Tekla Capital Management LLC

CIK

1300336

Location

BOSTON, MA

Portfolio Value

Mid $2,314,454,514

Diversification

Diversified

Filing Date

Global Rank

#831 / 6,901 ▼ 47 · as of Jun 2023

Top Industry

Drug Manufacturers - General 35.6%

3Y Alpha vs SPY

-9.0%

Period ended 3 years ago

Filed Aug 10, 2023 · 2y

14 quarters · since Mar 2020

Clone Performance

Jul 2023–Jul 2026 · vs SPY

Hypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.

Cloned portfolio

+40.1%

SPY

+76.0%

Annualised alpha

-8.8%

Max drawdown

−17.3%

Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.

Portfolio Concentration

127 positions · as of Jun 30, 2023 · Δ vs Mar 31, 2023

Top Position

5.9%

+0.2 pts

Top 5

26.0%

+0.4 pts

Top 10

44.5%

+0.4 pts

HHI

273

Diversified−2

Portfolio Trend

14 quarters · across all stocks

Sector Breakdown

As of Jun 30, 2023

Sector	% Portfolio	Value	Positions
Healthcare	98.3%	$2,274,023,744	115
Real Estate	1.7%	$40,430,770	12

Last Quarter's Activity

Export CSV

Jun 30, 2023 vs Mar 31, 2023

Added To

Positions the filer increased

24 positions

Ticker	Company	Δ Shares	Shares	Value
BAX	Baxter International Inc	+257,058	324,370	$14,778,297
IMVT	Immunovant, Inc.	+220,800	336,200	$6,377,714
FULC	Fulcrum Therapeutics, Inc.	+198,351	256,888	$847,730
PCVX	Vaxcyte, Inc.	+189,232	194,232	$9,699,946
MRK	Merck & Co., Inc.	+176,032	728,154	$84,021,690
BSX	Boston Scientific Corp	+91,800	657,790	$35,579,861
AMGN	Amgen Inc	+60,600	616,539	$136,883,988
IQV	Iqvia Holdings Inc.	+46,012	109,129	$24,528,925
LIVN	LivaNova PLC	+44,600	108,480	$5,579,126
APLS	Apellis Pharmaceuticals, Inc.	+38,124	173,248	$15,782,892
DHR	Danaher Corp /De/	+37,123	142,813	$30,385,750
ABBV	AbbVie Inc.	+34,030	545,629	$73,512,595
TCMD	Tactile Systems Technology Inc	+24,040	58,472	$1,457,706
MDGL	Madrigal Pharmaceuticals, Inc.	+21,953	34,434	$7,954,254
MRNA	Moderna, Inc.	+21,478	343,695	$41,758,942
EW	Edwards Lifesciences Corp	+18,451	189,597	$17,884,685
REGN	Regeneron Pharmaceuticals, Inc.	+18,365	161,418	$115,985,289
MEDP	Medpace Holdings, Inc.	+17,483	26,918	$6,464,896
ASND	Ascendis Pharma A/S	+15,000	138,791	$12,387,096
NVO	Novo Nordisk A S	+11,454	122,777	$9,934,500
SYK	Stryker Corp	+9,550	81,128	$24,751,341
BIIB	Biogen Inc.	+7,017	247,943	$70,626,563
TMO	Thermo Fisher Scientific Inc.	+5,282	98,987	$51,646,467
PHG	Koninklijke Philips NV	+4,905	114,765	$2,489,252
No positions match the current search.

Trimmed

Positions the filer reduced

25 positions

Ticker	Company	Δ Shares	Shares	Value
QURE	uniQure N.V.	−296,166	356,280	$4,082,968
BMY	Bristol Myers Squibb Co	−205,298	458,498	$29,320,947
PFE	Pfizer Inc	−150,600	1,624,476	$59,585,779
GH	Guardant Health, Inc.	−126,100	346,084	$12,389,807
SRPT	Sarepta Therapeutics, Inc.	−106,216	179,437	$20,549,125
BMRN	Biomarin Pharmaceutical Inc	−89,300	210,789	$18,271,190
CI	Cigna Group	−86,292	96,339	$27,032,723
ACHC	Acadia Healthcare Company, Inc.	−85,575	100,912	$8,036,631
LLY	ELI LILLY & Co	−75,565	213,352	$100,057,820
ABT	Abbott Laboratories	−71,400	552,455	$60,228,644
EWTX	Edgewise Therapeutics, Inc.	−44,607	150,418	$1,165,739
BCYC	Bicycle Therapeutics PLC	−44,338	44,338	$1,131,505
RMD	Resmed Inc	−38,485	34,704	$7,582,824
CRSP	CRISPR Therapeutics AG	−32,509	22,571	$1,267,135
ISRG	Intuitive Surgical Inc	−28,700	83,980	$28,716,121
UNH	Unitedhealth Group Inc	−27,212	206,961	$99,473,735
GILD	Gilead Sciences, Inc.	−26,000	1,533,884	$118,216,439
NTRA	Natera, Inc.	−24,636	24,636	$1,198,787
ARGX	Argenx SE	−22,757	65,553	$25,547,970
UTHR	UNITED THERAPEUTICS Corp	−19,735	41,465	$9,153,398
XENE	Xenon Pharmaceuticals Inc.	−16,208	67,506	$2,598,981
VRTX	Vertex Pharmaceuticals Inc / Ma	−12,300	318,043	$111,922,512
ILMN	Illumina, Inc.	−11,100	336,979	$61,459,342
CRL	Charles River Laboratories International, Inc.	−6,900	111,183	$23,376,225
HCA	HCA Healthcare, Inc.	−6,300	82,403	$25,007,662
No positions match the current search.

