8-K

UNITED STATESSECURITIES AND EXCHANGE COMMISSIONWashington, D.C. 20549

FORM 8-K

CURRENT REPORT****Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

June 27, 2022

Date of Report (Date of earliest event reported)

Bicycle Therapeutics plc

(Exact name of registrant as specified in its charter)

Registrant’s telephone number, including area code:

+44 1223

261503

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

Securities registered pursuant to Section 12(b) of the Act:

* Not for trading, but only in connection with the listing of the American Depositary Shares on The Nasdaq Stock Market LLC.

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).

Emerging growth company    ¨

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ¨

Item 5.07 Submission of Matters to a Vote of Security Holders

Bicycle Therapeutics plc (the “Company”) held its annual general meeting of shareholders (the “AGM”) on June 27, 2022. Each of the proposals set forth below were voted on and duly passed on a poll at the AGM. Detailed descriptions of these proposals and of the voting procedures applied at the AGM are contained in the Company’s definitive proxy statement on Schedule 14A filed with the Securities and Exchange Commission on April 29, 2022.

There were 23,743,875 ordinary shares of the Company represented in person or by proxy at the AGM, constituting approximately 80.08% of the issued and outstanding ordinary shares on June 27, 2022. Proxy appointments which gave the Chairman of the meeting discretion have been included in the “For” total. In accordance with the terms of the deposit agreement by and among the Company, Citibank, N.A. as depositary and holders and beneficial owners of American Depositary Shares (“ADSs”) dated May 28, 2019, holders of ADSs who did not provide the depositary bank with voting instructions on or before specified deadline were deemed to have instructed the depositary bank to give a discretionary proxy to a person designated by the Company to vote the underlying ordinary shares at the AGM and the voting results below reflect that. A vote withheld/abstain is not a vote in law and is not counted in the calculation of votes for or against a resolution.

Proposal 1 - To re-elect as a director PierreLegault.

Proposal 2 - To re-elect as a director RichardKender.

Proposal 3 - To approve, on advisory basis,the compensation of the Company’s named executive officers, as disclosed in this proxy statement.

Proposal 4 - To indicate, on an advisory basis,the preferred frequency of shareholder advisory votes on the compensation of the Company’s named executive officers.

Proposal 5 - To approve the amendment of theBicycle Therapeutics plc 2020 Equity Incentive Plan to increase the number of shares available for issuance under the plan.

Proposal 6 – To ratify the appointmentof PricewaterhouseCoopers LLP, a limited liability partnership organized under the laws of England, as the Company’s U.S. independentregistered public accounting firm for the year ending December 31, 2022.

Proposal 7 – To re-appoint PricewaterhouseCoopers LLP,a limited liability partnership organized under the laws of England, as the Company’s U.K. statutory auditors, to hold office untilthe conclusion of the next annual general meeting of shareholders.

Proposal 8 - To authorize the Audit Committeeto determine the Company’s U.K. statutory auditors’ remuneration for the year ending December 31, 2022.

Proposal 9 - To receive and adopt the Company’sU.K. statutory annual accounts and reports for the year ended December 31, 2021.

Proposal 10 - To approve the directors’remuneration report for the year ended December 31, 2021 (excluding the directors' remuneration policy).

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.