926,780	0.75%

25 quarters · across all stocks

26 quarters on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-03-31	$4,020,576	231,600	+159.4%	Shares	Sole	2026-05-15
2025-12-31	$1,682,412	89,300	-43.0%	Shares	Sole	2026-02-17
2025-06-30	$3,060,237	156,614	-51.3%	Shares	Sole	2025-08-14
2025-03-31	$5,713,831	321,906	-31.3%	Shares	Sole	2025-05-15
2024-12-31	$10,037,778	468,836	+50.0%	Shares	Sole	2025-02-14
2024-09-30	$9,758,561	312,524	+194.9%	Shares	Sole	2024-11-14
2024-06-30	$1,645,869	105,980	+19.3%	Shares	Sole	2024-08-14
2024-03-31	$940,540	88,814	-29.0%	Shares	Sole	2024-05-15
2023-12-31	$1,501,932	125,161	+130.1%	Shares	Sole	2024-02-14
2023-09-30	$380,800	54,400	-61.7%	Shares	Sole	2023-11-14
2023-06-30	$1,207,000	142,000	-48.6%	Shares	Sole	2023-08-14
2023-03-31	$2,525,418	276,304	+18.8%	Shares	Sole	2023-05-15
2022-12-31	$2,654,570	232,653	-53.8%	Shares	Sole	2023-02-14
2022-09-30	$8,568,787	503,454	+2.8%	Shares	Sole	2022-11-14
2022-06-30	$10,520,173	489,766	+66.9%	Shares	Sole	2022-08-15
2022-03-31	$10,851,534	293,364	+2.8%	Shares	Sole	2022-05-16
2021-12-31	$12,979,082	285,380	+55.2%	Shares	Sole	2022-02-14
2021-09-30	$11,650,701	183,852	+4175.6%	Shares	Sole	2021-11-15
2021-06-30	$393,536	4,300	-89.7%	Put	Sole	2021-08-16
2021-06-30	$3,825,536	41,800	+971.8%	Shares	Sole	2021-08-16
2021-03-31	$265,551	3,900	-99.0%	Call	Sole	2021-05-17
2021-03-31	$26,560,683	390,082	+9902.1%	Shares	Sole	2021-05-17
2021-03-31	$265,551	3,900	-96.5%	Put	Sole	2021-05-17
2020-12-31	$7,999,639	110,416	-55.3%	Shares	Sole	2021-02-16
2020-09-30	$9,365,033	246,838	+1378.1%	Shares	Sole	2020-11-16
2020-06-30	$591,681	16,700	—	Shares	Sole	2020-08-14
No 13F history on record for this holder in this stock.