PBYI · Puma Biotechnology, Inc.

$8.13 +0.14 (+1.75%) At close · Aug 6

Market Cap

$413.30M

50.90M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

The Jun 30, 2026 filing window is still open — showing the latest known positions. Funds that have not filed yet carry their prior-quarter positions; a fund that filed without this stock counts as sold out. Pick a completed quarter in the Quarter selector below to see a single quarter with position changes.

Quarter:

Holders: 157

Total Value: $211,764,337

Total Shares: 36,165,798

Showing 1–100 of 158 holdings by value · page 1 of 2

Institutional Ownership Trend

26 quarters

Holder Concentration

Across 157 13F filers

Top Holder

12.5%

of institutional value

Top 5

40.7%

of institutional value

Top 10

58.9%

of institutional value

HHI

501

Broadly held

Showing 100 of 158

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

Small ACORN CAPITAL ADVISORS, LLC

$26,399,000

12.47%

4,131,299

Mega BlackRock, Inc.

$22,997,299

10.86%

3,598,952

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	151,679	$969,228	4.2%	Sole
BlackRock Investment Management, LLC	146,339	$935,106	4.1%	Sole
BLACKROCK ADVISORS LLC	289,874	$1,852,294	8.1%	Sole
BlackRock Fund Advisors	1,553,953	$9,929,759	43.2%	Sole
BlackRock Institutional Trust Company, N.A.	1,357,725	$8,675,862	37.7%	Sole
BlackRock Asset Management Ireland Ltd	41,634	$266,041	1.2%	Sole
Aperio Group, LLC	57,748	$369,009	1.6%	Sole

Large RENAISSANCE TECHNOLOGIES LLC

$12,412,019

5.86%

1,942,413

Mega AMERICAN CENTURY COMPANIES INC

$12,245,450

5.78%

1,916,346

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AMERICAN CENTURY INVESTMENT MANAGEMENT INC	1,916,346	$12,245,450	100.0%	Defined

Mega VANGUARD CAPITAL MANAGEMENT LLC

$11,614,981

5.48%

1,817,681

Mega MILLENNIUM MANAGEMENT LLC

$9,441,346

4.46%

1,477,519

Mega DIMENSIONAL FUND ADVISORS LP

$9,176,715

4.33%

1,436,106

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dimensional Fund Advisors Ltd.	6,700	$42,813	0.5%	Defined
DFA Australia Ltd.	22,622	$144,554	1.6%	Defined
Dimensional Ireland Ltd	66,843	$427,126	4.7%	Defined
Held directly	1,339,941	$8,562,222	93.3%	Sole

Large O'SHAUGHNESSY ASSET MANAGEMENT, LLC

$7,272,899

3.43%

1,138,169

Mega GEODE CAPITAL MANAGEMENT, LLC

$6,500,815

3.07%

1,017,342

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	143,862	$919,278	14.1%	Defined
Held directly	873,480	$5,581,537	85.9%	Defined

Mega STATE STREET CORP

$5,863,400

2.77%

917,590

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	917,590	$5,863,400	100.0%	Defined

Mid KENNEDY CAPITAL MANAGEMENT LLC

$5,684,550

2.68%

889,601

Mega AQR CAPITAL MANAGEMENT LLC

$5,113,237

2.41%

800,194

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
KEB ASSET MANAGEMENT, LLC	1	$6	0.0%	Other
RF&L WEALTH MANAGEMENT, LLC	12	$76	0.0%	Other
Compound Planning, Inc.	16	$102	0.0%	Other
Arax Advisory Partners	1,797	$11,482	0.2%	Other
HALBERT HARGROVE GLOBAL ADVISORS, LLC	2,600	$16,614	0.3%	Other
Stokes Family Office, LLC	10,377	$66,309	1.3%	Other
Held directly	785,391	$5,018,648	98.2%	Defined

Large Connor, Clark & Lunn Investment Management Ltd.

