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Equibles

APLS

Apellis Pharmaceuticals, Inc.

Company with tickers: APLS

CIK
1492422
CUSIP
03753U106
Shares Outstanding
128,021,277
13F Activity (30d)
164 filings 153 filers

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Holders: 312
Total Value: $5,151,588,027
Total Shares: 128,053,398
Showing 1–100 of 329 holdings by value · page 1 of 4

Institutional Ownership Trend

26 quarters

Superinvestors Holding APLS

All superinvestors →
George Soros $42,482,880 Joel Greenblatt $3,168,112 Ray Dalio $1,404,549

Holder Concentration

Across 310 13F filers · Δ vs Dec 31, 2025
Top Holder
11.2%
Sep 2023 → Mar 2026 · range 9.0% – 13.7%
−0.7 pts
Top 5
32.4%
Sep 2023 → Mar 2026 · range 32.4% – 45.5%
−11.5 pts
Top 10
50.2%
Sep 2023 → Mar 2026 · range 50.2% – 60.2%
−8.2 pts
HHI
346
Sep 2023 → Mar 2026 · range 346 – 534
Broadly held−152

Quarterly Activity

vs Dec 31, 2025
New
154
Increased
65
Decreased
60
Sold Out
73
Unchanged
33
Holder count: +81
Institutional value: +426.9%
Shares held: +229.0%

Top Buyers

vs Dec 31, 2025
Institution Added Now Holds Open
Mega STATE STREET CORP +2,231,544 6,844,990
Mega UBS Group AG +2,020,459 6,206,681
Large Man Group plc +771,418 915,689
Mega FIRST TRUST ADVISORS LP +407,690 903,637
Large TUDOR INVESTMENT CORP ET AL +392,300 650,000

Top Sellers

vs Dec 31, 2025
Institution Sold Now Holds Open
Mega DEUTSCHE BANK AG\ −1,289,898 95,365
Large LOS ANGELES CAPITAL MANAGEMENT LLC −865,803 85,913
Large Caption Management, LLC −793,763 127,000
Large SG Americas Securities, LLC −537,445 29,601
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP −517,623 784,286

Top New Positions

vs Dec 31, 2025
Institution Acquired Value (USD) Open
— BIOGEN INC. 18,469,475 $743,026,979
Large Avoro Capital Advisors LLC 12,222,222 $491,699,991
Mega VANGUARD PORTFOLIO MANAGEMENT LLC 5,404,559 $217,425,408
Mega VANGUARD CAPITAL MANAGEMENT LLC 4,768,944 $191,854,617
Mid Deep Track Capital, LP 4,532,374 $182,337,406

