Operator
Good morning. Welcome to Lanthea's fourth quarter and full year 2025 conference call. All lines have been placed on mute. This call is being recorded and a replay will be available in the investors section of the company's website approximately two hours after the completion of the call and will be archived for at least 30 days. I'll now turn the call over to Mark Kinarny, Vice President of Investor Relations. Mark.
Thank you. Good morning. With me today are Marianne Haino, our CEO and Executive Chairperson, Amanda Morgan, our Chief Commercial Officer, and Bob Marshall, our CFO. We will begin with prepared remarks and then take your questions. This morning we issued a press release which was furnished to the SEC under Form 8K, reporting our fourth quarter and full year 2025 results. The release and today's slide presentation are available on the Investors section of our website. Any comments could include forward-looking statements. Actual results may differ materially from these statements due to a variety of risks and uncertainties, which are detailed in our SEC filings. Discussions will also include certain non-GAAP financial measures. Reconciliation of these measures to the most directly comparable GAAP financial measures is included in the Investors section of our website. I will now turn the call over to Mary Ann.
Thank you, Mark, and good morning, everyone. It's a pleasure to be back with you as CEO at an important moment for the company. I want to start by recognizing Brian for his leadership and for ensuring a smooth transition. While my role as CEO will be interim as we complete the search for the next Lancia CEO, I'm thrilled to be back in the operational leadership role with the same passion and commitment that those who work with me will remember. I have taken time to meet with shareholders over the past months and appreciate the ongoing opportunity to listen to your feedback. My intent is to seamlessly transition our strategy and the execution of that strategy to the incoming CEO. I will note the board and I are successfully progressing our CEO search, and I am pleased with the candidates we have met thus far. Before I offer comments about our business achievements for 2025, I would first like to share that Lampia's product helped impact the lives of approximately 7 million patients in 2025, underscoring the real-world importance of the work our teams do every day. Now, turning to the results, I would like to start by highlighting the important progress we made in 2025 to shape our strategic focus within the radiopharmaceutical industry. The decisive actions we took in 2025 include, we closed two complementary transactions that diversified and will accelerate our near-term revenue streams across our commercial radiodiagnostic portfolio. First, the acquisition of NeuroSeq, our beta-amyloid-targeted PET radiodiagnostic, which now serves as the commercial cornerstone of our Alzheimer's disease portfolio. We are excited both about the growth potential of NeuroSeq and the expanding amyloid PET imaging market. And in 2026, we expect NeuroSeq's growth will exceed that of the overall market. Second, our acquired product candidate, Octave, a neuroendocrine PET radio diagnostic currently under FDA review. Upon approval, Octave will enter the well-established gastroenteropancreatic, or GepNet, PET imaging market. This product fully complements our nuclear medicine customer base and allows us to broaden our offerings to the customers we already engage with for Polarify and NeuroSeat. In 2025, we also took meaningful steps to further build out the portfolio of radiodiagnostic products Lantheus offers to the prostate cancer community. Our primary focus in 2025 was defending our leadership position in the PSMA PET imaging space with Polarify, and we believe that position will serve as a key advantage as we prepare the market for our new formulation later this year. This past year, we also advanced Lantheus 24-0-1, our Phase III Ready Gastron-Releasing Peptide Receptor, or GRPR, targeted radiodiagnostic for prostate cancer. GRPR is a biologically distinct target from PSMA, and an estimated 15 to 30 percent of prostate cancer patients do not express PSMA. Lantheus 24-0-1 has the potential to complement PSMA PET imaging by identifying disease in patients who may be PSMA negative or equivocal, extending the addressable population while fitting within our existing prostate cancer franchise. That transition will take place with these acquisitions and the other activities accomplished to build out our pipeline, we believe that Lantius now has the broadest radio diagnostic pipeline among our peers in the radiopharmaceutical space. Finally, we completed the divestiture of our legacy sex business on January 1st of 2026. While the spec business was foundational to Lampea's renowned reputation in nuclear medicine over many decades, our strategic intent is to prioritize investment in and the commercialization of innovative pet radio diagnostics on a forward basis. For having narrowed our strategic focus to radio diagnostics, we believe we can deliver sustainable and attractive revenue growth in the mid and long term. Looking ahead to 2026, we are fully focused on commercial execution and revenue generation with our current commercialized assets, as well as successfully advancing a number of approval milestones for our registrational stage products. Our top priority is to maintain and strengthen our leadership in PSMA PET by sustaining Polarify volume growth while preparing the market for the launch of our new PSMA PET formulation. That transition will take place in the fourth quarter of 2026, with the material commercial impact of that launch beginning in 2027. In neurology, we are excited to drive momentum with NeuroSeq through expansion of our PMF manufacturing network, as well as the opportunity of introducing NeuroSeq to our existing nuclear medicine Polarify customers. NeuroSeq, as well as the radio diagnostic products currently under FDA review, will be offered to our nuclear medicine customer base as part of a comprehensive portfolio of Lancia's products in 2026 and beyond. We have the potential for multiple SEA approvals this year. The first, our new PSMA PET formulation, second, Octave, third, PNT2003, our radio equivalent and formulation of Lutifera for the treatment of gastroenteropancreatic neuroendocrine tumors, or GEPNES, and fourth, MK6240, our TAU-targeted PET radio diagnostics. Assuming approval for each of these products, the commercialization plan will be thoroughly targeted to align with market and access readiness, an approach we believe underpinned our successful Polarify launch. We are able to leverage our PMF network and commercial infrastructure, investing in line with the expected revenue growth opportunity of each product in 2027 and beyond. As I've already mentioned, our strategy and related investment going forward will focus on radio diagnostics. As a result, we are optimizing our cost structure to match this focus, enabling us to deliver on the EPS targets we announced today while leaving additional opportunity to further improve that profile in the future. We are selectively prioritizing first and best-in-class later stage PET radio diagnostic assets that complement our current commercialized portfolio and our nuclear medicine customer base. As part of this strategy we have decided to pursue value maximizing alternatives for the radiotherapeutic assets in our pipeline. Given the broad portfolio we have built to date, we do not anticipate pursuing any significant M&A activity in 2026, so we remain open to opportunistic tuck-in acquisitions of portfolio-aligned diagnostics. Our priority is to complete the integration of our recent transactions early in 2026 to fully capture their value. As I have outlined, 2026 will be a year of commercial execution and regulatory milestones as we focus our efforts and investments to serve our nuclear medicine customers. With strong mid- and long-term revenue drivers, a robust late-stage pipeline, and a clear strategic roadmap, we are confident in our ability to drive meaningful performance gains that support a compelling mid- and long-term outlook for our shareholders. Let me now hand over to Amanda, who will offer highlights on performance and commercial execution across our portfolio in oncology, neurology, and cardiology. She will then provide an update on our late-stage diagnostic pipeline. Amanda? Thank you, Marianne.
