Ladies and gentlemen, thank you for standing by. My name is Colby, and I'll be your conference operator today. At this time, I would like to welcome you to the CloudCoast Corporation's third quarter 2025 financial results conference call. Copies of the company's press release and quarterly summary document, both issued after the market closed today, are available at www.cloudcoast.com. All lines have been placed on mute to prevent any background noise, and after the speaker's remarks, there will be a question and answer session. If you'd like to ask a question at that time, please press star, then the number one on your telephone keypad. If you'd like to withdraw your question at any time, please press star one again. Please note, this call is being recorded and an archived replay will be available online in the investor relations section at www.cloudcoast.com. I'll now turn the call over to Chris Lewis, Vice President of Investor Relations and Corporate Affairs.

Thank you and good afternoon. Joining me is our Glacos Chairman and CEO, Tom Burns, President and COO Joe Gilliam, and CFO Alex Thurman. Similar to prior quarters, the company has posted a document on its Investor Relations website under the Financials and Filings Quarterly Results section type of quarterly summary. This document is designed to be read by investors before the regularly scheduled quarterly conference call to ensure ample time and opportunity to address everyone's questions we request that you limit yourself to one question and one follow-up if you still have additional questions you may get back into the queue please note that all statements other than statements of historical facts made on this call that address activities events or developments we expect believe or anticipate will or may occur in the future are forward-looking statements these include statements about our plans objectives strategies, and prospects regarding, among other things, our sales, products, pipeline technologies, and clinical trials, U.S. and international commercialization, market development efforts, product approvals, the efficacy of our current and future products, competitive market position, regulatory strategies, and reimbursement for our products, financial condition, and results of operations, as well as the expected impact of general macroeconomic conditions including foreign currency fluctuations on our business and operations these statements are based on current expectations about future events affecting us and are subject to risks uncertainties and factors relating to our operations and business environment all of which are difficult to predict and many of which are beyond our control therefore they may cause our actual results to differ materially from those expressed or implied by forward-looking statements Please review today's PREFS release and our recent SEC filings for more information about these risk factors. You'll find these documents in the Investors section of our website at www.cloudcoast.com. Finally, please note that during today's call, we will also discuss certain non-GAAP financial measures, including results on an adjusted basis. We believe these financial measures can facilitate a more complete analysis and greater transparency into Glaucos' ongoing results of operations, particularly when comparing underlying results from period to period. Please refer to the tables on our earnings press release available in the investor relations section of our website for reconciliation of these measures to the most directly comparable GAAP financial measure. With that, I'll turn the call over to Glaucos Chairman and CEO, Tom Burns.

