PMN · ProMIS Neurosciences Inc.
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AI Brief
Q2 FY26 earnings call · Aug 13, 2026TL;DR. ProMIS reported blinded six-month interim data from the PRECISE-AD Phase 1b trial of PMN310 in early Alzheimer's patients showing zero ARIA-E cases and directionally favorable biomarker movements (plasma pTau217 down ~15%, CSF MTBR-tau243 down ~13.3%), with unblinded 12-month topline results including cognitive outcomes expected in Q1 2027; the company ended Q2 with $53.4 million in cash, expected to fund operations through 2027.
- + Blinded interim PRECISE-AD analysis showed zero ARIA-E cases across all 136 safety-evaluable participants, including APOE4 homozygotes.
- + Blinded pooled biomarker data showed directionally favorable declines in plasma pTau217 (~15%) and CSF MTBR-tau243 (~13.3%), consistent with the trial's 75% active-drug allocation.
- + Cash position strengthened to $53.4 million with runway through 2027, beyond the anticipated Q1 2027 PRECISE-AD topline readout.
- + Pipeline advancing with PMN267 (TDP-43/ALS) progressing through IND-enabling studies and PMN442 (alpha-synuclein) advancing toward IND-enabling studies.
- + Company presented first human evidence of Aβ oligomer target engagement and removal by PMN310 at AAIC 2026.
- − Net loss widened to $11.7 million in Q2 2026 from $10.1 million in Q2 2025, with R&D expense rising to $9.5 million.
- − Accumulated deficit grew to $150.4 million as of June 30, 2026, reflecting continued operating losses.
AI-generated from the earnings call and 8-K · may contain errors · not investment advice
Equibles Rating
blended score · not investment adviceBlended from price, momentum, positioning, fundamentals & volatility · daily-close · not investment advice. Market backdrop is context, not part of the score.
Technicals
trend & momentum for long-term holders Strong SellIllustrative technical + ownership context — a signal mix, not investment advice.
Key metrics
the company's own KPIs, from written earnings releases and filings| Metric | Latest | Period | YoY |
|---|---|---|---|
| cash and short-term investments | $53.4M | As of June 30, 2026 | — |
| Expenditures for PMN310 | $7.8M | the three months ended June 30, 2026 filing | — |
Figures exactly as the company stated them in writing · click a metric with a to chart its history · period links open the stating document · "filing" marks figures stated in the 10-K/10-Q · YoY needs an exactly comparable prior-year period
Versus peers
Biotechnology — same industry group| Company | Mkt cap | YTD | Rev growth Y/Y | P/E | Short % shares |
|---|---|---|---|---|---|
|
PMN
this stock
ProMIS Neurosciences Inc.
|
$101.07M | +37.2% | — | — | 2.7% |
|
VRTX
Vertex Pharmaceuticals Inc / Ma
|
$133.37B | +11.1% | +46.2% | 30.7 | 1.9% |
|
REGN
Regeneron Pharmaceuticals, Inc.
|
$81.13B | -5.9% | +20.8% | 19.5 | 2.5% |
|
MRNA
Moderna, Inc.
|
$79.40B | +589.1% | +4.3% | — | 8.2% |
|
CSLLY
Csl Ltd
|
$61.25B | — | — | — | 0.0% |
Peers by industry group · P/E from as-reported trailing EPS · short % is of shares outstanding
At a glance
key data from every sectionPerformance
| 5D | 20D | 120D | MTD | YTD | |
|---|---|---|---|---|---|
| PMN | -12.0% | -25.6% | -22.2% | -13.6% | +37.2% |
| SPY | +1.2% | +0.6% | +11.6% | +1.6% | +13.6% |
| vs SPY | -13.2% | -26.2% | -33.8% | -15.2% | +23.6% |