New Positions

Positions the filer opened this quarter

6 positions

Ticker	Company	Shares	Value
PODD	Insulet Corp	43,847	$12,642,843
THC	Tenet Healthcare Corp	149,070	$12,131,316
INSP	Inspire Medical Systems, Inc.	22,018	$7,147,923
AMLX	Amylyx Pharmaceuticals, Inc.	104,007	$2,243,430
XNCR	Xencor Inc	56,675	$1,415,174
ZNTL	Zentalis Pharmaceuticals, Inc.	40,156	$1,132,800
No positions match the current search.

Sold Out

Positions the filer fully exited

11 positions

Ticker	Company	Shares	Value
TVTX	Travere Therapeutics, Inc.	418,520	$9,412,514
LNTH	Lantheus Holdings, Inc.	79,495	$6,563,107
ADUS	Addus HomeCare Corp	42,380	$4,524,488
KURA	Kura Oncology, Inc.	283,281	$3,464,526
RARE	Ultragenyx Pharmaceutical Inc.	67,065	$2,689,306
ARWR	Arrowhead Pharmaceuticals, Inc.	100,422	$2,550,718
SNDX	Syndax Pharmaceuticals Inc	117,717	$2,486,183
ALGN	Align Technology Inc	6,925	$2,313,919
OPCH	Option Care Health, Inc.	64,975	$2,064,255
ZLAB	Zai Lab Ltd	34,640	$1,152,126
BHVN	Biohaven Ltd.	35,087	$479,288
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

