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APLS

Apellis Pharmaceuticals, Inc.
$41.03 +0.00 (+0.00%) At close · May 15
Market Cap
$5.25B
Shares
128,021,277

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Holders: 327
Total Value: $6,500,053,954
Total Shares: 161,572,313
Showing 1–100 of 345 holdings by value · page 1 of 4

Institutional Ownership Trend

25 quarters

Superinvestors Holding APLS

All superinvestors →
George Soros $42,482,880 Joel Greenblatt $3,168,112 Ray Dalio $1,404,549 Mario Gabelli $844,830

Holder Concentration

Across 326 13F filers · Δ vs Dec 31, 2025
Top Holder
9.9%
Jun 2023 → Mar 2026 · range 9.0% – 13.7%
+0.2 pts
Top 5
35.9%
Jun 2023 → Mar 2026 · range 35.9% – 45.5%
−4.2 pts
Top 10
52.3%
Jun 2023 → Mar 2026 · range 52.3% – 60.8%
−8.3 pts
HHI
376
Jun 2023 → Mar 2026 · range 376 – 534
Broadly held−80

Quarterly Activity

vs Dec 31, 2025
New
125
Increased
92
Decreased
75
Sold Out
82
Unchanged
35
Holder count: +43
Institutional value: +97.5%
Shares held: +23.3%

Top Buyers

vs Dec 31, 2025
Institution Added Now Holds Open
Mega STATE STREET CORP +9,076,575 13,690,021
Mega BlackRock, Inc. +7,276,851 13,536,964
Large Point72 Asset Management, L.P. +3,586,246 4,183,918
Mega UBS Group AG +2,020,459 6,206,681
Mega JPMORGAN CHASE & CO +1,890,173 2,047,927

Top Sellers

vs Dec 31, 2025
Institution Sold Now Holds Open
Mega WELLINGTON MANAGEMENT GROUP LLP −12,471,717 249,635
Large RTW INVESTMENTS, LP −3,981,719 3,685,045
Mid Deep Track Capital, LP −3,217,626 4,532,374
Mega AQR CAPITAL MANAGEMENT LLC −1,848,717 427,970
Mega DEUTSCHE BANK AG\ −1,289,898 95,365

Top New Positions

vs Dec 31, 2025
Institution Acquired Value (USD) Open
— BIOGEN INC. 18,469,475 $743,026,979
Large Pentwater Capital Management LP 5,250,000 $211,207,500
Mega VANGUARD CAPITAL MANAGEMENT LLC 4,768,944 $191,854,617
Mid HBK INVESTMENTS L P 3,550,000 $142,816,500
Mid GLAZER CAPITAL, LLC 1,295,828 $52,131,158

