PBYI · Puma Biotechnology, Inc. · Holdings

$9.59 -0.01 (-0.10%) At close · Sep 21

Russell 2000 member Rebalance outlook locked

Market Cap

$495.55M

51.62M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP →

Quarter:

Holders: 161

Total Value: $314,473,040

Total Shares: 38,775,973

Showing 1–100 of 163 holdings by value · page 1 of 2

Institutional Ownership Trend

26 quarters

Holder Concentration

Across 161 13F filers · Δ vs Mar 31, 2026

Top Holder

10.7%

−0.2 pts

Top 5

36.5%

+0.6 pts

Top 10

57.5%

+1.4 pts

HHI

442

Broadly held+5

Quarterly Activity

vs Mar 31, 2026

New

Increased

Decreased

Sold Out

Unchanged

Holder count: +3

Institutional value: +29.6%

Shares held: +2.1%

Top Buyers

vs Mar 31, 2026

Institution	Added	Now Holds
Large LSV ASSET MANAGEMENT	+435,113	1,617,981
Mega AMERICAN CENTURY COMPANIES INC	+403,650	2,319,996
Mega GEODE CAPITAL MANAGEMENT, LLC	+322,063	1,339,405
Mega Invesco Ltd.	+205,958	301,002
Mega BlackRock, Inc.	+205,784	3,804,736

Top Sellers

vs Mar 31, 2026

Institution	Sold	Now Holds
Mega MILLENNIUM MANAGEMENT LLC	−875,279	602,240
Large Connor, Clark & Lunn Investment Management Ltd.	−139,852	642,946
Large RENAISSANCE TECHNOLOGIES LLC	−106,200	1,836,213
Mega MORGAN STANLEY	−94,072	265,670
Large SEI INVESTMENTS CO	−89,513	418,669

Top New Positions

vs Mar 31, 2026

Institution	Acquired	Value (USD)
Mega WELLINGTON MANAGEMENT GROUP LLP	126,091	$1,022,596
Large Trexquant Investment LP	72,223	$585,728
Mid Y-Intercept (Hong Kong) Ltd	26,222	$212,660
Mid MARTINGALE ASSET MANAGEMENT L P	25,364	$205,702
Micro Spark Investment Management LLC	17,000	$137,870

Top Sold-Out Positions

vs Mar 31, 2026

Institution	Previously Held	Last Value (USD)
Mega CITADEL ADVISORS LLC	29,959	$191,438
Small VIRTUS ADVISERS, LLC	29,347	$187,527
Mid Engineers Gate Manager LP	28,600	$182,754
Large LAZARD ASSET MANAGEMENT LLC	17,970	$114,828
Large Quadrature Capital Ltd	16,745	$107,000

Filter: New 21 Increased 61 Reduced 52 Sold out 18 Unchanged 27

Showing 100 of 163

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

ACORN CAPITAL ADVISORS, LLC

$33,504,834

10.65%

4,131,299

BlackRock, Inc.

$30,856,406

9.81%

3,804,736

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	139,924	$1,134,783	3.7%	Sole
BlackRock Investment Management, LLC	131,387	$1,065,548	3.5%	Sole
BLACKROCK ADVISORS LLC	301,000	$2,441,110	7.9%	Sole
BlackRock Fund Advisors	1,739,142	$14,104,441	45.7%	Sole
BlackRock Institutional Trust Company, N.A.	1,378,285	$11,177,891	36.2%	Sole
BlackRock Asset Management Ireland Ltd	34,292	$278,108	0.9%	Sole
Aperio Group, LLC	80,706	$654,525	2.1%	Sole

AMERICAN CENTURY COMPANIES INC

$18,815,167

5.98%

2,319,996

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AMERICAN CENTURY INVESTMENT MANAGEMENT INC	2,319,996	$18,815,167	100.0%	Defined

ACADIAN ASSET MANAGEMENT LLC

$16,654,071

5.30%

2,053,523

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Acadian Inc	2,053,523	$16,654,071	100.0%	Defined

RENAISSANCE TECHNOLOGIES LLC

$14,891,687

4.74%

1,836,213

VANGUARD CAPITAL MANAGEMENT LLC

$14,887,064

4.73%

1,835,643

VANGUARD PORTFOLIO MANAGEMENT LLC

$14,805,607

4.71%

1,825,599

LSV ASSET MANAGEMENT

$13,121,825

4.17%

1,617,981

DIMENSIONAL FUND ADVISORS LP

$12,311,092

3.91%

1,518,014

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dimensional Fund Advisors Ltd.	6,700	$54,337	0.4%	Defined
DFA Australia Ltd.	22,622	$183,464	1.5%	Defined
Dimensional Ireland Ltd	82,122	$666,009	5.4%	Defined
Held directly	1,406,570	$11,407,282	92.7%	Sole

