TWO SIGMA INVESTMENTS, LP

Position in OMER — Omeros Corp

CIK 1179392 NEW YORK, NY

Position in OMER

as of Mar 31, 2026 · filed May 15, 2026 Compact

Position Value

$3,025,165

-$5,990,160 QoQ

Shares Held

286,474

-45.4% QoQ

Ownership

0.396%

of shares outstanding

% of Portfolio

0.00%

of 13F equity value

Holder Rank

—

not a current holder

Holding Since

Mar 2020

23 quarters on record

Voting authority Sole 98.70843427326739.ToString("F0")% Shared 0.ToString("F0")% None 1.291565726732618.ToString("F0")%

Healthcare · as of Mar 31, 2026

TWO SIGMA INVESTMENTS, LP holds $5,506,832,621 across 316 Biotechnology names. OMER ranks #134 (0.1% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	ALNY	Alnylam Pharmaceuticals, Inc.	1,992,577	$659,283,951
2	REGN	Regeneron Pharmaceuticals, Inc.	812,236	$627,566,023
3	MRNA	Moderna, Inc.	9,086,404	$461,589,323
4	IONS	Ionis Pharmaceuticals Inc	5,857,629	$439,849,361
5	BBIO	BridgeBio Pharma, Inc.	3,120,631	$231,738,058
6	VRTX	Vertex Pharmaceuticals Inc / Ma	378,146	$168,857,314
7	RVMD	Revolution Medicines, Inc.	1,558,807	$151,593,980
8	VKTX	Viking Therapeutics, Inc.	4,432,142	$144,221,900

23 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-03-31	$3,025,165	286,474	-45.4%	Shares	Sole	2026-05-15
2025-12-31	$9,015,325	524,757	-43.8%	Shares	Sole	2026-02-17
2025-09-30	$3,826,587	933,314	+39.3%	Shares	Sole	2025-11-14
2025-06-30	$2,010,657	670,219	+534.4%	Shares	Sole	2025-08-14
2025-03-31	$868,352	105,639	-35.2%	Shares	Sole	2025-05-15
2024-12-31	$1,610,351	162,991	+8.8%	Shares	Sole	2025-02-14
2024-09-30	$594,666	149,790	-6.1%	Shares	Sole	2024-11-14
2024-06-30	$647,350	159,446	+190.3%	Shares	Sole	2024-08-14
2024-03-31	$189,467	54,918	+15.4%	Shares	Sole	2024-05-15
2023-12-31	$155,652	47,600	-69.0%	Shares	Sole	2024-02-14
2023-09-30	$448,114	153,464	+156.6%	Shares	Sole	2023-11-14
2023-06-30	$325,312	59,800	0.0%	Shares	Sole	2023-08-14
2023-03-31	$278,070	59,800	-70.0%	Shares	Sole	2023-05-15
2022-12-31	$450,275	199,237	+102.9%	Shares	Sole	2023-02-14
2022-09-30	$309,317	98,196	-85.7%	Shares	Sole	2022-11-14
2022-06-30	$1,891,736	687,904	+203.3%	Shares	Sole	2022-08-15
2022-03-31	$1,362,989	226,787	-58.6%	Shares	Sole	2022-05-16
2021-12-31	$3,525,684	548,318	+147.2%	Shares	Sole	2022-02-14
2021-09-30	$3,058,608	221,799	-43.9%	Shares	Sole	2021-11-15
2021-06-30	$5,866,533	395,319	+39.0%	Shares	Sole	2021-08-16
2021-03-31	$5,062,337	284,401	+223.7%	Shares	Sole	2021-05-17
2020-06-30	$1,293,181	87,852	+74.1%	Shares	Sole	2020-08-14
2020-03-31	$674,690	50,463	—	Shares	Sole	2020-05-15
No filing history on record for this holder in this stock.