ARCH Venture Management, LLC

CIK

1274403

Location

CHICAGO, IL

Portfolio Value

Mid $1,100,492,500

Diversification

Diversified

Filing Date

Global Rank

#1,796 / 8,517 ▲ 490

Top Industry

Biotechnology 99.2%

3Y Alpha vs SPY

+8.3%

Period ended 48 days ago

Filed Aug 14, 2026 · 3d

21 quarters · since Mar 2020

Clone Performance

Aug 2023–Aug 2026 · vs SPY

Hypothetical growth of buying every stock this filer reported holding, rebalancing on each filing and indexed to the same start. Option positions cannot be bought this way and are left out.

Cloned portfolio

+121.8%

SPY

+77.9%

Annualised alpha

+9.2%

Max drawdown

−58.8%

Estimate. 13F holdings are quarter-lagged, so the clone rebalances about 45 days after each period end — when the filing becomes public — and it excludes option and short positions. Returns use comparable raw closes and exclude dividends; a captured split can shorten the simulated window. It tracks 100% of reported value on average across 13 quarters. Past performance does not predict future results.

Portfolio Concentration

12 tracked positions · as of Jun 30, 2026 · Δ vs Mar 31, 2026

Top Position

15.9%

−2.2 pts

Top 5

68.5%

−17.0 pts

Top 10

99.3%

−0.7 pts

HHI

1,238

Diversified−330

Portfolio Trend

21 quarters · across all stocks

Sector Breakdown

As of Jun 30, 2026

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$1,100,492,500	12

Last Quarter's Activity

Export CSV

Jun 30, 2026 vs Mar 31, 2026

Added To

Positions the filer increased

No qualifying positions this quarter.

Trimmed

Positions the filer reduced

1 positions

Ticker	Company	Δ Shares	Shares	Value	Open
VIR	Vir Biotechnology, Inc.	−222,500	12,694,163	$129,353,520
No positions match the current search.

New Positions

Positions the filer opened this quarter

3 positions

Ticker	Company	Shares	Value
PBLS	Parabilis Medicines, Inc.	6,412,780	$175,517,788
SPTX	Seaport Therapeutics, Inc.	6,294,951	$136,726,335
BOLD	Boundless Bio, Inc.	2,694,095	$6,735,237
No positions match the current search.

Sold Out

Positions the filer fully exited

1 positions

Ticker	Company	Shares	Value	Open
QTTB	Q32 Bio Inc.	320,482	$2,057,494
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

12 tracked positions · $1,100,492,500 total · filing declares 12 positions · $1,100,261,770 · as of Jun 30, 2026

All sectors Healthcare

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
PBLS	Parabilis Medicines, Inc. Healthcare	NEW	6,412,780	NEW	$175,517,788	NEW	15.95%
BEAM	Beam Therapeutics Inc. Healthcare	Held	4,540,132	0	$155,817,330	+44.0%	14.16%
RAPP	Rapport Therapeutics, Inc. Healthcare	Held	3,728,738	0	$155,376,512	+33.2%	14.12%
SPTX	Seaport Therapeutics, Inc. Healthcare	NEW	6,294,951	NEW	$136,726,335	NEW	12.42%
ERAS	Erasca, Inc. Healthcare	Held	7,091,557	0	$129,917,324	+13.2%	11.81%
VIR	Vir Biotechnology, Inc. Healthcare	Reduced	12,694,163	-222,500	$129,353,520	+11.8%	11.75%
MAZE	Maze Therapeutics, Inc. Healthcare	Held	4,120,053	0	$122,942,381	−0.0%	11.17%
LYEL	Lyell Immunopharma, Inc. Healthcare	Held	3,247,162	0	$45,622,626	−30.0%	4.15%
GENB	Generate Biomedicines, Inc. Healthcare	Held	1,944,426	0	$32,802,466	+35.0%	2.98%
TXG	10x Genomics, Inc. Healthcare	Held	217,834	0	$8,351,755	+80.6%	0.76%
BOLD	Boundless Bio, Inc. Healthcare	NEW	2,694,095	NEW	$6,735,237	NEW	0.61%
GOSS	Gossamer Bio, Inc. Healthcare	Held	8,055,916	0	$1,329,226	−49.8%	0.12%

Covers the securities this platform tracks: U.S.-listed common stock and the put/call positions reported on it. A 13F can also report security types outside that coverage — preferred shares, bonds, warrants, untracked share classes — so the filing's own declared total can exceed the figures above. The source filing is linked at the top of this table.