GEODE CAPITAL MANAGEMENT, LLC

$10,862,574

3.45%

1,339,405

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	153,703	$1,246,531	11.5%	Defined
Held directly	1,185,702	$9,616,043	88.5%	Defined

O'SHAUGHNESSY ASSET MANAGEMENT, LLC

$9,113,880

2.90%

1,123,783

STATE STREET CORP

$7,722,058

2.46%

952,165

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	952,165	$7,722,058	100.0%	Defined

KENNEDY CAPITAL MANAGEMENT LLC

$7,082,081

2.25%

873,253

BRIDGEWAY CAPITAL MANAGEMENT, LLC

$6,420,005

2.04%

791,616

RITHOLTZ WEALTH MANAGEMENT

$6,080,861

1.93%

749,798

AQR CAPITAL MANAGEMENT LLC

$5,881,304

1.87%

725,192

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RF&L WEALTH MANAGEMENT, LLC	12	$97	0.0%	Other
Compound Planning, Inc.	16	$129	0.0%	Other
Arax Advisory Partners	1,703	$13,811	0.2%	Other
HALBERT HARGROVE GLOBAL ADVISORS, LLC	2,602	$21,102	0.4%	Other
Stokes Family Office, LLC	10,251	$83,135	1.4%	Other
Held directly	710,608	$5,763,030	98.0%	Defined

GOLDMAN SACHS GROUP INC

$5,426,855

1.73%

669,156

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	216,801	$1,758,256	32.4%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	452,355	$3,668,599	67.6%	Defined

NORTHERN TRUST CORP

$5,290,849

1.68%

652,386

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	645,430	$5,234,436	98.9%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	6,956	$56,413	1.1%	Other

Connor, Clark & Lunn Investment Management Ltd.

$5,214,292

1.66%

642,946

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Manager 1	642,946	$5,214,292	100.0%	Sole

UBS Group AG

$5,164,131

1.64%

636,761

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	12,321	$99,923	1.9%	Defined
UBS AG	527,956	$4,281,723	82.9%	Defined
UBS Europe SE	96,483	$782,477	15.2%	Defined
UBS Securities LLC	1	$8	0.0%	Defined

MILLENNIUM MANAGEMENT LLC

$4,884,166

1.55%

602,240

ARROWSTREET CAPITAL, LIMITED PARTNERSHIP

$4,318,169

1.37%

532,450

SEI INVESTMENTS CO

$3,395,405

1.08%

418,669

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SEI INVESTMENTS MANAGEMENT CORP	1,720	$13,949	0.4%	Sole
SEI TRUST CO	416,949	$3,381,456	99.6%	Sole

GLOBEFLEX CAPITAL L P

$3,104,564

0.99%

382,807

Bank of New York Mellon Corp

$2,925,551

0.93%

360,734

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation	161,757	$1,311,849	44.8%	Defined
The Bank of New York Mellon	69,634	$564,731	19.3%	Defined
Newton Investment Management North America, LLC	129,342	$1,048,963	35.9%	Defined
Held directly	1	$8	0.0%	Defined

D. E. Shaw & Co., Inc.

$2,565,541

0.82%

316,343

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
D. E. SHAW & CO, L.P.	32,696	$265,164	10.3%	Defined
D. E. Shaw Investment Management, L.L.C. joint	283,647	$2,300,377	89.7%	Defined

STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM

$2,506,849

0.80%

309,106

Invesco Ltd.

$2,441,124

0.78%

301,002

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	5,653	$45,845	1.9%	Defined
Invesco Trust Co joint	17,570	$142,492	5.8%	Defined
Invesco Capital Management LLC	277,779	$2,252,787	92.3%	Defined

Russell Investments Group, Ltd.

