Wave Life Sciences Ltd. Q1 FY2023 Earnings Call

Thank you, operator. Good morning, and thank you for joining us today to discuss our recent business progress and review Wave's first quarter 2023 financial results. Joining me today are Dr. Paul Bolno, President and Chief Executive Officer; Anne-Marie Li-Kwai-Cheung, Chief Development Officer; Kyle Moran, Chief Financial Officer; and Dr. Chandra Vargeese, Chief Technology Officer. The press release issued this morning is available on the Investors section of our website, www.wavelifesciences.com. Before we begin, I would like to remind you that discussions during this conference call will include forward-looking statements. These statements are subject to several risks and uncertainties that could cause our actual results to differ materially from those described in these forward-looking statements. The factors that could cause actual results to differ are discussed in the press release issued today and in our SEC filings, including our annual report on Form 10-K for the year ended December 31, 2022, and our quarterly report on Form 10-Q for the quarter ended March 31, 2023. We undertake no obligation to update or revise any forward-looking statements for any reason. I'd now like to turn the call over to Paul.

Thanks, Kate. Good morning, and thank you all for joining us on today's call. Today, I'll share highlights on our progress during the first quarter and then turn the call to Kyle to review our financials. Then we'll open up the call for questions. Anne-Marie and Chandra are also on the line today and will be available for Q&A. The first quarter marked a fundamental strategic change in how we at Wave are leveraging our leadership in oligonucleotide chemistry, including the formal beginning of our transformational collaboration with GSK, publicly announced in mid-December of last year. Let's take a moment to reflect on our evolution. More than 10 years ago, we started as a company focused on optimizing antisense oligonucleotide chemistry. We then leveraged, relatively well-understood biological mechanisms of RNA base-directed silencing and exon skipping. Gratifyingly, at this point in our evolution, we believe we are finally seeing the fruits of these chemistry efforts in our recent preclinical and clinical work. We see them in our positive DMD clinical data announced last December to which I will return, and we are seeing them in our recent preclinical data with strong and durable RNAi-mediated silencing in liver and beyond. Over recent years, advances in chemistry combined with emerging genetic and genomic insights have enabled us to think more aggressively about engaging novel target biology such as ADAR enzymes for editing, where we can use our validated chemistry to unlock high-value, first-in-class therapeutic franchises. Marrying novel biology with validated best-in-class chemistry opens opportunities to make first-in-class medicines that can grow into class leaders. More of the sorts of targets we're interested in with biological validation rooted in human genetics, when combined with validated pharmacology, have improved the probability of success in development. Our demonstration at Wave of best-in-class RNA editing, best-in-class exon skipping, and now also potentially best-in-class RNAi silencing, allows us to be driven in a way we describe as multi-modal in RNA medicine. This means we have a broad toolkit in RNA-directed pharmacology across multiple modalities, but we believe we can select the optimal tool for the job across the most attractive molecular target and associated disease space. It is rare for a company to have both a validated pharmacologic platform and access to genetically validated targets, and a decade of work has uniquely positioned us to capitalize on this opportunity. Today, Wave is leveraging our multi-modal platform to pioneer first-in-class RNA medicine with a strategic focus on protein restoration and repair targets, such as alpha-1 antitrypsin deficiency or AATD, that will provide life-changing medicines for patients and build major value for shareholders. Our unique capabilities enable us to quickly move beyond AATD to build value through pipeline expansion and derisking. We intend to hold an investor event in the third quarter of this year to highlight how we are translating our capabilities in protein restoration and repair into compelling new programs. Since we last gathered six weeks ago, we have made substantial progress in several aspects of our business, three of which I'd like to highlight today. First, our GSK collaboration with significant milestones that could be achieved in 2023 and beyond. Second, steadfast execution on driving WVE-006 to the clinic in alpha-1 antitrypsin deficiency and rapidly generating data on the next set of RNA editing programs. And third, continued progress advancing WVE-N531 for DMD, a wholly owned commercial opportunity for Wave into a study that would support potential accelerated approval. First, our transformational collaboration with GSK is off to a strong start. As a reminder, this partnership not only validates our leadership in RNA editing with our first-in-class ADAR editing modality, it also acknowledges our best-in-class multi-modal RNA medicine discovery and development platform. Through the collaboration, GSK provides Wave with proprietary genetic insights to expand our pipeline, both with partnered and wholly-owned Wave programs. It has been an exciting and productive start to the collaboration with both the Wave and GSK teams working together to begin advancing the first set of targets. It's important to remind everyone that GSK has made significant investments in genetic discovery, as well as has a long history and clear current leadership in respiratory medicine development and commercialization. Both of these capability sets make GSK the ideal partner for Wave's pioneering AATD program. Importantly, the GSK deal bolstered our balance sheet with $170 million in upfront cash and equity to accelerate our existing pipeline and provide meaningful near-term milestone payment opportunities, including clinical development milestones related to WVE-006. These potential milestone payments, while confidential in their quantity and trigger events, have the potential to add substantially to our already strong balance sheet in the near term, including meaningful milestones anticipated in 2023 and beyond. Next, we continue to make steady progress advancing WVE-006 towards our first-in-human trials. As a reminder, 006 is our first-in-class GalNAc-conjugated RNA editing candidate for AATD. Since our last update, we have successfully completed the in-life portion of GLP toxicology studies as planned for 006, and we are rapidly advancing towards CTA submissions this year. Among the field, we continue to generate excitement for our novel treatment approach to AATD, which is a first-in-class therapy designed for restoration of both healthy hepatic and pulmonary function with a reversible