127 positions · $2,314,454,514 total · as of Jun 30, 2023

All sectors Healthcare Real Estate

Showing 1–50 of 127 positions by value · page 1 of 3

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
AMGN	Amgen Inc Healthcare	Added	616,539	+60,600	$136,883,988	+1.8%	5.91%
JNJ	Johnson & Johnson Healthcare	Held	721,779	0	$119,468,860	+6.8%	5.16%
GILD	Gilead Sciences, Inc. Healthcare	Reduced	1,533,884	-26,000	$118,216,439	−8.7%	5.11%
REGN	Regeneron Pharmaceuticals, Inc. Healthcare	Added	161,418	+18,365	$115,985,289	−1.3%	5.01%
VRTX	Vertex Pharmaceuticals Inc / Ma Healthcare	Reduced	318,043	-12,300	$111,922,512	+7.5%	4.84%
LLY	ELI LILLY & Co Healthcare	Reduced	213,352	-75,565	$100,057,820	+0.8%	4.32%
UNH	Unitedhealth Group Inc Healthcare	Reduced	206,961	-27,212	$99,473,735	−10.1%	4.30%
MRK	Merck & Co., Inc. Healthcare	Added	728,154	+176,032	$84,021,690	+43.0%	3.63%
ABBV	AbbVie Inc. Healthcare	Added	545,629	+34,030	$73,512,595	−9.8%	3.18%
BIIB	Biogen Inc. Healthcare	Added	247,943	+7,017	$70,626,563	+5.4%	3.05%
ILMN	Illumina, Inc. Healthcare	Reduced	336,979	-11,100	$61,459,342	−21.9%	2.66%
ABT	Abbott Laboratories Healthcare	Reduced	552,455	-71,400	$60,228,644	−4.7%	2.60%
PFE	Pfizer Inc Healthcare	Reduced	1,624,476	-150,600	$59,585,779	−17.7%	2.57%
TMO	Thermo Fisher Scientific Inc. Healthcare	Added	98,987	+5,282	$51,646,467	−4.4%	2.23%
ELV	Elevance Health, Inc. Healthcare	Held	114,070	0	$50,680,160	−3.4%	2.19%
MRNA	Moderna, Inc. Healthcare	Added	343,695	+21,478	$41,758,942	−15.6%	1.80%
BSX	Boston Scientific Corp Healthcare	Added	657,790	+91,800	$35,579,861	+25.7%	1.54%
DHR	Danaher Corp /De/ Healthcare	Added	142,813	+37,123	$30,385,750	+28.7%	1.31%
MDT	Medtronic plc Healthcare	Reduced	344,417	-100	$30,343,137	+9.2%	1.31%
IDXX	Idexx Laboratories Inc /De Healthcare	Held	58,595	0	$29,428,166	+0.4%	1.27%
DXCM	Dexcom Inc Healthcare	Held	228,747	0	$29,396,276	+10.6%	1.27%
BMY	Bristol Myers Squibb Co Healthcare	Reduced	458,498	-205,298	$29,320,947	−36.3%	1.27%
ISRG	Intuitive Surgical Inc Healthcare	Reduced	83,980	-28,700	$28,716,121	−0.2%	1.24%
ALNY	Alnylam Pharmaceuticals, Inc. Healthcare	Held	143,214	0	$27,202,067	−5.2%	1.18%
CI	Cigna Group Healthcare	Reduced	96,339	-86,292	$27,032,723	−42.1%	1.17%
MCK	Mckesson Corp Healthcare	Reduced	61,955	-4,500	$26,473,991	+11.9%	1.14%
ARGX	Argenx SE Healthcare	Reduced	65,553	-22,757	$25,547,970	−22.4%	1.10%
HCA	HCA Healthcare, Inc. Healthcare	Reduced	82,403	-6,300	$25,007,662	+6.9%	1.08%
SYK	Stryker Corp Healthcare	Added	81,128	+9,550	$24,751,341	+21.1%	1.07%
IQV	Iqvia Holdings Inc. Healthcare	Added	109,129	+46,012	$24,528,925	+95.4%	1.06%
ZTS	Zoetis Inc. Healthcare	Held	136,914	0	$23,577,959	+3.5%	1.02%
CRL	Charles River Laboratories International, Inc. Healthcare	Reduced	111,183	-6,900	$23,376,225	−1.9%	1.01%
SRPT	Sarepta Therapeutics, Inc. Healthcare	Reduced	179,437	-106,216	$20,549,125	−47.8%	0.89%
MOH	Molina Healthcare, Inc. Healthcare	Held	61,856	0	$18,633,501	+12.6%	0.81%
JAZZ	Jazz Pharmaceuticals plc Healthcare	Held	147,779	0	$18,320,162	−15.3%	0.79%
BMRN	Biomarin Pharmaceutical Inc Healthcare	Reduced	210,789	-89,300	$18,271,190	−37.4%	0.79%
EW	Edwards Lifesciences Corp Healthcare	Added	189,597	+18,451	$17,884,685	+26.3%	0.77%
HUM	Humana Inc Healthcare	Held	36,794	0	$16,451,701	−7.9%	0.71%
APLS	Apellis Pharmaceuticals, Inc. Healthcare	Added	173,248	+38,124	$15,782,892	+77.1%	0.68%
BAX	Baxter International Inc Healthcare	Added	324,370	+257,058	$14,778,297	+441.3%	0.64%
EXEL	Exelixis, Inc. Healthcare	Held	726,639	0	$13,886,071	−1.5%	0.60%
NVS	Novartis AG Healthcare	Held	136,225	0	$13,746,464	+9.7%	0.59%
PODD	Insulet Corp Healthcare	NEW	43,847	NEW	$12,642,843	NEW	0.55%
GH	Guardant Health, Inc. Healthcare	Reduced	346,084	-126,100	$12,389,807	+11.9%	0.54%
ASND	Ascendis Pharma A/S Healthcare	Added	138,791	+15,000	$12,387,096	−6.7%	0.54%
THC	Tenet Healthcare Corp Healthcare	NEW	149,070	NEW	$12,131,316	NEW	0.52%
BNTX	BioNTech SE Healthcare	Held	103,858	0	$11,209,393	−13.4%	0.48%
NBIX	Neurocrine Biosciences Inc Healthcare	Held	112,908	0	$10,647,224	−6.8%	0.46%
NVO	Novo Nordisk A S Healthcare	Added	122,777	+11,454	$9,934,500	+12.2%	0.43%
ZBH	Zimmer Biomet Holdings, Inc. Healthcare	Held	67,356	0	$9,807,033	+12.7%	0.42%