Okay, thanks, Chris. Good afternoon to everyone and thank you all for joining us today in addition to discussing our record third quarter results today we're also excited to provide an update on epioxa our groundbreaking advancement in corneal crosslinking for the treatment of keratoconus following the fda approval that we announced last week let's first start with the record quarter today cost reported record third quarter consolidated net sales of 133.5 million up 38 percent on a reported basis or 37 percent on a constant currency basis versus the year ago quarter as a result of our strong performance we are raising our full year 2025 net sales guidance range to 490 to 495 million compared to 480 to 486 million previously our third quarter record results reflect the sustained growth acceleration in our business driven by growing idose tr adoption and utilization along with our broader intervention of glaucoma or ig initiatives globally within our u.s glaucoma franchise we delivered record third quarter net sales of 80.8 million on strong year-over-year growth of 57 percent driven by growing contributions from idos tr which generated sales of approximately 40 million dollars in the third quarter idos tr a first of its kind intracameral procedural pharmaceutical designed to continuously deliver glaucoma drug therapy for up to three years continues to build a commercial momentum supported by positive clinical outcomes and surgeon feedback that reaffirms our view that with the launch of idos tr we are pioneering a brand new therapeutic category that has the potential to reshape glaucoma management as we know it today our teams continue to make great progress in the execution of our detailed launch plans for idos tr and we're encouraged with the continuing growing momentum moving on our international glaucoma franchise delivered net sales of 29.4 million on a year-over-year growth of 20% on a reported basis and 17% on a constant currency basis. This strong growth was once again broad-based as we continue to scale our international infrastructure and execute our plans to drive things forward as a standard of care in each region and major market in the world. Last month, we were pleased to commence commercial launch activities for Iceland Infinite in our key European markets at the ESCRS annual meeting in Copenhagen. Surgeon's initial interest levels for Iceland Infinite were very high during the meeting, reaffirming our view that EU MDR certification for Iceland Infinite will help us not only maintain and grow our presence in Europe, but also advance and accelerate our broader IG initiatives globally in the years to come. And finally, our Cornell Health franchise delivered net sales of $23.3 million on the over-year growth of 13%, including Fortrexa net sales of $20.3 million. As discussed previously, our third quarter results reflect the continued impact of Fortrexa realized revenues as a result of our entry as a company into the Medicaid Drug Rebate Program, or MDRP. Our record third quarter results reflect strong execution against our key strategic priorities and are a testament to our evolution into a more diversified ophthalmic leader with transformational growth drivers that span across multiple geographies and disease states as we advance the standard of care in glaucoma and rare disease with IDOS-TR and non-epiconsa. Beyond that, we continue to advance a robust pipeline that supports our long-term, best-in-class growth potential while remaining disciplined in capital allocation, focusing on ROI-driven investments and operational efficiency. This quarter we saw continued gross margin accretion and maintain a strong balance sheet with $278 billion in cash and no debt. Now let's shift to our corneal health pipeline. As you know, last week we were delighted to announce the FDA approval of FDA a groundbreaking advancement in corneal cross-linking for the treatment of keratoconus a rare sighting threatening disease that is currently far too often under undiagnosed and untreated this approval marks a significant milestone for glaucose and ushers in a new standard of care for keratoconus patients and practitioners with the first and only FDA approved topical drug therapy that does not require removal of the choral epithelium the outermost layer of the front of the eye as a reminder epioxa utilizes a proprietary combination of an oxygen enriched novel therapeutic that is bioactivated by uv light in an incision-free procedure this is a result of more than a decade of research focused on slowing or halting the progression of keratoconus while significantly improving patient comfort and minimizing recovery time to provide a new wave forward for patients afflicted with this site-threatening rare disease. The FDA approval is based on results from two prospective multi-center double-mast phase three pivotal trials that randomized the total of over 400 patients. Both trials successfully achieved their pre-specified primary efficacy endpoints and demonstrated favorable tolerability and safety profiles. Keratoconus is a debilitating eye condition characterized by progressive thinning and weakening of the cornea that is often most aggressively advancing in patients under the age of 30. If left untreated, it can lead to loss of visual function and even blindness and is one of the leading causes of corneal transplants in the United States. Approximately 90% of cases of keratoconus are bilateral, and as many as 20% of untreated keratoconus patients ultimately require a corneal transplant. Conventional keratoconus treatments such as eyeglasses or contact lenses address visual symptoms only and do not slow or halt underlying disease progression. Before we discuss our plans for Epioxa, it's important to understand the historical journey of Atrexa, our first-generation cross-linking therapy that, unlike Epioxida, requires the removal of the corneal epithelium. The FDA approval of Atrexa as an orphan drug was a major breakthrough back in 2016, as it became the first and only FDA-approved pharmaceutical therapy shown to slow or halt keratoconus progression. Following our nearly half-billion-dollar acquisition of Avedra in 2019, we have subsequently deployed several hundred million dollars in commercial and r&d investments to grow our corneal health franchise driving new clinical trials expanding our sales force and commercial reach strengthening market access capabilities and enhancing patient education and support programs these efforts have successfully resulted in infratrex becoming the standard of care as excellent real-world outcomes have helped preserve visions for tens of thousands of patients While our disciplined commercial execution has delivered meaningful progress and our investments have made real impact on patients' lives over the past six years, the unfortunate reality is that the access to proper care still remains far too limited, evidenced by the fact that we are still only treating about 10,000 patients annually with protrexine today. We estimate fewer than one in five actively diagnosed unstable keratoconus patients are getting access to fitrexa today, and many more are never diagnosed at all, an unacceptable reality for patients that we must change moving forward. To make matters worse, only 13% of treated patients are under the age of 18, which is when many patients are most vulnerable to significant disease progression and vision loss. Given the invasive nature and extended recovery associated with the current vitrexia procedure, many patients are likely to delay or defer treatment. in we estimate that as many of as many as 40 percent of confirmed cases delay or decline for trexotherapy including procedures involving treated patients sac and thigh this is simply not good enough for patients and we are determined to do better for this rare disease community like other rare diseases we believe there are several key factors contributing to why care at Econus remains too often undiagnosed and untreated today, including one, lack of awareness and underdiagnosis, two, misdiagnosis and a focus on managing symptoms rather than proactively treating the underlying disease, and three, a burdensome and lengthy patient journey marked with reimbursement hurdles and fragmented care pathways. The FDA approval of Epioxab marks a pivotal moment, introducing the first incision-free treatment for keratoconus and offering a groundbreaking new therapy for patients. Just as important, it gives us the opportunity to reset and redefine our go-to-market approach to better address this site-threatening disease and truly expand patient access. With this approval, we plan to substantially increase our investments in patient awareness and access while addressing the long-standing challenges of under-diagnosed and under-treatment that have affected this rare disease community. Our new approach includes significantly enhanced awareness, education, and detection campaigns, driven by increased engagements with the optometric community to established KC detection centers, The development of a handheld KC screening device and expanded advocacy partnerships alongside new patient education efforts to identify and reach patients earlier. To ensure patients move seamlessly from awareness to clinical diagnosis and treatment efficiently, we will establish a network of engaged ODs and MDs and committed epioxys of care that maintain that maintain the sense of urgency that these vulnerable patients deserve. In parallel, we will launch comprehensive patient services and support programs through our patient access liaison teams to streamline care coordination, demystify the insurance approval process, and advance covered decisions where possible. These efforts are designed to support patients and families at every stage from awareness and diagnosis through ongoing treatment making the entire journey as seamless efficient and patient friendly this approval is a culmination of unrelenting research development and clinical efforts and i want to thank our dedicated employees who have put in countless hours to make this approval reality we are also deeply grateful to the clinical investigators and participants in the clinical trials who play instrumental roles in bringing Epioxa to the United States. Despite being a relatively young company, Glaucoz has invested over $1 billion in R&D over the years to develop a robust pipeline focused on chronic and rare ophthalmic diseases. Our continued investment in R&D remains best in class, underscoring our commitment to going first and advancing the standard of care for ophthalmic patients worldwide into the future. We also just broke ground on a new 200,000-square-foot research development and manufacturing facility in Huntsville, Alabama, to support long-term growth and innovation, including the eventual production of Epioxa. As you hope you can see from our comments today, we are very excited by the significant potential Epioxa offers patients living with keratoconus and believe it will deliver an exceptional value to patients, providers, the healthcare system. We've had several meaningful and informative conversations with key members of the physician and patient advocacy communities regarding this value in relation to pricing. Our approach for Epioxa reflects our commitment to responsible innovation, balancing clinical value, cost effectiveness, and patient access. These principles help inform our pricing decision which also reflects the significant investments we made thus far and those we plan to make going forward for this rare disease after several years of thorough and thoughtful evaluation based on these factors and supported by a robust set of internal pharmacoeconomic and published health economic analysis we have established a wholesale acquisition cost for Epioxa of $78,500, which represents a significantly lower price versus nearly all other rare disease drugs, including those within ophthalmology. This is particularly true when you consider that Epioxa is unique as a single administration therapy that is capable of slowing or halting disease progression in the vast majority of patients that are diagnosed with this site-threatening disease. We believe this not only provides a compelling value proposition for physicians and payers, but most importantly enables us to make a fundamentally different investment in patient and provider education and awareness to enable more patients over time to be properly diagnosed and treated at a younger age to preserve their needless loss of vision. Going forward, we anticipate that the OXA will be commercially available in the first quarter of 2026 under a miscellaneous J-code with a permanent J-code established by July 2026. As with all pharmaceutical launches, initial patient access will be gated by our site of care network deployment and typical payer adoption headwinds and hurdles, but we're investing in the infrastructure teams and processes necessary to get epioxide to as many patients as soon as possible in 2026 and beyond given the significant advancement epioxide represents in our commitment to ensuring patients gain access to state-of-the-art incision-free treatment for this rare debilitating disease we made the decision to discontinue for Atrexa commercial availability following a staged transition process. This transition will prioritize Epioxa as the primary treatment option, reflecting its safety, efficacy, and superior patient experience. Atrexa will remain temporarily available for patients unable to access Epioxa due to coverage or geographic limitations, and will transition all remaining patients through dedicated support programs designed to minimize disruption and ensure continuity of care. As we've discussed with the launch of Epioxxam, a critical focus of ours is to improve patient access to the site-saving Keratoconus treatment. With that in mind, in addition to our new awareness campaign and patient support programs discussed earlier, we will also deploy a new financial co-pay assistance program for eligible patients and intend to have a comprehensive specialty pharma option available for customers at launch. Our cross-functional teams have been hard at work putting these methodical plans together for several years now and we are ready and excited to commence execution and make a difference in the lives of these keratoconus patients. The enthusiasm and energy for this new therapy and launch is palpable throughout our organization. In summary, Epioxa represents not just a breakthrough in science, but a breakthrough in how we deliver on our promise to provide the best possible care to patients. Epioxa is more than a product. It's a reset moment and a new way forward for care in Tacoma's care. We're proud to lead the way once again in forging a new path to drive expanded patient access and enhance treatment standards. Finally, as discussed earlier, we are raising our 2025 revenue guidance to $490 to $495 million versus $480 to $486 million previously to reflect our third quarter of performance and continued underlying momentum. We are also introducing a highly preliminary 2026 revenue guidance range of $600 million to $620 million. This preliminary outlook factors in our expectations as it relates to the continued commercial rollout for I-DOS-TR, the surgical NAICS landscape, our international glaucoma franchise, as well as our corneal health franchise as we launch epioxazone and transition from protrexone. We expect to refine this guidance range and provide additional commentary during our fourth quarter 2025 earnings call expected to be held in February 2026. In conclusion, our record quarter highlights the strength of our strategy and execution as we continue evolving into a diversified economic leader with multiple growth drivers. IDOSTR is already driving meaningful growth today and we expect Epioxin will begin to contribute in 2026 and beyond as our patient-oriented initiatives take hold. Combined with our robust pipeline that spans glaucoma, rare disease, and retina in particular, along with our disciplined investment and strong balance sheet, we're well positioned to sustain our growth momentum and advance our mission to transform vision therapies for the benefit of patients worldwide. So with that, I'll open the call for questions. Operator.

