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AI Stock Screener ALVIS Describe a screen in plain English — or filter by any metric across every US-listed stock. One free screen — no signup

Short interest & flow

Most Shorted Highest short interest
Squeeze Risk Composite short-squeeze score
Largest Short Volume Daily short-volume leaders
Highest Off-Exchange Share Dark-pool / OTC volume leaders

Ownership & fundamentals

Insider Sentiment Where insiders are accumulating most
Largest Buybacks Biggest share-repurchase programs
Going-Concern Flags Companies disclosing going-concern doubt

Institutions

Filers & Rankings

Browse Filers All 13F institutional filers
Top by AUM Largest filers by assets
Smart Money Index Top funds' highest-conviction basket
Superinvestors Famous value investors' portfolios
AUM Movers Biggest assets-under-management swings
Most-Held Stocks Stocks owned by the most filers
Last Quarter's Movers Notable position changes
Overlap Matrix Compare filer portfolios side by side
Clone Backtest Backtest a combined clone of several filers
Beneficial Ownership Recent 13D / 13G >5% stakes

13F Activity

13F Statistics Aggregate filing statistics
Latest Filings Newest 13F submissions
13F Trends Sector and flow trends
Double-Down Report Increased-conviction buys
Conviction Heat Map Crowded positions at a glance

Markets

Insider Trading Corporate insider buys and sells
Funds & ETFs Registered funds and ETFs from Form NPORT-P
Investment Advisers SEC-registered Form ADV firms
Economic Data Federal Reserve and macro indicators
Economic Calendar Upcoming macro data releases
FDA Calendar Upcoming FDA advisory-committee meetings
Congress Net Worth Richest members by disclosed net worth
Congress Leaderboard Members ranked by portfolio performance

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Stocks

AI Stock Screener ALVIS
Short interest & flow
Most Shorted
Squeeze Risk
Largest Short Volume
Highest Off-Exchange Share
Ownership & fundamentals
Insider Sentiment
Largest Buybacks
Going-Concern Flags

Institutions

Filers & Rankings
Browse Filers
Top by AUM
Smart Money Index
Superinvestors
AUM Movers
Most-Held Stocks
Last Quarter's Movers
Overlap Matrix
Clone Backtest
Beneficial Ownership
13F Activity
13F Statistics
Latest Filings
13F Trends
Double-Down Report
Conviction Heat Map

Markets

Insider Trading
Funds & ETFs
Investment Advisers
Economic Data
Economic Calendar
FDA Calendar
Congress Net Worth
Congress Leaderboard

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Stocks
SYRE
10-K

10-K

Spyre Therapeutics, Inc. (SYRE)

10-K 2022-03-08 For: 2021-12-31

Added on April 10, 2026

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