and redoseable therapeutic. There is a major unmet need in AATD, with current therapies largely confined to treating either pulmonary or, in the future, hepatic manifestations of the disease. Despite the limitations of current therapy, AATD represents a substantial pharmaceutical market with augmentation therapy alone currently accounting for about $1.3 billion in annual pharmaceutical revenue worldwide, and this market is expected to grow. 006 is on track to be the first RNA-editing therapeutics taken into human clinical trials, where we intend to utilize validated biomarkers to deliver proof of concept for 006 and the field of RNA editing. Similar to the exponential growth of RNAi medicine following the derisking of GalNAc sRNA silencing in liver, we believe early clinical data with 006 would increase the probability of success of Wave's future RNA editing program in the liver and beyond. We believe this would enable us to build substantial shareholder value in a way that is comparable to the early pioneers of RNA medicine. As we continue to expand our wholly-owned pipeline, we are focused on investing in first-in-class RNA editing therapeutics, designed to repair and restore protein such as with our AATD program. Our discovery team is intensely working on the next Wave of RNA medicines to sustain our pipeline. We plan to hold an investor event in the third quarter of this year, during which we will demonstrate how we are continuing to extend our leadership in RNA editing, and we also expect to share preclinical data on new programs. In DMD, we are laser-focused on initiating our potentially registrational Phase II study of WVE-N531, our exon 53 skipping candidate, following our positive data in December. Our proof of concept data continues to be met with excitement by neuromuscular clinicians and the DMD community. As a reminder, these results included the impressive 53% exon skipping observed after just three consecutive biweekly doses, high muscle tissue concentration, and a favorable safety profile. With longer dosing, we expect these high levels of skip transcript to result in downstream accumulation of substantial fully functional dystrophin protein, as has been the case with other exon skipping strategies observed across the industry to date. A key distinction of exon skipping approaches such as N531 from gene therapy is the intent to generate functional Becker-like dystrophin protein, not mini or micro-truncated dystrophin. Functional dystrophin protein has been established by the FDA as a surrogate endpoint for accelerated approval in DMD, something that is still in question for microdystrophin. Moreover, our hope for the DMD community is that options for patients continue to expand, and we believe that convenient, safe production of endogenous functional dystrophin can be a highly valuable and attractive option for patients as an alternative to or in combination with gene therapy approaches should they become available. Our team is quickly moving to initiate dosing in Part B of our study, a Phase II open-label study with doses of 10 milligrams per kilogram administered every other week and plans to assess dystrophin protein after 24 weeks and 48 weeks of treatment. We will continue to share updates as we progress with Part B of the study, and we expect to share data in 2024. If the data are supportive, we intend to use them to file for accelerated approval. Importantly, our vision extends beyond exon 53, and we are planning a broad multi-exon strategy, which we would accelerate following positive dystrophin data for N531 to build a wholly-owned DMD franchise. Turning to WVE-004 and 003. Our CNS silencing programs are advancing in adaptive clinical trials, and as a reminder, these programs are part of an active collaboration with Takeda. WVE-004, our candidate for C9orf72 associated ALS and FTD, is being evaluated in the FOCUS-C9 clinical trial. We remain on track to deliver a substantial data set consisting of several single and multi-dose cohorts in the first half of this year. This will enable discussions with our partner and inform next steps for this program. WVE-003 is the first-in-class allele-selective candidate for Huntington's disease, which is being evaluated in patients with a SNP3 polymorphism in the SELECT-HD clinical trial. Last year, we adapted the SELECT-HD study to expand the single-dose cohorts based on initial positive clinical mutant and wild-type Huntington biomarker data. Recently, the vendor of our mutant Huntington assay announced that they were subject to a cybersecurity attack, and we remain in close contact with them as they work to address this issue. Our patient samples were not impacted, and we will ensure that our vendors' relevant computer systems are fully operational and validated before processing. With this shift in timing, we now expect to deliver additional single-dose biomarker and safety data along with some multi-dose data in the second half of 2023. Like with 004, these clinical data will also enable us to discuss next steps for the program with our partner. As a multi-modal RNA medicines company, we are able to leverage our collaborations to explore our best-in-class potential in RNAi balancing. RNAi is one of multiple modalities being leveraged in our strategic collaboration with GSK. Just a few weeks ago, we announced the first publication of our siRNA design in nucleic acid research, and we have since received highly positive feedback from our peers, recognizing the transformational impact these findings have for the field of RNAi. The published data demonstrated unprecedented Ago2 loading following administration of a single subcutaneous dose, leading to improved potency and durability in vivo as compared to a comparator from a commercial company with a clinically proven track record in RNAi. We believe these data are critical and highly enabling as the translatability of RNAi-based approaches from preclinical observation to clinical proof of concept have been well established. Further, there remain many high-value RNAi targets in attractive accessible tissue, and more novel targets continue to flow from leading work in human genetics, including work by our collaborator, GSK. In sum, we are building a leading multi-modal RNA medicines company with significant opportunity to expand our foundational work in the field of RNA editing. We are working with urgency to bring a novel RNA editing medicine to people living with AATD, and important new treatment options for boys with DMD. We will deliver two important data sets this year to inform our CNS silencing programs for the ALS/FTD and HD communities, and we are also excited to share more on our work with GSK and our emerging RNA editing portfolio beyond the AATD later this year. It is a uniquely busy time at Wave, and we believe we are well-positioned to capitalize on years of hard work to enable rapid pipeline development. With that, I will now turn the call over to Kyle Moran, our CFO, for a financial update.