Thank you. We will now begin the question and answer session. If you'd like to ask a question, please press star, then the number one on your telephone keypad to raise your hand and enter the queue. If you'd like to withdraw your question at any time, simply press star one again. Thank you. Your first question comes from the line of Tom Steffen from Stiefel. Your line is open.

Great. Hey, guys. Thanks for taking the questions. I'll start off with Eidos, and I wanted to ask about the CAC meeting. Tom or Joe, maybe if you can discuss just the impetus or the rationale of the CAC, maybe from what you have gathered in conversations with the MACs, and then maybe more importantly, talk to us about sort of what your views are on the potential outcomes here.

Sure. Hi, Tom. It's Joe. I'll start off, and as always, Tom can also add in the comments we've got at the end here. I'd say that from a rationale perspective, and maybe how we're viewing it from a macro standpoint, we see this really as a step in the process of educating these MACs and really educating them on, number one, the significant unmet need that IDOS meets for glaucoma patients, as you all know. Two, and as importantly, the robust FDA and peer-reviewed level one data evidence that supports its proper utilization in the care continuum. And three, ultimately really establishing the patient access that our glaucoma patients and physicians deserve around the product. And clearly, if you think about this moving forward you can make arguments uh both ways and we've seen some of that play out obviously in the in the early commentary from the investor community but in general we're pretty confident that the considerable data behind idos as an fda approved pharmaceutical more high quality evidence has been generated to support this pharmaceutical than virtually all of the glaucoma device solutions combined including in at least 15 peer-reviewed publications you know all that support and supported the FDA approval and the label that is, when you look at it, largely consistent with other pharmaceutical therapies of glaucoma. So I think there's a handful of different paths that can emerge as we go forward, but I think what's most important is that for these MACs, they're taking a step to make sure they understand and are educated on what we already know, which is that IDOS is a game changing solution with a lot of evidence and data behind it to change the treatment paradigm associated with with glaucoma patients here in the United States so from that standpoint we look forward to having that engagement and from them moving forward from a from a more educated basis to adjudicate the claims to come their way understand if I can to Joe's let's talk about some of the data that we already have in hand so we've got two phase three clinical trials which are

all aware of to establish the the NDA submission and PME approval of over a thousand patients that are validating the use of i-dose in standalone glaucoma patients and then more importantly i think we've been prescient also as well as as conducting a single arm prospective study in combination with cataract surgery which showed demonstrably powerful decreases in their ocular pressure 11.3 millimeters from pre-treatment means we're conducting a prospective level one study of eye dose in combination with cataract versus cataract surgery alone. And we're also, I think we were smart and also conducting a study that we're in the process of enrolling today, which is eye dose in combination with ISPEN infinite versus ISPEN infinite alone. And so we expect those studies will validate what we expect to see, which is incremental and cumulative advantage of using these different products, all of which should be conscribed and used under the current label.

That's great. Really appreciate that color. And then my follow-up is just on Epioxin. Congrats on approval. Maybe a quick two-parter. Can you just elaborate a bit on sort of your confidence in executing with this level of pricing just in terms of payer coverage and reimbursement? And then how should we be thinking about 2026 for corneal health, just as we consider the moving parts with epioxide ramping, as well as potrexia transitioning off? Thanks.

Thanks, Tom. I think as it relates to the coverage and continued access to or gaining access for epioxide to the patients, I think like everything else, that's a process where there's education at the payer level around the benefits associated with this therapy and the real cost associated with the continued progression of the disease and ultimately, as you heard Tom mention, too often these patients proceeding towards cordial transplants and other outcomes, let alone the continued impact from the visual impacts that keratoconus has on many of these patients. So I think we'll engage in that process as we go through it. We're confident, obviously, that we have a best-in-class solution that works well for the patients afflicted with keratoconus and and so we look forward to engaging those conversations with with the payer community as it relates to 2026 it's part of the reason why we decided to give the preliminary guidance for the year is to make sure that that was factored in at a macro level into the guidance in our expectations you heard tom mentioned some of these but if you think about epioxa rolling out over the course of the year we have work to do to obviously establish the site of care network, the drug availability itself timing in the first quarter, the reality of having a miscellaneous code throughout the first half of the year, the process of payers just updating their systems for the J code in the second half of the year, and alongside of that, customers updating their contracts, and generally what I'll call is the slow and methodical process of establishing, you know, proper payer coverage and patient access for any rare disease epioxide will be not dissimilar so you know this is certainly one where we're expecting in the context of the way we think about the 2026 impact that we will come out of the gate you know crawling before we before we walk um and before we jog as we exit uh 2026. your next question comes from the line of adam mater from piper sandler your line is open hi

good afternoon thank you for taking the questions and congrats on the uh the great quarter um you maybe just kind of piggyback with the preliminary 620 million for next year that's a little bit above consensus at the midpoint and you know companies don't typically do so and you know as we think about the different kind of components you know of that revenue range um i know you So Adam, you were breaking up pretty substantially, at least on our end throughout that.

