MGTX · MeiraGTx Holdings plc

The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 18, 2025.

The price reported reflects the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $13.59 to $14.00, inclusive.

The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price.

The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 18, 2025.

The price reported reflects the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $12.00 to $12.63, inclusive.

The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price.

The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 9, 2025.

The price reported reflects the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $13.36 to $14.31, inclusive.

The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price.

The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 9, 2025.

The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price.

The price reported reflects the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $14.47 to $15.33, inclusive.

Each restricted share unit converts into one ordinary share upon vesting.

Fifty percent of the restricted share unit award will vest on the second anniversary of the grant date and twenty-five percent of the restricted share unit award will vest on each of the third and fourth anniversaries of the grant date.

Each restricted share unit converts into one ordinary share upon vesting.

Fifty percent of the restricted share unit award will vest on the second anniversary of the grant date and twenty-five percent of the restricted share unit award will vest on each of the third and fourth anniversaries of the grant date.

Each restricted share unit converts into one ordinary share upon vesting.

Fifty percent of the restricted share unit award will vest on the second anniversary of the grant date and twenty-five percent of the restricted share unit award will vest on each of the third and fourth anniversaries of the grant date.

Each restricted share unit converts into one ordinary share upon vesting.

Fifty percent of the restricted share unit award will vest on the second anniversary of the grant date and twenty-five percent of the restricted share unit award will vest on each of the third and fourth anniversaries of the grant date.

Each restricted share unit converts into one ordinary share upon vesting.

Fifty percent of the restricted share unit award will vest on the second anniversary of the grant date and twenty-five percent of the restricted share unit award will vest on each of the third and fourth anniversaries of the grant date.

Each restricted share unit converts into one ordinary share upon settlement. The reporting person elected to have the restricted share units become settleable when the reporting person ceases to be a director.

The restricted share units shall vest in a single annual installment upon the earlier of (i) June 11, 2027 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2027.

Each restricted share unit converts into one ordinary share of the Issuer upon settlement. The restricted share units become settleable when Ellen Hukkelhoven ("Ms. Hukkelhoven") ceases to be a director of the Issuer.

The restricted share units shall vest in a single annual installment upon the earlier of (i) June 11, 2027 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2027.

Ms. Hukkelhoven is a Managing Director of Perceptive Advisors, LLC (the "Advisor"). The Advisor serves as the investment manager of Perceptive Life Sciences Master Fund Ltd. (the "Master Fund"). The Advisor may be deemed to have an indirect pecuniary interest in the securities reported herein because the Advisor has the right to receive the director compensation provided in respect of Ms. Hukkelhoven's board service through a partial management fee offset. Joseph Edelman ("Mr. Edelman") is the managing member of the Advisor. Each of Mr. Edelman, the Master Fund and the Advisor disclaim, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman, the Master Fund or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

Each restricted share unit converts into one ordinary share upon settlement.

The restricted share units shall vest in a single annual installment upon the earlier of (i) June 11, 2027 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2027.

Each restricted share unit converts into one ordinary share upon settlement. The reporting person elected to have the restricted share units become settleable when the reporting person ceases to be a director.

The restricted share units shall vest in a single annual installment upon the earlier of (i) June 11, 2027 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2027.

Each restricted share unit converts into one ordinary share upon settlement. The reporting person elected to have the restricted share units become settleable when the reporting person ceases to be a director.

The restricted share units shall vest in a single annual installment upon the earlier of (i) June 11, 2027 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2027.

Each restricted share unit converts into one ordinary share upon settlement. The reporting person elected to have the restricted share units become settleable when the reporting person ceases to be a director.

The restricted share units shall vest in a single annual installment upon the earlier of (i) June 11, 2027 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2027.

Each restricted share unit converts into one ordinary share upon settlement. The reporting person elected to have the restricted share units become settleable when the reporting person ceases to be a director.

The restricted share units shall vest in a single annual installment upon the earlier of (i) June 11, 2027 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2027.

Each restricted share unit converts into one ordinary share upon vesting.

The restricted share units vest in a single annual installment upon the earlier of (i) June 12, 2026 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2026.

Each restricted share unit converts into one ordinary share upon vesting.

The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 18, 2025.

The price reported reflects the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $8.96 to $9.32, inclusive.

The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price.

The option vests as to one quarter of the total grant on May 1, 2027 and vests as to the remainder in 36 equal monthly installments thereafter.

Each restricted share unit converts into one ordinary share upon vesting.

Fifty percent of the restricted share unit award will vest on May 1, 2028, and twenty-five percent of the restricted share unit award will vest on each of May 1, 2029 and May 1, 2030.

The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 18, 2025.

The price reported reflects the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $9.96 to $10.60, inclusive.

The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price.

The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the "Master Fund"). Perceptive Advisors LLC (the "Advisor") serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 9, 2025.

The price reported reflects the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $9.11 to $9.52, inclusive.

The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price.

On March 25, 2026, the Issuer, Credit Fund III, and the other parties to the Financing Agreement entered into an agreement whereby the exercise price of the warrants was adjusted to $8.00 per share.