We are positioning the business for its continued growth by driving commercial readiness ahead of multiple upcoming launches, beginning with our new PSMA PET formulation. First, let's discuss our fourth quarter results and priorities for 2026. I'll begin with Polarify, our market-leading agent, which posted solid performance in the fourth quarter in a highly competitive market with volume up approximately 4% year-over-year. Our continued successful commercial execution and pricing discipline were the drivers of this performance. Notably, the vast majority of our annual volume in 2025 came from longstanding accounts demonstrating the resilience and commitment of our customer base and the clinical value of Polarify. As a reminder, pricing concessions provided late in the second quarter of 2025 reset 340B pricing in the fourth quarter. Our best price, which determines what is offered as 340B pricing, was unchanged in the second half of 2025. Therefore, there will be no further change to our 340B pricing in the first half of 2026. We believe we have the broadest end-to-end coverage of PSMA PET imaging value chain, delivering consistent availability, reliability, and dependability to our customers. This level of operational excellence is a clear source of competitive advantage. We will extend this proven capability across each product we launch into the radio diagnostic market with the intent to accelerate adoption and drive both mid- and long-term growth. Now I will highlight performance of our commercialized Alzheimer's imaging product. Neuracy contributed $31 million for the quarter, driven by strong commercial execution. In 2026, we will further support that execution with the onboarding of six additional PMS sites. We are excited about the potential of NeuroSeq and Alzheimer's disease PET imaging market. As the already second most utilized and fastest growing beta amyloid PET imaging agent, NeuroSeq addresses a large and expanding opportunity. With more than 7 million people currently diagnosed with dementia in the U.S., demand for amyloid PET imaging is increasing, driven both by the adoption of Alzheimer's disease modifying therapies, or DMTs, as well as by guideline expansion for diagnostic use earlier in the care pathway for patients with mild cognitive impairment and early Alzheimer's disease. Finally, DFINITY remained a strong contributor to our overall performance and delivered over 85 million in the fourth quarter. 2026 marks DFINITY's 25th year on the market and it remains firmly positioned as the market leader with more than 80 percent share. Now turning to our promising late stage pipeline, 2026 is a critical and exciting year for commercial launch preparedness for several of our registrational stage assets. Specific to radio diagnostics, it is important to align investment and launch timing with market access and value chain readiness to optimally realize the commercial opportunity. We have three radio diagnostic assets and one radio equivalent therapeutic with near-term regulatory approval timelines. First, our new PSMA PEP formulation with a Paducah date of March 6 offers the same diagnostic properties of Polarify with a similar safety and efficacy profile while delivering manufacturing efficiency that will immediately improve supply availability. And as with any F-18 radio diagnostics, launch timing and success depends on having broad PMF network in place, as our focus will be on supply continuity. A central tenet of our launch strategy is to ensure we have coding, transitional pass-through status and broad payer coverage in place before commercial launch, thereby ensuring customers have access to and coverage for the new formulation. By leveraging our already established infrastructure and strong nuclear medicine customer relationships, our goal is to ensure the transition from Polarify to our new formulation will be a seamless experience while providing what will be the only F-18 based product in the PSMA imaging category with transitional pass-through reimbursement. This approach, informed by our deep experience in radio diagnostics, we executed on a rolling regional basis in the fourth quarter of 2026, which will minimize risk during the commercial launch. We believe these actions position a new formulation for continuous, sustainable growth beginning in 2027. Second, OCTAVI, our galleon-based PET radio diagnostic for NETS, with a PDUFA date of March 29th, will support clinical decision-making in patients with neuroendocrine tumors. Assuming FDA approval, we will have the opportunity to launch OCTAVI as the only neuroendocrine PET radio diagnostic with transitional pass-through reimbursement. As a gallium-based agent, Octave will be offered through existing radiopharmacy networks, which Lanthias has longstanding relationships with. Our team is eager to begin the launch process for both agents in the second half of this year with the expectation that they will begin to have a material impact on our performance in 2027. Turning to PMT-2003, our registrational-stage radio-provalent therapeutic to Lutathera. We are awaiting FDA approval and anticipate a port ruling mid-year on our Hatch-Waxman litigation. PMT-2003, like Octave, will be a natural addition to the lampiest commercial portfolio of products offered to our nuclear medicine customer base, enabling portfolio leverage across this common customer. MK-6240, our registrational-stage TAU-targeted PET radiodiagnostic for Alzheimer's disease, currently represents an important asset within our biomarker solutions portfolio and is the leading imaging agent supporting a late-stage Alzheimer's DMT development. It is currently the most widely used imaging agent in amyloid and TAU-targeted therapeutic candidate clinical programs. MK-5240 currently serves as the imaging agent for treatment eligibility in 17 pharma-sponsored therapeutic programs. The PDUFA date for MK-5240 is August 13th of this year. Collectively, our registrational stage assets will deliver on our strategy to maintain and expand our leadership in innovative PET radio diagnostics and drive sustainable, mid- and long-term growth. In 2026, our commercial priority is clear. Maximize the value of our current product portfolio by navigating a competitive marketplace of discipline and executing upcoming launches with excellence. I'll now turn the call over to Bob to provide more detail on our fourth quarter and full year results and outlook. Bob?