I believe that you were asking for more context or color around the guidance range of 2026 of 600, 620 million, and probably pushing a bit for a bit more granularity around the constituent parts of that. So assuming that I'm correct on that, I'll give you that answer, which is good. You know, I think, as I mentioned before, we felt like it was prudent with what we were announcing in terms of the epiaxia approval, some of what Tom announced today to make sure that we established what I'll call as a highly preliminary view of 2026 and to really anchor ourselves around what we think entering into the end of the year where we're at here in in october our goal and our plan would be to provide more granular views by franchise during the fourth quarter call but what i can say from a macro standpoint we feel confident in this early range and that a variety of paths through each of the franchises if you will uh u.s glaucoma international national glaucoma, and certainly the corneal health franchise, will enable us to meet the expectations of that $600 to $620 million range that we've established.

I wanted to ask for just a little bit more color around Idaho's performance in the quarter. you know, a really good number there, you know, did you still kind of guess that MAC that, you know, onboarded in early August, you know, just any colors of how IDOS is, you know, ramping as we head into Q4. And, you know, the second part of the question is really just around, you know, the utilization and kind of which patients are getting IDOS. Is this being done Apparently in the standalone setting, you know, how much is coming from combination with cataract? How much is with, you know, a second MIG? And thanks for the question.

Yeah, again, you're breaking up a little bit, but I think the question was largely around the EIDO's performance dynamics associated with that in the quarter, and then a little bit more granularity on the breakdown of standalone versus combo cataract utilization. So, obviously, we announced in the quarter approximately $40 million of sales, a very nice step up from where we've been running in the second quarter coming into the third. That I can say was broad-based in terms of what drove it. All of the MAC regions, if you will, contributed to that growth, as did growing early commercial and MedAdvantage utilization was a part of that. We saw new doctors picking up. We saw some who had maybe been a part of early trying and trialing, now having maybe received their payments from 2024, starting to get back into providing IDOSA, the therapeutic options for their patients. So it was really high quality. And I would say, you know, in terms of some of the contributions from, I couldn't hear you, but NGS obviously came online in August. um very early you know positive uh signs there but but realistically the quarter itself looked very much like in terms of its mix what we've seen in the second quarter where about 80 percent of the overall volumes were in the more established max regions if you will of noridian novatos and first coast so the growth balance was across the board but the weighting was still towards the more established regions in the country which is not a huge surprise at this point with that ngs announcement you wouldn't really expect to start seeing the impact of that until at best kind of the later part of this quarter and really as you start moving into the next year as it relates to the mix on the standalone versus combo cataract uh as you know that's not something we directly track we we obviously are providing iostr for the benefit of patients uh afflicted with glaucoma and how surgeons utilize that in the combination with anything else, including as a part of accommodation cataract procedure, is not something that we know when it goes out the door. Anecdotally, we know that those areas that have a little bit more established track record of reimbursement and professional fees, that the rate of utilization in combo cataract surgery is growing. That makes sense. Obviously, that's meeting the surgeon many times where they're already at, which is treating the cataract and trying to take care of the glaucoma disease in parallel. So, we are seeing some growth in that in terms of the anecdotally of the overall mix, but it's largely in those regions where you have more established reimbursement than some of the other MACs where we're a little bit further behind.

Your next question comes from the line of Larry Beigelson from Wells Fargo. Your line is open.

Good afternoon. Thanks for taking the question. I guess, Joe, I wanted to start with Epioxa. You know, what, for those of us who follow this a long time, know that when, you know, Petraxa, when Avidro came out with the $3,000 or so ASP, there was some pushback. So you're obviously moving a lot higher here. So what data are you going to use with payers, you know, that gives you the confidence that commercial payers will cover it? And how are you thinking about the growth in the 10,000 patients, I think you said earlier, treated per year with Patrexa today over time. Do you expect to grow that, or could you actually lose some patients to off-label corneal cross-linking treatments? And I had one follow-up.

Sure. I'll start, Larry, and others can comment as we go forward here. But for Epioxa, I think that first and foremost, and obviously the reset moment, as you heard Tom talk about, this is an education process. Just like you'll recall your point that I've been around with Avidro back in the day as they first had reimbursement around keratoconus itself with Botraxa, is to remind the constituents that are out there, including the parent community, that this is a rare disease. That by definition, you reference it yourself when you're talking about 10,000 patients being treated. In fact, that's an uber-rare disease and pretty consistent with the type of treatment numbers, as we understand it, from indications or for other rare disease therapies in ophthalmology, such as Oxervate or Topeza for thyroid eye disease. So when you compare from a payer perspective the relative value of a single procedure that can slow or halt the disease progression of a condition like this, And you think about that patient population and the cost or the wholesale acquisition cost that Tom talked about, I think you're going to find that it compares pretty favorably to the broader rare disease landscape, including that within ophthalmology. I think more broadly than that, the conversation is one of education around what it takes to make sure that you're responsibly innovating in a category like this for rare disease, and then what you have to do to drive meaningful change in awareness, in diagnosis, in detection, and in patient access, as you heard Tom talk about. This is a different way of looking at the situation, but it was one that we had to look inwardly and ask ourselves, what do we have to do to meaningfully change the outcomes that we're seeing in terms of too many patients not getting access to a site-threatening therapy in the form of Fortrexa? As we move forward with Epioxa, that's exactly what we're committed to do. Now, you asked about 10,000 patients. I have no doubt that in the early days, as you're working your way through the, you know, inevitable, you know, payer hurdles and the various things you have to do to drive education and get access through each individual payer, they will face some headwinds there. But clearly, as we move forward, the whole reason for what we're doing is to meaningfully expand that number. And you heard Tom reference that we today believe we're treating one in every five patients who have uncontrolled or unstable keratoconus with potrexid a day. And so I hope that in the coming years, we'll put a meaningful dent in getting to what was, by definition, a uber-rare disease with 10,000 patients to what would be merely considered a rare disease in the 50,000 patient range. And that's something that will be hard to work at, but it's not something that's going to be turned on overnight in 2026 for sure. But it's the reason because each one of those patients deserve to get access to an FDA-approved, incision-free, topical therapy that can arrest or certainly dramatically slow the progression of that disease.