Thanks, Paul. Turning to the financials. Our net loss for the first quarter of 2023 was $27.4 million compared to $37.8 million for the prior year quarter. The decrease in net loss was primarily due to revenue earned under our collaboration with GSK, which became effective January 2023. Revenue earned under the GSK and Takeda collaborations in the first quarter of 2023 was $12.9 million. In the prior year quarter, revenue of $1.8 million was primarily earned under the Takeda collaboration. Research and development expenses were $31 million for the first quarter of 2023, as compared to $27.5 million in the prior year quarter. The increase in R&D expenses was primarily due to increased external expenses related to our clinical program, as well as compensation-related expenses driven by growth to support our program. G&A expenses slightly declined for the first quarter to $12.2 million as compared to $12.4 million in the prior year quarter, primarily due to a decrease in compensation-related expenses. We ended the first quarter with $207.6 million in cash and cash equivalents, as compared to $88.5 million as of December 31, 2022. The increase is primarily attributable to upfront cash and equity investment of $170 million from Wave's strategic collaboration with GSK. We expect that our cash and cash equivalents will be sufficient to fund operations into 2025. As a reminder, we do not include future milestones or opt-in payments under our GSK or Takeda collaboration in our cash runway. As Paul stated earlier, Wave has the potential to receive meaningful near-term milestone payments in 2023 and beyond, including clinical development milestones related to WVE-006, our RNA editing candidate for the treatment of AATD.

Thanks, Kyle. This is an exciting time for Wave. We are sharply focused on execution as we approach several meaningful clinical milestones in 2023 and 2024. We are leading the field in RNA editing, and with WVE-006, we are on the cusp of bringing the first candidate from this innovative nucleic acid therapeutics to the clinic. We continue to leverage our multi-modal platform and our collaboration with GSK to build our pipeline. Importantly, we are well-capitalized to deliver on these near-term milestones, and I look forward to sharing continued progress with you over the course of the year. With that, I will now turn the call over to the operator for Q&A.