Top Sold-Out Positions

vs Dec 31, 2025
Institution Previously Held Last Value (USD) Open
Large Polar Capital Holdings Plc 3,706,510 $93,107,531
Mid Siren, L.L.C. 2,578,396 $64,769,307
Mid Logos Global Management LP 1,000,000 $25,120,000
Small Simplify Asset Management Inc. 538,008 $13,514,760
Large VOLORIDGE INVESTMENT MANAGEMENT, LLC 461,186 $11,584,992
Filter: New 154 Increased 65 Reduced 60 Sold out 73 Unchanged 33
Showing 100 of 329
All Common Calls Puts
Export CSV
Holder Value (USD) % of 13F Shares Open
— BIOGEN INC. $743,026,979 14.42% 18,469,475
Large Avoro Capital Advisors LLC $491,699,991 9.54% 12,222,222
Mega STATE STREET CORP $275,373,947 5.35% 6,844,990
Mega UBS Group AG $249,694,775 4.85% 6,206,681
Mega VANGUARD PORTFOLIO MANAGEMENT LLC $217,425,408 4.22% 5,404,559
Mega VANGUARD CAPITAL MANAGEMENT LLC $191,854,617 3.72% 4,768,944
Mid Deep Track Capital, LP $182,337,406 3.54% 4,532,374
Large Point72 Asset Management, L.P. $168,319,021 3.27% 4,183,918
Large RTW INVESTMENTS, LP $148,249,360 2.88% 3,685,045
Mid HBK INVESTMENTS L P $142,816,500 2.77% 3,550,000
Mid SUVRETTA CAPITAL MANAGEMENT, LLC $141,548,088 2.75% 3,518,471
Mega MILLENNIUM MANAGEMENT LLC $90,791,144 1.76% 2,256,802
Mega GEODE CAPITAL MANAGEMENT, LLC $83,480,267 1.62% 2,075,075
Mega JPMORGAN CHASE & CO $82,388,102 1.60% 2,047,927
Mega GOLDMAN SACHS GROUP INC $79,661,192 1.55% 1,980,144
Large Balyasny Asset Management L.P. $77,141,065 1.50% 1,917,501
Mid GLAZER CAPITAL, LLC $52,065,505 1.01% 1,294,196
Mid TIG Advisors, LLC $50,407,626 0.98% 1,252,986
Large TORONTO DOMINION BANK Bank $49,741,820 0.97% 1,236,436
Large HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND Pension $48,360,483 0.94% 1,202,100
Mega BANK OF AMERICA CORP /DE/ Bank $47,908,458 0.93% 1,190,864
Large Hudson Bay Capital Management LP $47,890,435 0.93% 1,190,416
Mega FIL Ltd $45,862,200 0.89% 1,140,000
Mid Kryger Capital LLC $44,253,000 0.86% 1,100,000
Mid SOROS FUND MANAGEMENT LLC $42,482,880 0.82% 1,056,000
Large CAPITOLIS LIQUID GLOBAL MARKETS LLC $40,773,105 0.79% 1,013,500
Large Woodline Partners LP $39,271,520 0.76% 976,175
Large RENAISSANCE TECHNOLOGIES LLC $37,653,590 0.73% 935,958
Large MARSHALL WACE, LLP $37,374,434 0.73% 929,019
Large Man Group plc $36,838,167 0.72% 915,689
Mega FIRST TRUST ADVISORS LP $36,353,316 0.71% 903,637
Mid Magnetar Financial LLC $34,969,082 0.68% 869,229
Mid ALPINE ASSOCIATES MANAGEMENT INC. $34,758,720 0.67% 864,000
Mid ODDO BHF ASSET MANAGEMENT SAS $33,189,750 0.64% 825,000
Mid Kynam Capital Management, LP $33,189,750 0.64% 825,000
Mega NORTHERN TRUST CORP Bank $29,707,438 0.58% 738,440
Mid Weiss Asset Management LP $28,161,000 0.55% 700,000
Mega CHARLES SCHWAB INVESTMENT MANAGEMENT INC $27,190,008 0.53% 675,864
Mega CITIGROUP INC $26,440,081 0.51% 657,223
Mega VANGUARD FIDUCIARY TRUST CO Bank $26,347,512 0.51% 654,922
Large TUDOR INVESTMENT CORP ET AL $26,149,500 0.51% 650,000
Mega ALLIANCEBERNSTEIN L.P. $25,678,446 0.50% 638,291
Mega BNP PARIBAS ARBITRAGE, SA $23,502,044 0.46% 584,192
Mid OSSIAM $22,365,989 0.43% 555,953
Mega Bank of New York Mellon Corp Bank $21,112,258 0.41% 524,789
Mega TWO SIGMA INVESTMENTS, LP $20,998,651 0.41% 521,965
Mega PRINCIPAL FINANCIAL GROUP INC $20,076,901 0.39% 499,053