That's helpful. I guess just for my follow-up, it truly is related. I guess I'm just thinking ahead, as many people probably are, 27, 28, 29. at $78,000 and 10,000 patients, and I assume 90%, you know, are done bilaterally, the numbers get pretty big. Is there anything else? I mean, could you be doing, you know, 20,000 eyes in 2027, Joe? And, you know, should we be using an ASP of $78,000 to help us frame that beyond 26 for hopefully obvious reasons, these are big numbers.

Yeah. Well, first, I think you have to do a blended average over time. I wouldn't do 78,500 in your long-term models. Obviously, we are a member of the Medicaid rebate program. We do provide that discounting for that patient population as a part of this. So when you think about a blended WAC, and we'll talk more about that as we actually get into making that drug available. I'm certainly, I think we went far enough in terms of providing our view our preliminary views on 2026 i'm not going to go uh that far as you'd like in terms of 2027 and beyond i've given you the bookend of what we're trying to target over a period of time in terms of meaningfully changing this for for those patients and and i would add that whatever you assume in our models over the course of the next several years you should also assume requisite investments associated with what we're talking about here to make sure that we're actually driving the awareness the education and the detection necessary to achieve those outcomes that you're that you're talking about 2027 and beyond your next question comes from a line of

ryan zimmerman from btig your line is open great can you uh hear me okay we can't write it okay good yeah choppy earlier but um so maybe for for you joe um a little bit on idos you know In the absence of the CAC meeting and, you know, kind of the, you know, permutations that could come out of that, I'm wondering if you could talk a little bit about how you think about the ramp of IDOS. And I ask that, you know, kind of in the context of 2026, and, you know, do we think of IDOS following the similar progression in kind of a linear fashion, you know, through 2026 and beyond? Is there a point at which you see an inflection occurring where kind of, you know, the scales tip, if you will? I'm wondering if you could kind of speak to that and kind of how you guys think internally about the progression and adoption of IDOS over time.

Yeah, right. I think that the world we live in is obviously multidimensional relative to when we're building models or we're trying to do this, and there's a lot of, you know, varying puts and takes when you think about that. But what we've clearly established is, you know, plus or minus a pretty solid, you know, linear type of launch in its early days. I think it's hard to assess that without looking at the constituent parts of that, right? And as you said, in the context of 2026, we sit here today having put up $40 million of revenue in the third quarter with, as I said earlier, 80 percent of that volume coming from the Medicare regions that represent about 50 percent of covered lots. So I think as we go forward, the CAC meeting, all the other education efforts that we're doing with these individual MACs to establish proper and appropriate fee coverage moving forward, that simply getting the Medicare arena to the right place alone continues to leave us optimistic around what that means for 2026 and certainly beyond. And that's before, and I think you're touching on it a little bit, you start to think about that broader utilization that we're starting to see in some accounts across all patients who deserve to get access to IDOS, irrespective of what insurance type they have, whether that's commercial, whether that's Medicare Advantage, or certainly Medicare fee-for-service or other areas. So as we make our way through, and more and more folks get focused simply on treating the disease and less on the insurance type, I think that's when they're able to start focusing on really driving meaningful awareness in the standard of care shift that we think IDOS represents for these patients' benefits. But until you get to that place where you've got a little bit more stability, if you will, around that market access landscape, it's hard for physicians to really focus holistically on the clinical care continuum. But once you get there, I don't want to say, you know, it'll be an inflection, but I think it's what underpins our bullish optimism of what Eidos will mean for Glaucos, for our customers, and for our patients, not just for 2026, but for the next decade as we continue to change the standard of care.

Okay. Just related to the CAC meeting, you know, the agenda was posted. The questions were posted a couple days ago. I don't want to leave the witness here, Joe, and I don't know if you're going to comment to this, but I'm going to try anyway. And, you know, the questions kind of infer that the studies weren't long enough, and I don't know if you have a reaction to that. You kind of articulated this earlier, but is that your sense that you're going to be educating them on the robust, you know, kind of evidence, the totality of the data, and that there is a misalignment in terms of understanding? Or do you feel like, you know, it's purely, you know, this is coming in with maybe a little more purpose, given how fast this is kind of, you know, bubbled up, if you will, relative to the historical efforts we've seen in legacy mix? I'm just, you know, I'm trying to still understand kind of why this has happened as quickly as it did, you know, so early in the launch cycle of EIDOS.

Yeah, I think part of what you're talking about in answer to the latter is that, you know, we've also been trying to aggressively, you know, educate and advocate on behalf of our customers, I think, you know, if you take a step back, Brian, you think about how much enthusiasm there is in the clinical community around EIDOS and what it means for the patients and the outcomes they're seeing, all the things that have led to the optimism that extends from that for you all in the investment community, that also leads to those physicians advocating to make sure that they're getting properly paid and the coverage associated with it. And I think a combination of that is probably what has led them to want to ask the questions of the broader advisory committee to make sure they understand. Anytime you go into one of those sessions, There's going to be questions within that that make sense in the context of the way we or our physician customers look at this and other questions that do not. And I think this preliminary question list reflects exactly that. There are some in there that you can understand, you know, where they're trying to understand the overall fit of Eidos into the treatment paradigm. And they want to ask that question of a group of network of experts, if you will. but there are others in there that clearly show they have not yet quite understood both the data of which there's a lot and so I don't I don't hold that against anyone that's a that's an education process that has to take place here in the coming you know weeks months if not years as we continue to try to streamline that broader reimbursement coverage thank you your next question comes from Alan Gong from JP Morgan your line is open thanks for the question just Just as a quick follow-up to that, one question I do have is, you know, you obviously won't get an LCD immediately after the CAC meeting, but should you get an LCD, what does that do to, you know, your coverage with the MACs that are currently holding out and the MACs that you're already working with?

Will that change, like, your relationship with the MACs that don't have you on the profi schedule yet? Will that accelerate that process, or will you still have to wait to get on profi?