Top Sold-Out Positions

vs Dec 31, 2025
Institution Previously Held Last Value (USD) Open
Mega VANGUARD GROUP INC 10,674,865 $268,152,606
Large Polar Capital Holdings Plc 3,706,510 $93,107,531
Mid Siren, L.L.C. 2,578,396 $64,769,307
Mid ORBIMED ADVISORS LLC 2,429,868 $61,038,284
Mega JENNISON ASSOCIATES LLC 1,504,299 $37,787,990
Filter: New 125 Increased 92 Reduced 75 Sold out 82 Unchanged 35
Showing 100 of 345
All Common Calls Puts
Export CSV
Holder Value (USD) % of 13F Shares Open
— BIOGEN INC. $743,026,979 11.43% 18,469,475
Mega BlackRock, Inc. $544,592,054 8.38% 13,536,964
Large Avoro Capital Advisors LLC $491,699,991 7.56% 12,222,222
Mega MORGAN STANLEY $404,005,708 6.22% 10,042,399
Mega STATE STREET CORP $275,375,597 4.24% 6,845,031
Mega STATE STREET CORP $275,373,947 4.24% 6,844,990
Mega UBS Group AG $249,694,775 3.84% 6,206,681
Large Pentwater Capital Management LP $211,207,500 3.25% 5,250,000
Mega VANGUARD CAPITAL MANAGEMENT LLC $191,854,617 2.95% 4,768,944
Mid Deep Track Capital, LP $182,337,406 2.81% 4,532,374
Large Point72 Asset Management, L.P. $168,319,021 2.59% 4,183,918
Large RTW INVESTMENTS, LP $148,249,360 2.28% 3,685,045
Mid HBK INVESTMENTS L P $142,816,500 2.20% 3,550,000
Mid SUVRETTA CAPITAL MANAGEMENT, LLC $141,548,088 2.18% 3,518,471
Mega MILLENNIUM MANAGEMENT LLC $90,791,144 1.40% 2,256,802
Mega GEODE CAPITAL MANAGEMENT, LLC $83,480,267 1.28% 2,075,075
Mega JPMORGAN CHASE & CO $82,388,102 1.27% 2,047,927
Mega GOLDMAN SACHS GROUP INC $79,661,192 1.23% 1,980,144
Large Balyasny Asset Management L.P. $77,141,065 1.19% 1,917,501
Mega DIMENSIONAL FUND ADVISORS LP $53,867,767 0.83% 1,338,995
Mid GLAZER CAPITAL, LLC $52,065,505 0.80% 1,294,196
Mid TIG Advisors, LLC $50,407,626 0.78% 1,252,986
Large TORONTO DOMINION BANK Bank $49,741,820 0.77% 1,236,436
Large HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND Pension $48,360,483 0.74% 1,202,100
Mega BANK OF AMERICA CORP /DE/ Bank $47,908,458 0.74% 1,190,864
Large Hudson Bay Capital Management LP $47,890,435 0.74% 1,190,416
Mega FIL Ltd $45,862,200 0.71% 1,140,000
Mid Kryger Capital LLC $44,253,000 0.68% 1,100,000
Mid SOROS FUND MANAGEMENT LLC $42,482,880 0.65% 1,056,000
Large CAPITOLIS LIQUID GLOBAL MARKETS LLC $40,773,105 0.63% 1,013,500
Large Woodline Partners LP $39,271,520 0.60% 976,175
Large RENAISSANCE TECHNOLOGIES LLC $37,653,590 0.58% 935,958
Large MARSHALL WACE, LLP $37,374,434 0.57% 929,019
Large Man Group plc $36,838,167 0.57% 915,689
Mega FIRST TRUST ADVISORS LP $36,353,316 0.56% 903,637
Mid Magnetar Financial LLC $34,969,082 0.54% 869,229
Mid ALPINE ASSOCIATES MANAGEMENT INC. $34,758,720 0.53% 864,000
Mid ODDO BHF ASSET MANAGEMENT SAS $33,189,750 0.51% 825,000
Mid Kynam Capital Management, LP $33,189,750 0.51% 825,000
Mega NORTHERN TRUST CORP Bank $29,707,438 0.46% 738,440
Mid Weiss Asset Management LP $28,161,000 0.43% 700,000
Mega CHARLES SCHWAB INVESTMENT MANAGEMENT INC $27,190,008 0.42% 675,864
Mega CITIGROUP INC $26,440,081 0.41% 657,223
Mega VANGUARD FIDUCIARY TRUST CO Bank $26,347,512 0.41% 654,922
Large TUDOR INVESTMENT CORP ET AL $26,149,500 0.40% 650,000
Mega ALLIANCEBERNSTEIN L.P. $25,678,446 0.40% 638,291
Mega BNP PARIBAS ARBITRAGE, SA $23,502,044 0.36% 584,192
Mid OSSIAM $22,365,989 0.34% 555,953