Small Absolute Gestao de Investimentos Ltda. $18,103,500 0.35% 450,000
Large Squarepoint Ops LLC $18,095,293 0.35% 449,796
Large Pictet Asset Management Holding SA $17,171,008 0.33% 426,821
Large LMR Partners LLP $16,237,713 0.32% 403,622
Large Verition Fund Management LLC $16,092,000 0.31% 400,000
Large Public Sector Pension Investment Board Pension $14,751,295 0.29% 366,674
Mid First Trust Capital Management L.P. $14,112,684 0.27% 350,800
Large Clear Street Group Inc. $14,080,500 0.27% 350,000
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $13,681,659 0.27% 340,086
Large GABELLI FUNDS LLC $12,921,876 0.25% 321,200
Small Beck Bode, LLC $12,585,593 0.24% 312,841
Mid Jump Financial, LLC $11,726,562 0.23% 291,488
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $11,288,538 0.22% 280,600
Mega RHUMBLINE ADVISERS $11,084,974 0.22% 275,540
Large CAPSTONE INVESTMENT ADVISORS, LLC $10,057,500 0.20% 250,000
Mid 683 Capital Management, LLC $10,057,500 0.20% 250,000
Mega WELLINGTON MANAGEMENT GROUP LLP $10,042,816 0.19% 249,635
Mid Granite Investment Partners, LLC $9,330,020 0.18% 231,917
Mega Legal & General Group Plc $9,182,697 0.18% 228,255
Mid Westchester Capital Management, LLC $9,151,882 0.18% 227,489
Mega Nuveen, LLC $8,855,185 0.17% 220,114
Large Jefferies Financial Group Inc. $8,810,370 0.17% 219,000
Mega BANK OF MONTREAL /CAN/ Bank $8,651,098 0.17% 215,041
Small SPHERA FUNDS MANAGEMENT LTD. $8,645,990 0.17% 214,914
Mega JANE STREET GROUP, LLC $8,484,507 0.16% 210,900
Large Trexquant Investment LP $8,255,960 0.16% 205,219
Small GABELLI & Co INVESTMENT ADVISERS, INC. $8,070,138 0.16% 200,600
Micro Chicago Capital Management, LLC $7,643,700 0.15% 190,000
Mega D. E. Shaw & Co., Inc. $7,517,096 0.15% 186,853
Mid BOOTHBAY FUND MANAGEMENT, LLC $7,383,090 0.14% 183,522
Large Rafferty Asset Management, LLC $7,260,348 0.14% 180,471
Mid Fiduciary Trust Co Bank $7,247,876 0.14% 180,161
Mega UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC $7,239,505 0.14% 179,953
Small GARDNER LEWIS ASSET MANAGEMENT L P $6,637,950 0.13% 165,000
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $6,581,628 0.13% 163,600
Mid Rock Springs Capital Management LP $6,547,432 0.13% 162,750
Mega JANE STREET GROUP, LLC $6,497,145 0.13% 161,500
Mega CITADEL ADVISORS LLC $6,267,834 0.12% 155,800
Large MACKENZIE FINANCIAL CORP $6,168,465 0.12% 153,330
Mid PICTON MAHONEY ASSET MANAGEMENT $6,034,500 0.12% 150,000
Mega Swiss National Bank Bank $6,014,385 0.12% 149,500
Large Empowered Funds, LLC $5,955,567 0.12% 148,038
Mid AQR Arbitrage LLC $5,897,878 0.11% 146,604
Small Slotnik Capital, LLC $5,431,050 0.11% 135,000
Small Twin Securities, Inc. Broker-Dealer $5,126,911 0.10% 127,440
Mega ROYAL BANK OF CANADA Bank $5,097,179 0.10% 126,701
Large Schonfeld Strategic Advisors LLC $4,981,439 0.10% 123,824
Large Quantinno Capital Management LP $4,878,692 0.09% 121,270
Small WATER ISLAND CAPITAL LLC $4,847,715 0.09% 120,500
Mid PRELUDE CAPITAL MANAGEMENT, LLC $4,484,357 0.09% 111,468
Mid Sagefield Capital LP $4,186,534 0.08% 104,065
Mega BARCLAYS PLC $3,955,694 0.08% 98,327
Mid NINE MASTS CAPITAL Ltd $3,921,539 0.08% 97,478

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