Thank you, Amanda, and good morning, everyone. I will provide details of the fourth quarter and full year 2025 financials. focusing on adjusted results with comparisons to the prior year quarter, unless otherwise noted. Revenue for the fourth quarter was $406.8 million, an increase of 4%. Revenue for the full year was $1,541.6 million, an increase of 0.5%. Turning to the details, radiopharmaceutical oncology, currently compromised solely of Polarify, generated fourth quarter revenue of $240.2 million flat sequentially and down 9.7%. For the full year, Polarify delivered $989.1 million, down 6.5% from the prior year period. The result was above expectations with price and volume favorability as compared to our previous estimates. Precision diagnostics delivered fourth quarter revenue of $143.2 million, representing a 22% increase. The category was driven by net sales of DFINITY at $85.3 million, or 1% lower, due to the prior year competitor supply challenges, which drove higher than expected revenue during Q4 2024. For full year results, we're $330.2 million, up 3.9%. Neuroseek delivered $31 million in the quarter and $51.4 million since the acquisition in late July. Technolite and other spec revenue for the quarter was $26.9 million for the fourth quarter and $111.4 million for the full year. Lastly, strategic partnerships and other revenue was $23.3 million, up 203.3%, due to a strong quarter for MK6240, as well as the recognition of a $6 million milestone receipt relating to an out-licensed asset. Full-year revenue was $59.4 million, with MK6240 contributing slightly less than half of that amount. Gross profit margin for the fourth quarter was 65.1%, down 289 basis points from fourth quarter 2024, due mainly to year-over-year decreases in polarifying net price and the inclusion during 2025 of the evergreen manufacturing facility and their receipt volumes, which were not in a comparative period, all offset in part by favorable clarified dose volumes. Operating expenses at 30.9% of net revenue were 179 basis points unfavorable from the prior year, but within previously guided spending levels. Increases in research and development, the majority of the year-over-year change. We're a continuation of our planned investments to advance our clinical stage portfolio. The sales and marketing increase was largely due to having a full quarter of the Neuroseed sales team and related activities. G&A was flat in the period despite ongoing and a litigation expense for our P&T 2003 asset and the inclusion of LMI and Evergreen operating expenses. Other income and expense was $2.3 million of expense. Operating profit for the quarter was $138.9 million, a decrease of 8.5%. Total adjustments in the quarter were $66.2 million of expense before taxes. Of this amount, $17.5 and $16.5 million of expense is associated with non-cash stock and incentive plans and acquired intangible amortization, respectively. The company recorded an unrecognized loss of $9.5 million, a tribute to its equity investments in prospective therapeutics and radio farm theranostics. Additionally, the company recognized a $5 million payment in the quarter relating to the Relistore royalty stream sale, which was reflected in other income. Further, the company incurred $21.7 million in acquisition, integration, and divestiture-related costs. The remaining $6 million is related to other non-recurring expenses. Our effective tax rate was 19% in the quarter and 25.3% for the full year. The resulting reported profit for the fourth quarter was $54.1 million and a profit of $110.7 million on an adjusted basis, a decrease of 4.1% from the prior year period. GAP fully diluted earnings per share for the fourth quarter were $0.82 and $1.67 on an adjusted basis, an increase of 4.7%. On a full year basis, GAP fully diluted earnings per share were a profit of $3.41 and a profit profit of $6.08 on an adjusted basis, a decrease of 10% from the prior year. Now turning to cash flow, fourth quarter operating cash flow totaled $90.2 million as compared to $157.7 million in Q4 2024. Capital expenditures totaled $8.8 million, $7.6 million less than the prior year. Free cash flow, which we define as operating cash flow less capital expenditures was $81.4 million in Q4 2025, a decrease of $60 million from the prior year period. The majority of the variance lies within working capital, with a $49.3 million decrease driven primarily by the acceleration of accounts payable associated with the cutover activities for the spec business ahead of the divestiture on January 1st. Increase in accounts receivable related to timing of sales and the go-live to a direct billing model transferred from one of our significant PMF partners, as well as an increase in inventory due to the timing of production runs and expansion of the PMF network. Additionally, the company repurchased $100 million or 1.77 million of its own shares during the quarter, leaving $200 million of authorization for buybacks outstanding. Lastly, cash and cash equivalents, net of restricted cash now stand at $359.1 million. Before turning to our expectations of the full year of 2026, there are a number of line items that I would like to clarify to put the right context on 2025 versus 2026 comparisons. Beginning with revenue, we completed the divestiture of our spec business effective January 1st, 2026. As such, you should remove $111.4 million from the 2025 baseline year. Further, as mentioned, we recognize the $6 million milestone payment related to an out-licensed asset in the fourth quarter. Taken together, the comparable baseline would be $1,424.2 million. The EPS impact on these adjustments equates to approximately $0.16. Operating expenses also require normalization adjustments for