$2,207,817

0.70%

272,234

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC	272,234	$2,207,817	100.0%	Defined

VANGUARD FIDUCIARY TRUST CO

$2,182,157

0.69%

269,070

MORGAN STANLEY

$2,154,580

0.69%

265,670

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	46	$373	0.0%	Defined
MORGAN STANLEY & CO. LLC	12,315	$99,874	4.6%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	38,731	$314,108	14.6%	Defined
MORGAN STANLEY SMITH BARNEY LLC	122,408	$992,728	46.1%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	92,170	$747,497	34.7%	Defined

FEDERATED HERMES, INC.

$2,033,712

0.65%

250,766

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FEDERATED MDTA LLC	250,766	$2,033,712	100.0%	Defined

Empowered Funds, LLC

$1,786,762

0.57%

220,316

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Bridgeway Capital Management, LLC	220,316	$1,786,762	100.0%	Other

PANAGORA ASSET MANAGEMENT INC

$1,764,289

0.56%

217,545

PRUDENTIAL FINANCIAL INC

$1,732,287

0.55%

213,599

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
PGIM Quantitative Solutions LLC	197,299	$1,600,094	92.4%	Defined
Prudential Trust Co	16,300	$132,193	7.6%	Defined

FMR LLC

$1,714,810

0.55%

211,444

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	210,638	$1,708,274	99.6%	Defined
STRATEGIC ADVISERS LLC	806	$6,536	0.4%	Defined

JPMORGAN CHASE & CO

$1,713,958

0.55%

211,339

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JPMorgan Chase Bank, N.A.	32,938	$267,127	15.6%	Defined
J.P. Morgan Investment Management Inc.	172,649	$1,400,183	81.7%	Defined
J.P. Morgan Securities LLC	195	$1,581	0.1%	Defined
J.P. Morgan Securities plc	5,557	$45,067	2.6%	Defined

STATE OF WISCONSIN INVESTMENT BOARD

$1,526,561

0.49%

188,232

FRANKLIN RESOURCES INC

$1,394,999

0.44%

172,010

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Brandywine Global Investment Management, LLC	29,860	$242,164	17.4%	Defined
FRANKLIN ADVISERS INC	135,870	$1,101,905	79.0%	Defined
FRANKLIN ADVISORY SERVICES LLC	3,276	$26,568	1.9%	Defined
PUTNAM ADVISORY CO LLC	3,004	$24,362	1.7%	Defined

Prospera Financial Services Inc

$1,287,559

0.41%

158,762

Haven Private, LLC

$1,203,913

0.38%

148,448

TWO SIGMA INVESTMENTS, LP

$1,140,160

0.36%

140,587

FIRST TRUST ADVISORS LP

$1,055,970

0.34%

130,206

Round Rock Advisors LLC

$1,045,476

0.33%

128,912

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$1,040,050

0.33%

128,243

WELLINGTON MANAGEMENT GROUP LLP

$1,022,596

0.33%

126,091

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	41,090	$333,239	32.6%	Defined
Wellington Trust Company, NA joint	79,408	$643,998	63.0%	Defined
Wellington Management Australia Pty Ltd	5,593	$45,359	4.4%	Defined

STRS OHIO

$686,106

0.22%

84,600

Nuveen, LLC

$667,436

0.21%

82,298

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	23,179	$187,981	28.2%	Defined
TEACHERS ADVISORS, LLC joint	59,119	$479,455	71.8%	Defined

EVERGREEN CAPITAL MANAGEMENT LLC

$597,958

0.19%

73,731

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Aperio Group, LLC	64	$519	0.1%	Other
Held directly	73,667	$597,439	99.9%	Sole

CANADA PENSION PLAN INVESTMENT BOARD

$596,085

0.19%

73,500

Trexquant Investment LP

$585,728

0.19%

72,223

Vise Technologies, Inc.

$584,163

0.19%

72,030

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$520,662

0.17%

64,200

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	64,200	$520,662	100.0%	Other

NOMURA ASSET MANAGEMENT INTERNATIONAL INC.

$496,778

0.16%

61,255

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NOMURA HOLDINGS INC joint	61,255	$496,778	100.0%	Defined

OpenArc Corporate Advisory, LLC

$482,472

0.15%

59,491

RHUMBLINE ADVISERS

$466,406

0.15%

57,510

D'Orazio & Associates, Inc.