Well, I think coverage and payment are two different things. And so from the standpoint that they attempt to appropriately value the procedural component associated with IDOS, that process continues ongoing. We continue to have constructive dialogue with each of the three remaining max around that. Clearly now we have, with NGS being added, 70% of Medicare lives with established professional fees and a whole lot of work that's gone in behind that to understand how to value that in price. So I think that process continues to unfold. What you're talking about in the way you asked it with LCDs and the like is much more around coverage determinations. And on that, I would just say that, you know, there are clearly scenarios that are positive for us, scenarios that present headwinds or areas where we have to educate them more fulsomely. But going into it, we don't have a bias either direction in that regard. We're just focused on making sure that we're educating them properly and that they understand what they're looking at in terms of IDOs. The one clear positive I'll say in any LCD that gets established is that alongside of that comes Medicare Advantage coverage policies as well. And so you do have to, you know, oftentimes the commercial carriers that are behind Medicare Advantage policies, they will wait until formal LCDs are established to force them into having policies of their own. And so you can argue that there's certainly some opportunity associated with that should LCD ultimately emerge from this line of work.

Your next question comes from the line of David Roman from Goldman Sachs. Your line is open.

Thank you. Good afternoon, everyone. I want to just come back to the market development and education efforts around EPIOC. So a lot of what you're laying out sounds like it actually more mirrors that of a more mass market disease and something that takes a lot of education. I don't know if it's direct to consumer. As I look across other sort of rare disease categories, and I'm thinking more on the traditional pharmaceutical and biotech categories, there is a lot of investment around payer education and physician education, but maybe you could help with how to just give a little bit more flavor of some of the specifics around the investments that you're making and how we see those show up and over what time period?

Yeah, David, it's Joe. So I think countered a little bit, I'll start macro, and then I'll get a little more micro for your question. But from a macro perspective, what you think of in terms of large population-based patient education is the legacy, I'll call it, direct patient advertising commercials that you see on broadband television during, you know, various sporting events or whatever it may be that is there to help make sure there's awareness being driven. What's different with rare disease is it's much more of a needle in a haystack to get yourself. And so that effort, those efforts around awareness and detection mirror that of that broader disease state of your mass market, as you said, but they're done in a much more targeted way to make sure that you're trying to find those patients who are most applicable based on where they're at in their own disease And so a lot more of that happens in different forums and different communities that are more digital in nature where folks are actively seeking out what's causing the change in their vision. You know, it's important to take a step back here and remember that you heard Tom say this, But when only 13% of patients are being treated under the age of 18, and we know the vast majority of damage is happening or certainly starting to happen and accelerating in the teenage years and into the 20s, and yet the vast majority of patients aren't getting access at that stage, you really have to redouble your efforts to find them much earlier in that journey based upon those early symptoms and the early things that could be signs of keratoconus to make sure that they're getting the detection and the various things that are necessary to at least diagnose them as a keratoconus suspect. And that's a really big investment from a commercial and marketing standpoint. And it's not just DTC, although that's obviously an important part of any education thing. There's a lot in terms of what you do with your field organizations. And just to put that in context, a little more micro level, David, You know, today, the majority or if not all of the treating physicians for Fortrexa are in the MD community, but you're very much reliant upon the optometric community where these patients first present themselves most often with visual acuity issues. But there are 50,000 optometrists and numerous other opticians that serve a little bit as a primary care physician. So how you get to driving education and awareness in that community, both digitally as well as with your Salesforce and other marketing-related activities, is a pretty significant investment. Now, that part of it is really just the beginning in terms of driving awareness and education, if you will. You also have to support, anytime you have a needle in a haystack patient, and again, you heard Tom reference the prepared remarks, but these patients, think about the number of insurance plans that are out there. And when you're only treating 10,000 patients, every single time one of those patients presents themselves asking for, you know, access to Potrexid, not the OXA, it's like it's the first time that that insurer has ever seen a claim. Because you're talking about 10,000 patients, there's 5,000 plans in the United States. So to that point of really making sure you demystify the insurance process, that you support them along that way with proper education as you go through that, And ultimately, to the extent qualified, provide them with assistance as they go through are all major, major investments for us. Now, the last thing you have to think is how that turns on. We're going to have, and Alex can comment on this in the context of the broader P&L, we're going to have some of this happens right away. So it certainly picks up steam as we make our way into 2026 at the beginning, and then as we start to get the JCO established and our site of care network up and running the second half, we'll try to elevate that up to, I'll call it, a full-scale effort supporting those patients in that process and their journey as we make our way and certainly as we exit 26 into 27.

Great. I'll leave it there.

Your next question comes from the line of Richard Newwitter from Truist. The line is open.

All right. Thanks for taking the question. I might have missed it, but I just want to make sure I'm understanding the components of your updated 25 guidance and kind of how we should be thinking about the areas for 4Q and what's implied there. Can you just run through the segment? I know you provided a prior outlook for corneal health, and I think it was flat to low single digit growth for the year. Could you just give us a sense as to what we should be modeling for that business and what the trend should be in the kind of the IDOS sequential trend?

Yeah, Richard, happy to. No, I haven't addressed it yet, obviously, other than us announcing the updated guidance range of $490 to $495 million. Yeah, I think first putting in context, the performance thus far in 2025 and obviously highlighted with the results in the third quarter has really continued to exceed our internal forecast. And based upon that, we did raise our expectations for the year. The biggest thing here in the fourth quarter is not new. We called it out on the last call, and that is to take into consideration the expected headwinds that may face our corneal health franchise in the fourth quarter as we and, you know, more importantly, our patients and customers prepare for the transition from Fotrexa to Epioxa. Secondarily, I would say that the fourth quarter is a little bit more of an elevated or more difficult comp from a year-over-year growth perspective in our U.S. and international glaucoma franchises, as you're thinking about and kind of looking at dialing that in relative to where we've been in the last couple of quarters. As you think about the individual franchises within that, I would say that for international glaucoma, the dynamics here really remain unchanged from what we've talked about previously. Obviously, we expect low double-digit growth in the fourth quarter based upon that slightly tougher comp that I mentioned and really combining that with the continued sort of competitive launch headwinds that exist in several T markets, so nothing new there. On the corneal health side, I referenced, I think a little bit of it, you'll back into the expectations there. We do expect to see a fairly material year-over-year decline, and that's certainly implied in the guidance as we navigate that transition that i mentioned before and and we've already started to see some early signs of that emerge even here in october um post the the approval of epioxa and we've even seen patients now starting to come and ask about epioxa in favor of the existing potrexia therapy that may be offered to them on the u.s glaucoma side we expect growth in the the the mid 40% range year over year in the fourth quarter, as our non IDOS business continues the expense and everything else continues to stabilize. We would expect a low single digit decline in the fourth quarter. So continue on that progress back to a more stabilized situation post the LCDs that have impacted it that part of the business earlier of the year. And we do expect continued growth, obviously in IDOS TR. Although you may find implied in the guidance, it's tempered a little bit sequentially versus the current trends, just given many surgeons have pretty full cataract schedules throughout the remainder of the year. I think it's a little bit early to start seeing the benefit from the NGS of call and professional feed tailwind. And again, in general, this quarter is a bit of a tougher year-over-year confident growth standpoint. But I think what you'll you'll find is that it continues to be largely all systems go across the majority of our business with the one step back being really in the corneal franchise as we transition there.