comparison's sake as well. During 2025, the company reduced accrued bonus expense, resulting in approximately $0.14 of benefit to 2025 that should not repeat in 2026. Further, the company recognized approximately $4 million or $0.04 of employee retention credit benefits occurring in Q2 of 2025, also not likely to repeat. Therefore, the appropriate adjusted EPS comparison should be $5.75. Now, turning to expectations for 2026 fiscal year. While we expect several product approvals this year, given the timing of commercial launches, as Amanda discussed, we don't anticipate meaningful revenue contribution this year. Our focus in 2026 will be the continued commercial execution, assuring a successful transition for our new PSMA PEP formulation, setting the stage for revenue and earnings growth acceleration exiting 2026. Now for the details. The forecast for Polarify considers the annualization of pricing decisions made in 2025 and related impacts as well as the potential for renewed competitive dynamics as the year progresses, notably as the only one other commercially available F-18 agent nears the end of its traditional pass-through period as of September 30th. Therefore, we see Polarify net revenue declining 8 to 10 percent year over year, consisting of increased volume offset by modest price erosion. To assist with modeling, each quarter should be fairly similar sequentially from a net revenue perspective, with volumes and discounts growing throughout the year. This includes the fourth quarter, during which we will undertake the transition of our PMF channel partners from Polarify to our new formulation on a rolling geographic basis. We see Neuroseat growing triple digits inorganically, and DFINITY is expected to grow low to mid single digits. Taken together, we forecast worldwide net revenue of $1.4 to $1.45 billion for 2026. Moving down the P&L, gross margin continues to model at approximately 65.5%. While we have the opportunity to leverage our established infrastructure and common targeted customer base, we will continue to invest in sales and marketing in support of our new PSMA pet formulation, as well as OCTAVI to ensure broad availability and access. R&D is expected to move to 10% to 11% of revenue, an increase of approximately 200 basis points across a number of phase-gated projects anchored by our GRPR diagnostic agent. G&A should be essentially flat with 2025 at 10% of net revenue. Our net interest expense and other is expected to change in 2026 to $5 million of expense from approximately $4 million of net income in 2025. This $9 million headwind is due largely to lost interest income on funds we used on our 2025 M&A activity, as well as through share repurchases executed throughout 2025. The effective tax rate is expected to increase slightly by about a point to 26%. Fully diluted shares outstanding should average 66 million shares for the year. Altogether, we forecast EPS in a range of $5 to $5.25. cents. As Marianne noted, following last year's considerable M&A activity, we are undertaking a full review of our pipeline portfolio and expense base. We are committed to focusing on investment in related commercial efforts, largely on our diagnostic portfolio. For the therapeutic assets in our pipeline, we are contemplating alternative opportunities to advance these assets and optimize their value for the company and our shareholders. This process will take the better part of 2026, during which we are confident that there will be further opportunities to rebase the company's earnings profile and growth trajectory with annualized synergies achieved, in addition to the avoidance of higher costs of late-stage R&D development often associated with therapeutic product candidates. We believe that the therapeutic pipeline has material value, and this plan is intended to unlock that value for shareholders, which is not reflected in our stock price or our With that, let me turn the call back over to Mary Ann.
Thank you, Bob. While we focused in 2025 on the competitive dynamics experience in the PSMA PET imaging market and our work to successfully integrate acquisitions, we are now taking purposeful steps to sharpen our focus on our strategic priorities, especially in the diagnostic space, and leverage both our capabilities and portfolio in 2026 and beyond. Allow me to again state our priorities for 2026. Maintain our market leadership in PSMA PET by sustaining Polarify volume growth. Execute a seamless transition to the new PSMA PET formulation beginning in the fourth quarter. Increase momentum for NeuroSeq by expanding our manufacturing footprint and driving deeper penetration in existing accounts and accounts where a strong Polarify relationship already exists. Advance our assets currently under FDA review through regulatory approval milestones and affect fit-for-purpose launch activities with those assets that offer the earliest and best revenue returns. Selectively develop other pipeline assets toward capital with discipline, prioritizing radio diagnostics, seeking to optimize the value of our radiotherapeutic pipeline, and maintaining financial flexibility while committing to a leveraged P&L that delivers value to our shareholders. We enter 2026 with confidence in our strategy and our ability to deliver, recognizing this represents a year of intentional investment and portfolio prioritization that will position the company for solid financial performance and durable value creation. As we do so, we remain focused on the patients we serve, having helped impact the lives of approximately 7 million impatience in 2025. I want to thank our shareholders, employees, and our loyal customers for their continued support and dedication. With that, I'll turn it over to Q&A. Operator?