Hi, good morning. This is Mike Linden representing Salim. Thank you for taking our questions. I have a couple for you. Regarding DMD, WVE-N531, since the Phase 2 results indicate it may be registrational, could you provide more details on what that could entail? Specifically, do you anticipate needing more than 10 patients for registration or to have confidence in the patient number? Additionally, for WVE-004, considering the recent approval for ALS based on NfL, how does that influence your thinking about the potential registrational path moving forward?

Thank you, Mike for your question. Anne-Marie, I'll hand it to you in a minute. But just to follow-up on the potentially registrational design. When we did move into Part B, as we provided the update earlier this year, we designed that study to be powered for greater dystrophin than the existing commercial program. And so in those calculations, that included the number of patients that we're including in the study. If we go back to some of the other therapies that were approved in the exon skipping space, they're approved on studies with low patient numbers. So we believe that the study is significantly powered enough to give us dystrophin as a clinical surrogate endpoint for filing for accelerated approval. And subsequently, we continue to do the work necessary to have the confirmatory or what we call Phase III study up and enrolling at the time that we would file for that. So the study in both its design and powering was set up to deliver on that potential registration pathway. Anne-Marie, is there anything you want to add to that question?

I think I would just add, there's clearly a registrational path using accelerated approval utilizing dystrophin, and so, we would expect to access that pathway with multiple studies.

For the second question relative to the impact on the recent AdCom and the tofersen approval looking at NfL as a biomarker on the 004 programming study. I think absolutely, I mean when we have those data now with single and multi-dose data, the study has a long enough follow-up period of time with repeat doses for us to make similar investments and access similar pathways. But we've got to wait till the data is cut and analyzed before we make that decision. Anne-Marie, anything to add to that?

I think I would just add to that, obviously, the first time experiences provide a really interesting biomarker in NfL. And we know that NfL is important, we'll be assessing it in its totality within white blood cells in CSF and protein in CSF as well as the safety in the pharmacodynamic effect.

All right. Thanks for taking our questions. Given that neurofilament light chain is now an approvable surrogate biomarker for analysts, are there any studies you can point to that show correlation between poly(GP) reductions and improvements in either functional or reductions in neurofilament light chain? And I have a follow-up.

Yes, what’s interesting about your question is that, as we mentioned earlier, following the outcome, the evaluation of the potential for 004 to have a pathway to accelerated approval is intriguing. However, similar to how SOD1 was not correlated to NfL reduction, the study has shown that target engagement resulted in a change in outcomes, which is linked to the decrease in NfL. Therefore, there are no correlations between poly(GP) and NfL as we conduct this study. The first study that will be presented will provide data on poly(GP) related to NfL for this specific molecule. This is why these data could be significant when considering a potential accelerated approval, especially if we do observe a correlation between these two biomarkers.

No, nothing to add to that, Paul.

Okay. Great. And on the RNA editing front, our understanding is that one of your peer company or maybe companies are delivering their guide RNA for ADAR-mediated RNA editing using LNP for AATD. Can you remind us of your delivery strategy and any thoughts on packaging it with LNP? And I just have one last follow-up.

Yes. I mean I think the beauty from when we introduced our RNA editing platform a couple of years ago, and we're doing the work on chemical optimization as we talked about the evolution of Wave. The ability not to have to use LNPs. I mean the challenge in developing chemistries that are compatible with LNPs is a very short unstable oligo. When we think about the data that's been shown by our peers, it shows protein levels in the course of ours. I think the key for us has been durability, potency and accessibility absent the need for delivery vehicles, starting with the opportunity we have, which is without the need for vehicles, it means we can think about editing in multiple tissues, where LNPs can't go. So that opens up the possibility of thinking about CNS, renal, other tissues. I think what's been exciting about us in starting our RNA editing platform in AATD with GalNAc has been taking advantage of the precedent of GalNAc in subcutaneous low doses, accessibility of hepatocyte, durability and stable constructs and then being able to leverage much like the RNAi silencing world and our peers there, created the uniformity of, if you see data in this, then the probability of success of programs two, three, four, five, and beyond gets better and better. And I think the advantage we have and why we're excited to provide that updates later this year is taking advantage of GalNAc and what we've done in silencing and applying it to the field of editing gives us highly potent, highly durable, subcutaneously administered therapies that we're excited about, not just for AATD, but continuing to open up that space for other substantial indications. I mean, we shared this data on NHPs in our Nature Biotech paper. But I think the field of LNP deals move beyond that, where you have oligos that don't require them. And we've really, from the beginning, made that a fundamental component of building out the editing franchise.