$5,002,079

2.36%

782,798

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Manager 1	782,798	$5,002,079	100.0%	Sole

Mid BRIDGEWAY CAPITAL MANAGEMENT, LLC

$4,954,428

2.34%

775,341

Mid RITHOLTZ WEALTH MANAGEMENT

$4,947,828

2.34%

774,308

Mega GOLDMAN SACHS GROUP INC

$4,279,504

2.02%

669,719

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	169,483	$1,082,996	25.3%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	500,236	$3,196,508	74.7%	Defined

Mega NORTHERN TRUST CORP Bank

$4,100,799

1.94%

641,753

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	635,771	$4,062,575	99.1%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	5,982	$38,224	0.9%	Other

Mega ARROWSTREET CAPITAL, LIMITED PARTNERSHIP

$3,438,810

1.62%

538,155

Mega UBS Group AG

$3,413,710

1.61%

534,227

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	11,880	$75,913	2.2%	Defined
UBS AG	522,347	$3,337,797	97.8%	Defined

Large SEI INVESTMENTS CO

$3,247,282

1.53%

508,182

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SEI INVESTMENTS MANAGEMENT CORP	1,720	$10,990	0.3%	Sole
SEI TRUST CO	506,462	$3,236,292	99.7%	Sole

Mega MORGAN STANLEY

$2,298,748

1.09%

359,742

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	226	$1,444	0.1%	Defined
MORGAN STANLEY & CO. LLC	22,125	$141,378	6.2%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	90,562	$578,691	25.2%	Defined
MORGAN STANLEY SMITH BARNEY LLC	150,923	$964,397	42.0%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	95,906	$612,838	26.7%	Defined

Mega D. E. Shaw & Co., Inc.

$2,244,391

1.06%

351,235

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
D. E. Shaw Investment Management, L.L.C. joint	351,235	$2,244,391	100.0%	Defined

Small GLOBEFLEX CAPITAL L P

$2,234,269

1.06%

349,651

Mega Bank of New York Mellon Corp Bank

$2,222,958

1.05%

347,881

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation	154,929	$989,996	44.5%	Defined
The Bank of New York Mellon	63,609	$406,461	18.3%	Defined
Newton Investment Management North America, LLC	129,342	$826,495	37.2%	Defined
Held directly	1	$6	0.0%	Defined

Large STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM Pension

$1,743,767

0.82%

272,890

Large PRUDENTIAL FINANCIAL INC

$1,616,919

0.76%

253,039

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
PGIM Quantitative Solutions LLC	223,039	$1,425,219	88.1%	Defined
Prudential Trust Co	30,000	$191,700	11.9%	Defined

Mega VANGUARD FIDUCIARY TRUST CO Bank

$1,608,254

0.76%

251,683

Large Russell Investments Group, Ltd.

$1,608,062

0.76%

251,653

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC	251,653	$1,608,062	100.0%	Defined

Large FEDERATED HERMES, INC.

$1,518,998

0.72%

237,715

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FEDERATED MDTA LLC	237,715	$1,518,998	100.0%	Defined

Mega JPMORGAN CHASE & CO

$1,410,425

0.67%

220,724

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JPMorgan Chase Bank, N.A.	33,334	$213,004	15.1%	Defined
J.P. Morgan Investment Management Inc.	183,594	$1,173,165	83.2%	Defined
J.P. Morgan Securities LLC	195	$1,246	0.1%	Defined
J.P. Morgan Securities plc	3,601	$23,010	1.6%	Defined

Mega FRANKLIN RESOURCES INC

$1,376,346

0.65%

215,391

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Brandywine Global Investment Management, LLC	29,860	$190,805	13.9%	Defined
FRANKLIN ADVISERS INC	177,707	$1,135,547	82.5%	Defined
FRANKLIN ADVISORY SERVICES LLC	3,102	$19,821	1.4%	Defined
PUTNAM ADVISORY CO LLC	4,722	$30,173	2.2%	Defined

