D. E. Shaw & Co., Inc.

Position in PBYI — Puma Biotechnology, Inc.

CIK 1009207 New York, NY

Back to PBYI Full portfolio

Position in PBYI

as of Mar 31, 2026 · filed May 15, 2026 Compact

Position Value

$2,244,391

-$6,470 QoQ

Shares Held

351,235

-7.2% QoQ

Ownership

0.690%

of shares outstanding

% of Portfolio

0.00%

of 13F equity value

Holder Rank

—

not a current holder

Holding Since

Mar 2020

19 quarters on record

Voting authority Sole 99% Shared 0% None 1%

Common Shares in PBYI Over Time

Shares Held

Position Value (USD)

Derivatives in PBYI

reported options exposure · as of Dec 31, 2020

CallValue

CallShares

PutValue

$290,358

PutShares

28,300

Notional value of option positions as reported on Form 13F. Calls and puts are disclosed separately and do not net against the common-share stake above.

Position in Biotechnology

Healthcare · as of Mar 31, 2026

D. E. Shaw & Co., Inc. holds $4,328,350,520 across 180 Biotechnology names. PBYI ranks #111 (0.1% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	INSM	INSMED Inc	5,625,825	$919,934,903
2	ALNY	Alnylam Pharmaceuticals, Inc.	1,059,062	$350,411,843
3	BBIO	BridgeBio Pharma, Inc.	2,545,486	$189,027,789
4	PCVX	Vaxcyte, Inc.	2,865,318	$166,503,628
5	EXEL	Exelixis, Inc.	3,603,063	$154,535,371
6	HALO	Halozyme Therapeutics, Inc.	1,868,708	$120,774,597
7	PTCT	Ptc Therapeutics, Inc.	1,640,381	$111,759,157
8	VRTX	Vertex Pharmaceuticals Inc / Ma	248,960	$111,170,598

All Filings in PBYI

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23 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-03-31	$2,244,391	351,235	-7.2%	Shares	Defined	2026-05-15
2025-12-31	$2,250,861	378,296	-24.1%	Shares	Defined	2026-02-17
2025-09-30	$2,647,555	498,598	-22.2%	Shares	Defined	2025-11-14
2025-06-30	$2,197,875	640,780	+12.1%	Shares	Defined	2025-08-14
2025-03-31	$1,692,128	571,665	+156.8%	Shares	Defined	2025-05-15
2024-12-31	$678,954	222,608	+287.9%	Shares	Defined	2025-02-14
2024-09-30	$146,339	57,388	-56.6%	Shares	Defined	2024-11-14
2022-12-31	$559,138	132,184	-75.5%	Shares	Defined	2023-02-14
2022-09-30	$1,276,349	538,544	-43.9%	Shares	Defined	2022-11-14
2022-06-30	$2,736,204	960,072	-4.6%	Shares	Defined	2022-08-15
2022-03-31	$2,897,230	1,005,983	+36.7%	Shares	Defined	2022-05-16
2021-12-31	$2,237,324	735,962	+1364.0%	Shares	Defined	2022-02-14
2021-09-30	$352,406	50,272	-54.9%	Shares	Defined	2021-11-15
2021-06-30	$1,023,625	111,506	+39.0%	Shares	Defined	2021-08-16
2021-03-31	$779,505	80,196	+130.4%	Shares	Defined	2021-05-17
2020-12-31	$357,140	34,809	+15.2%	Shares	Defined	2021-02-16
2020-12-31	$290,358	28,300	0.0%	Put	Defined	2021-02-16
2020-09-30	$285,547	28,300	0.0%	Put	Defined	2020-11-16
2020-09-30	$304,888	30,217	-84.1%	Shares	Defined	2020-11-16
2020-06-30	$1,981,814	190,011	+21.7%	Shares	Defined	2020-08-14
2020-06-30	$295,169	28,300	0.0%	Put	Defined	2020-08-14
2020-03-31	$1,317,424	156,093	—	Shares	Defined	2020-05-15
2020-03-31	$238,852	28,300	—	Put	Defined	2020-05-15
No filing history on record for this holder in this stock.