Great. And one last question. AAV discovery for CNS-targeted delivery is a very active area of development with some recent progress. Do you have any thoughts on packaging your deliverables, especially RNAi, which can be vectorized in something like AAV, CNS-targeted AAV? And would you be open to collaborating with someone with that capability?

I mean, I think we watch this space. I think it's something that, obviously, we talked to a number of different companies. I think what's been interesting in thinking about CNS has really been the path to infrequent administration. So I think if one is relocated to monthly or less frequent administration, I think that changes the discussion. I think what we've seen is the ability for quarterly or twice a year dosing. I think as we look at some of our CNS RNAi silencing data, so the next generation of what we shared on our last earnings call about being able to use RNAi and CNS without having to use conjugates. We see potent durable silencing using mechanisms in other tissues and so prolong durability, such that I'm less concerned that we have to vectorize something and put added complexities and risk on a reversible medicine that has really infrequent dosing. So I think it's been exciting to do, but look at the work that we have getting beyond the antisense silencing in CNS, we showed last year potential for quarterly or twice a year dosing. I think we're excited by the progress we've made in RNAi and CNS and other technologies, too. So I think it's something we'll always continue to evaluate. But we really need to see where the advantage is coming over some of the therapies that are already in our RNA medicines toolbox.

Great. Thank you. Thanks, Paul.

Thank you.

Hi, this is Julian on for Paul. Thanks so much for taking our question. In the prepared remarks, you spoke at length about your collaboration with GSK and how you're working together to advance a set of targets. In terms of INDs that are coming down the pipeline, I guess, how do you anticipate the distribution to play out in terms of what may be wholly owned versus partnered with GSK? And any initial perspectives on how that may differ across specific therapeutic areas or disease targets would be great to hear. Thanks so much.

Thank you for the question. You're right. I mean, we're excited about the collaboration, because it's not distributed across therapeutic areas. I think what's important in the collaboration is really opening up access to the extent of work GSK has been doing in genetic insights on targets uniformly and broadly, both with the collaborations with the U.K. Biobank and 23andMe and other genetic datasets that they've spent a lot of resources in investing in. So the exciting thing to us is really to think about GSK's partnership with Wave in three approaches. One is, and to be very clear, we will continue to deliver wholly owned programs out of our portfolio, and we'll share more on the RNA editing space. They are unaffiliated with GSK. So these will be programs that we've done our own genetic work on advancing in the protein repair and restoration space. Second will be programs that GSK has identified that we're advancing with them, and that will span across the field of RNA editing and sRNA silencing and beyond. And we will have some interesting work, as we said at the beginning of this call, those targets are underway and initiated that we're working on with them. And then the third piece, to your point, is our opportunity set, and we are evaluating those targets now. So as part of that initiation, that process has already begun of looking at targets from that genetic database that we ourselves are interested in and continuing to evaluate and analyze. So I think the key is, it's a new collaboration coming fresh off the first quarter where it's initiated. I think both teams are energized in terms of the work that's coming off of it. So there was a lot of foundational work in the lead-up to this that enabled us both to start this collaboration and be progressing it with targets very near-term. And we'll provide more updates on that. I think a nice place for that next update will be at our Investor Day that we alluded to in the third quarter, where we will be able to share more not just about the work that we're doing, the preclinical work that we're doing on target, but really begin to start guiding to a future sustainable pipeline. And that's what I think we're excited about. A sustainable pipeline of new genetic medicines.

Excellent. Thanks so much.

Hi guys. Thanks for taking the call. I guess, a little more of a structural question around GSK partnership. Obviously, baked into terms of that, a lot of opportunities to bring in substantial amounts of free cash flow around opt-in based, et cetera, for new programs and targets. Can you give us a sense of mechanically in that partnership? So how far along does the asset need to be free or engaged? Is that defined as how mature that the preclinical data has to be before an opt-in decision gets made? Just give us a little bit of clarity into that, so we can think about when we would you start really bringing the register on that cash flow.

Yes. No. I mean, I think there's really two ways to think about cash flow in 2023 and beyond. And the first is, before we get into the programs themselves, it's just on the progress that we're making with 006. So the advancement of WVE-006, our alpha-1 antitrypsin, RNA editing program has substantial milestones associated with its progress. And so that's one sleeve with which we can look at substantial cash inflows going forward. I think the second, which you bring up, is looking at this concept of milestones related to programs. And I think what's important is the notion of the programmatic milestones, I mean, one, they're independent of data that's getting generated more program initiation. So you can think of it as the start and identification of programs. And as those programs move forward, they then have their own milestones leaves to them as those programs advance through the clinic and commercial. So I think we can start and say, we're off to a really good start around the work on the targets, and we can provide updates as these programs become initiated. So we have the initiation of program payments, candidate payments when they translate and then beyond as they become clinical programs. So I can't provide updates on the exact timing at this stage with each of those programs now. But I think it is important to note that they don't have certain data inflections that are requirements for those program initiation fees.