Operator
Thank you. As a reminder, to ask a question, please press star one one on your telephone and wait for your name to be announced. To withdraw your question, please press star one one again. Please limit yourself to one question per person. One moment for questions. Our first question comes from Anthony Petrone with Mizuho Cap Financial Group. You may proceed.
Thank you. And hi, Mary, and welcome back. Hope you're doing well. Hi, Bob, Amanda, Mark. Hope everyone's doing well. Maybe I'll start off with two quick ones. Just know a lot of folks are on the line here, but start with, you know, just the March 6th PDUFA date for NextGen PSMA Pat Imaging Agent. Thanks for the updates there on a fourth quarter rollout. But when we think about taking a glass half full approach, assuming, you know, the PDUFA date goes as expected and we get clearance, you know, what will be the timing when we do secure coding, you know, when we get realization on what the TPT sort of reimbursement rate will be, and maybe a little bit of detail on how you will begin that transition, specifically with long-term contracts that are out there, and I'll have one quick follow-up.
Anthony, I'll take that, and thank you so much. It is, as I said, great to be back in my operational role here, and as you noted, it is absolutely a glass wonderfully heftful about our new PSMA PET formulation. Let me review some of the dates we're assuming here, and that will also then, I think, explain our strategy as we move forward. As you noted, our PADUFA date is March 6th. The two items that Amanda – well, two of the items that Amanda referenced that are important with a launch of any pet-based product is you need to ensure that you have secured a HIC-6 code as well as transitional pass-through status. And those are two separate activities. We would anticipate that we would have in place by October 1st our HCPCS code and that for having submitted our transitional pass-through application by June 1st, that that will also be in place by October 1st. And it's very important that those events precede your commercial entry into the market. That is why you hear us referring to late 2026, or specifically the fourth quarter, for the operational rollout of the PMF. And as you can remember from our Polarify launch and from the other launches of F-18-based assets into this category, you have to stand up or get approved each PMF separately because they each represent a GMP-approved manufacturing site. Our goal is to make sure that we never have disruption of land-based product availability in that market. So we've chosen a regional rollout, allowing for duplicity so that we absolutely still have service in place to flip from Polarify to our new formulation, which we will offer a name and start using as soon as it's approved. And we anticipate for making sure that that is the risk that that will take us the fourth quarter to accomplish. So coming out of the fourth quarter, we will have a network as broad as we have in place currently for Polarify in place for our new formulation. And that is why we keep referencing to say that significant revenue related to that product will really occur beginning in 27 and not as much in 26. But we feel like we've got all bases covered here. We're all waiting for the March 6th date. It is right in front of us now, and you can certainly imagine that there will be a press release around that date to communicate what we've heard from the FDA.
Excellent. And just a quick one is just the market dynamics for Polarify, as is today, down 8% to 10%. We know that there's a study out there, POSLUMA versus Polarify, a head-to-head study. I believe it reads out at ASCO. And so maybe what is baked into the negative 8% to 10% for share shifts? How does the outcome of this study play into that? Thanks again. Welcome back.
Thanks, Anthony. And kind of interesting to talk about that study, because I will be honest and say we do absolutely have some concerns regarding the study design that was used. First and foremost, there's no randomization in the study. If you read the protocol and you see how it was executed, the polarify images were always captured first and in a fully randomized trial you probably expect to see something different also it's concerning there's no truth standard if you look at the design of the study they're really measuring just suv and detection rate and the kind of the odd thing of that is when you measure detection rate that way you actually give yourself credit for false positives so the high detection rate may be due to the false positives that are already noted in that that product package insert. Also, if it's just from a math perspective, the study was not powered to show statistical significance. And from a clinical perspective, there's really two relevant comments here. First, bladder SUV values do not impact diagnostic performance. And that is what the study is really measuring. Second, and very much not in line with current clinical practice, The men in the study, because, of course, it was all male patients, were not allowed. They were actually prevented from voiding prior to having their scan done. And that is very much the opposite of what happens in clinical practice today. So I will say we are glad to see continued scientific investigation into this incredibly important class. But we also would very much hope that it would be rigorous scientific evaluation. And I will share with you, because you referenced how did that bake into our forecast, the results of that study really do not bake into our forecast.
Operator
Thank you. Our next question comes from Richard Newhater with Truist. You may proceed.
Thanks for taking the questions. So, I just wanted to put a finer point on what your kind of pricing and unit growth played out in 4Q25. You were at 3% unit growth, I think you said. In the third quarter, you had about a 500 basis point, 340B driven price headwind to contend with in the fourth quarter. I'm getting like a high single digit unit growth rate in 4Q. And is that right? And then, you know, what was behind that? Did the market improve?