Okay, thanks. And then maybe just a question to follow up consensus for for idols for 26 is somewhere in the 220 to 225 million range. I think. Anything you can express in terms of comfort or not kind of there just so we can benchmark ourselves as we put preliminary numbers out there?

And then second follow-up, just on the trial timelines that you were talking about for combo cataract and MIGS plus side dose, can you just give us a sense as to when those that are going to read out and the ones that have read out uh where they are so i'll start and then i'll let tom comment on the the trials associated with idos continue to be ongoing um you know really richard as i mentioned earlier i think we're gonna we're gonna stay with the broader guidance that we've given for next year of 600 620 we'll talk a bit more on the constituent parts of that on the fourth quarter call you know you referenced the consensus and idos clearly as we enter into next year um idos is no longer the only uh i'll call it material variable that you all will be focused on and assessing and so i want to make sure that we talk about that in the same context at the same time as we talk about our expectations for fboxd and the corneal franchise uh throughout the year you know what i what i had said based on the earlier question was if you think about the third quarter uh results of 40 million um we're at this point already kind of on 160 million dollar uh run rate uh based again largely on the continued progress within the the three max that have established professional fee coverages entering the quarter that being uh novitas and iridian and first coast so i i feel good about the momentum in that part of business and where it's heading and what that'll mean for

2026 but we'll get more granular on the exact numbers um as we said uh or update our guides for the for the full year when we get on the fourth quarter call so i'd be happy to answer the questions we're looking at two uh pretty major level one baseboard clinical studies and that's a look at idos plus cataract versus cataract surgery alone which we're currently enrolling and as well we're looking at a study that evaluates idos plus infinite versus infinite alone and so you can imagine the goals of both those studies which will be to validate and to show the incremental advantage of using idos in combination with cataract surgery and certainly idos in combination with infinite versus infinite alone so these are important studies as we go forward and and really they're both currently under enrollment it really will depend on when we choose to be able to show what length of data we want to show and so i would probably prepare the investment community for a 2027 timeline which would give us the ability to have really six months to a year of follow-up in each of these patients that we would publish and it may come as early as late 2026 if we choose to be able to terminate the study or or I should say be able to look at these patients at earlier time points. Typically three months would be the earliest that I'd be able to publish so I'd set you parameters to look at a late 2026 to 27 with some very, very important follow-up clinical data for the use of iGOS.

Due to time allotted for the question and answer session, we please ask you to limit yourself to one question. Thank you. Your next question comes from a line of Mason Carrico from Steffens. The line is open.

Hey, guys. Thanks for fitting me in here. So, in the context of epioxide pricing, could you just remind us how the bulk of FOTREXA volumes are billed today? Do you guys utilize a book and bill strategy with clinics? And if so, how much of your volumes rely on that? Yeah, Mason, with FOTREXA today, we offer both buy and bill acquisition options as well as specialty pharmacy. The specialty pharmacy option is something that we've really brought online primarily over the last couple of years, and that's been a growing percentage of the overall mix. But beyond that, I'm not prepared to disclose the exact mix between those. But I will say that specialty pharmacy has become an increasing material portion of the overall acquisition mix.

Your next question comes on the line of David Saxon from Needham & Co. your line is open.

Great. Yeah, thanks, guys. Thanks for fitting me in. Yeah, just another one on Epioxa. So, can you just talk about the cadence of getting coverage by commercial payers in 2026? I mean, if Fotrexa will be phased out next year, how much coverage do you think you can end the year with, 2026 with? And then in terms of, you know, placing the new cross-linking machines for Epioxa, kind of what's the strategy there for either upgrading or trading out the current install base? Thanks so much.

Yeah, David, I'll start with on the, you know, capital equipment and in establishing the Cytocare network. Epioxa does require a new piece of capital equipment, an O2N system that will be made available. We are already now with the approval in hand hard at work out in the with customers to establish that changeover as you might expect on a launch of this nature we've got a variety of options for customers to acquire to lease and to swap out their existing equipment to make sure that the capital equipment component this is not an impediment to them getting into providing Epioxa as a therapeutic solution. For the payer coverage side, you may recall on prior calls that we've been investing pretty heavily in this part of our organization alongside our field-based reimbursement. And that team is already hard at work, similar to establishing our site of care but in this case with the payers around direct education efforts meetings that make sure they understand what we've just disclosed here today in terms of the therapy benefits to patients engaging with those in the medical community to make sure that they're educated around that and ultimately trying to establish that coverage i think on the positive side But this is not the first launch in the category, and many payers already recognize that corneal crosslinking is the standard of care when it comes to arresting the progression of this site-threatening disease. And from that standpoint, we need to educate them then on the patient benefits, of which there are many. You heard Tom mention them during his remarks as to the why behind the patient need to achieve access to Epioxx going forward. So that process is already well underway. You know, we'll provide updates as we make our way throughout the year, but it's a little bit premature for us to establish benchmarks in terms of payer coverage expectations. I'm optimistic that when we engage in the conversation around the benefits that we're providing to the patients that are at the end of this, that we'll move the needle as aggressive as we can with those payers to get that access going throughout the course.

Your next question comes from the line of Joanne Hulich from Citibank. Line is open.

Thank you so much. I have so many questions, but I'm going to try and stick to my one. Which is, when you gave guidance for 2026, what is included in that for Epioxa, and what is included for that for IDOS? I'm just trying to piece it all together, because at that ASP, those numbers can ramp really fast.

