SPTX

Seaport Therapeutics, Inc.

Company with tickers: SPTX

CIK

2042347

CUSIP

81221K108

Shares Outstanding

53,027,817

Trades by corporate insiders — officers, directors and holders of more than 10% of the shares — disclosed to the SEC on Forms 3, 4 and 5. Form 4 must be filed within two business days of the trade.

Date	Insider	Role	Type	Shares	Price	Value	After
2026-05-04	Chen Michael Cunyuan	Chief Scientific Officer	Other	10,526	—	—	0
2026-05-04	PureTech Health plc	10% Owner	Other	965,255	—	—	16,685,013
2026-05-04	PureTech Health plc	10% Owner	Other	2,681,265	—	—	15,719,758
2026-05-04	Torres Denice	Director	Other	13,406	—	—	13,406
2026-05-04	PureTech Health plc	10% Owner	Other	12,736,014	—	—	13,038,493
2026-05-04	PAUL STEVEN M	Director	Other	67,031	—	—	863,031
2026-05-04	Chen Michael Cunyuan	Chief Scientific Officer	Other	3,351	—	—	3,351
2026-05-04	General Atlantic (SP), L.P.	Director, 10% Owner	Other	6,101,582	—	—	6,101,582
2026-05-04	PureTech Health plc	10% Owner	Other	3,031,578	—	—	0
2026-05-04	Gladstein Lana	General Counsel	Other	33,515	—	—	33,515
2026-05-04	ARCH Venture Partners XII, LLC	10% Owner	Other	2,681,265	—	—	5,194,951
2026-05-04	HEALY JAMES	Director	Other	6,052,631	—	—	0
2026-05-04	HEALY JAMES	Director	Other	804,379	—	—	2,731,538
2026-05-04	PureTech Health plc	10% Owner	Other	40,000,000	—	—	0
2026-05-04	White Lauren	Chief Financial Officer	Other	6,702	—	—	6,702
2026-05-04	HEALY JAMES	Director	Other	1,927,159	—	—	1,927,159
2026-05-04	GAP Coinvestments CDA, L.P.	Director, 10% Owner	Other	6,101,582	—	—	6,101,582
2026-05-04	HEALY JAMES	Director	Other	2,526,315	—	—	0
2026-05-04	ARCH Venture Partners XII, LLC	10% Owner	Other	2,513,686	—	—	0
2026-05-04	PAUL STEVEN M	Director	Other	210,526	—	—	0
2026-05-04	PureTech Health plc	10% Owner	Other	8,421,052	—	—	0
2026-05-04	Torres Denice	Director	Other	42,105	—	—	0
2026-05-04	ARCH Venture Partners XII, LLC	10% Owner	Other	2,681,265	—	—	0
2026-05-04	ARCH Venture Partners XII, LLC	10% Owner	Buy	1,100,000	$18.00	$19,800,000	6,294,951
2026-05-04	White Lauren	Chief Financial Officer	Other	21,052	—	—	0
2026-05-04	ARCH Venture Partners XII, LLC	10% Owner	Other	2,513,686	—	—	2,513,686
2026-05-04	Loebel Antony	Director	Other	20,109	—	—	20,109
2026-05-04	Gladstein Lana	General Counsel	Other	105,263	—	—	0
2026-05-04	Loebel Antony	Director	Other	63,157	—	—	0
2026-04-30	HEALY JAMES	Director	Other	0	—	—	0
2026-04-30	White Lauren	Chief Financial Officer	Other	0	—	—	0
2026-04-30	PureTech Health plc	10% Owner	Other	302,479	—	—	302,479
2026-04-30	White Lauren	Chief Financial Officer	Other	0	—	—	0
2026-04-30	Zohar Daphne	Director, Chief Executive Officer	Award	1,486,786	—	—	1,486,786
2026-04-30	Chen Michael Cunyuan	Chief Scientific Officer	Other	0	—	—	0
2026-04-30	Mates Sharon	Director	Award	49,033	—	—	49,033
2026-04-30	PETERSON SANDRA E	Director	Other	0	—	—	0
2026-04-30	Gladstein Lana	General Counsel	Other	0	—	—	0
2026-04-30	PureTech Health plc	10% Owner	Other	0	—	—	0
2026-04-30	PAUL STEVEN M	Director	Other	0	—	—	0
2026-04-30	Loebel Antony	Director	Other	0	—	—	0
2026-04-30	Torres Denice	Director	Award	12,258	—	—	12,258
2026-04-30	PAUL STEVEN M	Director	Other	0	—	—	0
2026-04-30	ARCH Venture Partners XII, LLC	10% Owner	Other	0	—	—	0
2026-04-30	Wheadon David E.	Director	Other	0	—	—	0
2026-04-30	Zohar Daphne	Director, Chief Executive Officer	Other	0	—	—	0
2026-04-30	Pitts Jason	Director	Other	0	—	—	0
2026-04-30	PETERSON SANDRA E	Director	Award	12,258	—	—	12,258
2026-04-30	Wheadon David E.	Director	Award	12,258	—	—	12,258
2026-04-30	White Lauren	Chief Financial Officer	Award	63,680	—	—	63,680

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