SHPH · Shuttle Pharmaceuticals Holdings, Inc.

Each Restricted Stock Unit ("RSU"s) represents the contingent right to receive one share of common stock.

One-third of these RSUs will vest on each of 08/08/2026, 08/08/2027 and 08/08/2028.

Each Restricted Stock Unit ("RSU"s) represents the contingent right to receive one share of common stock.

One-third of these RSUs will vest on each of 08/08/2026, 08/08/2027 and 08/08/2028.

Each Restricted Stock Unit ("RSU"s) represents the contingent right to receive one share of common stock.

One-third of these RSUs will vest on each of 08/08/2026, 08/08/2027 and 08/08/2028.

Each Restricted Stock Unit ("RSU"s) represents the contingent right to receive one share of common stock.

One-third of these RSUs will vest on each of 08/08/2026, 08/08/2027 and 08/08/2028.

Each Restricted Stock Unit ("RSU"s) represents the contingent right to receive one share of common stock.

One-third of these RSUs will vest on each of 08/08/2026, 08/08/2027 and 08/08/2028.

Each Restricted Stock Unit ("RSU"s) represents the contingent right to receive one share of common stock.

These RSUs will vest on 02/08/2026.

Represents 209,790 restricted stock units ("RSUs") issued to the Reporting Person under the Shuttle Pharmaceuticals Holdings, Inc. 2018 Equity Incentive Plan. The 209,790 RSUs which are scheduled to vest in one third increments on each of 12/31/2025, 12/31/2026 and 12/31/2027.

Consists of (1) 214 shares of common stock and (2) 209,790 RSUs which remain subject to vesting.

Represents 209,790 restricted stock units ("RSUs") issued to the Reporting Person under the Shuttle Pharmaceuticals Holdings, Inc. 2018 Equity Incentive Plan. The 209,790 RSUs which are scheduled to vest in one third increments on each of 12/31/2025, 12/31/2026 and 12/31/2027.

Consists of (1) 135,785 shares of common stock and (2) 210,832 RSUs, which remain subject to vesting.

Represents 209,790 restricted stock units ("RSUs") issued to the Reporting Person under the Shuttle Pharmaceuticals Holdings, Inc. 2018 Equity Incentive Plan. The 209,790 RSUs are scheduled to vest in one third increments on each of 12/31/2025, 12/31/2026 and 12/31/2027.

Consists of (1) 214 shares of common stock and (2) 209,790 RSUs which remain subject to vesting.

The Reporting Person received a grant of 1,791 restricted stock units ("RSUs") on May 1, 2023 (14,326 RSUs on a pre-reverse split basis), which RSUs are subject to vesting over a period of three years. The first vesting of 598 RSUs occurred on May 1, 2024.

Consists of (i) 134,522 shares of common stock and (ii) 1,193 RSUs which remain subject to vesting. All share and RSU numbers reflect a 1-for-8 reverse stock split effected by the issuer on August 13, 2024.

Represents the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs") held by the Reporting Person. Upon vesting of the RSUs, the sales are automatic, routine, non-discretionary transactions mandated by the Issuer under its equity incentive plan in order to satisfy the Reporting Person's tax withholding obligations which are funded by "sell to cover" transactions. These transactions are exempt under Section 16b-3 and do not represent discretionary trades by the Reporting Person.

Consists of (i) 15,201 shares of common stock and (ii) 11,863 RSUs which remain subject to certain vesting conditions.

Represents the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs") held by the Reporting Person. Upon vesting of the RSUs, the sales are automatic, routine, non-discretionary transactions mandated by the Issuer under its equity incentive plan in order to satisfy the Reporting Person's tax withholding obligations which are funded by "sell to cover" transactions. These transactions are exempt under Section 16b-3 and do not represent discretionary trades by the Reporting Person.

Consists of (i) 1,077,943 shares of common stock and (ii) 16,667 RSUs which remain subject to certain vesting conditions.

Represents 2,100,000 shares held by the spouse of the Reporting Person, and over which the Reporting Person disclaims any beneficial ownership or control. Prior to the contribution, the Reporting Person's spouse held a total of 3,204,407 shares. On August 14, 2023, she contributed 2,100,000 shares to PAL Trust, a trust formed for the benefit of her adult children.

Consists of 1,104,407 shares held by the spouse of the Reporting Person. The inclusion in this report of the 1,104,407 shares held by the Reporting Person's spouse shall in no way be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose.

Consists of 2,100,000 shares gifted by the Reporting Person's spouse to PAL Trust, a trust formed for the benefit of the Reporting Person's adult children and for which a third party serves as external trustee and two of the Reporting Person's children serve as co-trustees. Beneficial ownership is disclaimed except to the extent the Reporting Person's spouse maintains any pecuniary interest therein. The inclusion in this report of the 2,100,000 shares held by the trust for the benefit of the Reporting Person's adult children shall in no way be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose.

The Reporting Person received 25,000 stock options ("Stock Options") to purchase shares of SHPH common stock on February 15, 2023, which Stock Options vest in full on the first anniversary of the date of grant.

Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of 2,702 restricted stock units ("RSUs") held by the Reporting Person. Upon vesting of the RSUs, the sales are automatic, routine, non-discretionary transactions mandated by the Issuer under its equity incentive plan in order to satisfy the Reporting Person's tax withholding obligations which are funded by "sell to cover" transactions. These transactions are exempt under Section 16b-3 and do not represent discretionary trades by the Reporting Person.

Consists of 1,072,531 shares of SHPH common stock.

Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of 3,843 restricted stock units ("RSUs") held by the Reporting Person. Upon vesting of the RSUs, the sales are automatic, routine, non-discretionary transactions mandated by the Issuer under its equity incentive plan in order to satisfy the Reporting Person's tax withholding obligations which are funded by "sell to cover" transactions. These transactions are exempt under Section 16b-3 and do not represent discretionary trades by the Reporting Person.

Consists of 2,429 shares of SHPH common stock.

Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of 2,702 restricted stock units ("RSUs") held by the Reporting Person. Upon vesting of the RSUs, the sales are automatic, routine, non-discretionary transactions mandated by the Issuer under its equity incentive plan in order to satisfy the Reporting Person's tax withholding obligations which are funded by "sell to cover" transactions. These transactions are exempt under Section 16b-3 and do not represent discretionary trades by the Reporting Person.

Consists of (i) 1,707 shares of Common Stock held by the Reporting Person and (ii) 182,364 shares of common stock held by the William Henry Adkins and Pauline Adkins 1993 Revocable Trust (the "Adkins Trust").

Represents the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of 11,862 restricted stock units ("RSUs") held by the Reporting Person. Upon vesting of the RSUs, the sales are automatic, routine, non-discretionary transactions mandated by the Issuer under its equity incentive plan in order to satisfy the Reporting Person's tax withholding obligations which are funded by "sell to cover" transactions. These transactions are exempt under Section 16b-3 and do not represent discretionary trades by the Reporting Person.

Consists of 7,496 shares of SHPH common stock and 23,725 RSUs, with each RSU representing the right to receive one share of SHPH common stock upon vesting, which RSUs remain subject to certain vesting conditions.

Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of 6,095 restricted stock units ("RSUs") held by the Reporting Person. Upon vesting of the RSUs, the sales are automatic, routine, non-discretionary transactions mandated by the Issuer under its equity incentive plan in order to satisfy the Reporting Person's tax withholding obligations which are funded by "sell to cover" transactions. These transactions are exempt under Section 16b-3 and do not represent discretionary trades by the Reporting Person.

Consists of 3,852 shares of SHPH common stock.

Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of 4,417 restricted stock units ("RSUs") held by the Reporting Person. Upon vesting of the RSUs, the sales are automatic, routine, non-discretionary transactions mandated by the Issuer under its equity incentive plan in order to satisfy the Reporting Person's tax withholding obligations which are funded by "sell to cover" transactions. These transactions are exempt under Section 16b-3 and do not represent discretionary trades by the Reporting Person.

Consists of 2,791 shares of SHPH common stock.

Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of 22,748 restricted stock units ("RSUs") held by the Reporting Person. Upon vesting of the RSUs, the sales are automatic, routine, non-discretionary transactions mandated by the Issuer under its equity incentive plan in order to satisfy the Reporting Person's tax withholding obligations which are funded by "sell to cover" transactions. These transactions are exempt under Section 16b-3 and do not represent discretionary trades by the Reporting Person.

Consists of 1,085,200 shares of common stock held directly by the Reporting Person.

Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of 10,380 restricted stock units ("RSUs") held by the Reporting Person. Upon vesting of the RSUs, the sales are automatic, routine, non-discretionary transactions mandated by the Issuer under its equity incentive plan in order to satisfy the Reporting Person's tax withholding obligations which are funded by "sell to cover" transactions. These transactions are exempt under Section 16b-3 and do not represent discretionary trades by the Reporting Person.

Consists of 6,560 shares of SHPH common stock.

Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of 892 restricted stock units ("RSUs") held by the Reporting Person. Upon vesting of the RSUs, the sales are automatic, routine, non-discretionary transactions mandated by the Issuer under its equity incentive plan in order to satisfy the Reporting Person's tax withholding obligations which are funded by "sell to cover" transactions. These transactions are exempt under Section 16b-3 and do not represent discretionary trades by the Reporting Person.

Consists of 1,071,388 shares of SHPH common stock.

Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of 2,702 restricted stock units ("RSUs") held by the Reporting Person. Upon vesting of the RSUs, the sales are automatic, routine, non-discretionary transactions mandated by the Issuer under its equity incentive plan in order to satisfy the Reporting Person's tax withholding obligations which are funded by "sell to cover" transactions. These transactions are exempt under Section 16b-3 and do not represent discretionary trades by the Reporting Person.

Consists of 1,707 shares of SHPH common stock.

Consists of warrants to purchase 138,889 shares of common stock held by the Adkins Trust. The Adkins Trust was a holder of the Issuer's Series A convertible preferred stock, which stock converted into commons stock upon completion of the Issuer's IPO and at which time the warrants were issued to the Series A holders in accordance with the terms of the Series A preferred stock offering.