Did you just call back some share if that is in fact right and then maybe Bob can you can you give us a little more on what the market assumptions are for 26 for polarify and kind of what your unit and price assumptions kind of are within that thank you yeah so rich I'll take that in terms of growth I mean listen it was it was a great quarter from a polarify perspective obviously above our expectations but it was both volume and and a little bit of benefit actually coming from the growth to net price change. And, you know, I think when we talked about it during kind of the fourth quarter, you know, following our call and whatnot, we had sort of pegged it at sort of the mid-teens, and that's effectively what we saw. And that was maybe slightly more favorable than the actual teens growth that we were kind of thinking. So, you know, as I think Amanda pointed out, it was like 4% volume growth. And it did turn out to be our single greatest sort of volume performance in the quarter. I mean, excuse me, for the full year. When I think about assumptions going into how we're playing out 2026, so we are thinking sort of a similar sort of low single digit volume growth for the year, much not too dissimilar from 2025. And from a pricing perspective, what we've done is that we've, while we've seen a lot of consistency in the market from a pricing perspective over the last couple of quarters you know as we think about one of those competitors losing pass through that they may actually look to try to use pricing as a mechanism to drive share and we've been really pretty disciplined and we've been really explicit that as we think about executing our strategy that we're going to stay disciplined we're going to chase business that is not good for the medium to long-term value of that franchise so the guide assumes that we see sort of a continuation of of some you know incremental price that would sort of move us from sort of the mid teens of where we are now to you know maybe the high teens as we progress through the year from a gross to net adjustment perspective and that's why you see sort of what I've laid out as sort of a sequentially net revenue sort of neutral outcome for each of the quarters throughout 2026.
So, Rich, this is Marion. Does that answer your question?
Yeah, it does. So, it sounds like you're not seeing any dramatic changes to the pricing environment currently. To be prudent, because this is what took you by surprise and all of us by surprise last year, you're embedding that assumption that there will be another kind of regular way price erosion situation, or you'll have to walk away from that business incrementally. And that's a placeholder in your guide. And you don't really assume any contribution from 2.0. So there could be upside if those things don't play out that way. And you start to get some benefit from 2.0 if all goes well next week, and you can execute on the transition faster. Is that a fair way to look at these numbers?
Yes, Rich, absolutely. And I have to say, it's such a great pleasure to have Adams like yourself monitoring our business where you know the market so well and also understand our strategy. But you are really spot on with how we're thinking about the market.
Operator
Thank you. Our next question comes from Ryan Ruiz with Learink Partners, you may proceed.
Hey, morning, everyone. So, I was curious, could you elaborate a bit more on one of your comments about pursuing value-maximizing alternatives for radiotherapeutic assets to support long-term growth? It made me think about, are you thinking about different features of products that you're looking for? Could this be part of near-term BD? I know you mentioned on the comments possible tuck-ins this year, So I was just curious if you could explain a bit more there.
Absolutely. And I'm glad that everyone is kind of picking up on the comments that both Bob and I made about this intentional focusing of our strategy. We really see it as the natural outcome of all the activity that we had in 25 and even 24. We have now a very broad portfolio of both diagnostic and therapeutic assets. and our intent is to and we think our obligation to our shareholders is to make sure that the value of each of those is considered but we certainly could not handle or accomplish the advancement of that entire portfolio so we've chosen to focus in on on the diagnostic assets and as you'll see I had a pipeline slide in the middle of my presentation and also showed again at the end it really is a very broad portfolio there when we refer to the therapeutic assets, what we're referring to is, and we have undertaken a full review of our whole portfolio, but looking really at what are the stage gates for the therapeutic assets that really define value for them so that as we consider how they should be then driven further, and it will be through external alternatives or partnered alternatives, how is it best for us to present the value and the clinical utility of these products. And so a lot more to come on that as we talk throughout the year. I will mention, and it really comes back to what you mentioned with tuck-ins, further tuck-ins for diagnostic opportunities. If we find them and they fit, then yes, absolutely, we'll consider them. But even as we talk about the therapeutic assets, I probably should be clear to say that when I talk about that, I'm not talking about PNT-220-03. That product is right before us as far as regulatory approval opportunity. It's a natural fit into our portfolio of products and, again, our customer base. So we are already committed to what we believe will be a very successful launch of that product.
Operator
Thank you. Our next question comes from Matt Taylor with Jeffries. You may proceed.
Hi, good morning. Thanks for taking the question. And I guess the last one on NeuroSeq came in nicely in Q4, and your guidance, you said, was, I think, at least triple-digit growth. You know, I guess not that that's a bad growth rate, but why couldn't it actually be higher than that, given the momentum that you have and also the sequential growth that we're seeing in some of these Alzheimer's therapeutics?
Oh, math. we absolutely do see a triple digit pretty pretty good here matt and i think what what you are also hearing from us again we inherited that product as a we'll call it mid-year last year and one of the things and again this comes back to f18 based products in this market you have to have the manufacturing footprint to be able to bring your product broadly to patients and i will say um i I think the numbers have been discussed before, but the number of standing PMS for NeuroSeek, at the time you acquired it, was called at mid-20s. We added a few, and someone might correct me if I'm wrong there, but we added a few, and then our intent is to add six more this coming year. Therefore, we will start to approach having what we consider a broad geographic footprint for their product, and I'm sorry, I've been corrected. The starting number of PMS when we inherited the product was 16, and again, we will continue to add. That really is the way that we measure how far we can take the product into new areas. And then the other part of what we think is a very promising forecast is our ability to take the product deeper into the accounts where it already is based on some changes in guidelines and the broadening that we saw in the PIs last year, as well as by also leveraging the relationships that we have in accounts with other Lanthius products. So, again, happy to be wrong here and have it even further exceed what we have, but I think we've been very practical, optimistic, but practical with our forecast. And, Bob, do you want to add something there?