Large STATE OF WISCONSIN INVESTMENT BOARD

$1,333,069

0.63%

208,618

Large Empowered Funds, LLC

$1,303,821

0.62%

204,041

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Bridgeway Capital Management, LLC	204,041	$1,303,821	100.0%	Other

Mid Prospera Financial Services Inc

$1,287,559

0.61%

158,762

Large PANAGORA ASSET MANAGEMENT INC

$1,245,327

0.59%

194,887

Mega FMR LLC

$1,225,812

0.58%

191,833

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	191,059	$1,220,867	99.6%	Defined
STRATEGIC ADVISERS LLC	774	$4,945	0.4%	Defined

Micro Haven Private, LLC

$1,203,913

0.57%

148,448

Small Round Rock Advisors LLC

$823,747

0.39%

128,912

Mega FIRST TRUST ADVISORS LP

$789,248

0.37%

123,513

Mega CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$740,696

0.35%

115,915

Large STRS OHIO

$686,106

0.32%

84,600

Mega Invesco Ltd.

$607,330

0.29%

95,044

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	5,294	$33,828	5.6%	Defined
Invesco Trust Co joint	13,724	$87,696	14.4%	Defined
Invesco Capital Management LLC	76,026	$485,806	80.0%	Defined

Mid EVERGREEN CAPITAL MANAGEMENT LLC

$597,958

0.28%

73,731

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Aperio Group, LLC	64	$519	0.1%	Other
Held directly	73,667	$597,439	99.9%	Sole

Mega Nuveen, LLC

$505,454

0.24%

79,101

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	23,179	$148,113	29.3%	Defined
TEACHERS ADVISORS, LLC joint	55,922	$357,341	70.7%	Defined

Small State of Wyoming

$484,413

0.23%

75,808

Mid OpenArc Corporate Advisory, LLC

$482,472

0.23%

59,491

Mid WINTON GROUP Ltd

$423,867

0.20%

66,333

Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP

$406,404

0.19%

63,600

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	63,600	$406,404	100.0%	Other

Small D'Orazio & Associates, Inc.

$394,794

0.19%

48,680

Large NOMURA ASSET MANAGEMENT INTERNATIONAL INC.

$391,419

0.18%

61,255

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NOMURA HOLDINGS INC joint	61,255	$391,419	100.0%	Defined

Small EntryPoint Capital, LLC

$341,634

0.16%

53,464

Mega RHUMBLINE ADVISERS

$338,900

0.16%

53,036

Mega JANE STREET GROUP, LLC

$303,525

0.14%

47,500

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	46,000	$293,940	96.8%	Defined
Jane Street Options, LLC	1,500	$9,585	3.2%	Defined

Large Man Group plc

$302,726

0.14%

47,375

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Numeric Investors LLC	47,375	$302,726	100.0%	Defined

Small Baron Wealth Management LLC

$294,976

0.14%

36,372

Mega BANK OF AMERICA CORP /DE/ Bank

$257,925

0.12%

40,364

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	40,364	$257,925	100.0%	Defined

Mid Vise Technologies, Inc.

$257,504

0.12%

40,298

Small Kathmere Capital Management, LLC

$252,804

0.12%

31,172

Large Universal- Beteiligungs- und Servicegesellschaft mbH

$251,178

0.12%

39,308

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Universal-Investment-Gesellschaft mbH	39,308	$251,178	100.0%	Defined

Mega ENVESTNET ASSET MANAGEMENT INC

$236,730

0.11%

29,190

Mega LPL Financial LLC

$233,989

0.11%

36,618

Mid Y-Intercept (Hong Kong) Ltd

$212,660

0.10%

26,222

Mega DEUTSCHE BANK AG\ Bank

$211,796

0.10%

33,145

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS Investments UK Ltd	33,145	$211,796	100.0%	Defined