Mega Bank of New York Mellon Corp Bank $21,112,258 0.32% 524,789
Mega TWO SIGMA INVESTMENTS, LP $20,998,651 0.32% 521,965
Mega PRINCIPAL FINANCIAL GROUP INC $20,076,901 0.31% 499,053
Small Absolute Gestao de Investimentos Ltda. $18,103,500 0.28% 450,000
Large Squarepoint Ops LLC $18,095,293 0.28% 449,796
Mega Invesco Ltd. $17,615,427 0.27% 437,868
Mega AQR CAPITAL MANAGEMENT LLC $17,217,231 0.26% 427,970
Large Pictet Asset Management Holding SA $17,171,008 0.26% 426,821
Large LMR Partners LLP $16,237,713 0.25% 403,622
Large Verition Fund Management LLC $16,092,000 0.25% 400,000
Large Public Sector Pension Investment Board Pension $14,751,295 0.23% 366,674
Mid First Trust Capital Management L.P. $14,112,684 0.22% 350,800
Large Clear Street Group Inc. $14,080,500 0.22% 350,000
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $13,681,659 0.21% 340,086
Large GABELLI FUNDS LLC $12,921,876 0.20% 321,200
Small Beck Bode, LLC $12,585,593 0.19% 312,841
Mid METEORA CAPITAL, LLC $12,069,000 0.19% 300,000
Mid Jump Financial, LLC $11,726,562 0.18% 291,488
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $11,288,538 0.17% 280,600
Mega RHUMBLINE ADVISERS $11,084,974 0.17% 275,540
Mega JANUS HENDERSON GROUP PLC $10,143,189 0.16% 252,130
Large CAPSTONE INVESTMENT ADVISORS, LLC $10,057,500 0.15% 250,000
Mid 683 Capital Management, LLC $10,057,500 0.15% 250,000
Mega WELLINGTON MANAGEMENT GROUP LLP $10,042,815 0.15% 249,635
Mid Granite Investment Partners, LLC $9,330,020 0.14% 231,917
Mega Legal & General Group Plc $9,182,697 0.14% 228,255
Mid Westchester Capital Management, LLC $9,151,882 0.14% 227,489
Mega Nuveen, LLC $8,855,185 0.14% 220,114
Large Jefferies Financial Group Inc. $8,810,370 0.14% 219,000
Mega BANK OF MONTREAL /CAN/ Bank $8,651,098 0.13% 215,041
Small SPHERA FUNDS MANAGEMENT LTD. $8,645,990 0.13% 214,914
Mega JANE STREET GROUP, LLC $8,484,507 0.13% 210,900
Large Trexquant Investment LP $8,255,960 0.13% 205,219
Small GABELLI & Co INVESTMENT ADVISERS, INC. $8,070,138 0.12% 200,600
Micro Chicago Capital Management, LLC $7,643,700 0.12% 190,000
Mega D. E. Shaw & Co., Inc. $7,517,096 0.12% 186,853
Mega AMERIPRISE FINANCIAL INC $7,385,342 0.11% 183,578
Mid BOOTHBAY FUND MANAGEMENT, LLC $7,383,090 0.11% 183,522
Large Rafferty Asset Management, LLC $7,260,348 0.11% 180,471
Mid Fiduciary Trust Co Bank $7,247,876 0.11% 180,161
Mega UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC $7,239,505 0.11% 179,953
Small GARDNER LEWIS ASSET MANAGEMENT L P $6,637,950 0.10% 165,000
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $6,581,628 0.10% 163,600
Mid Rock Springs Capital Management LP $6,547,432 0.10% 162,750
Mega JANE STREET GROUP, LLC $6,497,145 0.10% 161,500
Mega CITADEL ADVISORS LLC $6,267,834 0.10% 155,800
Large MACKENZIE FINANCIAL CORP $6,168,465 0.09% 153,330
Mid PICTON MAHONEY ASSET MANAGEMENT $6,034,500 0.09% 150,000
Mega Swiss National Bank Bank $6,014,385 0.09% 149,500
Large Empowered Funds, LLC $5,955,567 0.09% 148,038
Mid AQR Arbitrage LLC $5,897,878 0.09% 146,604
Small Slotnik Capital, LLC $5,431,050 0.08% 135,000
Key facts CIK 1492422 CUSIP 03753U106 13F (30d) 2 filings 2 filers Visit website

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