Issued to Perceptive Credit Holdings III, LP ("Credit Fund III") in connection with the senior secured financing arrangement (the "Financing Agreement") by and among the Issuer, PCH III, and the other parties thereto. Perceptive Credit Advisors LLC ("Perceptive Credit Advisors") serves as the investment advisor to Credit Fund III and as a relying advisor under the Advisor. Mr. Edelman is the managing member of Perceptive Credit Advisors. Each of Perceptive Credit Advisors, the Advisor and Mr. Edelman disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that any of Perceptive Credit Advisors, the Advisor and Mr. Edelman is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

On March 25, 2026, the Issuer, Credit Fund III, and the other parties to the Financing Agreement entered into an agreement whereby the exercise price of the warrants was adjusted to $8.00 per share.

Issued to Perceptive Credit Holdings III, LP ("Credit Fund III") in connection with the senior secured financing arrangement (the "Financing Agreement") by and among the Issuer, PCH III, and the other parties thereto. Perceptive Credit Advisors LLC ("Perceptive Credit Advisors") serves as the investment advisor to Credit Fund III and as a relying advisor under the Advisor. Mr. Edelman is the managing member of Perceptive Credit Advisors. Each of Perceptive Credit Advisors, the Advisor and Mr. Edelman disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that any of Perceptive Credit Advisors, the Advisor and Mr. Edelman is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

On March 25, 2026, the Issuer, Credit Fund III, and the other parties to the Financing Agreement entered into an agreement whereby the exercise price of the warrants was adjusted to $8.00 per share.

Issued to Perceptive Credit Holdings III, LP ("Credit Fund III") in connection with the senior secured financing arrangement (the "Financing Agreement") by and among the Issuer, PCH III, and the other parties thereto. Perceptive Credit Advisors LLC ("Perceptive Credit Advisors") serves as the investment advisor to Credit Fund III and as a relying advisor under the Advisor. Mr. Edelman is the managing member of Perceptive Credit Advisors. Each of Perceptive Credit Advisors, the Advisor and Mr. Edelman disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that any of Perceptive Credit Advisors, the Advisor and Mr. Edelman is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

On March 25, 2026, the Issuer, Credit Fund III, and the other parties to the Financing Agreement entered into an agreement whereby the exercise price of the warrants was adjusted to $8.00 per share.

Issued to Perceptive Credit Holdings III, LP ("Credit Fund III") in connection with the senior secured financing arrangement (the "Financing Agreement") by and among the Issuer, PCH III, and the other parties thereto. Perceptive Credit Advisors LLC ("Perceptive Credit Advisors") serves as the investment advisor to Credit Fund III and as a relying advisor under the Advisor. Mr. Edelman is the managing member of Perceptive Credit Advisors. Each of Perceptive Credit Advisors, the Advisor and Mr. Edelman disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that any of Perceptive Credit Advisors, the Advisor and Mr. Edelman is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 18, 2025.

The price reported reflects the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $7.27 to $7.56, inclusive.

The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price.

Represents vesting of one-quarter of restricted share units granted on February 21, 2023.

Each restricted share unit converts into one ordinary share upon vesting.

Shares withheld for payment of taxes upon vesting of award.

Each restricted share unit converts into one ordinary share upon vesting.

Represents vesting of one-quarter of restricted share units granted on February 21, 2023.

Represents vesting of one-quarter of restricted share units granted on February 21, 2023.

Each restricted share unit converts into one ordinary share upon vesting.

Each restricted share unit converts into one ordinary share upon vesting.

Represents vesting of one-quarter of restricted share units granted on February 21, 2023.

Represents vesting of one-quarter of restricted share units granted on February 21, 2023.

Each restricted share unit converts into one ordinary share upon vesting.

Each restricted share unit converts into one ordinary share upon vesting.

Represents vesting of one-quarter of restricted share units granted on February 21, 2023.

Shares withheld for payment of taxes upon vesting of award.

Shares withheld for payment of taxes upon vesting of award.

Shares withheld for payment of taxes upon vesting of award.

Shares withheld for payment of taxes upon vesting of award.

Represents vesting of one-quarter of restricted share units granted on February 21, 2023.

Each restricted share unit converts into one ordinary share upon vesting.

Represents vesting of one-quarter of restricted share units granted on February 21, 2023.

Each restricted share unit converts into one ordinary share upon vesting.

Each restricted share unit converts into one ordinary share upon vesting.

Represents vesting of one-quarter of restricted share units granted on February 21, 2023.

Each restricted share unit converts into one ordinary share upon vesting.

Represents vesting of one-quarter of restricted share units granted on February 21, 2023.

Each restricted share unit converts into one ordinary share upon vesting.

Represents vesting of one-half of restricted share units granted on January 17, 2024.

Represents vesting of one-half of restricted share units granted on January 17, 2024.

Each restricted share unit converts into one ordinary share upon vesting.

Shares withheld for payment of taxes upon vesting of award.

Represents vesting of one-half of restricted share units granted on January 17, 2024.

Each restricted share unit converts into one ordinary share upon vesting.

Shares withheld for payment of taxes upon vesting of award.