Micro C2C Wealth Management, LLC

$191,558

0.09%

23,620

Mega CITADEL ADVISORS LLC

$191,438

0.09%

29,959

Small VIRTUS ADVISERS, LLC

$187,527

0.09%

29,347

Mega Vanguard Global Advisers, LLC

$186,415

0.09%

29,173

Mid Engineers Gate Manager LP

$182,754

0.09%

28,600

Mega CITIGROUP INC

$175,711

0.08%

21,666

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	21,666	$175,711	100.0%	Defined

Mid Metis Global Partners, LLC

$161,436

0.08%

25,264

Large Creative Planning

$147,692

0.07%

23,113

Mid BAILARD, INC.

$146,791

0.07%

18,100

Mega CANADA PENSION PLAN INVESTMENT BOARD Pension

$145,692

0.07%

22,800

Small One Wealth Advisors, LLC

$134,694

0.06%

21,079

Large MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. Mutual Fund

$131,857

0.06%

20,635

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Global X Management CO LLC joint	20,635	$131,857	100.0%	Defined

Large Police & Firemen's Retirement System of New Jersey Pension

$127,481

0.06%

15,719

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Capital	15,719	$127,481	100.0%	Defined

Mid PRELUDE CAPITAL MANAGEMENT, LLC

$117,882

0.06%

18,448

Large LAZARD ASSET MANAGEMENT LLC

$114,828

0.05%

17,970

Mid Caprock Group, LLC

$112,420

0.05%

13,862

Large Allspring Global Investments Holdings, LLC

$109,051

0.05%

17,066

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Allspring Global Investments, LLC	17,066	$109,051	100.0%	Defined

Small PERKINS CAPITAL MANAGEMENT INC

$108,674

0.05%

13,400

Large WEALTH ENHANCEMENT ADVISORY SERVICES, LLC

$107,076

0.05%

13,203

Mid Quadrature Capital Ltd

$107,000

0.05%

16,745

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Quadrature US Inc.	16,745	$107,000	100.0%	Other

Mega WELLS FARGO & COMPANY/MN

$103,984

0.05%

16,273

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	16,273	$103,984	100.0%	Defined

Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP

$102,808

0.05%

16,089

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	16,089	$102,808	100.0%	Other

Large MetLife Investment Management, LLC

$101,230

0.05%

15,842

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
METLIFE INC	15,842	$101,230	100.0%	Defined

Large CWM, LLC

$97,530

0.05%

15,263

Small R Squared Ltd

$97,247

0.05%

11,991

Mid XTX Topco Ltd

$96,591

0.05%

15,116

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
XTX EXECUTION SERVICES LLC joint	15,116	$96,591	100.0%	Defined

Large IEQ CAPITAL, LLC

$95,217

0.04%

14,901

Large Mariner, LLC

$93,607

0.04%

14,649

Small Abel Hall, LLC

$93,427

0.04%

11,520

Mega BARCLAYS PLC

$89,382

0.04%

13,988

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	11,817	$75,510	84.5%	Defined
BARCLAYS CAPITAL INC.	2,171	$13,872	15.5%	Defined

Mega ALLIANCEBERNSTEIN L.P.

$88,182

0.04%

13,800

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	13,800	$88,182	100.0%	Defined

Micro Williams & Novak, LLC

$85,065

0.04%

10,489

Mid Ethic Inc.

$83,289

0.04%

10,270

Large Cerity Partners LLC

$83,152

0.04%

13,013

Mega TWO SIGMA INVESTMENTS, LP

$83,070

0.04%

13,000

Mid TOCQUEVILLE ASSET MANAGEMENT L.P.

$82,814

0.04%

12,960

Mega MANUFACTURERS LIFE INSURANCE COMPANY, THE Insurance

$75,178

0.04%

11,765

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MANULIFE FINANCIAL CORP joint	11,765	$75,178	100.0%	Defined

Key facts CIK 1401667 CUSIP 74587V107 13F (30d) 40 filings 40 filers Visit website Investor relations