$394,794

0.13%

48,680

Vanguard Global Advisers, LLC

$375,225

0.12%

46,267

DEUTSCHE BANK AG\

$350,287

0.11%

43,192

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS Investments UK Ltd	43,192	$350,287	100.0%	Defined

Man Group plc

$336,613

0.11%

41,506

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Numeric Investors LLC	41,506	$336,613	100.0%	Defined

WINTON GROUP Ltd

$328,527

0.10%

40,509

XTX Topco Ltd

$326,800

0.10%

40,296

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
XTX EXECUTION SERVICES LLC joint	40,296	$326,800	100.0%	Defined

State of Wyoming

$323,045

0.10%

39,833

WELLS FARGO & COMPANY/MN

$304,984

0.10%

37,606

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	37,605	$304,976	100.0%	Defined
WELLS FARGO CLEARING SERVICES, LLC	1	$8	0.0%	Defined

EntryPoint Capital, LLC

$303,200

0.10%

37,386

Baron Wealth Management LLC

$294,976

0.09%

36,372

PRICE T ROWE ASSOCIATES INC /MD/

$294,741

0.09%

36,343

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	36,343	$294,741	100.0%	Defined

Creative Planning

$289,827

0.09%

35,737

LPL Financial LLC

$280,095

0.09%

34,537

Universal- Beteiligungs- und Servicegesellschaft mbH

$279,673

0.09%

34,485

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Universal-Investment-Gesellschaft mbH	34,485	$279,673	100.0%	Defined

BANK OF AMERICA CORP /DE/

$257,468

0.08%

31,747

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	31,747	$257,468	100.0%	Defined

Kathmere Capital Management, LLC

$252,804

0.08%

31,172

ENVESTNET ASSET MANAGEMENT INC

$236,730

0.08%

29,190

Y-Intercept (Hong Kong) Ltd

$212,660

0.07%

26,222

MARTINGALE ASSET MANAGEMENT L P

$205,702

0.07%

25,364

Metis Global Partners, LLC

$204,891

0.07%

25,264

MetLife Investment Management, LLC

$201,720

0.06%

24,873

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
METLIFE INC	24,873	$201,720	100.0%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$195,451

0.06%

24,100

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	24,100	$195,451	100.0%	Other

C2C Wealth Management, LLC

$191,558

0.06%

23,620

CITIGROUP INC

$175,711

0.06%

21,666

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	21,666	$175,711	100.0%	Defined

PRELUDE CAPITAL MANAGEMENT, LLC

$174,754

0.06%

21,548

ALLIANCEBERNSTEIN L.P.

$173,229

0.06%

21,360

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	21,360	$173,229	100.0%	Defined

One Wealth Advisors, LLC

$170,950

0.05%

21,079

MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.

$165,306

0.05%

20,383

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Global X Management CO LLC joint	20,383	$165,306	100.0%	Defined

BAILARD, INC.

$146,791

0.05%

18,100

Allspring Global Investments Holdings, LLC

$145,533

0.05%

17,945

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Allspring Funds Management, LLC reporting on behalf of Morgan Stanley Smith Barney, LLC	342	$2,773	1.9%	Defined
Allspring Global Investments, LLC reporting on behalf of UBS ASSET MANAGEMENT AMERICAS INC	17,603	$142,760	98.1%	Defined

JANE STREET GROUP, LLC

$141,925

0.05%

17,500

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	17,500	$141,925	100.0%	Defined

Spark Investment Management LLC

$137,870

0.04%

17,000

Police & Firemen's Retirement System of New Jersey

$127,481

0.04%

15,719

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Capital	15,719	$127,481	100.0%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$125,510

0.04%

15,476

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	15,476	$125,510	100.0%	Other

Lido Advisors, LLC

$122,014

0.04%

15,045

Mariner, LLC

$120,587

0.04%

14,869

Caprock Group, LLC

$112,420

0.04%

13,862

PERKINS CAPITAL MANAGEMENT INC

$108,674

0.03%

13,400

TOCQUEVILLE ASSET MANAGEMENT L.P.

$107,960

0.03%

13,312

WEALTH ENHANCEMENT ADVISORY SERVICES, LLC

$107,076

0.03%

13,203

OSAIC HOLDINGS, INC.

$98,690

0.03%

12,169

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
OSAIC WEALTH, INC.	1,019	$8,264	8.4%	Defined
Osaic Advisory Services, LLC	11,150	$90,426	91.6%	Defined

MANUFACTURERS LIFE INSURANCE COMPANY, THE

$97,774

0.03%

12,056

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MANULIFE FINANCIAL CORP joint	12,056	$97,774	100.0%	Defined

R Squared Ltd

$97,247

0.03%

11,991

Abel Hall, LLC

$93,427

0.03%

11,520

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