That's helpful. Thanks, guys.

Excellent. Thanks for taking our questions. This is Lisa on for Luca. First, maybe just one on DMD. I'm just wondering about the regulatory path for the potentially registrational Phase II study. Will the accelerated approval path still be open to you if beyond this 53 ends up gaining full approval based on their Phase III study, which is ongoing? Just any color there would be helpful.

Yes, I'll pass the call to Anne-Marie now. This is why we feel the need to act swiftly with our current plan and ensure that we conduct a confirmatory study alongside our efforts starting next year to validate that work. We are making strides in both directions. It's crucial that full approval based on the clinical study confirms dystrophin as a valid clinical surrogate endpoint, which would provide us with an advantage. Additionally, we want to ensure that we establish functional outcomes and clinical data for our molecule independent of the accelerated approval pathway. Anne-Marie, do you have anything to add?

Yes. I think what I'd add is that, it's important to note that the accelerated approval pathway is open to conditions that are serious, of course, and where you have a surrogate endpoint, but also meet an unmet medical need. I think everybody would agree that there is still unmet need. And even if it just becomes fully approved, there is still significant unmet need in DMD. And certainly, that's the case we would be making.

Right. That's helpful. And then maybe just a follow-up. For a confirmatory trial, would you also use the six-minute walk test as the primary endpoint?

Sure. I think it's too early for us to talk about what that endpoint would be. But I think what you're alluding to is the need to demonstrate that we're having impact on functional outcomes, which are, of course, the whole aim of producing dystrophin and helping us preserve function for boys with DMD. So the endpoints that we will select will reflect that and will be agreed with regulators.

I want to emphasize the significance of our preclinical data for N531, especially in relation to our clinical data, as there is a notable connection between the two. In our preclinical studies involving double knockout mice and nonhuman primates, we observed significantly higher exon skipping in the heart and diaphragm compared to skeletal muscle. Specifically, we noted 53% exon skipping in skeletal muscle, which likely underestimates the exon skipping occurring in heart and diaphragm. This finding sets us apart from other exon skipping therapies currently available or in development. As we consider the potential going forward, we are looking to expand our endpoints beyond just measuring walking and skeletal muscle. We aim to include other endpoints that truly impact the quality of life for boys and may affect mortality. Additionally, I would like to touch on a point related to the previous question concerning GSK. While the focus was on program initiation milestones, it's important to remember that all research phases prior to program initiation are fully funded by GSK. This means we have cash inflows from pre-specified research expenses completely covered by GSK, which will support our discovery research efforts at Wave. This funding complements the initiation payments from the eight programs GSK can launch. I want to clarify that there are additional cash inflows from research payments to Wave before receiving those initiation payments, which is an important distinction to make.

That's helpful. And maybe just one last one on the A1AT study. Just wondering, will you include liver biopsies as part of the trial design in these A1AT patients, in order to assess editing efficiency as well as maybe potential impact on Z protein globules and fibrosis in the liver as well?

Sure. In our initial studies, we will focus on restoring liver function. As you know, our approach involves editing to create an anti-phenotype in patients. Therefore, a reduction of a specific biomarker confirms that we have successfully made the necessary edits.

I think to your question on liver biopsies, the full protocol is being analyzed. But to Anne-Marie's point, I think what we've seen preclinically and clinically, that the most important assessment of whether we are editing is the generation of the desired protein. So we should be able to see that based on our modeling and as part of that clinical trial design. And obviously, that becomes critically important that biomarker, not just for assessment of alpha-1 antitrypsin for the AATD program itself, but really unlocking our GalNAc-conjugated ADAR editing platform and our editing platform more broadly. Thank you, everyone, for joining the call this morning. We made significant progress advancing our pipeline in sustaining our leadership position in RNA editing in the first quarter. And we are grateful to every Wave employee for their dedication and focus on our mission and on the patients and families we serve. Have a great day. Thank you.

Thank you for your participation in today's conference. This does conclude the program. You may now disconnect.