I do, because I just – well, people can figure this out from a mathematical situation. By triple digits, we're talking something in, like, call it the 140% to 150% range. inorganic growth off of what was a very good fourth quarter, which was the first full quarter that we actually had the asset in the portfolio commercially.
Does that answer your question?
Operator
Our next question comes from Paul Troy with Goldman Sachs. You may proceed.
Hi, thank you for taking our question. This is Karishma on for Paul. If the upcoming BID data does show meaningful TOW reduction but no benefit on cognitive measures, how does this affect your go-forward investment in your TAO program? Thank you so much.
I'm sorry, can you repeat what you're referring to? No, this time. Can you repeat the first part of your question, please?
Yeah, sorry. If the upcoming biogen data shows meaningful TAO reduction, but no benefit of obvious measures, how does this affect your go-forward investment in your TAO program?
I'm sorry, we just didn't hear the first part of your question. but it makes the perfect sense. We will, of course, are very eagerly awaiting those data, but I think there's very, very strong scientific evidence already that the presence of tau and the quantification of tau is aligned with cognitive performance of patients, and that really is something that's slightly different than the role that amyloid plays. Amyloid, and, you know, to think about it, I guess, the amyloid comes early, but it doesn't always match to cognitive change in patients, where there is a much stronger correlation between rise of tau, especially in certain areas of the brain, and unfortunately related cognitive defects for patients. So I think what we're seeing in this market, and we're kind of all seeing it in real time because that's a wonderful thing that's happening around us. There really is now a market that is willing and acting on taking these products that are disease-modifying and starting to use them in patients. And the kind of complementary use, increased and increased use of imaging, both amyloid and tau, will come along with that. But I won't speculate on data that are not out yet, other than to say we are, from a scientific perspective, we are fairly confident in the role of tau in the market. As you heard Amanda mention, in our biomarker business, how is our product, MK6240, is the number one product that's used in what we see as the 17 ongoing studies in the market?
Operator
Thank you. Our next question comes from Larry Solo with CJS Securities. You may proceed.
Great. Thank you. And I echo the welcome back, Marianne. It sounds like the CEO search is progressing now, so is this going to be like a six-month, 12-month type of thing? Any thoughts on just timing?
So it is progressing, Larry, and it's good to be talking with you again. I'm going to say two things that I think are in our favor. I think this is an incredible opportunity for someone to step into what the future of our company and where we're going to be taking this company. And so I think as exciting as that is to me, I think it's also something that is exciting to the candidates we're talking to. And the other thing I will say is, as everyone knows, we sit fairly adjacent to what is an incredibly active market in the United States, and that is the life sciences market in Cambridge. And so that is also, I think, then very much a boon for us in our search. I will say, and this will not be a surprise to anyone, that the potential slate of candidates for us who are purely radiopharmaceutical or have radiopharmaceutical is very narrow. This is just not a large industry. Just from a history perspective, there haven't been a lot of CEOs in this industry. And as you can imagine, those of us who are here probably have competitive locks from going to competitors in a role as significant But having said that, I will reiterate what I said. I'm very pleased with the candidates that we've met. And to me, it's also a declaration or a demonstration of how far radiopharmaceuticals have come and what they mean and represent in overall life sciences now.
Operator
Thank you. Our next question comes from Yuanji with B. Riley. You may proceed.
Good morning. Thank you for taking our questions. Maybe to Marianne, when comparing new receipts to the number one leader in that space, where do you see improvement opportunities to catch up in market shares? Is it availability, guidance difference, or pricing? Any additional color will be appreciated.
Sorry, your voice was actually very muffled while you asked your question, and we're going to have to ask you to repeat it.
Yes, I'm sorry. When comparing NeuroSeq with the number one leader in that space, where do you see improvement opportunities to catch up in market shares? Is it availability or guidance or pricing, anything you see opportunities in?
Yes, I'm very well understood now. Thanks so much. Let me first start by correcting. NeuroSeq is the second most utilized amyloid data imaging agent in the space. The product with the highest market share in the space right now is actually Lily's product, Amazid. As far as where we see the growth opportunities for NeuroSeq in the market short, mid, and long term is, first and foremost, there have been some changes to the guidelines regarding use of amyloid imaging for diagnosis of patients with different levels of Alzheimer's disease. So that's a first, and very much testament to that, I think the launch and now what we see is continued uptake of the DMTs, the drug-modifying therapies for Alzheimer's disease, come with what will be associated imaging, not only to validate that the patients would be eligible for those therapies, but then there's also the potential to monitor those patients during therapy. And both of those activities would add volume to the amyloid imaging market. Finally, very specific to NeuroSeq, this is not a price play. You mentioned, is this going to come purely from price or growth? And the answer to that is no. It really is driven by two factors. The first is, and most important, broadening the geographic footprint from which NeuroSeq is available for distribution to all of the centers that do amyloid-based PET imaging. And the second is that within those accounts, and especially accounts where there's already a polarified relationship, deepening the penetration of NeuroSeq use in those areas. You heard me refer several times throughout my comments to the nuclear medicine customer base. We feel very strongly that we have a key advantage in our relationship there, long-standing history. That has been the central focus of Lanthias' commercials efforts since we were essentially launched as a company back in the late 50s. So it's a long relationship, it's a deep relationship, and it's a very trusting relationship for having brought them all the products before, but certainly Polarify. So where we find ourselves now, very fortunately, which we absolutely intend to take advantage of, is that we have the ability to bring a portfolio of products into this customer space, and one of those will certainly be Neuroseek. I'd also like to clarify a comment that I made before regarding the POSLUMA versus Polarify head-to-head study about the final point about patients not being allowed to void. That is not an accurate statement. What I should have said is that while patients were encouraged to drink, and they were encouraged to drink, they weren't instructed to avoid or were not made to avoid. So I apologize for that error in how I presented it.