Yeah, thanks, Joanne. And so, you know, as I mentioned before, I think we wanted to make sure that we were establishing an overall range for 2026 in light of the epiaxia approval and announcement and the number of moving parts. And for right now, I think I'll just leave it as what I said earlier, that we're confident in that range and we're confident there's a variety of paths that should enable us to meet those expectations. We'll provide a lot more color on our fourth quarter call around the individual constituent parts of that. But you raise a totally valid and somewhat obvious point in that with the wholesale acquisition cost and what that means in terms of, you know, relative to that, implied in there is a material step down in the number of patients being treated with Epioxide in 2026 as we navigate all the things that I've already mentioned, including getting the site of care network established, the miscellaneous code before established J code, the time in which it takes to update the payers for that J code in the second half. It will be a journey through the year of really getting the foundation underneath us so that we can be focused primarily on clinical care as we exit the year and head into 2027.

Your next question comes from the line of Michael Sarcone with Jefferies. Your line is open.

Hey, good afternoon and thanks for squeezing me in. I was just going to try to ask the mixed case for eidos in a little different way. Joe, when you think about your internal modeling and what you're expecting for Eidos maybe over the next three years, call it the midterm range, how do you think about the mix of Eidos performed in the standalone setting versus combo cataract?

I think that's very surgeon-specific, and if you look even at the adoption we've had now, our highest volume customers today do actually very little eye dose in combination with cataract surgery. Clearly, as you make the product available in that wider arena, the lower hanging fruit for some surgeons who primarily focus on cataract surgery is for them to be doing it in combination. And so I think in the intermediate term, some of that, quote, unquote, lower hanging fruit for that portion of the community could drive the mix a little bit closer to or with a little bit more oriented towards the combo cataract setting. But certainly as you get out into the three, five, and 10-year time horizon, the vast, vast majority of it is interventional in nature and standalone being the key driver of our long-term opportunity.

Your next question comes from the line of Anthony Patron from MesaHo Group.

Anthony Patron Thanks. Maybe one on the follow-up discussion with FDA on Eidos reapplications. You mentioned in the prepared comments and the materials for the third quarter that those discussions are still ongoing. So, maybe just what is the latest there and when do you expect FDA to make, you know, some sort of announcement on the supplement for EIDOS reapplications and what is really the read-through of that element of the EIDOS story as we head into the CAEC meeting on November 12th? Thanks.

Yeah, I think I'll be happy to take the first part of that question. So just to reiterate, the PDUFA data has already been established by the FDA. It will be January 28th of this coming year 2026 and we expect them to get an answer to our appeal to be able to to have readministration of the idols device as I've said many many times before we take a belt and suspenders approach to this the reason we have I dose T-rex already in a clinical trial and moving forward is to have the ability for surgeons to have a de facto exchange product available when their their current implantations of idols come to term in three plus years and so we think we're in great shape from that perspective as I've said before and I'll choose my words carefully here we are heart we are hopeful but we're not counting the FDA giving us the nod to move forward with the re-administration.

And as it relates to the, I think, your second part of your question on the on the CAC meeting and some of the considerations around there, it's actually, I think, a thoughtful question because it's important to think about Eidos is an FDA-approved pharmaceutical with a label and it's in use. It's pretty similar to topical PGAs and other glaucoma medications. That's different than a medical device. And I say that because what matters in a FDA-approved pharmaceutical is what is the contraindications that are with it and the currently re-implantation is the primary contraindication for idos tr it's not whether it's utilized in combination with cataract surgery other migs devices or heart medication for that matter um today idos tr is approved with a with an open label um that's very similar to those topical pgas if indeed as tom is talking about, we were to achieve that, the fiducia date around re-implantation, that would bring that to remove or at least modify that contraindication and certainly help us in terms of opening up that part of the market.

Thank you.

Your next question comes from the line of Danielle Ntalfi from UBS. Your line is open.

Hey, good afternoon, guys. Thanks so much for taking the question. I was at the AAO meeting a few weeks ago and I felt like the takeaway from my perspective, I'm there looking for specific things, right? But was the focus on building out, you know, standalone MIG practices. I attended a lunch session that was focused on that. And I'm just, I'm just curious about how you guys think the launch of iSent Infinite into standalone is going, where you see standalone as a percent, I'm not asking IDOS, right, I'm asking for the total MIGS, you know, patient population here, where you see standalone MIGS going over the next three to five years, and what are the sort of logistical things with practices that you think need to happen in order to enable continued growth in that market? Thanks so much.

Yeah, Daniel, I think it's a great question and a good one here as we are wrapping up this conversation. I mean, everything that we've been doing for a couple of years now, and certainly as we are moving forward, is around driving that standard of care towards interventional glaucoma and acting on behalf of these patients. And so from that standpoint, it doesn't surprise me, although I'm always happy to hear that as you were doing your checks and and and rounds at uh at aao that you heard that same thing there's a anytime you you have a profound standard care shift there are logistical hurdles but the first one you have to get through is the clinical component of this and the clinical buy-in from the community and you've heard us say this before but i'll reiterate it we couldn't be more happy with the receptivity from the physician community around the need to act on behalf of these patients in an interventional way. And whether that tool is Eidos, whether that tool is Iced and Infinite, or any of the other things that might be a part of their toolkit, if you will, in trying to tackle this site-threatening disease, it's encouraging to hear that they continue to sort of move forward. But on the logistical side, it does change. It's changing the education of the optometry referral community. It's changing the scheduling blocks. It's changing the time and allocation of that time within their OR time, their surgery centers and the like. There's a lot that goes into this over time. It's about establishing proper reimbursement and market access for the various tools that are there to treat patients the way you want to treat them as a surgeon or a physician. So each one of these things play themselves out, and none of them are overnight success stories. Each one of the things you make incremental progress every day, every week, every month, and every year. And I think it's why when we look out over a three-, five-, or ten-year period, we're so optimistic about where this is all heading because it's all rooted in the right paradigm shift of clinical care. The rest of it we have to keep our head down and keep executing against that. And if we do that, you're talking about a market opportunity, as you've probably said many times, that there are 21 or 22 million eyes in the United States with ocular hypertension or glaucoma. 12 to 13 million of those eyes today are already being actively treated, maybe imperfectly in the form of topical eye drops, but they're being treated. You compare that to what we're talking about in the earlier days of combination, cataract, and mix, where you had about half a million eyes. So when we look at this over a prolonged period of time, we expect that the vast majority of procedures, irrespective of the tool, to be done in that standalone and interventional glaucoma market, sheer limit because of the relative size of those market opportunities and the clinical need for that.

Thank you. And with no further questions in queue, I would like to turn the conference back over to the company for closing remarks.

Okay, thank you all for your time and attention today, and I want to thank you for your continued interest and support of Glucose. Goodbye.

This concludes today's conference call. You may now discuss.