Operator
Thank you. Our next question goes from Justin Walsh with Jones Trading. You may proceed.
Hi, thanks for taking the question. In the medium to long term, can you comment on your expectations for the relative revenue contributions for your product portfolio segments?
I'm just wondering how important prostate cancer is versus other solid tumors versus neurology and PET imaging.
So I absolutely am happy to comment on that. And I hope also that that kind of came through in our comments to say that while we are incredibly fortunate to have up to four approvals this year, I think I was repetitive, as was Bob and even Amanda, in sharing that we expect revenue uptake to begin significantly in 2027. And that really is related to the nature of how these products come out into the market and the very important considerations of ensuring that you have access and coverage, as well as insurance coverage. But here we're talking about market coverage as well, in place before you put your commercial effort really behind it. It doesn't mean we're not getting ready for the launches. It just means that we won't execute the launches and see the return for them. We're seeing largely in 27. From a revenue perspective, I hope you appreciate how much effort we did throughout end of 24, all through 25 to diversify our revenue base. But going forward, it's safe to assume that revenue derived from our prostate cancer franchise of products will be the main driver. We see lovely, lovely contribution from NewerSeek. We absolutely have strong expectations for contributions from our other launch products that we will be taking to market, but fair to say that the cornerstone and the majority of our revenue will be from Polarify. That's why for 2026, and we've again repeated this several times, We are laser-focused on the transition to and introduction of our new PSMA tech formulation.
Operator
Thank you. Our next question goes from Andy Sy with William Blair. You may proceed.
Thanks for taking our question. So, like a Neuroseek, you're going to be launching into markets with incumbents with Octave and the Therapeutic 2003. and then three.
So can you outline some product-specific and commercial infrastructure differentiation that you can leverage to gain an upper hand as you launch these two products in the future? Thank you.
Yes. Very good question. Just to clarify, of course, NeuroSeek is already in the market. We didn't launch NeuroSeek. Those products have been in the market for over a decade. But I will say that NeuroSeek is the second most utilized product in what is a a three product market. Important notes about the other products that you mentioned, and we'll put two zero zero three aside because that's a therapeutic, but as Amanda mentioned in her comments, Octevi, one of the important considerations of Octevi is that it will have transitional password status and reimbursement, as will our new formulation in the PSMA franchise, and so that will be an important consideration and is an important consideration for many customers, especially given that the ATSI market is approximately 80% hospital-based, and as everyone is aware, the concept of transitional pass-through payment is really applicable for traditional Medicare patients who are seen in the hospital setting, so we see that as a key advantage as we take that product to market. From MK6240, which also has, you know, an approval and a PDUFA date later this year, that is a product that is already well-established through our biomarker solution business. And there we will continue to support that its role as being the number one tracer used in what are the wealth of clinical trials being undertaken by pharma in the study of tau and amyloid-based Alzheimer's disease.
Operator
Thank you. And as a reminder, you may re-enter the queue after you ask your question. please press star one one on your telephone to ask a question. Our next question comes from Kemp Dolliver with Brookline Capital Markets. You may proceed.
Quickly for Bob, could you go through the comments again on the sales and marketing guidance for 26?
Manage that. So more or less what we're thinking of in terms of like total OpEx, you're going to see two of our sort of three sort of OpEx categories. sort of increase in spend. I did note specifically that we would see R&D up around that 10, 11 percent mark. But with regard to sales and marketing, and I do think that this is when I look at consensus files, this is, I think, the one sort of like under appreciation for the work that we need to put in front of 20, you know, the different products that we're hoping to launch, you know, going into 2027, and the work, and it mirrors almost what we did with Polarify back in, when was that, 2021. So from that perspective, I think you're going to model it somewhere and call it the 12-ish, 12.5% range of revenue. And that, I think, together with a flat gna um you know again keeping keeping some leverage in those functions that are supporting but really kind of putting the money in the investment where we hope to see it a solid return for shareholders that's uh how you should model things thank you ladies and gentlemen there are no further oh sorry i just did want to add a comment there uh that kind of finishes out bob's thought i think also what what we were also trying to communicate that's important here is that we have leverage as we take these new launches, and certainly sales and marketing expense is part of that, as we take these new launches out to the market,
that one of the great opportunities we have is leverage as we've already got a full voice and presence with that customer base. So you heard me say, and I'll repeat it again, fit-for-purpose investments commensurate with the opportunity, but also with the investments we've made prior in those same customer bases. And I would say overall in the channel.
Operator
Thank you. Ladies and gentlemen, there are no further questions at this time. Thank you for participating in today's conference. This concludes the program. You may disconnect and have a wonderful day.
